Glucocorticoid receptor pathway (Homo sapiens)

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50Growth and apoptosisInflammationTranscriptionTransportOtherTranscriptionSignaltransductionInflammationMetabolismNuclear receptors11111111111111JUNNR3C15NFKB2GenesTATA boxNR3C1NR3C1HSP90AA1GR ligandHSP90AA1NR3C1HSP90AA15, 21NR3C1Ligand5NR3C15LigandLigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGREPTGES3PTGES3PTGES3BHLHE40NAV3IL11AMIGO2SERTAD2ARL5BCXCR7CUL1FGFBP1KTN1SERPINB9CCL2ENC1PTGS2ZIC2PMP2PDE4BPLK2GR inhibitorytarget genesCCL20EDN2MGAMRGS2ALOX5APTSC22D3CDC42EP3SNAI2BIRC3SPINK13SPRY1GADD45BPRRG4FGD4SLC26A2EPB41L4BGPR115PPP1R14CBIRC2GPR153TGFBR3ANGPTL4LRRC8AANKRD1THBDCDKN1CSCNN1ASLC19A2TNFAIP3SRGNSTOMSEC14L1DNAJC15DNERMFGE8ABHD2CPEB4SDPRMT1IPETNK2B3GNT5AKAP13POU5F1TNS4S100PNR1I3NR1I246RXRA4622, 32, 46GR stimulatorytarget genesGrowth and apoptosis11SignaltransductionOther1111


Description

The glucocorticoid receptor (GR, a.k.a. NR3C1) is a nuclear receptor that is activated upon binding of cortisol or glucocorticoids. It mainly regulates gene expression of several groups of genes in two ways. It can stimulate anti-inflammatory genes, or inhibit the transcription of pro-inflammatory genes.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
135147view23:26, 6 August 2024EweitzRemove obsolete "Version" metadata
135146view23:23, 6 August 2024EweitzEconomize layout
135145view23:17, 6 August 2024EweitzRefine alignment
135144view23:15, 6 August 2024EweitzIncrease font size
135143view21:59, 6 August 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
135142view21:57, 6 August 2024EweitzEconomize layout
135141view21:55, 6 August 2024EweitzEconomize layout
135140view21:53, 6 August 2024EweitzEconomize layout
135139view21:48, 6 August 2024EweitzEconomize layout
135138view21:47, 6 August 2024EweitzEconomize layout
117734view12:38, 22 May 2021EweitzModified title
112288view13:15, 9 October 2020Fehrhart
112287view13:14, 9 October 2020Fehrhart
87558view02:13, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87557view02:13, 25 July 2016AlexanderPicoOntology Term : 'glucocorticoid signaling pathway' added !
79615view10:14, 29 March 2015EgonwConverted the 'ligand' labels to DataNode's and gave them ChEBI IDs.
79548view09:53, 25 March 2015FehrhartUpdate of GenIDs and comments
79522view09:45, 24 March 2015Riannefijtenadded reference and changed interaction lines (for X) to graphical elements
79521view09:43, 24 March 2015RiannefijtenModified description
79494view13:39, 23 March 2015RiannefijtenUpdated connections and annotations
78505view10:29, 7 January 2015MaintBotadded missing graphIds
78258view22:21, 17 December 2014KhanspersModified title
78227view15:34, 14 December 2014MaintBotUpdated the GPML schema.
78222view15:26, 14 December 2014MaintBotModified title
78093view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABHD2GeneProductENSG00000140526 (Ensembl Human)
AKAP13GeneProductENSG00000170776 (Ensembl Human)
ALOX5APGeneProductENSG00000132965 (Ensembl Human)
AMIGO2GeneProductENSG00000139211 (Ensembl Human)
ANGPTL4GeneProductENSG00000167772 (Ensembl Human)
ANKRD1GeneProductENSG00000148677 (Ensembl Human)
ARL5BGeneProductENSG00000165997 (Ensembl Human)
B3GNT5GeneProductENSG00000176597 (Ensembl Human)
BHLHE40GeneProductENSG00000134107 (Ensembl Human)
BIRC2GeneProductENSG00000110330 (Ensembl Human)
BIRC3GeneProductENSG00000023445 (Ensembl Human)
CCL20GeneProductENSG00000115009 (Ensembl Human)
CCL2GeneProductENSG00000108691 (Ensembl Human)
CDC42EP3GeneProductENSG00000163171 (Ensembl Human)
CDKN1CGeneProductENSG00000129757 (Ensembl Human)
CPEB4GeneProductENSG00000113742 (Ensembl Human)
CUL1GeneProductENSG00000055130 (Ensembl Human)
CXCR7GeneProductENSG00000144476 (Ensembl Human)
DNAJC15GeneProductENSG00000120675 (Ensembl Human)
DNERGeneProductENSG00000187957 (Ensembl Human)
EDN2GeneProductENSG00000127129 (Ensembl Human)
ENC1GeneProductENSG00000171617 (Ensembl Human)
EPB41L4BGeneProductENSG00000095203 (Ensembl Human)
ETNK2GeneProductENSG00000143845 (Ensembl Human)
FGD4GeneProductENSG00000139132 (Ensembl Human)
FGFBP1GeneProductENSG00000137440 (Ensembl Human)
GADD45BGeneProductENSG00000099860 (Ensembl Human)
GPR115GeneProductENSG00000153294 (Ensembl Human)
GPR153GeneProductENSG00000158292 (Ensembl Human)
HSP90AA1GeneProductENSG00000080824 (Ensembl Human)
IL11GeneProductENSG00000095752 (Ensembl Human)
JUNGeneProductENSG00000177606 (Ensembl Human)
KTN1GeneProductENSG00000126777 (Ensembl Human)
LRRC8AGeneProductENSG00000136802 (Ensembl Human)
MFGE8GeneProductENSG00000140545 (Ensembl Human)
MGAMGeneProductENSG00000179087 (Ensembl Human)
MT1IPGeneProduct644314 (Entrez Gene)
NAV3GeneProductENSG00000067798 (Ensembl Human)
NFKB2GeneProductENSG00000077150 (Ensembl Human)
NR1I2GeneProductENSG00000144852 (Ensembl Human)
NR1I3GeneProductENSG00000143257 (Ensembl Human)
NR3C1GeneProductENSG00000113580 (Ensembl Human)
PDE4BGeneProductENSG00000184588 (Ensembl Human)
PLK2GeneProductENSG00000145632 (Ensembl Human)
PMP2GeneProductENSG00000147588 (Ensembl Human)
POU5F1GeneProductENSG00000204531 (Ensembl Human)
PPP1R14CGeneProductENSG00000198729 (Ensembl Human)
PRRG4GeneProductENSG00000135378 (Ensembl Human)
PTGES3GeneProductENSG00000110958 (Ensembl Human)
PTGS2GeneProductENSG00000073756 (Ensembl Human)
RGS2GeneProductENSG00000116741 (Ensembl Human)
RXRAGeneProductENSG00000186350 (Ensembl Human)
S100PGeneProductENSG00000163993 (Ensembl Human)
SCNN1AGeneProductENSG00000111319 (Ensembl Human)
SDPRGeneProductENSG00000168497 (Ensembl Human)
SEC14L1GeneProductENSG00000129657 (Ensembl Human)
SERPINB9GeneProductENSG00000170542 (Ensembl Human)
SERTAD2GeneProductENSG00000179833 (Ensembl Human)
SLC19A2GeneProductENSG00000117479 (Ensembl Human)
SLC26A2GeneProductENSG00000155850 (Ensembl Human)
SNAI2GeneProductENSG00000019549 (Ensembl Human)
SPINK13GeneProductENSG00000214510 (Ensembl Human)
SPRY1GeneProductENSG00000164056 (Ensembl Human)
SRGNGeneProductENSG00000122862 (Ensembl Human)
STOMGeneProductENSG00000148175 (Ensembl Human)
TGFBR3GeneProductENSG00000069702 (Ensembl Human)
THBDGeneProductENSG00000178726 (Ensembl Human)
TNFAIP3GeneProductENSG00000118503 (Ensembl Human)
TNS4GeneProductENSG00000131746 (Ensembl Human)
TSC22D3GeneProductENSG00000157514 (Ensembl Human)
ZIC2GeneProductENSG00000043355 (Ensembl Human)

Annotated Interactions

No annotated interactions

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