Complement and coagulation cascades (Rattus norvegicus)
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Cross-linked
Muscle contraction,
Chemotaxis,
Phagocyte recruitment,
Inflammation, etc.
C4a
Cell adhesion,
migration,
proliferation, etc.
Cell adhesion,
migration,
proliferation, etc.
membrane attack complex
Collagen,
basement membrane,
activated platelets, etc.
Complement Cascade
C3b/Bb
Lectin Pathway
Degredation
Coagulation Cascade
fibrin polymer
Alternative Pathway
Antibody/antigen
complex
Extrinsic pathway
Clot
Kinin kallikrein system
C5a
Cell lysis
Vascular injury
Fibrinolytic system
C3b
Zymosan
insulin, etc.
Fibrin
monomer
Mediators
Classical Pathway
C3
Convertase
Platelet, monocyte,
lymphocyte,
endothelial cells,
smooth muscle cells
activation etc.
C3a
C3b/4b, C3b, C3d
C4b/2a
fibrin degredation
products
F2
Kng1
Plat
Plg
C3
Mcp
Mbl1
C6
C2
F13b
Thbd
Serpinf2
Serpine1
A2m
Cfi
C8b
F7
Serpind1
H2-Bf
C3ar1
Masp2
Crry
Cfh
F9
Hc
Plaur
Fgb
C7
C1s
C9
F10
Serpina1
C1qg
C4bp
Tfpi
Bdkrb1
C5r1
Serpinc1
Cd59
Serpina5
C1qb
F5
RGD:727845
F2r
Proc
RGD:621759
Plau
Crry
Klkb1
Pros1
F3
C1qa
Cr2
F11
RGD:735225
Daf2
Cpb2
Masp1
Daf1
C4a
Bradykinin
Adn
F12
C1r
Description
No description
Comments
GenMAPP notes
http://www.genome.jp/dbget-bin/get
pathway?org name=mmu&mapno=04610
GenMAPP remarks
Adapted from KEGG (see notes)
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Quality Tags
Ontology Terms
Saving...
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Bibliography
No bibliography
History
View all...
Compare
Revision
Action
Time
User
Comment
116949
view
10:05, 16 May 2021
Eweitz
Modified title
106999
view
13:45, 17 September 2019
MaintBot
HMDB identifier normalization
91912
view
21:08, 3 April 2017
Khanspers
Modified description
91911
view
21:07, 3 April 2017
Khanspers
removed GenMAPP comments
83032
view
02:42, 18 November 2015
Mkutmon
fix outdated identifier
79832
view
09:22, 17 April 2015
Egonw
Replaced a gene name with its Entrez Gene identifier.
79658
view
17:51, 1 April 2015
Khanspers
replacing non-numeric Entrez
69384
view
18:57, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67785
view
15:14, 26 June 2013
Ddigles
Ontology Term : 'complement system pathway' added !
67125
view
10:09, 26 June 2013
Christine Chichester
Ontology Term : 'coagulation cascade pathway' added !
41700
view
02:37, 2 March 2011
MaintBot
Removed redundant pathway information and comments
38702
view
19:27, 23 September 2010
AlexanderPico
34319
view
22:12, 9 December 2009
Khanspers
Added connectors
34313
view
22:09, 9 December 2009
Khanspers
Periodical save, work in progress
34283
view
21:59, 9 December 2009
Khanspers
Periodical save, work in progress
34254
view
21:48, 9 December 2009
Khanspers
Periodical save, work in progress
34230
view
21:37, 9 December 2009
Khanspers
Periodical save, work in progress
22596
view
13:44, 14 November 2008
Thomas
Changed pathway title (was duplicate of WP81)
21830
view
11:32, 14 November 2008
MaintBot
[[Pathway:Rattus norvegicus:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:WP547]]: Moved to stable identifier
7976
view
13:46, 7 January 2008
MaintBot
[[Pathway:Rat:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:Rattus norvegicus:Complement and Coagulation Cascades KEGG]]: Renaming species
7612
view
16:04, 18 December 2007
MaintBot
fixed category names
7469
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
6528
view
22:19, 22 May 2007
169.230.77.174
gpml file for [[Rat:Complement_and_Coagulation_Cascades_KEGG]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
A2m
GeneProduct
24153 (Entrez Gene)
Adn
GeneProduct
54249 (Entrez Gene)
Bdkrb1
GeneProduct
81509 (Entrez Gene)
Bradykinin
Metabolite
HMDB04246 (HMDB)
C1qa
GeneProduct
298566 (Entrez Gene)
C1qb
GeneProduct
29687 (Entrez Gene)
C1qg
GeneProduct
362634 (Entrez Gene)
C1r
GeneProduct
312705 (Entrez Gene)
C1s
GeneProduct
192262 (Entrez Gene)
C2
GeneProduct
24231 (Entrez Gene)
C3
GeneProduct
24232 (Entrez Gene)
C3ar1
GeneProduct
84007 (Entrez Gene)
C4a
GeneProduct
24233 (Entrez Gene)
C4bp
GeneProduct
24234 (Entrez Gene)
C5r1
GeneProduct
113959 (Entrez Gene)
C6
GeneProduct
24237 (Entrez Gene)
C7
GeneProduct
117517 (Entrez Gene)
C8b
GeneProduct
313421 (Entrez Gene)
C9
GeneProduct
117512 (Entrez Gene)
Cd59
GeneProduct
25407 (Entrez Gene)
Cfh
GeneProduct
155012 (Entrez Gene)
Cfi
GeneProduct
79126 (Entrez Gene)
Cpb2
GeneProduct
113936 (Entrez Gene)
Cr2
GeneProduct
289395 (Entrez Gene)
Crry
GeneProduct
54243 (Entrez Gene)
Daf1
GeneProduct
64036 (Entrez Gene)
Daf2
GeneProduct
F10
GeneProduct
29243 (Entrez Gene)
F11
GeneProduct
290757 (Entrez Gene)
F12
GeneProduct
306761 (Entrez Gene)
F13b
GeneProduct
289055 (Entrez Gene)
F2
GeneProduct
29251 (Entrez Gene)
F2r
GeneProduct
25439 (Entrez Gene)
F3
GeneProduct
25584 (Entrez Gene)
F5
GeneProduct
304929 (Entrez Gene)
F7
GeneProduct
260320 (Entrez Gene)
F9
GeneProduct
24946 (Entrez Gene)
Fgb
GeneProduct
24366 (Entrez Gene)
H2-Bf
GeneProduct
294257 (Entrez Gene)
Hc
GeneProduct
24441 (Entrez Gene)
Klkb1
GeneProduct
25048 (Entrez Gene)
Kng1
GeneProduct
24903 (Entrez Gene)
Masp1
GeneProduct
64023 (Entrez Gene)
Masp2
GeneProduct
64459 (Entrez Gene)
Mbl1
GeneProduct
24548 (Entrez Gene)
Mcp
GeneProduct
29333 (Entrez Gene)
Plat
GeneProduct
25692 (Entrez Gene)
Plau
GeneProduct
25619 (Entrez Gene)
Plaur
GeneProduct
50692 (Entrez Gene)
Plg
GeneProduct
85253 (Entrez Gene)
Proc
GeneProduct
25268 (Entrez Gene)
Pros1
GeneProduct
81750 (Entrez Gene)
RGD:621759
GeneProduct
116669 (Entrez Gene)
RGD:727845
GeneProduct
302470 (Entrez Gene)
RGD:735225
GeneProduct
295703 (Entrez Gene)
Serpina1
GeneProduct
24648 (Entrez Gene)
Serpina5
GeneProduct
65051 (Entrez Gene)
Serpinc1
GeneProduct
304917 (Entrez Gene)
Serpind1
GeneProduct
79224 (Entrez Gene)
Serpine1
GeneProduct
24617 (Entrez Gene)
Serpinf2
GeneProduct
287527 (Entrez Gene)
Tfpi
GeneProduct
29436 (Entrez Gene)
Thbd
GeneProduct
83580 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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DataNodes
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No annotated interactions