IL-6 signaling pathway (Gallus gallus)

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Plasma membraneSumoylationDMolecular associationECDDCY->NUGODeacetylationENDDMitochondrionRecruitmentAccession Number: NetPath 18DesumoylationAutophosphorylationDephosphorylationCY->NUProteins in a complex interactionNUUbiquitinationEREnzyme complexGene SymbolCY->ENEndosomeCY->NUComplex formationCYNucleusMolecule in the pathwayMethylationDDCY->NULigandGlycosylationCytoplasmTranslocationDControlCY->NUEarly EndosomesMTDInhibitionEndoplasmic reticulumProteolytic cleavageReactions through unknown mechanisms/moleculesPhosphorylationDPalmitoylationReceptorDPMExtracellularGolgi apparatusActivation(Protein-Protein interaction)DDAcetylationDeubiquitinationCY->NUDDemethylationPPP2CASTAT3PPP2R2CNLKPPP2R5EFOSSOS1MAPK14MAP2K2PPP2R5CSTAT3IL6PPP2CBJUNPPP2R3AAKT1TECPTK2BSTAT5ACEBPBPIK3R2RCJMB04_5f2BMXINPPL1FGRPRKCDJAK2LYNHRASMAP2K6FOXO3VAV1FOXO4RCJMB04_17i9PPP2R5DPXNCASP9RAF1STAT3PPP2R2BCDK5R1MAP3K7JAK1PPP2R3BMAP3K4MAP2K1RCJMB04_17i9DAXXHCKARFYNIL6STRCJMB04_4j14CD40SOCS3PPP2R1BRCJMB04_17i9GAB2PTPN11FOXO1ANFKB1PPP2R4IL6RPLCG1ERBB3SGK1CREBBPEIF4ETYK2PTK2ERBB2NCOA1STAT3CASP3BADMAPK14STAT3NFKB1RB1PPP2R5BCDK9MAPK3RPS6KA2EIF2AIL6RGSK3BSGK1MAPTIL6STMAPK1SHC1GRB2IL6FESPIK3R1PPP2R1AHSP90AA1MAP3K7HSPB1RCJMB04_17i9HDAC1GAB1CDK5STAT3PPP2R5AMAPKAPK2MAPK8INPP5DCEBPBSTAT3STAT5BBTKSTAT3RAC1HNF1AMAP2K4EIF4EBP1EP300


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP364(r28142) with a 78% conversion rate.

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
117995view11:24, 23 May 2021EweitzModified title
86939view13:08, 15 July 2016MkutmonOntology Term : 'interleukin-6 signaling pathway' added !
68870view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
41010view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
33931view18:11, 9 December 2009MaintBotAutomatic update of empty xrefs
31494view21:30, 13 August 2009MaintBotFixed text labels
30319view20:42, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
ARGeneProduct422165 (Entrez Gene)
BADGeneProduct
BMXGeneProduct428003 (Entrez Gene)
BTKGeneProduct374075 (Entrez Gene)
CASP3GeneProduct395476 (Entrez Gene)
CASP9GeneProduct426970 (Entrez Gene)
CD40GeneProduct395385 (Entrez Gene)
CDK5GeneProduct100190948 (Entrez Gene)
CDK5R1GeneProduct
CDK9GeneProduct417226 (Entrez Gene)
CEBPBGeneProduct396185 (Entrez Gene)
CREBBPGeneProduct416667 (Entrez Gene)
DAXXGeneProduct
EIF2AGeneProduct425042 (Entrez Gene)
EIF4EGeneProduct422703 (Entrez Gene)
EIF4EBP1GeneProduct426773 (Entrez Gene)
EP300GeneProduct418000 (Entrez Gene)
ERBB2GeneProduct426130 (Entrez Gene)
ERBB3GeneProduct693245 (Entrez Gene)
FESGeneProduct429374 (Entrez Gene)
FGRGeneProduct
FOSGeneProduct396512 (Entrez Gene)
FOXO1AGeneProduct374231 (Entrez Gene)
FOXO3GeneProduct421769 (Entrez Gene)
FOXO4GeneProduct428703 (Entrez Gene)
FYNGeneProduct396294 (Entrez Gene)
GAB1GeneProduct422456 (Entrez Gene)
GAB2GeneProduct419027 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
GSK3BGeneProduct418335 (Entrez Gene)
HCKGeneProduct419280 (Entrez Gene)
HDAC1GeneProduct373961 (Entrez Gene)
HNF1AGeneProduct416967 (Entrez Gene)
HRASGeneProduct396229 (Entrez Gene)
HSP90AA1GeneProduct423463 (Entrez Gene)
HSPB1GeneProduct396227 (Entrez Gene)
IL6GeneProduct395337 (Entrez Gene)
IL6RGeneProduct
IL6STGeneProduct395684 (Entrez Gene)
INPP5DGeneProduct424745 (Entrez Gene)
INPPL1GeneProduct428692 (Entrez Gene)
JAK1GeneProduct395681 (Entrez Gene)
JAK2GeneProduct374199 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
LYNGeneProduct421127 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAP2K4GeneProduct417312 (Entrez Gene)
MAP2K6GeneProduct
MAP3K4GeneProduct421579 (Entrez Gene)
MAP3K7GeneProduct421808 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPK3GeneProduct
MAPK8GeneProduct423778 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
MAPTGeneProduct426737 (Entrez Gene)
NCOA1GeneProduct422016 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
NLKGeneProduct417669 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
PLCG1GeneProduct
PPP2CAGeneProduct416318 (Entrez Gene)
PPP2CBGeneProduct396021 (Entrez Gene)
PPP2R1AGeneProduct
PPP2R1BGeneProduct777130 (Entrez Gene)
PPP2R2BGeneProduct416350 (Entrez Gene)
PPP2R2CGeneProduct422858 (Entrez Gene)
PPP2R3AGeneProduct424733 (Entrez Gene)
PPP2R3BGeneProduct418670 (Entrez Gene)
PPP2R4GeneProduct426329 (Entrez Gene)
PPP2R5AGeneProduct421372 (Entrez Gene)
PPP2R5BGeneProduct
PPP2R5CGeneProduct423460 (Entrez Gene)
PPP2R5DGeneProduct421250 (Entrez Gene)
PPP2R5EGeneProduct423512 (Entrez Gene)
PRKCDGeneProduct415905 (Entrez Gene)
PTK2GeneProduct396416 (Entrez Gene)
PTK2BGeneProduct421998 (Entrez Gene)
PTPN11GeneProduct395815 (Entrez Gene)
PXNGeneProduct395832 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RB1GeneProduct386582 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_4j14GeneProduct417637 (Entrez Gene)
RCJMB04_5f2GeneProduct419523 (Entrez Gene)
RPS6KA2GeneProduct421570 (Entrez Gene)
SGK1GeneProduct395133 (Entrez Gene)
SHC1GeneProduct395934 (Entrez Gene)
SOCS3GeneProduct395299 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
STAT5AGeneProduct
STAT5BGeneProduct395556 (Entrez Gene)
TECGeneProduct396407 (Entrez Gene)
TYK2GeneProduct395741 (Entrez Gene)
VAV1GeneProduct

Annotated Interactions

No annotated interactions
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