Novel Jun-Dmp1 pathway (Mus musculus)

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1Growth Arrest or ApoptosisS PhaseInk4aC-JunMEKMdm2p53ArfTranscription factor AP-1Cdk4MitogenCyclin D1ERKRbDmp1JunbEts1Raf1rasE2f1Ets2MycEts2Transcription factor AP-1Ets1


Description

Ras-Raf-MEK-ERK pathway interacting with Arf/Mdm2/p53 cell cycle pathway to regulate cell growth and proliferation. The signalling of a mitogen acts through the Ras-Raf-MEK-ERK pathway to inhibit the Rb protein and allow Myc and E2fs to continue into S phase and inhibits the Arf/Mdm2/p53 pathway leading to growth arrest or apoptosis. The Ras-Raf-MEK-ERK pathway also directly acts on the Arf/Mdm2/p53 pathway with Dmp1 to prevent tumor formation by activating Arf. Arf inhibits Mdm2 allowing p53 to lead the cell to growth arrest or apoptosis.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K; ''Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123275view15:48, 9 July 2022EgonwMade two pathways clickable
116721view10:01, 11 May 2021EweitzModified title
90077view23:30, 12 October 2016KhanspersModified title
90076view23:30, 12 October 2016Khanspersdefine AP-1 transcription factor
90071view20:02, 11 October 2016KhanspersModified title
90070view20:01, 11 October 2016KhanspersExpanded Ras-Raf-MEK cascade, cleaned up
89114view19:03, 22 August 2016AAR&CoChanged data node
89113view19:01, 22 August 2016AAR&CoChanged data node
88469view23:19, 9 August 2016AAR&CoOntology Term : 'cell cycle pathway, mitotic' added !
88468view23:18, 9 August 2016AAR&CoAdded New Data Nodes
88467view23:15, 9 August 2016AAR&CoEdited Interactions and Labels
87629view08:54, 25 July 2016LindarieswijkOntology Term : 'Ras superfamily mediated signaling pathway' added !
87402view11:05, 22 July 2016MaintBotadded missing graphids
85921view18:10, 21 June 2016AAR&CoModified description
85920view18:09, 21 June 2016AAR&CoAdded Citation
85782view21:53, 12 June 2016AAR&CoModified description
85781view21:50, 12 June 2016AAR&CoEdit interaction
85780view21:36, 12 June 2016AAR&CoUnconnected Lines Fixed
85779view20:10, 12 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ArfGeneProductENSMUSG00000048076 (Ensembl) Arf Not Specified
C-JunProteinQ9WVI9 (Uniprot-TrEMBL)
Cdk4GeneProductENSMUSG00000006728 (Ensembl)
Cyclin D1ProteinQ790L7 (Uniprot-TrEMBL)
Dmp1GeneProductENSMUSG00000029307 (Ensembl)
E2f1GeneProduct13555 (Entrez Gene)
ERKGeneProduct26413 (NCBI Protein)
Ets1GeneProductENSMUSG00000032035 (Ensembl)
Ets2GeneProductENSMUSG00000022895 (Ensembl)
Ink4aGeneProductENSMUSG00000044303 (Ensembl)
JunbGeneProductENSMUSG00000052837 (Ensembl)
MEKGeneProduct17242 (NCBI Protein)
Mdm2GeneProductENSMUSG00000020184 (Ensembl)
MitogenGeneProductGeneral Term
MycGeneProductENSMUSG00000022346 (Ensembl)
Raf1GeneProductENSMUSG00000000441 (Ensembl)
RbGeneProduct19645 (NCBI Protein)
Transcription factor AP-1ProteinP05627 (Uniprot-TrEMBL)
p53GeneProductENSMUSG00000059552 (Ensembl)
rasGeneProduct20130 (Entrez Gene) Ras Not Specified

Annotated Interactions

No annotated interactions

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