Statin pathway (Canis familiaris)

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1Liver cellCell MembraneLegendRepressesActivatesPlasmaTissuesHDLAcetyl-CoATriglycerideVLDLAPOEPhospholipidABCA1LIPCHMGCRSCARB1LRP1LDLRStatinCholesterolCholesterol esterAPOA1CETPAPOA4Fatty acidIDLDGAT1APOC1LOC486962Cholic AcidCholesterolAPOC3PLTPSOAT1LPLTRNPAPOC2LDLLCAT


Description

What are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP430(r29996) with a 73% conversion rate.

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Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117462view10:55, 21 May 2021EweitzModified title
106054view11:57, 16 August 2019MaintBotHMDB identifier normalization
82698view18:44, 22 October 2015EgonwMore specific ChEBI identifiers.
71465view19:17, 17 October 2013MaintBotAutomated update of data sources
68537view22:22, 5 July 2013MaintBotUpdated to 2013 gpml schema
67659view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
40693view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
38713view19:31, 23 September 2010AlexanderPico
35539view14:18, 12 February 2010Thomasadded literature, layout change to remove overlap with infobox
33977view18:30, 9 December 2009MaintBotAutomatic update of empty xrefs
31773view12:09, 14 August 2009MaintBotFixed group labels
30726view22:57, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProduct481651 (Entrez Gene)
APOA1GeneProduct479427 (Entrez Gene)
APOA4GeneProduct489392 (Entrez Gene)
APOC1GeneProduct476437 (Entrez Gene)
APOC2GeneProduct442969 (Entrez Gene)
APOC3GeneProduct442970 (Entrez Gene)
APOEGeneProduct476438 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
CETPGeneProduct
CholesterolMetabolite
Cholesterol esterMetaboliteC02530 (KEGG Compound)
Cholic AcidMetabolite
DGAT1GeneProduct482093 (Entrez Gene)
Fatty acidMetaboliteC00162 (KEGG Compound)
HDLMetaboliteCHEBI:39025 (ChEBI)
HMGCRGeneProduct479182 (Entrez Gene)
IDLMetaboliteC01834 (KEGG Compound)
LCATGeneProduct479680 (Entrez Gene)
LDLMetaboliteCHEBI:39026 (ChEBI)
LDLRGeneProduct
LIPCGeneProduct478320 (Entrez Gene)
LOC486962GeneProduct486962 (Entrez Gene)
LPLGeneProduct403626 (Entrez Gene)
LRP1GeneProduct481124 (Entrez Gene)
PLTPGeneProduct485903 (Entrez Gene)
PhospholipidMetaboliteC00865 (KEGG Compound)
SCARB1GeneProduct486241 (Entrez Gene)
SOAT1GeneProduct490325 (Entrez Gene)
StatinMetabolite
TRNPGeneProduct
TriglycerideMetaboliteC00422 (KEGG Compound)
VLDLMetaboliteCHEBI:39027 (ChEBI)

Annotated Interactions

No annotated interactions
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