Overview of nanoparticle effects (Homo sapiens)

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5, 13Astrocytesdepletion in hepatocytes4COX2 (PTGS2)CytoskeletonlamininTNF-a SignalingTNF-acollagen IVPI3KMetallothionein NanoparticleDNA damage responseCell adhesionCell deathProstaglandin NecrotopsisIL-6Bcl-2NF-kBAngiogenesisfibronectinMitochondria potentialCoronary heart disease, plaques, DICApoptosisEndocytosisExocytosisPhagocytosisDifferentiationAcute lung effects: hypercoagulation, hypofibrinolysis, etc.ActinDNA damageIl-6 signalingImmune systemup or down regulationOxidative stressGlutathione Cell cycleProstaglandin pathwayMigrationGenotoxicity / CancerCOX1 (PTGS1)FAK (PTK2)ferritin C-reactive proteinInflammationNecrosisAKTP-cadherincyclin D3Il-8HMOX1IntegrinAutophagic cell deathBlood coagulationBax159, 1251, 1581831032, 146, 11313, 19171, 7, 1683


Description

This pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle specific effect known, there is a cascade of effects triggered if cells or organisms are exposed to nanoparticles: The most abundantly observed event is oxidative stress which causes DNA damage, protein and lipid oxidation, and cell death. The mere overload of nanoparticles in the vesicular system lead to cytoskeleton and cell adhesion problems and interfere with the cells autophagic system. Some specific nanoparticles are reported to interfere with the cell membrane, others stimulate the blood coagulation system. The release of metal ions from specific nanoparticles challenges the metal disposal system of the cell.

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Bibliography

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  1. Zolnik BS, Gonzalez-Fernandez A, Sadrieh N, Dobrovolskaia MA; ''Nanoparticles and the immune system.''; Endocrinology, 2010 PubMed Europe PMC Scholia
  2. Chen T, Hu J, Chen C, Pu J, Cui X, Jia G; ''Cardiovascular effects of pulmonary exposure to titanium dioxide nanoparticles in ApoE knockout mice.''; J Nanosci Nanotechnol, 2013 PubMed Europe PMC Scholia
  3. Li JG, Li WX, Xu JY, Cai XQ, Liu RL, Li YJ, Zhao QF, Li QN; ''Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation.''; Environ Toxicol, 2007 PubMed Europe PMC Scholia
  4. Triboulet S, Aude-Garcia C, Carriere M, Diemer H, Proamer F, Habert A, Chevallet M, Collin-Faure V, Strub JM, Hanau D, Van Dorsselaer A, Herlin-Boime N, Rabilloud T; ''Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses.''; Mol Cell Proteomics, 2013 PubMed Europe PMC Scholia
  5. Nel A, Xia T, Maedler L, Li N; ''Toxic potential of materials at the nanolevel.''; Science, 2006 PubMed Europe PMC Scholia
  6. Ilinskaya AN, Dobrovolskaia MA; ''Immunosuppressive and anti-inflammatory properties of engineered nanomaterials.''; Br J Pharmacol, 2014 PubMed Europe PMC Scholia
  7. Hohnholt MC, Geppert M, Luther EM, Petters C, Bulcke F, Dringen R; ''Handling of iron oxide and silver nanoparticles by astrocytes.''; Neurochem Res, 2013 PubMed Europe PMC Scholia
  8. Nawrot TS, Perez L, Kuenzli N, Munters E, Nemery B; ''Public health importance of triggers of myocardial infarction: a comparative risk assessment.''; Lancet, 2011 PubMed Europe PMC Scholia
  9. Johnson-Lyles DN, Peifley K, Lockett S, Neun BW, Hansen M, Clogston J, Stern ST, McNeil SE; ''Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction.''; Toxicol Appl Pharmacol, 2010 PubMed Europe PMC Scholia
  10. Ma YH, Huang CP, Tsai JS, Shen MY, Li YK, Lin LY; ''Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway.''; Toxicol Lett, 2011 PubMed Europe PMC Scholia
  11. Rauch J, Kolch W, Laurent S, Mahmoudi M; ''Big signals from small particles: regulation of cell signaling pathways by nanoparticles.''; Chem Rev, 2013 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
121705view04:38, 26 February 2022EweitzUse gene symbol
118405view14:13, 27 May 2021Mkutmonfix publication refs
113822view16:55, 28 November 2020EgonwChanged to use rounded rectangles
110681view13:07, 28 May 2020Fehrhartgave nanoparticle a class and ID
107141view14:22, 17 September 2019MaintBotChEBI identifier normalization
89371view06:15, 10 September 2016EgonwConnected lines.
88835view13:18, 15 August 2016Fehrhartconnecting unconnected lines
88266view14:32, 1 August 2016FehrhartOntology Term : 'nanomaterial response pathway' added !
87252view13:14, 20 July 2016LindarieswijkChanged necroptosis instead of necrotopsis
84570view12:23, 3 March 2016Mkutmonfix literature references
84569view12:18, 3 March 2016Mkutmonadded missing graph ids
82926view12:57, 13 November 2015FehrhartAdded identifiers (now complete, except nanoparticle)
82925view12:51, 13 November 2015FehrhartAdded identifiers
82924view10:27, 13 November 2015FehrhartAdded identifiers
80967view11:41, 6 July 2015MkutmonModified title
80961view12:25, 2 July 2015FehrhartModified description
80960view12:20, 2 July 2015FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTGeneProductENSG00000117020 (Ensembl)
ActinGeneProduct
Acute lung effects: hypercoagulation, hypofibrinolysis, etc.
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP2507 (WikiPathways)
Autophagic cell deathPathwayWP2509 (WikiPathways)
BaxGeneProductENSG00000087088 (Ensembl)
Bcl-2GeneProductENSG00000171791 (Ensembl)
Blood coagulationPathwayWP558 (WikiPathways)
C-reactive proteinGeneProductENSG00000132693 (Ensembl)
COX1 (PTGS1)GeneProductENSG00000095303 (Ensembl)
COX2 (PTGS2)GeneProductENSG00000073756 (Ensembl)
Cell adhesionPathwayWP306 (WikiPathways)
Cell cyclePathwayWP179 (WikiPathways)
Cell death
Coronary heart disease, plaques, DIC
CytoskeletonPathwayWP51 (WikiPathways)
DNA damage
DNA damage responsePathwayWP707 (WikiPathways)
DifferentiationPathway
Endocytosis

Exocytosis

Phagocytosis		Pathway
FAK (PTK2)GeneProductENSG00000169398 (Ensembl)
Genotoxicity / Cancer
Glutathione Metabolite16856 (ChEBI)
HMOX1GeneProductENSG00000100292 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
Il-6 signalingPathwayWP364 (WikiPathways)
Il-8GeneProductENSG00000169429 (Ensembl)
Immune system up or down regulationPathwayWP2783 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
IntegrinGeneProduct
Metallothionein GeneProduct
MigrationPathway
Mitochondria potential
NF-kBGeneProductENSG00000170322 (Ensembl)
Nanoparticle
NecrosisPathwayWP2513 (WikiPathways)
NecrotopsisPathwayWP2513 (WikiPathways)
Oxidative stressPathwayWP408 (WikiPathways)
P-cadherinGeneProductENSG00000062038 (Ensembl)
PI3KGeneProductENSG00000171608 (Ensembl)
Prostaglandin Metabolite
Prostaglandin pathwayPathwayWP98 (WikiPathways)
TNF-a SignalingPathwayWP231 (WikiPathways)
TNF-aGeneProductENSG00000232810 (Ensembl)
collagen IVGeneProduct
cyclin D3GeneProductENSG00000112576 (Ensembl)
ferritin GeneProduct
fibronectinGeneProduct
lamininGeneProduct

Annotated Interactions

No annotated interactions

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