Histidine biosynthesis I (Oryza sativa)

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1cytosolplastid stromaH2Ophosphoribulosylformimino-AICAR-PL-histidinol-phosphateimidazoleacetol-phosphateD-erythro-imidazole-glycerol-phosphatephosphoribosyl-AMPNADHphosphoribosylformiminoAICAR-phosphateNAD+histidinoldehydrogenase(LOC_OS01G13190.1)L-GluL-histidinalH2Ohistidinoldehydrogenase(LOC_OS01G13190.1)NAD+2OGNADHH2OL-GlnH2OATPphosphoribosyltransferase(LOC_OS03G04169.1)ATPPiPPiimidazoleglycerol-phosphatedehydratase(LOC_OS04G52710.1)L-GluH2Ophosphoribosyl-ATPphosphoribosyl-ATPpyrophosphohydrolase(LOC_OS01G16940.1)phosphoribosyl-ATPpyrophosphohydrolase(LOC_OS01G16940.1)L-HisPPiPRPP1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase(LOC_OS05G33260.1)inositol-phosphatephosphatase(LOC_OS07G09330.1)histidinol-phosphatetransferase(LOC_OS02G47940.1)AICARL-histidinol1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase(LOC_OS05G33260.1)


Description

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Ontology Terms

 

Bibliography

  1. Stepansky A, Leustek T.; ''Histidine biosynthesis in plants.''; PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
118307view12:16, 26 May 2021EweitzModified title
82112view14:43, 8 September 2015Anweshafixing title, data source, & tagging incomplete pathways
80529view14:49, 25 June 2015AnweshaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide

isomerase

(LOC_OS05G33260.1)
ProteinB8AY22 (Uniprot-TrEMBL) Facilitates the conversion of phosphoribulosylformimino-AICAR-P to D-erythro-imidazole-glycerol-phosphate.
2OGMetaboliteCHEBI:30915 (ChEBI)
AICARMetaboliteCHEBI:18406 (ChEBI)
ATP

phosphoribosyltransferase

(LOC_OS03G04169.1)
ProteinQ10S55 (Uniprot-TrEMBL) Facilitates the conversion of 5-phosphoribosyl 1-pyrophosphate to phosphoribosyl-ATP.
ATPMetaboliteCHEBI:15422 (ChEBI)
D-erythro-imidazole-glycerol-phosphateMetaboliteCHEBI:17805 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
L-GlnMetaboliteCHEBI:18050 (ChEBI)
L-GluMetaboliteCHEBI:16015 (ChEBI)
L-HisMetaboliteCHEBI:15971 (ChEBI)
L-histidinalMetaboliteCHEBI:27676 (ChEBI)
L-histidinol-phosphateMetaboliteCHEBI:16996 (ChEBI)
L-histidinolMetaboliteCHEBI:16255 (ChEBI)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
PPiMetaboliteCHEBI:29888 (ChEBI)
PRPPMetaboliteCHEBI:17111 (ChEBI)
PiMetaboliteCHEBI:18367 (ChEBI)
histidinol

dehydrogenase

(LOC_OS01G13190.1)
ProteinQ5NAY4 (Uniprot-TrEMBL) Faciliates the conversion of histidinol to histidinal.
histidinol-phosphate

transferase

(LOC_OS02G47940.1)
ProteinQ0DY86 (Uniprot-TrEMBL) Faciliates the conversion of imidazole acetol-phosphate to L-histidinol-phosphate.
imidazole acetol-phosphateMetaboliteCHEBI:16426 (ChEBI)
imidazoleglycerol-phosphate

dehydratase

(LOC_OS04G52710.1)
ProteinQ25AR2 (Uniprot-TrEMBL) Facilitates the conversion of D-erythro-imidazole-glycerol-phosphate to imidazole acetol-phosphate.
inositol-phosphate

phosphatase

(LOC_OS07G09330.1)
ProteinQ6Z4I1 (Uniprot-TrEMBL) Facilitates the conversion of L-histidinol-phosphate to histidinol.
phosphoribosyl-AMPMetaboliteCHEBI:18374 (ChEBI)
phosphoribosyl-ATP

pyrophosphohydrolase

(LOC_OS01G16940.1)
ProteinQ5NBQ1 (Uniprot-TrEMBL) Facilitates the conversion of phosphoribosyl-ATP to phosphoribosyl-AMP.
phosphoribosyl-ATPMetaboliteCHEBI:18263 (ChEBI)
phosphoribosylformiminoAICAR-phosphateMetaboliteCHEBI:18302 (ChEBI)
phosphoribulosylformimino-AICAR-PMetaboliteCHEBI:27735 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide

isomerase

(LOC_OS05G33260.1)
mim-catalysis1120832 (Reactome)
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide

isomerase

(LOC_OS05G33260.1)
mim-catalysis1121446 (Reactome)
1120056 (Reactome) 5-phosphoribosyl 1-pyrophosphate is converted to phosphoribosyl-ATP by enzymatic activity of ATP phosphoribosyltransferase.
1120127 (Reactome) D-erythro-imidazole-glycerol-phosphate is converted to imidazole acetol-phosphate by enzymatic activity of imidazoleglycerol-phosphate dehydratase.
1120150 (Reactome) Phosphoribosyl-AMP is converted to phosphoribosylformiminoAICAR-phosphate by enzymatic activity of phosphoribosyl-ATP pyrophosphatase.
1120316 (Reactome) L-histidinol-phosphate is converted to histidinol by enzymatic activity of inositol-phosphate phosphatase.
1120451 (Reactome) Phosphoribosyl-ATP is converted to phosphoribosyl-AMP by enzymatic activity of phosphoribosyl-ATP pyrophosphatase.
1120647 (Reactome) Histidinal is converted to L-histidine by enzymatic activity of histidinol dehydrogenase.
1120792 (Reactome) Histidinol is converted to histidinal by enzymatic activity of histidinol dehydrogenase.
1120832 (Reactome) PhosphoribosylformiminoAICAR-phosphate is converted to phosphoribosylformimino-AICAR-P by enzymatic activity of 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase.
1121105 (Reactome) Imidazole acetol-phosphate is converted to L-histidinol-phosphate by enzymatic activity of histidinol-phosphate transaminase.
1121446 (Reactome) Phosphoribulosylformimino-AICAR-P is converted to D-erythro-imidazole-glycerol-phosphate by enzymatic activity of 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase.
2OGArrow1121105 (Reactome)
AICARArrow1121446 (Reactome)
ATP

phosphoribosyltransferase

(LOC_OS03G04169.1)
mim-catalysis1120056 (Reactome)
ATP1120056 (Reactome)
D-erythro-imidazole-glycerol-phosphate1120127 (Reactome)
D-erythro-imidazole-glycerol-phosphateArrow1121446 (Reactome)
H2O1120150 (Reactome)
H2O1120316 (Reactome)
H2O1120451 (Reactome)
H2O1120647 (Reactome)
H2OArrow1120127 (Reactome)
L-Gln1121446 (Reactome)
L-Glu1121105 (Reactome)
L-GluArrow1121446 (Reactome)
L-HisArrow1120647 (Reactome)
L-histidinal1120647 (Reactome)
L-histidinalArrow1120792 (Reactome)
L-histidinol-phosphate1120316 (Reactome)
L-histidinol-phosphateArrow1121105 (Reactome)
L-histidinol1120792 (Reactome)
L-histidinolArrow1120316 (Reactome)
NAD+1120647 (Reactome)
NAD+1120792 (Reactome)
NADHArrow1120647 (Reactome)
NADHArrow1120792 (Reactome)
PPiArrow1120056 (Reactome)
PPiArrow1120451 (Reactome)
PRPP1120056 (Reactome)
PiArrow1120316 (Reactome)
histidinol

dehydrogenase

(LOC_OS01G13190.1)
mim-catalysis1120647 (Reactome)
histidinol

dehydrogenase

(LOC_OS01G13190.1)
mim-catalysis1120792 (Reactome)
histidinol-phosphate

transferase

(LOC_OS02G47940.1)
mim-catalysis1121105 (Reactome)
imidazole acetol-phosphate1121105 (Reactome)
imidazole acetol-phosphateArrow1120127 (Reactome)
imidazoleglycerol-phosphate

dehydratase

(LOC_OS04G52710.1)
mim-catalysis1120127 (Reactome)
inositol-phosphate

phosphatase

(LOC_OS07G09330.1)
mim-catalysis1120316 (Reactome)
phosphoribosyl-AMP1120150 (Reactome)
phosphoribosyl-AMPArrow1120451 (Reactome)
phosphoribosyl-ATP

pyrophosphohydrolase

(LOC_OS01G16940.1)
mim-catalysis1120150 (Reactome)
phosphoribosyl-ATP

pyrophosphohydrolase

(LOC_OS01G16940.1)
mim-catalysis1120451 (Reactome)
phosphoribosyl-ATP1120451 (Reactome)
phosphoribosyl-ATPArrow1120056 (Reactome)
phosphoribosylformiminoAICAR-phosphate1120832 (Reactome)
phosphoribosylformiminoAICAR-phosphateArrow1120150 (Reactome)
phosphoribulosylformimino-AICAR-P1121446 (Reactome)
phosphoribulosylformimino-AICAR-PArrow1120832 (Reactome)
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