Heart development (Mus musculus)

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3551677788622RVFibroblastSecond Heart FieldLVFirst Heart FieldDay 28Cardiac Neural CrestLAASCardiac Reprogramming FactorsRACTCtnnb1miR145Hand2Gata6Hey1miR143Foxc2Foxh1Gata4Fgf8Isl1Tbx1Foxa2Irx4SrfTbx20Smyd1Gata4Tbx5SrfTbx5Nfatc4Bhlhe40Ptpn11Bmp2Hey2Nfatc2VegfbNkx2-5Nkx2-5Notch1Mapk1ShhFoxc1Tbx5Bmpr1AGata4Tbx2Smad4Erbb3Hand1Nfatc1Tbx5miR1-1Bmp10Gata4VegfcBmp4Bmpr2Nkx2-5Tbx20Mef2cFgf10Nkx2-5Bmp2Nfatc3Mef2cTbx2Nkx2-5Smad1Notch1Pitx2VegfaMef2cSternal GenesCombination of First and SecondHeart Fields (Heart Valves)


Description

This pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impact the regional specificity of the human heart. Activating signals are indicated by arrows while inhibitory signals are indicated by T-bars. Special thanks to Kim Cordes for her assistance in revising this pathway, based on recent heart development research.

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Ontology Terms

 

Bibliography

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  1. Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O; ''BMP and BMP receptor expression during murine organogenesis.''; Gene Expr Patterns, 2009 PubMed Europe PMC Scholia
  2. Fulcoli FG, Huynh T, Scambler PJ, Baldini A; ''Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.''; PLoS One, 2009 PubMed Europe PMC Scholia
  3. Srivastava D; ''Making or breaking the heart: from lineage determination to morphogenesis.''; Cell, 2006 PubMed Europe PMC Scholia
  4. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D; ''Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.''; Cell, 2010 PubMed Europe PMC Scholia
  5. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D; ''miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.''; Nature, 2009 PubMed Europe PMC Scholia
  6. Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT; ''Development of heart valves requires Gata4 expression in endothelial-derived cells.''; Development, 2006 PubMed Europe PMC Scholia
  7. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D; ''A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.''; Nat Cell Biol, 2009 PubMed Europe PMC Scholia
  8. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP; ''An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.''; Cell, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126370view17:50, 25 April 2023EgonwLicense is CCZero
116830view10:29, 14 May 2021EweitzModified title
88634view14:46, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
84685view19:46, 15 March 2016Khanspersswitched interactions for graphical lines
84684view19:45, 15 March 2016KhanspersPeriodical save, work in progress
78407view10:25, 7 January 2015MaintBotadded missing graphIds
77161view21:43, 29 July 2014Khanspersconnected interactions and changed colors to improve readability
69145view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
59049view20:53, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45788view19:40, 10 November 2011Nsalomonisminor symbol changes
45787view19:37, 10 November 2011NsalomonisNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Bhlhe40GeneProductENSMUSG00000030103 (Ensembl) In other species, this is BHLHB2
Bmp10GeneProductENSMUSG00000030046 (Ensembl)
Bmp2GeneProductENSMUSG00000027358 (Ensembl)
Bmp4GeneProductENSMUSG00000021835 (Ensembl)
Bmpr1AGeneProductENSMUSG00000021796 (Ensembl)
Bmpr2GeneProductENSMUSG00000067336 (Ensembl)
Ctnnb1GeneProductENSMUSG00000006932 (Ensembl)
Erbb3GeneProductENSMUSG00000018166 (Ensembl)
Fgf10GeneProductENSMUSG00000021732 (Ensembl)
Fgf8GeneProductENSMUSG00000025219 (Ensembl)
Foxa2GeneProductENSMUSG00000037025 (Ensembl)
Foxc1GeneProductENSMUSG00000050295 (Ensembl)
Foxc2GeneProductENSMUSG00000046714 (Ensembl)
Foxh1GeneProductENSMUSG00000033837 (Ensembl)
Gata4GeneProductENSMUSG00000021944 (Ensembl)
Gata6GeneProductENSMUSG00000005836 (Ensembl)
Hand1GeneProductENSMUSG00000037335 (Ensembl)
Hand2GeneProductENSMUSG00000038193 (Ensembl)
Hey1GeneProductENSMUSG00000040289 (Ensembl)
Hey2GeneProductENSMUSG00000019789 (Ensembl)
Irx4GeneProductENSMUSG00000021604 (Ensembl)
Isl1GeneProductENSMUSG00000042258 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mef2cGeneProductENSMUSG00000005583 (Ensembl)
Nfatc1GeneProductENSMUSG00000033016 (Ensembl)
Nfatc2GeneProductENSMUSG00000027544 (Ensembl)
Nfatc3GeneProductENSMUSG00000031902 (Ensembl)
Nfatc4GeneProductENSMUSG00000023411 (Ensembl)
Nkx2-5GeneProductENSMUSG00000015579 (Ensembl)
Notch1GeneProductENSMUSG00000026923 (Ensembl)
Pitx2GeneProductENSMUSG00000028023 (Ensembl)
Ptpn11GeneProductENSMUSG00000043733 (Ensembl)
ShhGeneProductENSMUSG00000002633 (Ensembl)
Smad1GeneProductENSMUSG00000031681 (Ensembl)
Smad4GeneProductENSMUSG00000024515 (Ensembl)
Smyd1GeneProductENSMUSG00000055027 (Ensembl)
SrfGeneProductENSMUSG00000015605 (Ensembl)
Tbx1GeneProductENSMUSG00000037477 (Ensembl)
Tbx20GeneProductENSMUSG00000031965 (Ensembl)
Tbx2GeneProductENSMUSG00000000093 (Ensembl)
Tbx5GeneProductENSMUSG00000018263 (Ensembl)
VegfaGeneProductENSMUSG00000023951 (Ensembl)
VegfbGeneProductENSMUSG00000024962 (Ensembl)
VegfcGeneProductENSMUSG00000031520 (Ensembl)
miR1-1GeneProductENSMUSG00000070144 (Ensembl)
miR143GeneProductENSMUSG00000065445 (Ensembl)
miR145GeneProductENSMUSG00000065592 (Ensembl)

Annotated Interactions

No annotated interactions

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