Vascular smooth muscle contraction (Bos taurus)

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Intravasal pressure/stretchReduction of intracellular Ca2+ concentrationVasoconstrictorsHyperpolarizationContractionReduction of contractile system Ca2+ sensitivity-pCrossbreidgeMyofilamentsDepolarization+pRELAXCATION+pphospholipase A2RAMP3ANPMHCACTA2KCNMB4CALML6CNPGUCY1A2GNAQCGRPITPR3DAGCALMPLA2G12AADRA1AADORA2BPLA2G1BPRKACACACNA1CADCY6IP3Calcium signal PathwayPLCB2PLA2G4AADCY5ARAFBRAFAngiotensin IIEETArachidonic acid metabolismADCY8ADCY2ITPR1PLCB3PRKACBphospholipase A2PKGPGI2AVPR1BPLCB1Ca2+ADCY1MYL6IRAGPPP1R12CAdenosinePLA2G2AcGMPMYLKMYLK4GNA11GNA13KCNU1GUCY1B3CYP4A11PLA2G3KCNMA120-HETERAMP1PRKCHPLA2G4DPLA2G12BCALCRLvasopressinITPR2NOPRKCBPRKCDCACNA1FCa2+K+NPR-AAGTR1CALM1ARHGEF12ADRA1DGNA12EndothelinAVPR1APLA2G2CGUCY1A3PLCB4ADCY9PLA2G2D1CPI-17KCNMB3ADCY3MYL6BCAMPPRKCGArachidonateKCNMB1RAMP2PRKCAADCY7MAPK3KCNMB2CYP4A22ROCK1PLA2G2ACALM3PPP1CAADCY4PPP1R12BACTG2CACNA1SPLA2G2FMAP2K1CALML5PLA2G2EMYLK3CaDPPP1CBNorepinephrineROCK2RhOAPPP1CCMYL9PLA2G4EARHGEF11PLA2G4BGsADRA1BCALM2ADORA2ACa2+CACNA1DPRKCQARHGEF1PLA2G4FMAP2K2MAPK1PTGIRPLA2G2D4AdrenomedullinPLA2G10PRKXPRKCEPLA2G5MYLK2K+BNPPLA2G6NPR-BEDNRARAF1PPP1R12ACACNA1FCACNA1DCACNA1SCACNA1CKCNMB2KCNU1KCNMB3KCNMB4KCNMB1KCNMA1ITPR2ITPR1ITPR3MYLK2MYLKMYLK4MYLK3MyosinACTG2MYL6MHCMYL9ACTA2MYL6BMyosinPPP1CCPPP1CBPPP1R12CPPP1CAPPP1R12BPPP1R12AVasodilators+p+p+p+p+p+p+p+p-p


Description

Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. The main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to high blood pressure, while excessive vasodilation as in shock leads to low blood pressure (http://en.wikipedia.org/wiki/Vascular_smooth_muscle).

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History

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CompareRevisionActionTimeUserComment
107057view14:14, 17 September 2019MaintBotChEBI identifier normalization
87857view11:54, 25 July 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
82870view16:22, 10 November 2015JmeliusCorrect outdated id
80970view12:08, 6 July 2015Mkutmonfixed graphid problem
80968view12:00, 6 July 2015Mkutmonfixed unconnected lines
79750view08:51, 9 April 2015Zarichanged identyfier for CACNA1C
79732view11:42, 7 April 2015ZariModified description
79731view11:34, 7 April 2015ZariNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
20-HETEMetabolite34306 (ChEBI)
ACTA2GeneProduct515610 (Entrez Gene)
ACTG2GeneProduct281595 (Entrez Gene)
ADCY1GeneProduct281601 (Entrez Gene)
ADCY2GeneProduct510708 (Entrez Gene)
ADCY3GeneProduct535603 (Entrez Gene)
ADCY4GeneProduct788151 (Entrez Gene)
ADCY5GeneProduct505740 (Entrez Gene)
ADCY6GeneProduct509936 (Entrez Gene)
ADCY7GeneProduct281603 (Entrez Gene)
ADCY8GeneProduct535017 (Entrez Gene)
ADCY9GeneProduct525482 (Entrez Gene)
ADORA2AGeneProduct617828 (Entrez Gene)
ADORA2BGeneProduct529760 (Entrez Gene)
ADRA1AGeneProduct282134 (Entrez Gene)
ADRA1BGeneProduct407140 (Entrez Gene)
ADRA1DGeneProduct539543 (Entrez Gene)
AGTR1GeneProduct281607 (Entrez Gene)
ANPMetabolite80233 (ChEBI)
ARAFGeneProduct540421 (Entrez Gene)
ARHGEF11GeneProduct511220 (Entrez Gene)
ARHGEF12GeneProduct503575 (Entrez Gene)
ARHGEF1GeneProduct513377 (Entrez Gene)
AVPR1AGeneProduct538439 (Entrez Gene)
AVPR1BGeneProduct282861 (Entrez Gene)
AdenosineMetabolite
AdrenomedullinMetabolite80339 (ChEBI)
Angiotensin IIMetabolite2719 (ChEBI)
ArachidonateMetabolite15843 (ChEBI)
Arachidonic acid metabolismPathway
BNPMetabolite80234 (ChEBI)
BRAFGeneProduct536051 (Entrez Gene)
CACNA1CGeneProduct408015 (Entrez Gene)
CACNA1CGeneProductENSBTAG00000010660 (Ensembl)
CACNA1DGeneProduct408013 (Entrez Gene)
CACNA1FGeneProduct509779 (Entrez Gene)
CACNA1SGeneProduct100337204 (Entrez Gene)
CALCRLGeneProduct527140 (Entrez Gene)
CALM1GeneProduct617095 (Entrez Gene)
CALM2GeneProduct100297344 (Entrez Gene)
CALMGeneProduct326597 (Entrez Gene)
CALM3GeneProduct520277 (Entrez Gene)
CALML5GeneProduct520404 (Entrez Gene)
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CAMPMetabolite17489 (ChEBI)
CGRPMetabolite80337 (ChEBI)
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CPI-17GeneProduct615348 (Entrez Gene)
CYP4A11GeneProduct511890 (Entrez Gene)
CYP4A22GeneProduct516085 (Entrez Gene)
Ca2+Metabolite29108 (ChEBI)
Ca2+Metabolite29108 (ChEBI)
CaDGeneProduct281660 (Entrez Gene)
Calcium signal PathwayPathway
DAGMetabolite18035 (ChEBI)
EDNRAGeneProduct281749 (Entrez Gene)
EETMetabolite34157 (ChEBI)
EndothelinMetabolite80240 (ChEBI)
GNA11GeneProduct281788 (Entrez Gene)
GNA12GeneProduct515159 (Entrez Gene)
GNA13GeneProduct505611 (Entrez Gene)
GNAQGeneProduct536654 (Entrez Gene)
GUCY1A2GeneProduct613600 (Entrez Gene)
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GUCY1B3GeneProduct282433 (Entrez Gene)
GsGeneProduct281793 (Entrez Gene)
IP3Metabolite16595 (ChEBI)
IRAGGeneProduct281918 (Entrez Gene)
ITPR1GeneProduct317697 (Entrez Gene)
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K+Metabolite29103 (ChEBI)
KCNMA1GeneProduct282573 (Entrez Gene)
KCNMB1GeneProduct407176 (Entrez Gene)
KCNMB2GeneProduct534568 (Entrez Gene)
KCNMB3GeneProduct539609 (Entrez Gene)
KCNMB4GeneProduct520448 (Entrez Gene)
KCNU1GeneProduct524144 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
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MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MHCGeneProduct
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MYL6BGeneProduct515421 (Entrez Gene)
MYL9GeneProduct505964 (Entrez Gene)
MYLK2GeneProduct533378 (Entrez Gene)
MYLKGeneProduct338037 (Entrez Gene)
MYLK3GeneProduct526379 (Entrez Gene)
MYLK4GeneProduct518025 (Entrez Gene)
NOMetabolite16480 (ChEBI)
NPR-AGeneProduct533048 (Entrez Gene)
NPR-BGeneProduct281357 (Entrez Gene)
NorepinephrineMetabolite18357 (ChEBI)
PGI2Metabolite15552 (ChEBI)
PKGGeneProduct
PLA2G10GeneProduct613966 (Entrez Gene)
PLA2G12AGeneProduct527214 (Entrez Gene)
PLA2G12BGeneProduct100337447 (Entrez Gene)
PLA2G1BGeneProduct282457 (Entrez Gene)
PLA2G2AGeneProduct507201 (Entrez Gene)
PLA2G2AGeneProduct521383 (Entrez Gene)
PLA2G2CGeneProduct504978 (Entrez Gene)
PLA2G2D1GeneProduct494318 (Entrez Gene)
PLA2G2D4GeneProduct503625 (Entrez Gene)
PLA2G2EGeneProduct506243 (Entrez Gene)
PLA2G2FGeneProduct541294 (Entrez Gene)
PLA2G3GeneProduct527631 (Entrez Gene)
PLA2G4AGeneProduct525072 (Entrez Gene)
PLA2G4BGeneProduct505485 (Entrez Gene)
PLA2G4DGeneProduct531209 (Entrez Gene)
PLA2G4EGeneProduct526364 (Entrez Gene)
PLA2G4FGeneProduct522866 (Entrez Gene)
PLA2G5GeneProduct614911 (Entrez Gene)
PLA2G6GeneProduct535381 (Entrez Gene)
PLCB1GeneProduct287026 (Entrez Gene)
PLCB2GeneProduct508888 (Entrez Gene)
PLCB3GeneProduct515669 (Entrez Gene)
PLCB4GeneProduct281985 (Entrez Gene)
PPP1CAGeneProduct516175 (Entrez Gene)
PPP1CBGeneProduct538829 (Entrez Gene)
PPP1CCGeneProduct282318 (Entrez Gene)
PPP1R12AGeneProduct538606 (Entrez Gene)
PPP1R12BGeneProduct100337338 (Entrez Gene)
PPP1R12BGeneProductENSBTAG00000011772 (Ensembl)
PPP1R12CGeneProduct512431 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKACBGeneProduct282323 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKXGeneProduct505773 (Entrez Gene)
PTGIRGeneProduct520278 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAMP1GeneProduct617017 (Entrez Gene)
RAMP2GeneProduct504230 (Entrez Gene)
RAMP3GeneProduct613547 (Entrez Gene)
ROCK1GeneProduct785911 (Entrez Gene)
ROCK2GeneProduct282041 (Entrez Gene)
RhOAGeneProduct338049 (Entrez Gene)
cGMPMetabolite16356 (ChEBI)
phospholipase A2GeneProduct104974671 (Entrez Gene)
phospholipase A2GeneProduct615045 (Entrez Gene)
vasopressinMetabolite34543 (ChEBI)

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