Class I MHC mediated antigen processing and presentation (Homo sapiens)

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2, 8, 20, 23, 32...6, 18, 69, 70, 76...14, 63, 81, 8522, 26325, 10055, 11131, 46, 53, 8724, 91, 10517, 22, 2637, 72, 8216, 35, 38, 49, 75...14, 81, 8529, 47, 9453, 8628, 68, 864955, 106, 11122, 26, 443, 10, 39, 43, 51...30, 88, 10967, 9514, 81, 8546, 5533, 45, 64, 78, 89...52, 62, 71, 909, 44, 57, 705, 13, 80, 83, 1024, 27, 50, 56, 74...1, 7, 66, 7722, 2622, 2611, 731946, 10414, 65, 81, 8521, 41, 42, 50, 561, 44, 66ER to Golgi transport vesiclephagocytic vesicleendoplasmic reticulum lumenGolgi lumenendoplasmic reticulum membraneclathrin-coated endocytic vesiclephagolysosomeearly endosomecytosolHLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B35 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B82 class I MHC B59 class I MHC B50 L-Phe HLA class I histocompatibility antigen, A-34 alpha chain L-Asp PSMD5 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBC(381-456) L-Asp UBE2A TRAIP HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B52 HLA class I histocompatibility antigen, A-30 alpha chain RNF14 HLA class I histocompatibility antigen, A-3 alpha chain precursor STUB1 class I MHC B44 UBE2W HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain PSMD8 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor (Glc)1 (GlcNAc)2 (Man)9 CUL3 ATG7 class I MHC B57 class I MHC B40 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor UBC(609-684) UBE4A CUL7 ExogenousParticulate antigen(Ag)HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B81 UBC(153-228) L-Phe UBA52(1-76) PSMA6 PJA1 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain LTN1 HERC5 HLA class I histocompatibility antigen, alpha chain F precursor ANAPC11 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B55 HLA-B HLA class I histocompatibility antigen, A-33 alpha chain UBB(1-76) SIAH1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-26 alpha chain BAP31 oligomer ASB3 HERC1 HLA class I histocompatibility antigen, A-30 alpha chain UBE2L3 HLA class I histocompatibility antigen, A-43 alpha chain RNF130 MR/other probablereceptorsUBE2C class I MHC B8 HLA-H RNF130 TRAF7 TRIM11 MYLIP class I MHC B46 E3:K48-polyubiquitinated substrateHLA class I histocompatibility antigen, A-23 alpha chain PSMB11 Antigen peptide class I MHC B59 class I MHC B42 UBE2E1 HLA class I histocompatibility antigen, Cw-16 alpha chain Antigen peptidebound class I MHCRBX1 PSME4 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B27 Exogenous soluble antigen class I MHC B18 HLA class I histocompatibility antigen, A-33 alpha chain oligopeptide fragment L-Lys class I MHC B39 PSMB5 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-16 alpha chain ARIH2 HECTD2 RNF220 class I MHC B58 MGRN1 PSMC3 HLA class I histocompatibility antigen, Cw-18 alpha chain ANAPC10 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PSMD7 HLA class I histocompatibility antigen, A-31 alpha chain SEC24B L-Gln HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B13 ANAPC1 RNF19A class I MHC B14 class I MHC B38 class I MHC B52 UBE2E1 STUB1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B35 TCEB1 L-Tyr class I MHC B50 TAP1 class I MHC B13 HLA class I histocompatibility antigen, A-34 alpha chain L-Glu class I MHC B42 FCGR class I MHC B8 L-Val FBXO6 class I MHC B82 RNF144B KLHL20 class I MHC B41 class I MHC B51 class I MHC B73 PSMF1 HSPA5 HLA class I histocompatibility antigen, A-43 alpha chain RNF182 HLA-C Antigen peptide PARK2 TRIM39 ANAPC2 HLA class I histocompatibility antigen, A-32 alpha chain SOCS3 class I MHC B40 UBAC1 class I MHC B15 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor UBC(381-456) L-Met MEX3C HLA class I histocompatibility antigen, A-43 alpha chain PSMD12 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B42 precursor peptidefragment (>16 aa)PSMD2 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor RBCK1 class I MHC B59 RNF19B L-Amino Acidsclass I MHC B57 UBE2V1 class I MHC B35 DTX3L MKRN1 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-25 alpha chain L-Ser HLA class I histocompatibility antigen, A-74 alpha chain FBXO17 class I MHC B42 SEC24A HLA class I histocompatibility antigen, Cw-17 alpha chain SEC24D UBE3A ANAPC4 HLA class I histocompatibility antigen, A-80 alpha chain L-Ile HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ExogenousParticulate antigen(Ag)PSMC1 class I MHC B46 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B47 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain L-Arg class I MHC B41 HECTD3 RNF213 class I MHC B35 HLA class I histocompatibility antigen, A-24 alpha chain CUL5 CD207 L-Phe PSME3 class I MHC B42 ANAPC13 class I MHC B51 TRIM36 class I MHC B18 RNF123 ASB12 DTX3L class I MHC B44 class I MHC B39 UBE2Q2 FBXO2 KLHL20 ADPL-Pro SEC24A VHL UBE2W LRSAM1 HLA class I histocompatibility antigen, A-29 alpha chain HSPA5 UBE2Q1 L-Tyr class I MHC B55 HLA class I histocompatibility antigen, Cw-16 alpha chain L-Arg HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B42 SPSB1 MRC2 class I MHC B41 HLA class I histocompatibility antigen, A-80 alpha chain UBC(305-380) VHL ANAPC2 CUL3 class I MHC B38 class I MHC B54 ASB15 class I MHC B13 class I MHC B27 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B56 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor CTSL2 L-Cys ANAPC11 class I MHC B15 class I MHC B55 HLA class I histocompatibility antigen, A-3 alpha chain precursor L-Pro HECTD2 class I MHC B47 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B38 class I MHC B54 class I MHC B49 class I MHC B81 HLA-H class I MHC B59 L-Arg class I MHC B59 ASB13 HLA class I histocompatibility antigen, alpha chain G precursor TRIM39 HLA class I histocompatibility antigen, Cw-12 alpha chain oligopeptidefragmentSEC24C class I MHC B55 CYBA HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B45 ANAPC1 class I MHC B78 ASB16 HLA class I histocompatibility antigen, A-29 alpha chain SIAH1 class I MHC B27 class I MHC B53 FBXO4 class I MHC B38 CDC23 PDIA3class I MHC B59 Gly HLA class I histocompatibility antigen, Cw-18 alpha chain MEX3C HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B27 L-Gln UBC(457-532) GAN class I MHC B73 class I MHC B35 RNF217 RNF213 class I MHC B52 WWP1 class I MHC B73 class I MHC B81 class I MHC B58 UBC(533-608) HLA-B PSMD12 class I MHC B46 UFL1 class I MHC B42 RNF115 class I MHC B7 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain PSMB9 CUL1 class I MHC B40 LTN1 HLA class I histocompatibility antigen, A-29 alpha chain FBXW11 ANAPC10 class I MHC B7 UBC(229-304) SEC24C PSMD14 class I MHC B39 TRIP12 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B8 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B52 E2Ubiquitin-conjugating enzymeUBB(1-76) UBE2D2 FBXO3 SEC24class I MHC B57 L-Pro 26S proteasomePSMD13 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B50 class I MHC B40 class I MHC B27 Antigen peptidebound class IMHC:BAP31 oligomerSIAH2 HLA class I histocompatibility antigen, alpha chain F precursor oligopeptidefragment (8-16aa)L-Asp UBE2V2 HLA class I histocompatibility antigen, Cw-8 alpha chain ASB15 B2M(21-119) class I MHC B52 class I MHC B27 NADP+RNF213 SAR1B:GDPKLHL11 CDC34 L-Met class I MHC B82 SOCS1 UBE2O class I MHC B38 Gly RLIM H2Oclass I MHC B41 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ASB17 KLHL9 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B54 L-Tyr class I MHC B42 class I MHC B51 class I MHC B46 class I MHC B37 ATPCALRUBB(153-228) LNPEP L-Ile TRIM9 HLA class I histocompatibility antigen, A-11 alpha chain Antigen peptidebound class I MHCHLA-H ASB16 class I MHC B73 class I MHC B56 TRIM71 UBE2S Ag-substrate:E3:E2:Ubclass I MHC B50 UBC(305-380) HERC3 class I MHC B52 PSMB2 HLA class I histocompatibility antigen, A-23 alpha chain PSMB2 FBXO44 L-Thr L-Amino AcidsRBBP6 class I MHC B27 ASB3 LRRC41 PJA2 class I MHC B81 SIAH2 antigenic substrate class I MHC B59 Antigen peptideL-Met RNF144B HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B78 PSMB3 class I MHC B49 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B44 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B54 PSMF1 class I MHC B46 UBB(1-76) (Glc)1 (GlcNAc)2 (Man)9 class I MHC B67 MRC1 HLA class I histocompatibility antigen, A-68 alpha chain H2Oclass I MHC B7 HLA-H LRR1 HLA class I histocompatibility antigen, alpha chain F precursor GDP PSMC5 WSB1 HLA-H VPRBP TRIM36 PSMC2 HLA class I histocompatibility antigen, A-74 alpha chain UBE2V1 (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain CDC34 MR:soluble antigenASB7 class I MHC B81 precursor peptidefragment (>16 aa)HLA class I histocompatibility antigen, Cw-6 alpha chain precursor O2HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor L-Trp class I MHC B45 UBC(1-76) SEC24B class I MHC B46 L-Amino AcidsFBXO44 FBXO31 class I MHC B15 ZNRF1 ASB13 PARK2 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B15 SPSB1 UBE3D TAPHLA class I histocompatibility antigen, E alpha chain precursor UBA7 UBE2D2 L-Ser class I MHC B45 HLA class I histocompatibility antigen, A-66 alpha chain SAR1B HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B57 HLA class I histocompatibility antigen, Cw-8 alpha chain L-Asn ASB8 HLA class I histocompatibility antigen, Cw-12 alpha chain SEC24A UBE2G1 PSMD11 class I MHC B51 HLA class I histocompatibility antigen, A-31 alpha chain UBE2U HLA class I histocompatibility antigen, Cw-3 alpha chain precursor SEC24B class I MHC B14 FBXO4 class I MHC B41 UBE2U UBE3B class I MHC B67 FBXW7 RNF6 HLA class I histocompatibility antigen, alpha chain G precursor L-Met class I MHC B8 HLA class I histocompatibility antigen, A-33 alpha chain L-Ile UBR2 ASB2 HACE1 class I MHC B59 HLA class I histocompatibility antigen, Cw-14 alpha chain CDC23 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor CD207 L-Ile antigenic substrate HLA class I histocompatibility antigen, Cw-7 alpha chain precursor SMURF1 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain PDIA3 class I MHC B82 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B56 PSMA5 HLA class I histocompatibility antigen, A-33 alpha chain HERC2 class I MHC B15 Antigen peptide HLA class I histocompatibility antigen, A-74 alpha chain MIB2 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor L-Gln FBXW8 HLA-B HLA class I histocompatibility antigen, A-68 alpha chain HLA-B class I MHC B67 LRSAM1 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain UBE2Z DTX3L HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B49 HLA class I histocompatibility antigen, A-68 alpha chain PSMD14 UBE2F B2M(21-119) HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B27 ASB10 UBE2G2 class I MHC B56 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor COPII vesicle withMHC class IRNF123 class I MHC B47 L-Glu ASB18 RNF115 HLA class I histocompatibility antigen, A-34 alpha chain RNF126 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B53 UBB(77-152) FBXW7 HECTD2 ANAPC13 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B45 UBE4A UBE2V2 class I MHC B40 class I MHC B45 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B13 class I MHC B45 class I MHC B58 GAN SOCS3 SPSB2 class I MHC B8 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain HLA-C class I MHC B39 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain FBXW7 class I MHC B73 PSMD6 class I MHC B7 UBE2R2 HERC6 UBE2B class I MHC B18 HLA class I histocompatibility antigen, A-66 alpha chain PSMB11 PSMB8 HLA class I histocompatibility antigen, A-2 alpha chain RNF217 CDC27 PSMD4 HLA class I histocompatibility antigen, A-36 alpha chain TCEB2 B2M(21-119) UBE3B Exogenous solubleantigenASB17 PSMD6 class I MHC B59 L-Asn class I MHC B39 HLA class I histocompatibility antigen, Cw-17 alpha chain SEC31A TRAIP RCHY1 class I MHC B8 class I MHC B54 HLA-H HLA class I histocompatibility antigen, A-31 alpha chain SEC23A HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B44 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B27 class I MHC B45 TRIP12 UBC(1-76) HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBA7 FBXO4 PSMA2 class I MHC B18 class I MHC B44 UBE2E1 PSMD2 class I MHC B50 HLA class I histocompatibility antigen, alpha chain F precursor KLHL11 HLA class I histocompatibility antigen, A-23 alpha chain FBXL4 FBXO31 SKP1 L-Val HLA class I histocompatibility antigen, A-1 alpha chain precursor SEC61A1 class I MHC B53 HLA class I histocompatibility antigen, A-74 alpha chain SOCS1 SEC61A2 class I MHC B13 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B67 HLA class I histocompatibility antigen, A-25 alpha chain HECW2 class I MHC B49 HLA class I histocompatibility antigen, A-29 alpha chain PSME2 UBE2L6 HECTD3 class I MHC B18 class I MHC B73 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B14 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B78 PSMD7 L-Thr UBA7 UBC(77-152) PSMD9 L-Amino AcidsHLA class I histocompatibility antigen, A-11 alpha chain class I MHC B56 COPII vesicle withMHC class IClass I MHC:B2Mclass I MHC B52 class I MHC B18 HERC1 UBE2N HLA class I histocompatibility antigen, Cw-15 alpha chain ASB16 LNX1 PSMA6 SAR1B:GTP:SEC23:SEC24class I MHC B27 L-Trp UBB(77-152) TRAF7 SPSB2 class I MHC B8 class I MHC B49 L-Ala TRAIP GAN (Glc)1 (GlcNAc)2 (Man)9 class I MHC B14 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor SEC61G UBB(153-228) class I MHC B51 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor UBE2H class I MHC B18 ZNRF1 HLA class I histocompatibility antigen, A-69 alpha chain PSMA7 class I MHC B7 class I MHC B55 HLA class I histocompatibility antigen, alpha chain G precursor TRIM69 class I MHC B81 HLA class I histocompatibility antigen, A-26 alpha chain UNKL HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B82 PSMB7 HLA class I histocompatibility antigen, A-31 alpha chain FBXO17 PJA2 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B49 Chaperonescalnexin/BiPUBC(609-684) HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B41 class I MHC B40 class I MHC B42 UBC(77-152) class I MHC B50 TRIM11 HERC4 PSMA7 UBE2L3 class I MHC B59 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B38 L-Thr HLA class I histocompatibility antigen, Cw-4 alpha chain precursor RNF25 TRIM63 class I MHC B53 HECTD1 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B44 UBE2F HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B52 class I MHC B56 BTBD1 TRIM39 class I MHC B54 HLA class I histocompatibility antigen, A-80 alpha chain ITGB5 ASB5 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-2 alpha chain PSMB10 HLA class I histocompatibility antigen, E alpha chain precursor CDC20 NEDD4 MRC1 TRIM71 class I MHC B13 RNF34 GTP HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B50 class I MHC B44 HUWE1 H+HLA class I histocompatibility antigen, alpha chain G precursor TRIM69 class I MHC B18 KLHL21 SAR1B HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PSMB3 Antigen peptide HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor CTSL1(114-288) HLA class I histocompatibility antigen, Cw-1 alpha chain UBC(457-532) HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B82 HLA class I histocompatibility antigen, Cw-8 alpha chain LNX1 SIAH1 PSMA8 class I MHC B13 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B27 class I MHC B35 UBC(229-304) class I MHC B51 CBLB HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B46 (Glc)1 (GlcNAc)2 (Man)9 MRC1 class I MHC B50 class I MHC B37 class I MHC B56 RNF114 TRIM4 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B14 SEC23A class I MHC B37 RCHY1 ZBTB16 class I MHC B78 class I MHC B46 HLA class I histocompatibility antigen, Cw-12 alpha chain CDC26 L-Asp 4xPalmC-CD36 class I MHC B44 L-Ala UBE2Q1 TPP2 class I MHC B13 class I MHC B38 FCGRA class I MHC B78 AMPUBR4 class I MHC B53 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain FBXO44 HLA class I histocompatibility antigen, Cw-2 alpha chain RNF182 B2M(21-119) class I MHC B81 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B59 class I MHC B46 HLA class I histocompatibility antigen, A-80 alpha chain CUL7 UBE3C TRIM32 HLA class I histocompatibility antigen, Cw-1 alpha chain TRIM4 class I MHC B56 HLA class I histocompatibility antigen, Cw-12 alpha chain SKP1 RNF217 PSMB5 class I MHC B53 FBXO31 HLA class I histocompatibility antigen, A-29 alpha chain UBE3A TRIM32 HLA class I histocompatibility antigen, A-69 alpha chain TAP1 FBXW11 TRIM41 class I MHC B78 TAPBPSAR1B L-Gln class I MHC B41 ZBTB16 LTN1 HLA class I histocompatibility antigen, Cw-2 alpha chain NEDD4L HLA class I histocompatibility antigen, Cw-2 alpha chain FBXO17 HLA class I histocompatibility antigen, Cw-16 alpha chain B2M(21-119) HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B57 ANAPC13 RPS27A(1-76) ASB11 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B13 HLA class I histocompatibility antigen, A-25 alpha chain RNF111 SEC24B class I MHC B67 RNF19A ASB2 HLA class I histocompatibility antigen, Cw-12 alpha chain L-Cys HLA class I histocompatibility antigen, Cw-17 alpha chain AREL1 UBC(533-608) (Glc)1 (GlcNAc)2 (Man)9 class I MHC B39 PSMB1 class I MHC B37 FBXO27 class I MHC B50 class I MHC B53 class I MHC B14 HLA class I histocompatibility antigen, A-3 alpha chain precursor RNF41 class I MHC B37 CUL7 HLA class I histocompatibility antigen, Cw-15 alpha chain PSMA3 class I MHC B7 PSMD9 class I MHC B35 L-Trp RNF111 RNF19B ITGAV(31-1048) HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B45 HLA class I histocompatibility antigen, A-26 alpha chain PSMD13 HLA class I histocompatibility antigen, Cw-12 alpha chain HECTD2 HLA class I histocompatibility antigen, A-23 alpha chain CUL3 class I MHC B37 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBE2J1 class I MHC B47 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B41 class I MHC B13 class I MHC B42 B2M(21-119) UBA5 UBE2H class I MHC B45 KLHL11 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B8 class I MHC B46 class I MHC B37 class I MHC B67 class I MHC B82 FBXO6 SEC24B B2M(21-119)HLA-B TRIP12 FBXO6 PSMC1 HLA class I histocompatibility antigen, Cw-18 alpha chain ASB8 SEC24D TRIM21 Mg2+HLA class I histocompatibility antigen, Cw-4 alpha chain precursor KEAP1 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA-B UBC(609-684) class I MHC B18 class I MHC B53 ANAPC7 HLA class I histocompatibility antigen, Cw-14 alpha chain L-Phe class I MHC B35 class I MHC B50 PSMA2 class I MHC B81 class I MHC B15 class I MHC B37 HLA class I histocompatibility antigen, A-11 alpha chain UbHLA class I histocompatibility antigen, A-36 alpha chain ZBTB16 PSMC2 GTP UBAC1 MGRN1 MYLIP HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain Mg2+class I MHC B49 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-16 alpha chain SKP2 HUWE1 TCEB2 class I MHC B46 class I MHC B7 CDC16 UFL1 HLA class I histocompatibility antigen, E alpha chain precursor HERC5 RNF123 partially digestedAgTRIM41 SMURF2 L-Arg HLA class I histocompatibility antigen, A-69 alpha chain L-Ile BAP31 oligomerclass I MHC B67 class I MHC B82 HLA class I histocompatibility antigen, A-69 alpha chain UBE2J1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ASB15 SKP1 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B57 class I MHC B44 ATPHLA class I histocompatibility antigen, Cw-18 alpha chain FBXL8 UBC(229-304) HLA class I histocompatibility antigen, Cw-1 alpha chain (Glc)1 (GlcNAc)2 (Man)9 MEX3C HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B56 HLA-B HLA class I histocompatibility antigen, A-1 alpha chain precursor ASB6 TAPBP HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B81 ASB13 MKRN1 HLA class I histocompatibility antigen, A-3 alpha chain precursor ANAPC11 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B14 class I MHC B40 class I MHC B55 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B55 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B53 class I MHC B52 ASB2 PSMC4 HLA class I histocompatibility antigen, alpha chain G precursor SEC24D PJA1 class I MHC B15 CD207 SEC24D PSMA6 class I MHC B81 L-Ser HLA class I histocompatibility antigen, Cw-18 alpha chain TRIM63 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B35 ADPUbUBE2K class I MHC B38 HLA class I histocompatibility antigen, A-24 alpha chain K48polyUb-partiallydigested Agclass I MHC B56 PSMD11 ZNRF2 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B42 UBE2D4 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B49 UBA52(1-76) UBE3B Antigen peptide class I MHC B57 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor TRAF7 CANX GAN HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B50 class I MHC B52 class I MHC B59 class I MHC B52 class I MHC B57 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B27 HLA class I histocompatibility antigen, Cw-8 alpha chain UBA6 HLA class I histocompatibility antigen, A-2 alpha chain HERC2 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ASB5 ASB7 TCEB2 SEC24C class I MHC B47 PSME4 ERAP1/2class I MHC B57 HECTD3 class I MHC B44 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain UBE2R2 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain SPSB1 HLA class I histocompatibility antigen, A-34 alpha chain UBE2D4 class I MHC B44 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ANAPC7 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B51 LNPEP UBE2G2 oligopeptidefragment (8-16aa)HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain RBX1 ASB18 oligopeptidefragmentRNF126 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B7 class I MHC B8 SEC23:SEC24HLA class I histocompatibility antigen, A-3 alpha chain precursor UBE2D1 TRIM63 ATPclass I MHC B82 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor p-T154,S315-NCF4 HLA-H UBE2D1 HLA class I histocompatibility antigen, alpha chain F precursor MRC1 B2M(21-119) RLIM HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RNF34 class I MHC B41 FBXO3 class I MHC B55 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain UBR1 L-Thr MR:soluble antigenHLA-B class I MHC B50 HLA class I histocompatibility antigen, Cw-18 alpha chain PSMD10 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA-H L-Lys UBC(153-228) HLA class I histocompatibility antigen, alpha chain F precursor SEC31A HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B18 RNF14 ASB14 HERC1 RNF14 UBC(1-76) class I MHC B44 PJA2 TRIM4 RNF130 MRC2 (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B56 ASB10 HLA class I histocompatibility antigen, A-1 alpha chain precursor UBE2D4 class I MHC B41 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain RNF138 LNX1 class I MHC B58 RNF126 class I MHC B18 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain ASB14 HLA class I histocompatibility antigen, A-32 alpha chain L-Tyr HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain PDIA3 HLA class I histocompatibility antigen, A-23 alpha chain KLHL9 TRIM11 class I MHC B8 RNF41 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B78 RLIM class I MHC B39 TransloconUBA52(1-76) class I MHC B82 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B52 class I MHC B67 class I MHC B53 class I MHC B41 SAR1B:GTPHLA class I histocompatibility antigen, A-3 alpha chain precursor PARK2 L-Asp class I MHC B82 class I MHC B41 LONRF1 class I MHC B42 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain PiHLA class I histocompatibility antigen, Cw-15 alpha chain SEC23ASPSB4 HLA class I histocompatibility antigen, A-80 alpha chain RNF130 class I MHC B38 class I MHC B40 CDC27 ASB4 FBXL8 GTP HLA class I histocompatibility antigen, A-29 alpha chain FBXW8 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor ASB18 class I MHC B46 CDC16 SPSB1 class I MHC B81 ASB11 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B27 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B49 L-Asp HLA class I histocompatibility antigen, Cw-2 alpha chain L-Val L-Asn HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B81 KLHL21 class I MHC B8 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain L-Leu HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B82 class I MHC B58 class I MHC B50 class I MHC B81 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B27 HLA class I histocompatibility antigen, A-2 alpha chain PSMD12 SEC24A Class I MHC peptideloading complexclass I MHC B54 (Glc)1 (GlcNAc)2 (Man)9 E3 ligases inproteasomaldegradationclass I MHC B52 MIB2 class I MHC B54 class I MHC B73 class I MHC B82 MHCclassIHC:Calnexin/BiP:Erp57B2M(21-119) HLA class I histocompatibility antigen, Cw-14 alpha chain HLA-B HLA-H UBE2K class I MHC B54 UBE2L6 class I MHC B7 UBR4 UBB(1-76) ANAPC5 UBE2N PSMC6 class I MHC B39 class I MHC B51 PSMB2 class I MHC B14 UBC(609-684) RNF25 class I MHC B49 Particulate Ag:DCreceptorsGDPclass I MHC B42 DET1 AREL1 MHC:B2M peptideloading complexUBAC1 HLA class I histocompatibility antigen, A-24 alpha chain HECTD3 class I MHC B41 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, Cw-8 alpha chain RNF25 HLA class I histocompatibility antigen, Cw-8 alpha chain VPRBP HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain ANAPC13 HLA class I histocompatibility antigen, A-36 alpha chain CDC16 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-43 alpha chain SAR1B PSMB1 VPRBP RNF144B PSMD13 HLA class I histocompatibility antigen, Cw-8 alpha chain SEC13 HLA class I histocompatibility antigen, A-31 alpha chain L-Leu class I MHC B67 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B44 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor HERC6 CANX class I MHC B56 class I MHC B42 Gly HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B14 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor CUL2 class I MHC B35 Gly LRRC41 FBXW8 HLA class I histocompatibility antigen, E alpha chain precursor Gly Antigen ASB8 class I MHC B38 SPSB4 UBE2Q1 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain UBE3C L-Ala class I MHC B73 UBE2N HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor E1 bound ubiquitinHLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain HLA-H UBB(77-152) class I MHC B14 class I MHC B41 PSMB8 HLA class I histocompatibility antigen, Cw-16 alpha chain PPiUBB(77-152) p-6S-NCF1 HLA class I histocompatibility antigen, Cw-1 alpha chain (Glc)1 (GlcNAc)2 (Man)9 Antigen peptidebound class I MHCSKP1 SEC31APSMA8 SEC61B HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HECTD1 class I MHC B82 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain SPSB2 CD207 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-69 alpha chain UBE2G1 MEX3C class I MHC B13 HECW2 HLA class I histocompatibility antigen, A-68 alpha chain PSMD1 ANAPC10 HLA class I histocompatibility antigen, A-24 alpha chain ITGB5 class I MHC B82 class I MHC B78 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B58 class I MHC B51 UBC(381-456) HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B27 class I MHC B15 B2M(21-119) TRIM11 class I MHC B18 UBC(381-456) L-Glu LONRF1 HLA class I histocompatibility antigen, Cw-18 alpha chain UBA3 HLA class I histocompatibility antigen, A-80 alpha chain FCGR PSME3 class I MHC B15 RNF111 RNF182 class I MHC B73 PSMC3 class I MHC B73 L-His class I MHC B73 HLA class I histocompatibility antigen, A-80 alpha chain SMURF2 class I MHC B55 UBE2L6 monoglucosylated MHCclass IHC:Calnexin/BiPDZIP3 UBC(77-152) class I MHC B40 KLHL13 CDC16 class I MHC B53 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B14 TAP2 HUWE1 UBE2G1 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain PSMB4 L-Ala class I MHC B46 class I MHC B37 ITCH class I MHC B42 class I MHC B37 ERAP2 PSMC3 HLA class I histocompatibility antigen, A-26 alpha chain PSMB5 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor VPRBP UBE2B ASB6 class I MHC B49 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBE2G2 TCEB2 class I MHC B18 HLA class I histocompatibility antigen, A-68 alpha chain ASB6 L-Cys SEC24C class I MHC B52 HLA class I histocompatibility antigen, Cw-17 alpha chain K48polyUb-antigenicsubstrateHLA class I histocompatibility antigen, Cw-14 alpha chain MRC2 class I MHC B7 class I MHC B50 FBXO17 SEC24C PSMC5 class I MHC B51 ASB3 CTSS HLA class I histocompatibility antigen, A-66 alpha chain UFL1 TRIM4 HLA class I histocompatibility antigen, alpha chain G precursor HECTD1 HLA class I histocompatibility antigen, Cw-17 alpha chain SEC13TRIM50 HLA class I histocompatibility antigen, A-43 alpha chain ASB2 class I MHC B57 CUL5 class I MHC B50 SH3RF1 BTRC class I MHC B67 ARIH2 UBE2D1 HLA class I histocompatibility antigen, A-33 alpha chain Piclass I MHC B40 HLA class I histocompatibility antigen, A-33 alpha chain UNKL HLA-B UBA7 TRIM36 HLA class I histocompatibility antigen, A-32 alpha chain BLMH RNF111 L-Leu HLA class I histocompatibility antigen, A-66 alpha chain UBE2J1 class I MHC B8 Exogenous Particulate antigen (Ag) HLA class I histocompatibility antigen, A-31 alpha chain TCEB1 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor SEC24A UBE2K HERC6 PJA1 RNF114 class I MHC B81 VHL TRAF7 HERC6 SEC24D CDC23 L-Pro HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B47 class I MHC B39 class I MHC B42 HLA class I histocompatibility antigen, A-11 alpha chain ANAPC7 STUB1 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor CDC26 class I MHC B51 class I MHC B53 class I MHC B14 class I MHC B47 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B44 UBA1 L-Glu ERAP1 HLA class I histocompatibility antigen, A-1 alpha chain precursor RNF123 L-Asn HLA class I histocompatibility antigen, A-30 alpha chain TRIM50 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor UBC(229-304) ASB11 PSMD10 HLA class I histocompatibility antigen, A-43 alpha chain UBC(457-532) UBE2J2 SEC24D UBE2B Antigen peptide B2M(21-119) HLA class I histocompatibility antigen, A-68 alpha chain PSME2 ZNRF1 class I MHC B41 SH3RF1 PSMA8 class I MHC B67 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B38 MIB2 class I MHC B55 PSMA5 ASB5 class I MHC B8 B2M(21-119) MGRN1 ATPTCEB1 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B51 class I MHC B41 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B82 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain KEAP1 HLA class I histocompatibility antigen, A-11 alpha chain FCGRA class I MHC B45 HLA class I histocompatibility antigen, A-69 alpha chain TRIM37 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain L-Val CDC20 HERC4 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain L-Amino Acidsclass I MHC B7 PSMB10 class I MHC B67 class I MHC B57 L-Ala Exogenous soluble antigen precursor peptidefragment (>16 aa)FZR1 class I MHC B15 TRAIP UBB(153-228) HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B44 UBC(305-380) HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain Antigen peptide HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain SIAH1 FBXW11 KLHL21 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B45 ANAPC5 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B78 class I MHC B47 class I MHC B18 class I MHC B82 UBC(153-228) TRIM69 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor L-Ile RBBP6 HLA class I histocompatibility antigen, A-34 alpha chain UBC(305-380) FBXL4 CUL2 UBR2 CUL5 ITCH HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B8 HLA class I histocompatibility antigen, A-23 alpha chain WWP1 HLA class I histocompatibility antigen, A-30 alpha chain KEAP1 UBE2Q2 B2M(21-119) class I MHC B46 CALRANAPC4 NEDD4 UBE2A UBE4A HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B27 class I MHC B35 ASB6 PSMA1 LRR1 HLA class I histocompatibility antigen, A-74 alpha chain UBR1 PJA2 class I MHC B39 RNF19B LRSAM1 HLA class I histocompatibility antigen, Cw-18 alpha chain SAR1B UBC(77-152) class I MHC B39 FBXW8 RNF138 TRIM37 CTSS-like proteinsUBE3C UBA3 HERC3 HLA class I histocompatibility antigen, A-24 alpha chain SMURF1 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain PSMA7 HLA class I histocompatibility antigen, A-11 alpha chain L-Met HLA class I histocompatibility antigen, alpha chain G precursor ASB13 UBE2M class I MHC B54 UBC(457-532) HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain UBC(381-456) HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B38 HLA-H class I MHC B35 CUL1 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B47 HLA class I histocompatibility antigen, Cw-14 alpha chain FZR1 TRIM39 class I MHC B38 class I MHC B59 Antigen peptidebound class I MHCTRIM21 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor RNF138 RNF115 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B58 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B15 UBB(1-76) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor WSB1 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor CBLB class I MHC B13 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B57 UBE3D HLA class I histocompatibility antigen, A-23 alpha chain SKP2 HLA class I histocompatibility antigen, E alpha chain precursor PSMC6 class I MHC B37 class I MHC B42 KLHL13 MR/other probablereceptorsUBC(305-380) HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B35 ANAPC5 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B15 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B41 class I MHC B67 class I MHC B47 Exogenous solubleantigenANAPC4 UBE2A KLHL20 4xPalmC-CD36 CUL1 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B14 H2Oclass I MHC B41 class I MHC B50 HLA class I histocompatibility antigen, A-2 alpha chain L-Gln RNF4 PPiclass I MHC B38 class I MHC B49 HLA class I histocompatibility antigen, A-69 alpha chain L-Tyr L-Amino AcidsCDC27 CALR PSMA2 CDC26 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain MGRN1 ASB9 UBC(533-608) BTRC class I MHC B55 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain ASB14 class I MHC B56 UBB(153-228) SEC23A PSMD4 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain SEC24C L-Phe SMURF1 ANAPC1 ZNF645 class I MHC B78 UBE2J2 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain FBXO31 Antigen peptidebound class I MHCHLA-B ASB10 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-11 alpha chain UBC(153-228) HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B58 class I MHC B52 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ZNRF1 class I MHC B73 PSMA4 TRIP12 HLA class I histocompatibility antigen, A-2 alpha chain TRIM37 HLA class I histocompatibility antigen, Cw-15 alpha chain PSMB4 DZIP3 class I MHC B14 Exogenous soluble antigen FBXO27 PSMD8 SIAH2 HLA class I histocompatibility antigen, A-1 alpha chain precursor RNF34 MYLIP class I MHC B55 PSME2 HLA class I histocompatibility antigen, A-29 alpha chain SMURF2 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B50 class I MHC B47 PSMC2 CUL5 class I MHC B55 CALR PSMD5 class I MHC B73 class I MHC B78 HLA class I histocompatibility antigen, A-24 alpha chain UBE2J2 class I MHC B7 HLA class I histocompatibility antigen, Cw-1 alpha chain FBXO2 class I MHC B55 TAPHLA class I histocompatibility antigen, A-69 alpha chain UBE3D HLA class I histocompatibility antigen, Cw-1 alpha chain PPiSEC13 RPS27A(1-76) ASB12 class I MHC B56 UBC(609-684) HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B58 ANAPC10 FBXO3 class I MHC B51 SH3RF1 UBR1 RNF25 HLA class I histocompatibility antigen, A-66 alpha chain UBC(305-380) class I MHC B46 TRIM9 class I MHC B35 class I MHC B15 RNF217 HLA class I histocompatibility antigen, A-36 alpha chain DZIP3 ITGB5 L-Cys KLHL13 FBXO4 HLA class I histocompatibility antigen, alpha chain F precursor PSMB9 class I MHC B38 class I MHC B56 PSME1 class I MHC B58 HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B67 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B54 UFL1 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B44 class I MHC B8 HLA class I histocompatibility antigen, Cw-15 alpha chain NEDD4L ASB11 UBC(1-76) class I MHC B7 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain ASB14 UBE2Q2 class I MHC B53 ANAPC4 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain PSMB4 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B42 class I MHC B57 PSMB7 L-Leu class I MHC B78 ASB17 KLHL11 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B13 PSMD1 COPIICYBB RPS27A(1-76) UBR2 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B40 FBXO27 class I MHC B81 26S proteasomeHLA-B UBR4 UBC(609-684) ASB18 L-Arg HLA class I histocompatibility antigen, A-2 alpha chain HECW2 HERC3 HLA class I histocompatibility antigen, A-25 alpha chain K48polyUb-antigenic substrate HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain ANAPC2 class I MHC B15 SOCS3 SPSB2 PSMA1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor monoglucosylated MHCclass I HCUBC(1-76) HLA class I histocompatibility antigen, alpha chain G precursor antigenic substrateTRIM21 UBE2E3 BTRC class I MHC B59 SPSB4 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain TRIM71 ITCH TRIM9 ASB4 SKP2 FBXO6 NEDD4 class I MHC B59 MIB2 TCEB1 UBE2U TRIM41 UBA1 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B13 O2.-FBXL8 HLA-H HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B58 HLA-B class I MHC B39 HLA class I histocompatibility antigen, E alpha chain precursor NPEPPS TRIM32 class I MHC B45 E3:Ub:substrateclass I MHC B58 HLA-B HECTD1 HLA class I histocompatibility antigen, A-3 alpha chain precursor Ag peptide boundclass I MHCSMURF1 WSB1 HLA class I histocompatibility antigen, Cw-14 alpha chain MRC1 TAPBPARIH2 ANAPC1 class I MHC B45 ASB7 HLA class I histocompatibility antigen, A-25 alpha chain L-Ser HLA class I histocompatibility antigen, A-33 alpha chain FBXO2 UBE2D2 class I MHC B81 class I MHC B47 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B35 class I MHC B15 MR:soluble antigenclass I MHC B15 HLA class I histocompatibility antigen, A-32 alpha chain Antigen peptide class I MHC B73 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain PSMA3 class I MHC B18 class I MHC B35 UBE2H class I MHC B53 class I MHC B27 UBE2O RPS27A(1-76) class I MHC B56 class I MHC B13 SMURF2 class I MHC B14 RNF213 class I MHC B58 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, B-48 alpha chain class I MHC B58 HLA class I histocompatibility antigen, Cw-1 alpha chain KEAP1 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain TRIM36 UBE2L3 HLA class I histocompatibility antigen, A-68 alpha chain PSMF1 MRC2 RNF220 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B57 RNF4 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B45 class I MHC B44 HLA class I histocompatibility antigen, A-31 alpha chain L-His L-Pro HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B45 class I MHC B14 UBC(153-228) UNKL class I MHC B45 HLA class I histocompatibility antigen, A-34 alpha chain RNF34 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B53 LTN1 L-Gln CANX HLA class I histocompatibility antigen, Cw-17 alpha chain HLA-H HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBR4 STUB1 ASB9 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B14 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B7 Ubiquitin activatingE1 enzymesclass I MHC B54 UBE2Z class I MHC B37 CUL2 UBC(457-532) HLA class I histocompatibility antigen, A-3 alpha chain precursor RNF19A TRIM50 class I MHC B40 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain RNF4 class I MHC B52 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B57 FBXL4 ATG7 ZBTB16 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B54 CDC20 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B27 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor UBE3B L-Trp class I MHC B15 class I MHC B59 HECW2 ASB12 class I MHC B54 RBCK1 RBBP6 class I MHC B38 RNF6 HLA class I histocompatibility antigen, A-1 alpha chain precursor PARK2 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B50 LRR1 HERC5 L-Ala PDIA3 PSMB8 HLA class I histocompatibility antigen, E alpha chain precursor PSMD10 class I MHC B41 UBC(229-304) HLA class I histocompatibility antigen, A-68 alpha chain HLA-B PSMB9 HUWE1 ASB12 class I MHC B58 class I MHC B52 class I MHC B40 UBE2E3 L-Cys class I MHC B40 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B49 HLA-B L-Trp ASB1 p-T233-NCF2 UBE2E2 class I MHC B40 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBB(77-152) UBOX5 BTBD1 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B8 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B18 class I MHC B78 HLA class I histocompatibility antigen, A-2 alpha chain RNF220 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor TRIM71 L-His class I MHC B39 class I MHC B55 RBCK1 LONRF1 Antigen peptidebound class I MHCclass I MHC B81 HLA class I histocompatibility antigen, A-69 alpha chain HLA-H MYLIP HLA class I histocompatibility antigen, A-29 alpha chain TRIM41 class I MHC B47 UBC(381-456) HLA class I histocompatibility antigen, Cw-2 alpha chain ASB7 CDC20 (Glc)1 (GlcNAc)2 (Man)9 class I MHC B53 class I MHC B57 UBE2E2 class I MHC B40 UBE2V2 HLA class I histocompatibility antigen, A-31 alpha chain ASB9 L-Leu SEC23A class I MHC B73 ASB5 HLA class I histocompatibility antigen, Cw-15 alpha chain FBXO27 RNF41 ZNF645 SEC13 HERC4 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBC(533-608) ITGAV(31-1048) RNF6 BTBD1 UBE2M class I MHC B56 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-8 alpha chain RNF19A HLA class I histocompatibility antigen, alpha chain F precursor ZNRF2 HLA class I histocompatibility antigen, A-26 alpha chain NEDD4 class I MHC B15 PSMC5 ASB1 class I MHC B51 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B45 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-12 alpha chain ZNRF2 class I MHC B47 DZIP3 CUL2 class I MHC B37 UBE3C PSMA3 PSMD2 class I MHC B39 UBE4A class I MHC B51 HLA class I histocompatibility antigen, A-32 alpha chain PSMD9 PSMC4 class I MHC B56 class I MHC B54 KLHL13 L-Ser class I MHC B51 ANAPC2 HLA class I histocompatibility antigen, Cw-14 alpha chain UBC(533-608) class I MHC B49 LRRC41 HLA class I histocompatibility antigen, B-48 alpha chain WSB1 PSMC6 ZNF645 class I MHC B37 class I MHC B67 class I MHC B13 class I MHC B54 class I MHC B35 class I MHC B45 RNF138 UBA6 HLA class I histocompatibility antigen, A-30 alpha chain CBLB HLA class I histocompatibility antigen, A-25 alpha chain Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IHLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B42 class I MHC B54 Exogenous solubleantigenASB4 B2M(21-119) HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B46 MHC HC:B2M:Erp57HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor PSMC1 HLA class I histocompatibility antigen, alpha chain G precursor PSMB7 FZR1 PJA1 HLA class I histocompatibility antigen, A-80 alpha chain PSMD6 NEDD4L UBA7 class I MHC B18 HLA class I histocompatibility antigen, A-34 alpha chain PSMB3 UBC(229-304) class I MHC B46 class I MHC B58 class I MHC B55 class I MHC B49 DC receptorsrecognizingapoptotic cellsclass I MHC B40 L-Lys class I MHC B82 HLA class I histocompatibility antigen, A-31 alpha chain L-His class I MHC B7 BTBD1 UBA5 HLA-B class I MHC B35 SAR1B PSMD4 HLA class I histocompatibility antigen, A-25 alpha chain L-Tyr HLA class I histocompatibility antigen, Cw-12 alpha chain L-Leu class I MHC B67 TAPBP SEC24A UBE2V1 class I MHC B56 HACE1 HSPA5 SEC24B B2M(21-119) MKRN1 class I MHC B73 PSMD7 UBE2Z PSME1 UBAC1 HLA class I histocompatibility antigen, Cw-15 alpha chain IRAP in complex withMHC class IDC receptorsrecognizingapoptotic cellsHERC3 HLA class I histocompatibility antigen, A-74 alpha chain UBE3A HLA class I histocompatibility antigen, A-29 alpha chain TRIM9 HLA class I histocompatibility antigen, A-11 alpha chain SIAH2 class I MHC B35 FZR1 class I MHC B49 LRSAM1 Gly HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain PSMA5 class I MHC B49 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain PSMB6 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain CUL1 class I MHC B73 HACE1 ANAPC11 SKP2 class I MHC B58 class I MHC B73 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ZNF645 class I MHC B37 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain UBC(77-152) UBC(533-608) HLA class I histocompatibility antigen, E alpha chain precursor UBA52(1-76) FBXO2 UBOX5 26S proteasomeclass I MHC B37 Ubiquitin:E2conjugating enzymesUBE2E3 class I MHC B38 PSMD3 CDC27 class I MHC B13 HLA class I histocompatibility antigen, A-23 alpha chain TRIM37 PSMD3 HERC4 TRIM50 class I MHC B37 UNKL HLA class I histocompatibility antigen, A-24 alpha chain UBE3D Antigen peptideclass I MHC B57 L-Met HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B81 class I MHC B55 RNF182 HLA class I histocompatibility antigen, A-66 alpha chain SEC23A ExogenousParticulate antigen(Ag)SEC24A HLA class I histocompatibility antigen, Cw-1 alpha chain ASB4 HLA class I histocompatibility antigen, A-11 alpha chain SEC24B HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HERC2 class I MHC B37 UBE2F LRR1 HLA class I histocompatibility antigen, A-34 alpha chain UBA52(1-76) HLA-H RNF19B class I MHC B51 UBC(77-152) HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B47 L-Glu PSMB6 HLA class I histocompatibility antigen, A-30 alpha chain UBE2C HLA class I histocompatibility antigen, A-80 alpha chain RNF114 class I MHC B13 class I MHC B78 UBE2W UBE2M HLA class I histocompatibility antigen, A-33 alpha chain AREL1 PSMB10 L-Val HLA class I histocompatibility antigen, Cw-2 alpha chain partially digestedAgCBLB class I MHC B82 HLA class I histocompatibility antigen, Cw-12 alpha chain L-Trp HLA class I histocompatibility antigen, Cw-2 alpha chain UBE2S SEC24C class I MHC B18 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B55 RBCK1 HLA class I histocompatibility antigen, A-43 alpha chain ATPHLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain PSMD3 class I MHC B47 class I MHC B59 HLA-H KLHL21 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor L-Glu class I MHC B78 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor PDIA3UBE2D3 class I MHC B44 HLA-H TRIM63 class I MHC B7 class I MHC B50 L-His UBE2D3 BAP31 oligomer HLA class I histocompatibility antigen, Cw-7 alpha chain precursor NEDD4L L-Cys UBE2R2 RCHY1 UBR1 HLA class I histocompatibility antigen, A-25 alpha chain L-Val WWP1 TRIM21 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-31 alpha chain UBE2D3 PSMC4 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PSMB6 MKRN1 DET1 LRRC41 CDC23 SEC31A HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B81 CDC26 SOCS3 UBB(153-228) FBXL8 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B54 HERC1 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain RNF4 RNF126 class I MHC B47 BTRC class I MHC B78 HLA class I histocompatibility antigen, alpha chain G precursor SAR1B HLA class I histocompatibility antigen, A-24 alpha chain SEC23A PSMA1 PSMA4 FCGR class I MHC B52 HLA class I histocompatibility antigen, A-24 alpha chain RNF14 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain PSMA4 ANAPC7 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B47 HLA class I histocompatibility antigen, A-32 alpha chain SOCS1 UBB(1-76) CUL7 LONRF1 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor DTX3L B2M(21-119) HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain FBXL4 PSMB1 UBE3A class I MHC B55 class I MHC B15 PSME1 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B53 UBOX5 class I MHC B58 ITGAV(31-1048) class I MHC B45 class I MHC B13 FBXW11 TAP1 VHL class I MHC B49 class I MHC B7 PDIA3 RCHY1 class I MHC B67 HLA class I histocompatibility antigen, A-74 alpha chain (Glc)1 (GlcNAc)2 (Man)9 RPS27A(1-76) HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain L-Arg HLA class I histocompatibility antigen, Cw-18 alpha chain TRIM69 RBX1 class I MHC B39 CD207 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain CDC34 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B18 UBOX5 ANAPC5 UBR2 HLA-H HLA class I histocompatibility antigen, alpha chain G precursor L-Thr HLA class I histocompatibility antigen, Cw-8 alpha chain PSMD14 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B78 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PSMD8 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B14 L-His RBX1 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B54 RBBP6 class I MHC B37 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B14 NOX2 complexclass I MHC B52 PSME4 class I MHC B78 HLA class I histocompatibility antigen, A-23 alpha chain ZNRF2 GTP KLHL9 PSMD5 ASB8 UBB(77-152) RNF115 HLA class I histocompatibility antigen, A-69 alpha chain MRC2 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B67 class I MHC B27 class I MHC B39 class I MHC B46 HLA class I histocompatibility antigen, alpha chain G precursor UBE2E2 HLA class I histocompatibility antigen, A-43 alpha chain SH3RF1 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B53 class I MHC B40 class I MHC B59 UBC(1-76) HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B47 TAP2 CD36 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor AMPclass I MHC B40 ASB1 HLA class I histocompatibility antigen, E alpha chain precursor B2M(21-119) HLA class I histocompatibility antigen, A-34 alpha chain UBE2S SOCS1 SPSB4 L-Lys AREL1 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain ASB15 RLIM UBA52(1-76) ASB17 GTPHLA class I histocompatibility antigen, A-32 alpha chain class I MHC B39 class I MHC B46 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain AMPHLA class I histocompatibility antigen, A-69 alpha chain RPS27A(1-76) HLA class I histocompatibility antigen, A-74 alpha chain CUL3 RNF6 class I MHC B59 ASB9 HLA class I histocompatibility antigen, Cw-15 alpha chain IFN gamma stimulatedaminopeptidasesAntigen class I MHC B49 ASB16 class I MHC B8 class I MHC B67 SEC24D class I MHC B38 DET1 class I MHC B78 FBXW7 HLA-H PSMD1 HLA class I histocompatibility antigen, A-2 alpha chain FBXO44 class I MHC B7 PSME3 FBXO3 HLA class I histocompatibility antigen, A-2 alpha chain LNX1 KLHL20 L-Lys class I MHC B7 L-Asn L-Lys UBE2O HLA class I histocompatibility antigen, A-66 alpha chain L-Asn class I MHC B73 UBB(153-228) HLA class I histocompatibility antigen, Cw-4 alpha chain precursor L-Pro class I MHC B44 HLA class I histocompatibility antigen, Cw-14 alpha chain RNF41 DET1 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain ITCH HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B51 RNF220 HLA class I histocompatibility antigen, A-36 alpha chain RNF114 ARIH2 class I MHC B53 WWP1 GTP NADPHPSMD11 TRIM32 HERC2 ASB3 L-Ser RNF144B class I MHC B51 UBC(457-532) HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B8 class I MHC B39 HACE1 L-Phe class I MHC B39 HLA class I histocompatibility antigen, A-23 alpha chain L-Thr class I MHC B57 ASB1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B38 UBC(153-228) HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B58 HLA class I histocompatibility antigen, A-43 alpha chain TAP2 HLA class I histocompatibility antigen, A-34 alpha chain KLHL9 class I MHC B57 UBE2C PSMB11 class I MHC B8 HERC5 ASB10 1640106, 1089815389612, 34, 36, 54, 58...96971597159696


Description

Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface. View original pathway at:Reactome.

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  70. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
  71. Houde M, Bertholet S, Gagnon E, Brunet S, Goyette G, Laplante A, Princiotta MF, Thibault P, Sacks D, Desjardins M.; ''Phagosomes are competent organelles for antigen cross-presentation.''; PubMed Europe PMC Scholia
  72. Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF.; ''NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.''; PubMed Europe PMC Scholia
  73. Hu Q, Guo C, Li Y, Aronow BJ, Zhang J.; ''LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.''; PubMed Europe PMC Scholia
  74. Huang AY, Bruce AT, Pardoll DM, Levitsky HI.; ''In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter.''; PubMed Europe PMC Scholia
  75. Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C.; ''CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.''; PubMed Europe PMC Scholia
  76. Ladasky JJ, Boyle S, Seth M, Li H, Pentcheva T, Abe F, Steinberg SJ, Edidin M.; ''Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules.''; PubMed Europe PMC Scholia
  77. Ohnishi T, Muroi M, Tanamoto K.; ''N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.''; PubMed Europe PMC Scholia
  78. Kloetzel PM, Ossendorp F.; ''Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.''; PubMed Europe PMC Scholia
  79. Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL.; ''Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.''; PubMed Europe PMC Scholia
  80. Franz J, Jerome J, Lear T, Gong Q, Weathington NM.; ''The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.''; PubMed Europe PMC Scholia
  81. Burgdorf S, Kurts C.; ''Endocytosis mechanisms and the cell biology of antigen presentation.''; PubMed Europe PMC Scholia
  82. Craiu A, Akopian T, Goldberg A, Rock KL.; ''Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.''; PubMed Europe PMC Scholia
  83. Beninga J, Rock KL, Goldberg AL.; ''Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase.''; PubMed Europe PMC Scholia
  84. Mulherkar SA, Sharma J, Jana NR.; ''The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.''; PubMed Europe PMC Scholia
  85. Aderem A, Underhill DM.; ''Mechanisms of phagocytosis in macrophages.''; PubMed Europe PMC Scholia
  86. Loureiro J, Ploegh HL.; ''Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.''; PubMed Europe PMC Scholia
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  90. Neefjes JJ, Momburg F, Hämmerling GJ.; ''Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.''; PubMed Europe PMC Scholia
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  92. Fortier JM, Kornbluth J.; ''NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.''; PubMed Europe PMC Scholia
  93. Hatakeyama S, Nakayama KI.; ''U-box proteins as a new family of ubiquitin ligases.''; PubMed Europe PMC Scholia
  94. Nakano A, Luini A.; ''Passage through the Golgi.''; PubMed Europe PMC Scholia
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  96. van Wijk SJ, Timmers HT.; ''The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.''; PubMed Europe PMC Scholia
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  98. Saper MA, Bjorkman PJ, Wiley DC.; ''Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution.''; PubMed Europe PMC Scholia
  99. Hochman JH, Shimizu Y, DeMars R, Edidin M.; ''Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin.''; PubMed Europe PMC Scholia
  100. Procko E, Gaudet R.; ''Antigen processing and presentation: TAPping into ABC transporters.''; PubMed Europe PMC Scholia
  101. Ackerman AL, Kyritsis C, Tampé R, Cresswell P.; ''Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells.''; PubMed Europe PMC Scholia
  102. Diedrich G, Bangia N, Pan M, Cresswell P.; ''A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  103. Harris MR, Yu YY, Kindle CS, Hansen TH, Solheim JC.; ''Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.''; PubMed Europe PMC Scholia
  104. Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J.; ''G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.''; PubMed Europe PMC Scholia
  105. Lührig S, Kolb S, Mellies N, Nolte J.; ''The novel BTB-kelch protein, KBTBD8, is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis.''; PubMed Europe PMC Scholia
  106. Stronge VS, Saito Y, Ihara Y, Williams DB.; ''Relationship between calnexin and BiP in suppressing aggregation and promoting refolding of protein and glycoprotein substrates.''; PubMed Europe PMC Scholia
  107. Bouin AP, Grandvaux N, Vignais PV, Fuchs A.; ''p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process.''; PubMed Europe PMC Scholia
  108. Howe C, Garstka M, Al-Balushi M, Ghanem E, Antoniou AN, Fritzsche S, Jankevicius G, Kontouli N, Schneeweiss C, Williams A, Elliott T, Springer S.; ''Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules.''; PubMed Europe PMC Scholia
  109. Lange S, Perera S, Teh P, Chen J.; ''Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.''; PubMed Europe PMC Scholia
  110. Lin ML, Zhan Y, Villadangos JA, Lew AM.; ''The cell biology of cross-presentation and the role of dendritic cell subsets.''; PubMed Europe PMC Scholia
  111. Vieira OV, Botelho RJ, Grinstein S.; ''Phagosome maturation: aging gracefully.''; PubMed Europe PMC Scholia
  112. Paulsson KM, Wang P.; ''Quality control of MHC class I maturation.''; PubMed Europe PMC Scholia
  113. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES.; ''Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate.''; PubMed Europe PMC Scholia
  114. Katayama K, Noguchi K, Sugimoto Y.; ''FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.''; PubMed Europe PMC Scholia
  115. Kloetzel PM.; ''Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.''; PubMed Europe PMC Scholia
  116. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO.; ''Mechanisms of ubiquitin transfer by the anaphase-promoting complex.''; PubMed Europe PMC Scholia
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  118. Ramachandra L, Simmons D, Harding CV.; ''MHC molecules and microbial antigen processing in phagosomes.''; PubMed Europe PMC Scholia
  119. Hotton SK, Callis J.; ''Regulation of cullin RING ligases.''; PubMed Europe PMC Scholia
  120. Rothwarf DM, Zandi E, Natoli G, Karin M.; ''IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.''; PubMed Europe PMC Scholia
  121. Kong Q, Zeng W, Wu J, Hu W, Li C, Mao B.; ''RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination.''; PubMed Europe PMC Scholia
  122. Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL.; ''26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.''; PubMed Europe PMC Scholia
  123. Abe F, Van Prooyen N, Ladasky JJ, Edidin M.; ''Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  124. Deshaies RJ, Joazeiro CA.; ''RING domain E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  125. Kloetzel PM.; ''The proteasome and MHC class I antigen processing.''; PubMed Europe PMC Scholia
  126. Doherty GJ, McMahon HT.; ''Mechanisms of endocytosis.''; PubMed Europe PMC Scholia
  127. York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL.; ''The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.''; PubMed Europe PMC Scholia
  128. Burgdorf S, Lukacs-Kornek V, Kurts C.; ''The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.''; PubMed Europe PMC Scholia
  129. Crotzer VL, Blum JS.; ''Autophagy and its role in MHC-mediated antigen presentation.''; PubMed Europe PMC Scholia
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  131. Antoniou AN, Powis SJ, Elliott T.; ''Assembly and export of MHC class I peptide ligands.''; PubMed Europe PMC Scholia
  132. Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S.; ''Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.''; PubMed Europe PMC Scholia
  133. Danilczyk UG, Cohen-Doyle MF, Williams DB.; ''Functional relationship between calreticulin, calnexin, and the endoplasmic reticulum luminal domain of calnexin.''; PubMed Europe PMC Scholia
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  135. Meroni G, Diez-Roux G.; ''TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  136. Ware FE, Vassilakos A, Peterson PA, Jackson MR, Lehrman MA, Williams DB.; ''The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteins.''; PubMed Europe PMC Scholia
  137. D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, Dynlacht B, Pagano M.; ''SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.''; PubMed Europe PMC Scholia
  138. Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y.; ''E6AP promotes the degradation of the PML tumor suppressor.''; PubMed Europe PMC Scholia
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  141. Sato K, Nakano A.; ''Mechanisms of COPII vesicle formation and protein sorting.''; PubMed Europe PMC Scholia
  142. Kallijärvi J, Lahtinen U, Hämäläinen R, Lipsanen-Nyman M, Palvimo JJ, Lehesjoki AE.; ''TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117684view12:08, 22 May 2021EweitzModified title
114758view16:24, 25 January 2021ReactomeTeamReactome version 75
113202view11:26, 2 November 2020ReactomeTeamReactome version 74
112427view15:37, 9 October 2020ReactomeTeamReactome version 73
101331view11:21, 1 November 2018ReactomeTeamreactome version 66
100869view20:55, 31 October 2018ReactomeTeamreactome version 65
100410view19:28, 31 October 2018ReactomeTeamreactome version 64
99959view16:13, 31 October 2018ReactomeTeamreactome version 63
99514view14:45, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99156view12:41, 31 October 2018ReactomeTeamreactome version 62
94507view09:31, 14 September 2017Mkutmonreactome version 61
87162view19:18, 18 July 2016MkutmonOntology Term : 'adaptive immune response pathway' added !
87068view11:35, 18 July 2016ReactomeTeamReactome version 56
83467view12:31, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Glc)1 (GlcNAc)2 (Man)9 MetaboliteCHEBI:59080 (ChEBI)
26S proteasomeComplexR-HSA-68819 (Reactome)
4xPalmC-CD36 ProteinP16671 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANAPC1 ProteinQ9H1A4 (Uniprot-TrEMBL)
ANAPC10 ProteinQ9UM13 (Uniprot-TrEMBL)
ANAPC11 ProteinQ9NYG5 (Uniprot-TrEMBL)
ANAPC13 ProteinQ9BS18 (Uniprot-TrEMBL)
ANAPC2 ProteinQ9UJX6 (Uniprot-TrEMBL)
ANAPC4 ProteinQ9UJX5 (Uniprot-TrEMBL)
ANAPC5 ProteinQ9UJX4 (Uniprot-TrEMBL)
ANAPC7 ProteinQ9UJX3 (Uniprot-TrEMBL)
AREL1 ProteinO15033 (Uniprot-TrEMBL)
ARIH2 ProteinO95376 (Uniprot-TrEMBL)
ASB1 ProteinQ9Y576 (Uniprot-TrEMBL)
ASB10 ProteinQ8WXI3 (Uniprot-TrEMBL)
ASB11 ProteinQ8WXH4 (Uniprot-TrEMBL)
ASB12 ProteinQ8WXK4 (Uniprot-TrEMBL)
ASB13 ProteinQ8WXK3 (Uniprot-TrEMBL)
ASB14 ProteinA6NK59 (Uniprot-TrEMBL)
ASB15 ProteinQ8WXK1 (Uniprot-TrEMBL)
ASB16 ProteinQ96NS5 (Uniprot-TrEMBL)
ASB17 ProteinQ8WXJ9 (Uniprot-TrEMBL)
ASB18 ProteinQ6ZVZ8 (Uniprot-TrEMBL)
ASB2 ProteinQ96Q27 (Uniprot-TrEMBL)
ASB3 ProteinQ9Y575 (Uniprot-TrEMBL)
ASB4 ProteinQ9Y574 (Uniprot-TrEMBL)
ASB5 ProteinQ8WWX0 (Uniprot-TrEMBL)
ASB6 ProteinQ9NWX5 (Uniprot-TrEMBL)
ASB7 ProteinQ9H672 (Uniprot-TrEMBL)
ASB8 ProteinQ9H765 (Uniprot-TrEMBL)
ASB9 ProteinQ96DX5 (Uniprot-TrEMBL)
ATG7 ProteinO95352 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ag peptide bound class I MHCComplexR-HSA-1236931 (Reactome)
Ag-substrate:E3:E2:UbComplexR-HSA-983126 (Reactome)
Antigen R-NUL-173548 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ComplexR-HSA-983132 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-1236934 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-198904 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983114 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983412 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983416 (Reactome)
Antigen peptide R-NUL-1236727 (Reactome)
Antigen peptide R-NUL-983033 (Reactome)
Antigen peptide R-NUL-983324 (Reactome)
Antigen peptide R-NUL-983326 (Reactome)
Antigen peptideR-NUL-1236727 (Reactome)
Antigen peptideR-NUL-983033 (Reactome)
B2M(21-119) ProteinP61769 (Uniprot-TrEMBL)
B2M(21-119)ProteinP61769 (Uniprot-TrEMBL)
BAP31 oligomer R-HSA-983323 (Reactome)
BAP31 oligomerR-HSA-983323 (Reactome)
BLMH ProteinQ13867 (Uniprot-TrEMBL)
BTBD1 ProteinQ9H0C5 (Uniprot-TrEMBL)
BTRC ProteinQ9Y297 (Uniprot-TrEMBL)
CALR ProteinP27797 (Uniprot-TrEMBL)
CALRProteinP27797 (Uniprot-TrEMBL)
CANX ProteinP27824 (Uniprot-TrEMBL)
CBLB ProteinQ13191 (Uniprot-TrEMBL)
CD207 ProteinQ9UJ71 (Uniprot-TrEMBL)
CD36 ProteinP16671 (Uniprot-TrEMBL)
CDC16 ProteinQ13042 (Uniprot-TrEMBL)
CDC20 ProteinQ12834 (Uniprot-TrEMBL)
CDC23 ProteinQ9UJX2 (Uniprot-TrEMBL)
CDC26 ProteinQ8NHZ8 (Uniprot-TrEMBL)
CDC27 ProteinP30260 (Uniprot-TrEMBL)
CDC34 ProteinP49427 (Uniprot-TrEMBL)
COPII vesicle with MHC class IComplexR-HSA-983414 (Reactome)
COPII vesicle with MHC class IComplexR-HSA-983418 (Reactome)
COPIIComplexR-HSA-204019 (Reactome)
CTSL1(114-288) ProteinP07711 (Uniprot-TrEMBL)
CTSL2 ProteinO60911 (Uniprot-TrEMBL)
CTSS ProteinP25774 (Uniprot-TrEMBL)
CTSS-like proteinsComplexR-HSA-4127472 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CUL1 ProteinQ13616 (Uniprot-TrEMBL)
CUL2 ProteinQ13617 (Uniprot-TrEMBL)
CUL3 ProteinQ13618 (Uniprot-TrEMBL)
CUL5 ProteinQ93034 (Uniprot-TrEMBL)
CUL7 ProteinQ14999 (Uniprot-TrEMBL)
CYBA ProteinP13498 (Uniprot-TrEMBL)
CYBB ProteinP04839 (Uniprot-TrEMBL)
Chaperones calnexin/BiPComplexR-HSA-983129 (Reactome)
Class I MHC peptide loading complexComplexR-HSA-1236932 (Reactome)
Class I MHC:B2MComplexR-HSA-1236930 (Reactome)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236899 (Reactome)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236904 (Reactome)
DET1 ProteinQ7L5Y6 (Uniprot-TrEMBL)
DTX3L ProteinQ8TDB6 (Uniprot-TrEMBL)
DZIP3 ProteinQ86Y13 (Uniprot-TrEMBL)
E1 bound ubiquitinComplexR-HSA-976164 (Reactome)
E2 Ubiquitin-conjugating enzymeComplexR-HSA-947628 (Reactome)
E3 ligases in

proteasomal

degradation		ComplexR-HSA-976075 (Reactome)
E3:K48-polyubiquitinated substrateComplexR-HSA-983134 (Reactome)
E3:Ub:substrateComplexR-HSA-983131 (Reactome)
ERAP1 ProteinQ9NZ08 (Uniprot-TrEMBL)
ERAP1/2ComplexR-HSA-983125 (Reactome)
ERAP2 ProteinQ6P179 (Uniprot-TrEMBL)
Exogenous

Particulate antigen

(Ag)		R-NUL-1236714 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-NUL-1236716 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-NUL-1236726 (Reactome)
Exogenous Particulate antigen (Ag) R-NUL-1236726 (Reactome)
Exogenous soluble antigenR-NUL-1236715 (Reactome)
Exogenous soluble antigenR-NUL-1236719 (Reactome)
Exogenous soluble antigenR-NUL-1236720 (Reactome)
Exogenous soluble antigen R-NUL-1236720 (Reactome)
Exogenous soluble antigen R-NUL-1236723 (Reactome)
Exogenous soluble antigen R-NUL-1236724 (Reactome)
FBXL4 ProteinQ9UKA2 (Uniprot-TrEMBL)
FBXL8 ProteinQ96CD0 (Uniprot-TrEMBL)
FBXO17 ProteinQ96EF6 (Uniprot-TrEMBL)
FBXO2 ProteinQ9UK22 (Uniprot-TrEMBL)
FBXO27 ProteinQ8NI29 (Uniprot-TrEMBL)
FBXO3 ProteinQ9UK99 (Uniprot-TrEMBL)
FBXO31 ProteinQ5XUX0 (Uniprot-TrEMBL)
FBXO4 ProteinQ9UKT5 (Uniprot-TrEMBL)
FBXO44 ProteinQ9H4M3 (Uniprot-TrEMBL)
FBXO6 ProteinQ9NRD1 (Uniprot-TrEMBL)
FBXW11 ProteinQ9UKB1 (Uniprot-TrEMBL)
FBXW7 ProteinQ969H0 (Uniprot-TrEMBL)
FBXW8 ProteinQ8N3Y1 (Uniprot-TrEMBL)
FCGR R-HSA-1236898 (Reactome)
FCGR R-HSA-1236905 (Reactome)
FCGRA R-HSA-1031694 (Reactome)
FZR1 ProteinQ9UM11 (Uniprot-TrEMBL)
GAN ProteinQ9H2C0 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
Gly MetaboliteCHEBI:15428 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HACE1 ProteinQ8IYU2 (Uniprot-TrEMBL)
HECTD1 ProteinQ9ULT8 (Uniprot-TrEMBL)
HECTD2 ProteinQ5U5R9 (Uniprot-TrEMBL)
HECTD3 ProteinQ5T447 (Uniprot-TrEMBL)
HECW2 ProteinQ9P2P5 (Uniprot-TrEMBL)
HERC1 ProteinQ15751 (Uniprot-TrEMBL)
HERC2 ProteinO95714 (Uniprot-TrEMBL)
HERC3 ProteinQ15034 (Uniprot-TrEMBL)
HERC4 ProteinQ5GLZ8 (Uniprot-TrEMBL)
HERC5 ProteinQ9UII4 (Uniprot-TrEMBL)
HERC6 ProteinQ8IVU3 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-1 alpha chain precursor ProteinP30443 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-11 alpha chain ProteinP13746 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-23 alpha chain ProteinP30447 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-24 alpha chain ProteinP05534 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-25 alpha chain ProteinP18462 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-26 alpha chain ProteinP30450 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-29 alpha chain ProteinP30512 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-3 alpha chain precursor ProteinP04439 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-30 alpha chain ProteinP16188 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-31 alpha chain ProteinP16189 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-32 alpha chain ProteinP10314 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-33 alpha chain ProteinP16190 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-34 alpha chain ProteinP30453 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-36 alpha chain ProteinP30455 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-43 alpha chain ProteinP30456 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-66 alpha chain ProteinP30457 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-68 alpha chain ProteinP01891 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-69 alpha chain ProteinP10316 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-74 alpha chain ProteinP30459 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-80 alpha chain ProteinQ09160 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, B-48 alpha chain ProteinP30486 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-1 alpha chain ProteinP30499 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-12 alpha chain ProteinP30508 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-14 alpha chain ProteinP30510 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-15 alpha chain ProteinQ07000 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-16 alpha chain ProteinQ29960 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-17 alpha chain ProteinQ95604 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-18 alpha chain ProteinQ29865 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-2 alpha chain ProteinP30501 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ProteinP04222 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ProteinP30504 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ProteinQ9TNN7 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ProteinQ29963 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ProteinP10321 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-8 alpha chain ProteinP30505 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, E alpha chain precursor ProteinP13747 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain F precursor ProteinP30511 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain G precursor ProteinP17693 (Uniprot-TrEMBL)
HLA-B ProteinP30486 (Uniprot-TrEMBL)
HLA-C ProteinP10321 (Uniprot-TrEMBL)
HLA-H ProteinP01893 (Uniprot-TrEMBL)
HSPA5 ProteinP11021 (Uniprot-TrEMBL)
HUWE1 ProteinQ7Z6Z7 (Uniprot-TrEMBL)
IFN gamma stimulated aminopeptidasesComplexR-HSA-983128 (Reactome)
IRAP in complex with MHC class IComplexR-HSA-1236916 (Reactome)
ITCH ProteinQ96J02 (Uniprot-TrEMBL)
ITGAV(31-1048) ProteinP06756 (Uniprot-TrEMBL)
ITGB5 ProteinP18084 (Uniprot-TrEMBL)
K48polyUb-antigenic substrateR-NUL-983123 (Reactome)
K48polyUb-antigenic substrate R-NUL-983123 (Reactome)
K48polyUb-partially digested AgR-NUL-1236918 (Reactome)
KEAP1 ProteinQ14145 (Uniprot-TrEMBL)
KLHL11 ProteinQ9NVR0 (Uniprot-TrEMBL)
KLHL13 ProteinQ9P2N7 (Uniprot-TrEMBL)
KLHL20 ProteinQ9Y2M5 (Uniprot-TrEMBL)
KLHL21 ProteinQ9UJP4 (Uniprot-TrEMBL)
KLHL9 ProteinQ9P2J3 (Uniprot-TrEMBL)
L-Ala MetaboliteCHEBI:16977 (ChEBI)
L-Amino AcidsComplexR-ALL-1225821 (Reactome)
L-Amino AcidsComplexR-ALL-400144 (Reactome)
L-Amino AcidsComplexR-ALL-983135 (Reactome)
L-Arg MetaboliteCHEBI:16467 (ChEBI)
L-Asn MetaboliteCHEBI:17196 (ChEBI)
L-Asp MetaboliteCHEBI:17053 (ChEBI)
L-Cys MetaboliteCHEBI:17561 (ChEBI)
L-Gln MetaboliteCHEBI:18050 (ChEBI)
L-Glu MetaboliteCHEBI:16015 (ChEBI)
L-His MetaboliteCHEBI:15971 (ChEBI)
L-Ile MetaboliteCHEBI:17191 (ChEBI)
L-Leu MetaboliteCHEBI:15603 (ChEBI)
L-Lys MetaboliteCHEBI:18019 (ChEBI)
L-Met MetaboliteCHEBI:16643 (ChEBI)
L-Phe MetaboliteCHEBI:17295 (ChEBI)
L-Pro MetaboliteCHEBI:17203 (ChEBI)
L-Ser MetaboliteCHEBI:17115 (ChEBI)
L-Thr MetaboliteCHEBI:16857 (ChEBI)
L-Trp MetaboliteCHEBI:16828 (ChEBI)
L-Tyr MetaboliteCHEBI:17895 (ChEBI)
L-Val MetaboliteCHEBI:16414 (ChEBI)
LNPEP ProteinQ9UIQ6 (Uniprot-TrEMBL)
LNX1 ProteinQ8TBB1 (Uniprot-TrEMBL)
LONRF1 ProteinQ17RB8 (Uniprot-TrEMBL)
LRR1 ProteinQ96L50 (Uniprot-TrEMBL)
LRRC41 ProteinQ15345 (Uniprot-TrEMBL)
LRSAM1 ProteinQ6UWE0 (Uniprot-TrEMBL)
LTN1 ProteinO94822 (Uniprot-TrEMBL)
MEX3C ProteinQ5U5Q3 (Uniprot-TrEMBL)
MGRN1 ProteinO60291 (Uniprot-TrEMBL)
MHC

class I

HC:Calnexin/BiP:Erp57		ComplexR-HSA-983119 (Reactome)
MHC HC:B2M:Erp57ComplexR-HSA-983136 (Reactome)
MHC:B2M peptide loading complexComplexR-HSA-983121 (Reactome)
MIB2 ProteinQ96AX9 (Uniprot-TrEMBL)
MKRN1 ProteinQ9UHC7 (Uniprot-TrEMBL)
MR/other probable receptorsComplexR-HSA-1236909 (Reactome)
MR/other probable receptorsComplexR-HSA-1236911 (Reactome)
MR:soluble antigenComplexR-HSA-1236923 (Reactome)
MR:soluble antigenComplexR-HSA-1236926 (Reactome)
MR:soluble antigenComplexR-HSA-1236929 (Reactome)
MRC1 ProteinP22897 (Uniprot-TrEMBL)
MRC2 ProteinQ9UBG0 (Uniprot-TrEMBL)
MYLIP ProteinQ8WY64 (Uniprot-TrEMBL)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEDD4 ProteinP46934 (Uniprot-TrEMBL)
NEDD4L ProteinQ96PU5 (Uniprot-TrEMBL)
NOX2 complexComplexR-HSA-1996217 (Reactome)
NPEPPS ProteinP55786 (Uniprot-TrEMBL)
O2.-MetaboliteCHEBI:18421 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
PARK2 ProteinO60260 (Uniprot-TrEMBL)
PDIA3 ProteinP30101 (Uniprot-TrEMBL)
PDIA3ProteinP30101 (Uniprot-TrEMBL)
PJA1 ProteinQ8NG27 (Uniprot-TrEMBL)
PJA2 ProteinO43164 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
Particulate Ag:DC receptorsComplexR-HSA-1236920 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RBBP6 ProteinQ7Z6E9 (Uniprot-TrEMBL)
RBCK1 ProteinQ9BYM8 (Uniprot-TrEMBL)
RBX1 ProteinP62877 (Uniprot-TrEMBL)
RCHY1 ProteinQ96PM5 (Uniprot-TrEMBL)
RLIM ProteinQ9NVW2 (Uniprot-TrEMBL)
RNF111 ProteinQ6ZNA4 (Uniprot-TrEMBL)
RNF114 ProteinQ9Y508 (Uniprot-TrEMBL)
RNF115 ProteinQ9Y4L5 (Uniprot-TrEMBL)
RNF123 ProteinQ5XPI4 (Uniprot-TrEMBL)
RNF126 ProteinQ9BV68 (Uniprot-TrEMBL)
RNF130 ProteinQ86XS8 (Uniprot-TrEMBL)
RNF138 ProteinQ8WVD3 (Uniprot-TrEMBL)
RNF14 ProteinQ9UBS8 (Uniprot-TrEMBL)
RNF144B ProteinQ7Z419 (Uniprot-TrEMBL)
RNF182 ProteinQ8N6D2 (Uniprot-TrEMBL)
RNF19A ProteinQ9NV58 (Uniprot-TrEMBL)
RNF19B ProteinQ6ZMZ0 (Uniprot-TrEMBL)
RNF213 ProteinQ63HN8 (Uniprot-TrEMBL)
RNF217 ProteinQ8TC41 (Uniprot-TrEMBL)
RNF220 ProteinQ5VTB9 (Uniprot-TrEMBL)
RNF25 ProteinQ96BH1 (Uniprot-TrEMBL)
RNF34 ProteinQ969K3 (Uniprot-TrEMBL)
RNF4 ProteinP78317 (Uniprot-TrEMBL)
RNF41 ProteinQ9H4P4 (Uniprot-TrEMBL)
RNF6 ProteinQ9Y252 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SAR1B ProteinQ9Y6B6 (Uniprot-TrEMBL)
SAR1B:GDPComplexR-HSA-203989 (Reactome)
SAR1B:GTP:SEC23:SEC24ComplexR-HSA-203997 (Reactome)
SAR1B:GTPComplexR-HSA-204003 (Reactome)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEC13ProteinP55735 (Uniprot-TrEMBL)
SEC23:SEC24ComplexR-HSA-203975 (Reactome)
SEC23A ProteinQ15436 (Uniprot-TrEMBL)
SEC23AProteinQ15436 (Uniprot-TrEMBL)
SEC24A ProteinO95486 (Uniprot-TrEMBL)
SEC24B ProteinO95487 (Uniprot-TrEMBL)
SEC24C ProteinP53992 (Uniprot-TrEMBL)
SEC24D ProteinO94855 (Uniprot-TrEMBL)
SEC24ComplexR-HSA-203991 (Reactome)
SEC31A ProteinO94979 (Uniprot-TrEMBL)
SEC31AProteinO94979 (Uniprot-TrEMBL)
SEC61A1 ProteinP61619 (Uniprot-TrEMBL)
SEC61A2 ProteinQ9H9S3 (Uniprot-TrEMBL)
SEC61B ProteinP60468 (Uniprot-TrEMBL)
SEC61G ProteinP60059 (Uniprot-TrEMBL)
SH3RF1 ProteinQ7Z6J0 (Uniprot-TrEMBL)
SIAH1 ProteinQ8IUQ4 (Uniprot-TrEMBL)
SIAH2 ProteinO43255 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SKP2 ProteinQ13309 (Uniprot-TrEMBL)
SMURF1 ProteinQ9HCE7 (Uniprot-TrEMBL)
SMURF2 ProteinQ9HAU4 (Uniprot-TrEMBL)
SOCS1 ProteinO15524 (Uniprot-TrEMBL)
SOCS3 ProteinO14543 (Uniprot-TrEMBL)
SPSB1 ProteinQ96BD6 (Uniprot-TrEMBL)
SPSB2 ProteinQ99619 (Uniprot-TrEMBL)
SPSB4 ProteinQ96A44 (Uniprot-TrEMBL)
STUB1 ProteinQ9UNE7 (Uniprot-TrEMBL)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IComplexR-HSA-983413 (Reactome)
TAP1 ProteinQ03518 (Uniprot-TrEMBL)
TAP2 ProteinQ03519 (Uniprot-TrEMBL)
TAPBP ProteinO15533 (Uniprot-TrEMBL)
TAPBPProteinO15533 (Uniprot-TrEMBL)
TAPComplexR-HSA-1236915 (Reactome)
TAPComplexR-HSA-983113 (Reactome)
TCEB1 ProteinQ15369 (Uniprot-TrEMBL)
TCEB2 ProteinQ15370 (Uniprot-TrEMBL)
TPP2 ProteinP29144 (Uniprot-TrEMBL)
TRAF7 ProteinQ6Q0C0 (Uniprot-TrEMBL)
TRAIP ProteinQ9BWF2 (Uniprot-TrEMBL)
TRIM11 ProteinQ96F44 (Uniprot-TrEMBL)
TRIM21 ProteinP19474 (Uniprot-TrEMBL)
TRIM32 ProteinQ13049 (Uniprot-TrEMBL)
TRIM36 ProteinQ9NQ86 (Uniprot-TrEMBL)
TRIM37 ProteinO94972 (Uniprot-TrEMBL)
TRIM39 ProteinQ9HCM9 (Uniprot-TrEMBL)
TRIM4 ProteinQ9C037 (Uniprot-TrEMBL)
TRIM41 ProteinQ8WV44 (Uniprot-TrEMBL)
TRIM50 ProteinQ86XT4 (Uniprot-TrEMBL)
TRIM63 ProteinQ969Q1 (Uniprot-TrEMBL)
TRIM69 ProteinQ86WT6 (Uniprot-TrEMBL)
TRIM71 ProteinQ2Q1W2 (Uniprot-TrEMBL)
TRIM9 ProteinQ9C026 (Uniprot-TrEMBL)
TRIP12 ProteinQ14669 (Uniprot-TrEMBL)
TransloconComplexR-HSA-1236927 (Reactome)
UBA1 ProteinP22314 (Uniprot-TrEMBL)
UBA3 ProteinQ8TBC4 (Uniprot-TrEMBL)
UBA5 ProteinQ9GZZ9 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBA6 ProteinA0AVT1 (Uniprot-TrEMBL)
UBA7 ProteinP41226 (Uniprot-TrEMBL)
UBAC1 ProteinQ9BSL1 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UBE2A ProteinP49459 (Uniprot-TrEMBL)
UBE2B ProteinP63146 (Uniprot-TrEMBL)
UBE2C ProteinO00762 (Uniprot-TrEMBL)
UBE2D1 ProteinP51668 (Uniprot-TrEMBL)
UBE2D2 ProteinP62837 (Uniprot-TrEMBL)
UBE2D3 ProteinP61077 (Uniprot-TrEMBL)
UBE2D4 ProteinQ9Y2X8 (Uniprot-TrEMBL)
UBE2E1 ProteinP51965 (Uniprot-TrEMBL)
UBE2E2 ProteinQ96LR5 (Uniprot-TrEMBL)
UBE2E3 ProteinQ969T4 (Uniprot-TrEMBL)
UBE2F ProteinQ969M7 (Uniprot-TrEMBL)
UBE2G1 ProteinP62253 (Uniprot-TrEMBL)
UBE2G2 ProteinP60604 (Uniprot-TrEMBL)
UBE2H ProteinP62256 (Uniprot-TrEMBL)
UBE2J1 ProteinQ9Y385 (Uniprot-TrEMBL)
UBE2J2 ProteinQ8N2K1 (Uniprot-TrEMBL)
UBE2K ProteinP61086 (Uniprot-TrEMBL)
UBE2L3 ProteinP68036 (Uniprot-TrEMBL)
UBE2L6 ProteinO14933 (Uniprot-TrEMBL)
UBE2M ProteinP61081 (Uniprot-TrEMBL)
UBE2N ProteinP61088 (Uniprot-TrEMBL)
UBE2O ProteinQ9C0C9 (Uniprot-TrEMBL)
UBE2Q1 ProteinQ7Z7E8 (Uniprot-TrEMBL)
UBE2Q2 ProteinQ8WVN8 (Uniprot-TrEMBL)
UBE2R2 ProteinQ712K3 (Uniprot-TrEMBL)
UBE2S ProteinQ16763 (Uniprot-TrEMBL)
UBE2U ProteinQ5VVX9 (Uniprot-TrEMBL)
UBE2V1 ProteinQ13404 (Uniprot-TrEMBL)
UBE2V2 ProteinQ15819 (Uniprot-TrEMBL)
UBE2W ProteinQ96B02 (Uniprot-TrEMBL)
UBE2Z ProteinQ9H832 (Uniprot-TrEMBL)
UBE3A ProteinQ05086 (Uniprot-TrEMBL)
UBE3B ProteinQ7Z3V4 (Uniprot-TrEMBL)
UBE3C ProteinQ15386 (Uniprot-TrEMBL)
UBE3D ProteinQ7Z6J8 (Uniprot-TrEMBL)
UBE4A ProteinQ14139 (Uniprot-TrEMBL)
UBOX5 ProteinO94941 (Uniprot-TrEMBL)
UBR1 ProteinQ8IWV7 (Uniprot-TrEMBL)
UBR2 ProteinQ8IWV8 (Uniprot-TrEMBL)
UBR4 ProteinQ5T4S7 (Uniprot-TrEMBL)
UFL1 ProteinO94874 (Uniprot-TrEMBL)
UNKL ProteinQ9H9P5 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
Ubiquitin activating E1 enzymesComplexR-HSA-947695 (Reactome)
Ubiquitin:E2 conjugating enzymesComplexR-HSA-976165 (Reactome)
VHL ProteinP40337 (Uniprot-TrEMBL)
VPRBP ProteinQ9Y4B6 (Uniprot-TrEMBL)
WSB1 ProteinQ9Y6I7 (Uniprot-TrEMBL)
WWP1 ProteinQ9H0M0 (Uniprot-TrEMBL)
ZBTB16 ProteinQ05516 (Uniprot-TrEMBL)
ZNF645 ProteinQ8N7E2 (Uniprot-TrEMBL)
ZNRF1 ProteinQ8ND25 (Uniprot-TrEMBL)
ZNRF2 ProteinQ8NHG8 (Uniprot-TrEMBL)
antigenic substrate R-NUL-983035 (Reactome)
antigenic substrateR-NUL-983035 (Reactome)
class I MHC B13 ProteinP30461 (Uniprot-TrEMBL)
class I MHC B14 ProteinP30462 (Uniprot-TrEMBL)
class I MHC B15 ProteinP30464 (Uniprot-TrEMBL)
class I MHC B18 ProteinP30466 (Uniprot-TrEMBL)
class I MHC B27 ProteinP03989 (Uniprot-TrEMBL)
class I MHC B35 ProteinP30685 (Uniprot-TrEMBL)
class I MHC B37 ProteinP18463 (Uniprot-TrEMBL)
class I MHC B38 ProteinQ95365 (Uniprot-TrEMBL)
class I MHC B39 ProteinP30475 (Uniprot-TrEMBL)
class I MHC B40 ProteinQ04826 (Uniprot-TrEMBL)
class I MHC B41 ProteinP30479 (Uniprot-TrEMBL)
class I MHC B42 ProteinP30480 (Uniprot-TrEMBL)
class I MHC B44 ProteinP30481 (Uniprot-TrEMBL)
class I MHC B45 ProteinP30483 (Uniprot-TrEMBL)
class I MHC B46 ProteinP30484 (Uniprot-TrEMBL)
class I MHC B47 ProteinP30485 (Uniprot-TrEMBL)
class I MHC B49 ProteinP30487 (Uniprot-TrEMBL)
class I MHC B50 ProteinP30488 (Uniprot-TrEMBL)
class I MHC B51 ProteinP18464 (Uniprot-TrEMBL)
class I MHC B52 ProteinP30490 (Uniprot-TrEMBL)
class I MHC B53 ProteinP30491 (Uniprot-TrEMBL)
class I MHC B54 ProteinP30492 (Uniprot-TrEMBL)
class I MHC B55 ProteinP30493 (Uniprot-TrEMBL)
class I MHC B56 ProteinP30495 (Uniprot-TrEMBL)
class I MHC B57 ProteinP18465 (Uniprot-TrEMBL)
class I MHC B58 ProteinP10319 (Uniprot-TrEMBL)
class I MHC B59 ProteinQ29940 (Uniprot-TrEMBL)
class I MHC B67 ProteinQ29836 (Uniprot-TrEMBL)
class I MHC B7 ProteinP01889 (Uniprot-TrEMBL)
class I MHC B73 ProteinQ31612 (Uniprot-TrEMBL)
class I MHC B78 ProteinP30498 (Uniprot-TrEMBL)
class I MHC B8 ProteinP30460 (Uniprot-TrEMBL)
class I MHC B81 ProteinQ31610 (Uniprot-TrEMBL)
class I MHC B82 ProteinQ29718 (Uniprot-TrEMBL)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ComplexR-HSA-983116 (Reactome)
monoglucosylated MHC class I HCComplexR-HSA-983120 (Reactome)
oligopeptide fragment (8-16aa)R-NUL-983032 (Reactome)
oligopeptide fragmentR-NUL-1236721 (Reactome)
oligopeptide fragmentR-NUL-983034 (Reactome)
oligopeptide fragment R-NUL-1236721 (Reactome)
p-6S-NCF1 ProteinP14598 (Uniprot-TrEMBL)
p-T154,S315-NCF4 ProteinQ15080 (Uniprot-TrEMBL)
p-T233-NCF2 ProteinP19878 (Uniprot-TrEMBL)
partially digested AgR-NUL-1236713 (Reactome)
partially digested AgR-NUL-1236718 (Reactome)
precursor peptide fragment (>16 aa)R-NUL-1236722 (Reactome)
precursor peptide fragment (>16 aa)R-NUL-983036 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-1236935 (Reactome)
26S proteasomemim-catalysisR-HSA-1236970 (Reactome)
26S proteasomemim-catalysisR-HSA-983150 (Reactome)
ADPArrowR-HSA-1236949 (Reactome)
ADPArrowR-HSA-983144 (Reactome)
AMPArrowR-HSA-983140 (Reactome)
AMPArrowR-HSA-983153 (Reactome)
AMPArrowR-HSA-983156 (Reactome)
ATPR-HSA-1236949 (Reactome)
ATPR-HSA-983140 (Reactome)
ATPR-HSA-983144 (Reactome)
ATPR-HSA-983153 (Reactome)
ATPR-HSA-983156 (Reactome)
Ag peptide bound class I MHCArrowR-HSA-1236971 (Reactome)
Ag peptide bound class I MHCR-HSA-1236965 (Reactome)
Ag-substrate:E3:E2:UbArrowR-HSA-983157 (Reactome)
Ag-substrate:E3:E2:UbR-HSA-983140 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ArrowR-HSA-983161 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		R-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236943 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236965 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983422 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983427 (Reactome)
Antigen peptide bound class I MHCR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCR-HSA-983426 (Reactome)
Antigen peptide bound class I MHCR-HSA-983427 (Reactome)
Antigen peptideArrowR-HSA-1236954 (Reactome)
Antigen peptideArrowR-HSA-983158 (Reactome)
Antigen peptideR-HSA-1236943 (Reactome)
Antigen peptideR-HSA-983161 (Reactome)
B2M(21-119)R-HSA-983146 (Reactome)
BAP31 oligomerArrowR-HSA-983138 (Reactome)
BAP31 oligomerR-HSA-983142 (Reactome)
CALRArrowR-HSA-1236971 (Reactome)
CALRArrowR-HSA-983161 (Reactome)
CALRR-HSA-983142 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983424 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983425 (Reactome)
COPII vesicle with MHC class IR-HSA-983422 (Reactome)
COPII vesicle with MHC class IR-HSA-983424 (Reactome)
COPIImim-catalysisR-HSA-983422 (Reactome)
CTSS-like proteinsmim-catalysisR-HSA-1236948 (Reactome)
Chaperones calnexin/BiPArrowR-HSA-983146 (Reactome)
Chaperones calnexin/BiPR-HSA-983145 (Reactome)
Class I MHC peptide loading complexR-HSA-1236971 (Reactome)
Class I MHC:B2MR-HSA-1236943 (Reactome)
DC receptors

recognizing

apoptotic cells		ArrowR-HSA-1236956 (Reactome)
DC receptors

recognizing

apoptotic cells		R-HSA-1236958 (Reactome)
E1 bound ubiquitinArrowR-HSA-983153 (Reactome)
E1 bound ubiquitinR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983140 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983156 (Reactome)
E2 Ubiquitin-conjugating enzymeR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymemim-catalysisR-HSA-983152 (Reactome)
E3 ligases in

proteasomal

degradation		ArrowR-HSA-983147 (Reactome)
E3 ligases in

proteasomal

degradation		R-HSA-983157 (Reactome)
E3 ligases in

proteasomal

degradation		mim-catalysisR-HSA-983140 (Reactome)
E3:K48-polyubiquitinated substrateArrowR-HSA-983156 (Reactome)
E3:K48-polyubiquitinated substrateR-HSA-983147 (Reactome)
E3:Ub:substrateArrowR-HSA-983140 (Reactome)
E3:Ub:substrateR-HSA-983156 (Reactome)
E3:Ub:substratemim-catalysisR-HSA-983156 (Reactome)
ERAP1/2mim-catalysisR-HSA-983158 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236956 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236963 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236938 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236958 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236963 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236940 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236939 (Reactome)
Exogenous soluble antigenR-HSA-1236948 (Reactome)
Exogenous soluble antigenR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236970 (Reactome)
GDPR-HSA-983422 (Reactome)
GTPArrowR-HSA-983422 (Reactome)
H+ArrowR-HSA-1236967 (Reactome)
H2OR-HSA-1236949 (Reactome)
H2OR-HSA-983144 (Reactome)
H2OR-HSA-983422 (Reactome)
IFN gamma stimulated aminopeptidasesmim-catalysisR-HSA-983162 (Reactome)
IRAP in complex with MHC class Imim-catalysisR-HSA-1236954 (Reactome)
K48polyUb-antigenic substrateArrowR-HSA-983147 (Reactome)
K48polyUb-antigenic substrateR-HSA-983150 (Reactome)
K48polyUb-partially digested AgR-HSA-1236935 (Reactome)
L-Amino AcidsArrowR-HSA-1236935 (Reactome)
L-Amino AcidsArrowR-HSA-1236948 (Reactome)
L-Amino AcidsArrowR-HSA-1236954 (Reactome)
L-Amino AcidsArrowR-HSA-1236970 (Reactome)
L-Amino AcidsArrowR-HSA-983150 (Reactome)
L-Amino AcidsArrowR-HSA-983158 (Reactome)
L-Amino AcidsArrowR-HSA-983162 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		ArrowR-HSA-983148 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		R-HSA-983146 (Reactome)
MHC HC:B2M:Erp57ArrowR-HSA-983146 (Reactome)
MHC HC:B2M:Erp57R-HSA-983142 (Reactome)
MHC:B2M peptide loading complexArrowR-HSA-983142 (Reactome)
MHC:B2M peptide loading complexR-HSA-983161 (Reactome)
MR/other probable receptorsArrowR-HSA-1236940 (Reactome)
MR/other probable receptorsR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236941 (Reactome)
MR:soluble antigenArrowR-HSA-1236955 (Reactome)
MR:soluble antigenR-HSA-1236940 (Reactome)
MR:soluble antigenR-HSA-1236941 (Reactome)
MR:soluble antigenR-HSA-1236955 (Reactome)
Mg2+ArrowR-HSA-983153 (Reactome)
Mg2+R-HSA-983153 (Reactome)
NADP+ArrowR-HSA-1236967 (Reactome)
NADPHR-HSA-1236967 (Reactome)
NOX2 complexmim-catalysisR-HSA-1236967 (Reactome)
O2.-ArrowR-HSA-1236967 (Reactome)
O2R-HSA-1236967 (Reactome)
PDIA3ArrowR-HSA-1236971 (Reactome)
PDIA3ArrowR-HSA-983161 (Reactome)
PDIA3R-HSA-983148 (Reactome)
PPiArrowR-HSA-983140 (Reactome)
PPiArrowR-HSA-983153 (Reactome)
PPiArrowR-HSA-983156 (Reactome)
Particulate Ag:DC receptorsArrowR-HSA-1236958 (Reactome)
Particulate Ag:DC receptorsR-HSA-1236956 (Reactome)
PiArrowR-HSA-1236949 (Reactome)
PiArrowR-HSA-983144 (Reactome)
R-HSA-1236935 (Reactome) Proteasomes are usually localized to the cytoplasm but are also present in the nucleus and ER. Houde et al. (2003) investigated the distribution of proteasomes in J774 macrophages and observed them on phagosomes. The proteasomes present on phagosomes may not come directly from ER, but instead assemble on phagosomes to play a function at a precise point during phagolysosomal biogenesis. Houde et al. also observed polyubiquitinated proteins on the cytoplasmic side of phagosomes and highlighted the link between the ubiquitination process and proteasomal degradation; translocated peptides are ubiquitinated and processed by the proteasome complex assembled on the cytoplasmic side of phagosomes, leading to the generation of MHC class I binding peptides.
R-HSA-1236938 (Reactome) Phagocytosed particulate antigens are partially digested in the lumen of phagolysosomes by various lysosomal hydrolases.
R-HSA-1236939 (Reactome) Soluble antigens are presented to dendritic cells (DCs) in some cases by receptor mediated endocytosis or fluid-phase endocytosis. Burgdorf et al. (2008) suggest that there are two different endocytic compartments for antigen processing: one dedicated to MHC class I (early endosomes) and the other one for MHC class II presentation (lysosomes). Sorting of cargo into these different compartments occurs at the plasma membrane and is likely to depend on the type of endocytic receptor the cargo is interacting with (Burgdorf et al. 2008, Zhuang et al. 2006). The mannose receptor (MR) is the best studied receptor that targets soluble antigens to early endosomes but not to lysosomes (Burgdorf et al. 2006). Antigens taken up by the MR are targeted towards a mildly acidic stable early endosomal compartment for exclusive presentation on MHC I molecules (Burgdorf et al. 2008).
R-HSA-1236940 (Reactome) Within the endosome the receptor and cargo separate and the receptor recycles back to the cell surface. Soluble antigens are targeted into the stable early endosome lumen for efficient cross presentation. Early endosomes are mildly acidic and relatively poor in proteases.
R-HSA-1236941 (Reactome) Receptor-bound exogenous antigens in coated pits on the cell surface are internalized into clathrin-coated vesicles.
R-HSA-1236943 (Reactome) Peptides generated by Cathepsin S or IRAP-mediated proteolysis in the endosomes are loaded onto MHC class I molecules, which are internalized and transported to early and late endosomal compartments where antigenic peptides can be loaded. A fraction of the internalized cell surface class I molecules enter MHC class II compartments (MIICs) within endocytic vesicles (Gromme et al. 1999, Kleijmeer et al. 2001). Microscopic analysis has revealed that surface MHC-I molecules are internalized and transported to early and late endosomal compartments (Basha et al. 2008, Lizee et al. 2003). A tyrosine-based endocytic trafficking motif (YXXA) is required for the constitutive internalization of MHC-I molecules from the cell surface into early/late endosomes for peptide loading (Basha et al. 2008, Lizee et al. 2003). Upon entry in to these endosomal compartments the MHC class I complexes exchange their pre-bound peptides with exogenously derived antigenic peptides.
R-HSA-1236947 (Reactome) Fusion of the maturing phagosome with the ER mediates the exchange of materials resulting in the formation of a hybrid ER-phagosome compartment (Gagnon et al. 2002, Guermonprez et al. 2003, Houde et al. 2003, Ackerman et al. 2003, Blanchard et al. 2010). This hybrid contains the retrotranslocon factor Sec61 that mediates the access of proteasomes on the cytosolic surface of the phagosome. Using fluorescence imaging, Houde et al. (2003) provided evidence for the role of Sec61 in the retrotranslocation of internalized exogenous proteins from phagosomes to the cytoplasmic face of J774 macrophages. Sec61 factor is a heterotrimeric complex composed of alpha, beta and gamma subunits forming the core of the mammalian ER translocon (Greenfield et al. 1999). Oligomers of the Sec61 complex form a transmembrane channel involved in the retrotranslocation of misfolded proteins from ER to the cytosol for degradation, and thus it has been proposed that Sec61 might be involved in the translocation of proteins in phagosomes to the cytosol (Kasturi et al. 2008).
R-HSA-1236948 (Reactome) Endocytic compartments contain many cysteine proteases such as cathepsin S that can generate cross-presented peptides. Cathepsins may participate in the generation of MHC class II-presentated peptides (Villadangos et al. 1999). Shen et al. (2004) demonstrated that cathepsin S contributes to TAP-independent cross-presentation in vivo, showing that ovalbumin was cross-presented by denritic cells (DCs) through both TAP-dependent and TAP-independent pathways. The TAP-independent pathway was sensitive to the cystine protease inhibitor leupeptin, but not to proteasome inhibitors. Further experiments with knockout mice showed that cathepsin S contributed to cross-presentation. DCs lacking cathepsin S lack the TAP-independent pathway (Khor et al. 2008, Shen et al. 2004).
R-HSA-1236949 (Reactome) After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.
R-HSA-1236954 (Reactome) While it is established that cathepsin S is involved in antigen processing in endocytotic vesicles, it is less certain whether other proteases present in endocytic vesicles are also involved in generating the peptide fragments. Insulin regulated aminopeptidase (IRAP) is an epitope-trimming zinc-dependent aminopeptidase closely related to ERAP1 and ERAP2. IRAP may be involved in vacuolar processing of the peptide fragments within endosomes (Saveanu et al. 2009, Segura et al. 2009). IRAP is detected predominantly in the early and recycling endosome fractions. Saveanu et al. (2009) observed the physical association of IRAP with internalized class I MHC molecules and suggested that this may favour a direct linkage between peptide trimming and MHC class I loading. They also showed that IRAP-dependent processing of antigens requires active proteasome but not lysosomal proteases, which suggests that this pathway utilizes cytosolic degradation followed by peptide transport into IRAP-containing endosomes.
R-HSA-1236955 (Reactome) The antigen:receptor complex moves from clathrin-coated vesicles to the early endosome membrane.
R-HSA-1236956 (Reactome) After internalization, F-actin is depolymerized from the phagosome, and the newly denuded vacuole membrane becomes accessible to early endosomes (Aderem & Underhill. 1999).
R-HSA-1236958 (Reactome) Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
R-HSA-1236963 (Reactome) Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.

fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.
R-HSA-1236964 (Reactome) Peptide-loaded MHC class I complexes are transported by an undefined mechanism back to the cell surface for cross-presentation to T cells.
R-HSA-1236965 (Reactome) Exogenous antigen loaded class I MHC molecules in phagosomes may be delivered to the surface by membrane recycling machinery.
R-HSA-1236967 (Reactome) After the fusion of phagosome and lysosome lumen acidity rises and the activity of lysosomal proteases increases, conferring proteolytic ability. However antigens must be spared from complete proteolytic destruction. Dendritic cells (DCs) achieve this by regulating the level of proteolysis and phagosomal acidification. DCs recruit the NADPH oxidase NOX2 to the phagosome and mediate sustained production of low levels of reactive oxygen species (ROS), causing active alkalization of the phagosomal lumen (Savina et al. 2006, Ramachandra et al. 2009). NOX2 consumes oxygen and protons (pumped by V-ATPase or other H+ voltage-gated channels) to produce ROS and this lowers phagosome acidity. This apparently reduces antigen proteolysis to a level that allows processing but does not fully destroy the antigenic peptides, favouring increased MHC-I cross presentation (Ramachandra et al. 2009). Rab27a controls the recruitment of NOX2 to DC phagosomes (Savina et al. 2007).
R-HSA-1236968 (Reactome) Endocytosed antigens must leave the endocytic structure to enter into the MHC I pathway before exhaustive degradation within lysosomes. The canonical pathway is the transporter associated with antigen processing (TAP)-dependent cytosolic pathway, which involves the translocation of endocytosed antigens into the cytosol where they are degraded into antigenic peptides by the proteasome and transported to ER through TAP. This hypothesis comes from indirect evidences showing that proteasome inhibitors block cross presentation of certain antigens (Amigorena et al. 2010, Burgdorf et al. 2008) . According to this model antigens are translocated into the cytosol by an undefined mechanism.
There are less well-characterized mechanisms for the delivery of exogenous antigens into the cytosol. Certain peptides with highly positively charged sequences derived from HIV tat protein or the Antennapedia homeodomain (AntHD) protein seem to penetrate into the cytosol directly across the plasma membrane (Monu et al. 2007, Vendeville et al. 2004). It is also proposed that some exogenous antigens can be exchanged between neighboring cells through gap junctions, leading to cross presentation by the recipient cell (Monu et al. 2007, Neijssen et al. 2005).
Once internalized antigens are routed into the cytosol, they follow the conventional pathway of proteasome digestion and TAP mediated transport of peptides into the ER lumen.
R-HSA-1236970 (Reactome) Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.
R-HSA-1236971 (Reactome) Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen.
R-HSA-1236972 (Reactome) Upon phagolysosomal proteolysis the phagocytosed proteins still need to gain access to the cytosol for proteasomal access, transport into the ER and loading onto MHC class I. The mechanism for this escape of phagocytosed antigens remain unknown.
R-HSA-203979 (Reactome) Sar1p-GTP recruits the cytoplasmic Sec23p-Sec24p complex. (Though not represented in the subsequent steps, Sec23p-Sec24p would bind to members of the p24 protein family of possible cargo receptors, and together with Sar1p bind the appropiate v-SNARE, and Rab-GTP.)



R-HSA-983138 (Reactome) When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.
R-HSA-983140 (Reactome) Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).
R-HSA-983142 (Reactome) Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptor–associated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules.
R-HSA-983144 (Reactome) Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.
R-HSA-983145 (Reactome) The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation.
R-HSA-983146 (Reactome) Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.
R-HSA-983147 (Reactome) K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.
R-HSA-983148 (Reactome) Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.
R-HSA-983150 (Reactome) The 26S proteasome complex consists of the 20S catalytic core particle which harbours the proteolytically active sites and the regulatory 19S particle which is responsible for substrate interaction. This process generates a vast number (perhaps hundreds) of different peptides, depending on the length and sequence of the substrate protein. Only a small fraction of these peptides (nearly 10%) form the exact length to be presented by class I MHC; most (approximately 70%) are too short to bind. The remaining proteasome products (10-20%) are N-terminally extended precursors that require additional cleavage by cytosolic aminopeptidases for presentation by MHC class I molecules.
R-HSA-983152 (Reactome) Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002).
R-HSA-983153 (Reactome) Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here.
R-HSA-983156 (Reactome) Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).
R-HSA-983157 (Reactome) Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).
R-HSA-983158 (Reactome) Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
R-HSA-983161 (Reactome) MHC class I heterodimers are only stable in peptide bound form and only as a trimer (with bound peptide) present on the cell surface. Class I MHC molecules prefer nonapeptides, and less frequently use octa- or deca-peptides. The peptide binding groove in MHC class I molecules is formed by the intimate association of the alpha1 and alpha2 domains of the heavy chain. Structural studies have revealed that the alpha1:alpha2 domains form a single peptide binding groove consisting of 2 parallel helices on a floor of 8 beta-strands. Hydrogen bonding networks are established in the binding groove with the antigenic peptide main chain and terminal atoms that enable largely sequence independent ligation. Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al, 2009; Garstka et al, 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al, 2009).
R-HSA-983162 (Reactome) Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).
R-HSA-983421 (Reactome) Cargo must pass through the various compartments of the Golgi complex to reach the plasma membrane. This may occur through either of the two well known models, cisternal maturation or vesicular transport (Refer to review articles Glick et al. 2009, Jackson 2009, Nakano et al. 2010).
R-HSA-983422 (Reactome) Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.
R-HSA-983424 (Reactome) Once the entire COPII coat has been assembled, the bud is separated from the ER membrane in the form of a COPII coated vesicle.
R-HSA-983425 (Reactome) Sec13-Sec31 binds the prebudding complex and this Sec13-Sec31 heterotetramer forms the outer structural scaffold of the coat. Sec13-Sec31 is likely to crosslink the prebudding complexes generating COPII-coated vesicles.
R-HSA-983426 (Reactome) The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.
R-HSA-983427 (Reactome) After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane.
SAR1B:GDPArrowR-HSA-983422 (Reactome)
SAR1B:GTP:SEC23:SEC24ArrowR-HSA-203979 (Reactome)
SAR1B:GTP:SEC23:SEC24R-HSA-983426 (Reactome)
SAR1B:GTPR-HSA-203979 (Reactome)
SEC13ArrowR-HSA-983422 (Reactome)
SEC13R-HSA-983425 (Reactome)
SEC23:SEC24R-HSA-203979 (Reactome)
SEC23AArrowR-HSA-983422 (Reactome)
SEC24ArrowR-HSA-983422 (Reactome)
SEC31AArrowR-HSA-983422 (Reactome)
SEC31AR-HSA-983425 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IArrowR-HSA-983426 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IR-HSA-983425 (Reactome)
TAPArrowR-HSA-983161 (Reactome)
TAPBPArrowR-HSA-1236971 (Reactome)
TAPBPArrowR-HSA-983161 (Reactome)
TAPBPR-HSA-983142 (Reactome)
TAPR-HSA-983142 (Reactome)
TAPmim-catalysisR-HSA-1236949 (Reactome)
TAPmim-catalysisR-HSA-983144 (Reactome)
Transloconmim-catalysisR-HSA-1236947 (Reactome)
UbArrowR-HSA-1236935 (Reactome)
UbArrowR-HSA-983150 (Reactome)
UbR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin activating E1 enzymesR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesmim-catalysisR-HSA-983153 (Reactome)
Ubiquitin:E2 conjugating enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983156 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983157 (Reactome)
antigenic substrateR-HSA-983157 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ArrowR-HSA-983145 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		R-HSA-983148 (Reactome)
monoglucosylated MHC class I HCR-HSA-983145 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-1236935 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983150 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983162 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-1236949 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-983144 (Reactome)
oligopeptide fragmentArrowR-HSA-1236949 (Reactome)
oligopeptide fragmentArrowR-HSA-983144 (Reactome)
oligopeptide fragmentR-HSA-1236971 (Reactome)
oligopeptide fragmentR-HSA-983158 (Reactome)
partially digested AgArrowR-HSA-1236938 (Reactome)
partially digested AgArrowR-HSA-1236947 (Reactome)
partially digested AgArrowR-HSA-1236972 (Reactome)
partially digested AgR-HSA-1236947 (Reactome)
partially digested AgR-HSA-1236972 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236948 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236970 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-983150 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-1236954 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-983162 (Reactome)
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