Photodynamic therapy-induced unfolded protein response (Homo sapiens)
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Description
Photodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, and ATF4.
Quality Tags
Ontology Terms
Bibliography
- Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M; ''Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.''; BMC Cancer, 2015 PubMed Europe PMC Scholia
- Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M; ''Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.''; Cancer Metastasis Rev, 2015 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ASNS | GeneProduct | 440 (Entrez Gene) | |
ATF3 | GeneProduct | 467 (Entrez Gene) | |
ATF4 | GeneProduct | 468 (Entrez Gene) | |
ATF6 | GeneProduct | 22926 (Entrez Gene) | |
BBC3 | GeneProduct | 27113 (Entrez Gene) | |
BCL2L11 | GeneProduct | 10018 (Entrez Gene) | |
CALR | GeneProduct | 811 (Entrez Gene) | |
DDIT3 | GeneProduct | 1649 (Entrez Gene) | |
DNAJB11 | GeneProduct | 51726 (Entrez Gene) | |
DNAJB9 | GeneProduct | 4189 (Entrez Gene) | |
DNAJC3 | GeneProduct | 5611 (Entrez Gene) | |
EDEM1 | GeneProduct | 9695 (Entrez Gene) | |
EIF2A | GeneProduct | 83939 (Entrez Gene) | |
EIF2AK3 | GeneProduct | 9451 (Entrez Gene) | |
ERN1 | GeneProduct | 2081 (Entrez Gene) | |
ERP27 | GeneProduct | 121506 (Entrez Gene) | |
HSP90B1 | GeneProduct | 7184 (Entrez Gene) | |
HSPA5 | GeneProduct | 3309 (Entrez Gene) | |
NARS | GeneProduct | 4677 (Entrez Gene) | |
NFE2L2 | GeneProduct | 4780 (Entrez Gene) | |
PDIA6 | GeneProduct | 10130 (Entrez Gene) | |
PPP1R15A | GeneProduct | 23645 (Entrez Gene) | |
SULT1E1 | GeneProduct | 6783 (Entrez Gene) | |
TRIB3 | GeneProduct | 57761 (Entrez Gene) | |
UBE2E1 | GeneProduct | 7324 (Entrez Gene) | |
WARS | GeneProduct | 7453 (Entrez Gene) | |
XBP1 | GeneProduct | 7494 (Entrez Gene) |
Annotated Interactions
No annotated interactions