Glucocorticoid receptor pathway (Homo sapiens)

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50InflammationOtherTranscriptionMetabolismTranscriptionSignaltransductionInflammationTransportGrowth and apoptosisNuclear receptors12121212121212JUNNR3C1NFKB224GenesTATA boxNR3C1NR3C1HSP90AA1GR ligandHSP90AA1NR3C1HSP90AA124, 38NR3C124LigandNR3C124LigandLigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGREPTGES3PTGES3PTGES3BHLHE40NAV3IL11AMIGO2SERTAD2ARL5BCXCR7CUL1FGFBP1KTN1SERPINB9CCL2ENC1PTGS2ZIC2PMP2PDE4BPLK2GR inhibitorytarget genesCCL20EDN2MGAMRGS2ALOX5APTSC22D3CDC42EP3SNAI2BIRC3SPINK13SPRY1GADD45BPRRG4FGD4SLC26A2EPB41L4BGPR115PPP1R14CBIRC2GPR153TGFBR3ANGPTL4LRRC8AANKRD1THBDCDKN1CSCNN1ASLC19A2TNFAIP3SRGNSTOMSEC14L1DNAJC15DNERMFGE8ABHD2CPEB4SDPRMT1IPETNK2B3GNT5AKAP13POU5F1TNS4S100PNR1I3NR1I225RXRA256, 10, 25GR stimulatorytarget genesGrowth and apoptosis12SignaltransductionOther1212


Description

The glucocorticoid receptor (GR, a.k.a. NR3C1) is a nuclear receptor that is activated upon binding of cortisol or glucocorticoids. It mainly regulates gene expression of several groups of genes in two ways. It can stimulate anti-inflammatory genes, or inhibit the transcription of pro-inflammatory genes.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
135147view23:26, 6 August 2024EweitzRemove obsolete "Version" metadata
135146view23:23, 6 August 2024EweitzEconomize layout
135145view23:17, 6 August 2024EweitzRefine alignment
135144view23:15, 6 August 2024EweitzIncrease font size
135143view21:59, 6 August 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
135142view21:57, 6 August 2024EweitzEconomize layout
135141view21:55, 6 August 2024EweitzEconomize layout
135140view21:53, 6 August 2024EweitzEconomize layout
135139view21:48, 6 August 2024EweitzEconomize layout
135138view21:47, 6 August 2024EweitzEconomize layout
117734view12:38, 22 May 2021EweitzModified title
112288view13:15, 9 October 2020Fehrhart
112287view13:14, 9 October 2020Fehrhart
87558view02:13, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87557view02:13, 25 July 2016AlexanderPicoOntology Term : 'glucocorticoid signaling pathway' added !
79615view10:14, 29 March 2015EgonwConverted the 'ligand' labels to DataNode's and gave them ChEBI IDs.
79548view09:53, 25 March 2015FehrhartUpdate of GenIDs and comments
79522view09:45, 24 March 2015Riannefijtenadded reference and changed interaction lines (for X) to graphical elements
79521view09:43, 24 March 2015RiannefijtenModified description
79494view13:39, 23 March 2015RiannefijtenUpdated connections and annotations
78505view10:29, 7 January 2015MaintBotadded missing graphIds
78258view22:21, 17 December 2014KhanspersModified title
78227view15:34, 14 December 2014MaintBotUpdated the GPML schema.
78222view15:26, 14 December 2014MaintBotModified title
78093view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABHD2GeneProduct11057 (Entrez Gene) abhydrolase domain containing 2
AKAP13GeneProduct11214 (Entrez Gene) A kinase (PRKA) anchor protein 13
ALOX5APGeneProduct241 (Entrez Gene) arachidonate 5-lipoxygenase-activating protein
AMIGO2GeneProduct347902 (Entrez Gene) adhesion molecule with Ig-like domain 2
ANGPTL4GeneProduct51129 (Entrez Gene) angiopoietin-like 4
ANKRD1GeneProduct27063 (Entrez Gene) ankyrin repeat domain 1 (cardiac muscle)
ARL5BGeneProduct221079 (Entrez Gene) ADP-ribosylation factor-like 5B
B3GNT5GeneProduct84002 (Entrez Gene) UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BHLHE40GeneProduct8553 (Entrez Gene) basic helix-loop-helix family, member e40
BIRC2GeneProduct329 (Entrez Gene) baculoviral IAP repeat containing 2
BIRC3GeneProduct330 (Entrez Gene) baculoviral IAP repeat containing 3
CCL20GeneProduct6364 (Entrez Gene) chemokine (C-C motif) ligand 20
CCL2GeneProduct6347 (Entrez Gene) chemokine (C-C motif) ligand 2
CDC42EP3GeneProduct10602 (Entrez Gene) CDC42 effector protein (Rho GTPase binding) 3
CDKN1CGeneProduct1028 (Entrez Gene) cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CPEB4GeneProduct80315 (Entrez Gene) cytoplasmic polyadenylation element binding protein 4
CUL1GeneProduct8454 (Entrez Gene) cullin 1
CXCR7GeneProduct57007 (Entrez Gene) atypical chemokine receptor 3
DNAJC15GeneProduct29103 (Entrez Gene) DnaJ (Hsp40) homolog, subfamily C, member 15
DNERGeneProduct92737 (Entrez Gene) delta/notch-like EGF repeat containing
EDN2GeneProduct1907 (Entrez Gene) endothelin 2
ENC1GeneProduct8507 (Entrez Gene) ectodermal-neural cortex 1 (with BTB domain)
EPB41L4BGeneProduct54566 (Entrez Gene) erythrocyte membrane protein band 4.1 like 4B
ETNK2GeneProduct55224 (Entrez Gene) ethanolamine kinase 2
FGD4GeneProduct121512 (Entrez Gene) FYVE, RhoGEF and PH domain containing 4
FGFBP1GeneProduct9982 (Entrez Gene) fibroblast growth factor binding protein 1
GADD45BGeneProduct4616 (Entrez Gene) growth arrest and DNA-damage-inducible, beta
GPR115GeneProduct221393 (Entrez Gene) adhesion G protein-coupled receptor F4
GPR153GeneProduct387509 (Entrez Gene) G protein-coupled receptor 153
GR ligandMetaboliteCHEBI:63562 (ChEBI)
HSP90AA1GeneProduct3320 (Entrez Gene) heat shock protein 90kDa alpha (cytosolic), class A member 1
IL11GeneProduct3589 (Entrez Gene) interleukin 11
JUNGeneProduct3725 (Entrez Gene) jun proto-oncogene
KTN1GeneProduct3895 (Entrez Gene) kinectin 1 (kinesin receptor)
LRRC8AGeneProduct56262 (Entrez Gene) leucine rich repeat containing 8 family, member A
LigandMetaboliteCHEBI:63562 (ChEBI)
MFGE8GeneProduct4240 (Entrez Gene) milk fat globule-EGF factor 8 protein
MGAMGeneProduct8972 (Entrez Gene) maltase-glucoamylase
MT1IPGeneProduct644314 (Entrez Gene) metallothionein 1I, pseudogene
NAV3GeneProduct89795 (Entrez Gene) neuron navigator 3
NFKB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR1I2GeneProduct8856 (Entrez Gene) nuclear receptor subfamily 1, group I, member 2
NR1I3GeneProduct9970 (Entrez Gene) nuclear receptor subfamily 1, group I, member 3
NR3C1GeneProduct2908 (Entrez Gene) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDE4BGeneProduct5142 (Entrez Gene) phosphodiesterase 4B, cAMP-specific
PLK2GeneProduct10769 (Entrez Gene) polo-like kinase 2
PMP2GeneProduct5375 (Entrez Gene) peripheral myelin protein 2
POU5F1GeneProduct5460 (Entrez Gene) POU class 5 homeobox 1
PPP1R14CGeneProduct81706 (Entrez Gene) protein phosphatase 1, regulatory (inhibitor) subunit 14C
PRRG4GeneProduct79056 (Entrez Gene) proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTGES3GeneProduct10728 (Entrez Gene) prostaglandin E synthase 3 (cytosolic)
PTGS2GeneProduct5743 (Entrez Gene) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2GeneProduct5997 (Entrez Gene) regulator of G-protein signaling 2
RXRAGeneProduct6256 (Entrez Gene) retinoid X receptor, alpha
S100PGeneProduct6286 (Entrez Gene) S100 calcium binding protein P
SCNN1AGeneProduct6337 (Entrez Gene) sodium channel, non voltage gated 1 alpha subunit
SDPRGeneProduct8436 (Entrez Gene) serum deprivation response
SEC14L1GeneProduct6397 (Entrez Gene) SEC14-like 1 (S. cerevisiae)
SERPINB9GeneProduct5272 (Entrez Gene) serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERTAD2GeneProduct9792 (Entrez Gene) SERTA domain containing 2
SLC19A2GeneProduct10560 (Entrez Gene) solute carrier family 19 (thiamine transporter), member 2
SLC26A2GeneProduct1836 (Entrez Gene) solute carrier family 26 (anion exchanger), member 2
SNAI2GeneProduct6591 (Entrez Gene) snail family zinc finger 2
SPINK13GeneProduct153218 (Entrez Gene) serine peptidase inhibitor, Kazal type 13 (putative)
SPRY1GeneProduct10252 (Entrez Gene) sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGNGeneProduct5552 (Entrez Gene) serglycin
STOMGeneProduct2040 (Entrez Gene) stomatin
TGFBR3GeneProduct7049 (Entrez Gene) transforming growth factor, beta receptor III
THBDGeneProduct7056 (Entrez Gene) thrombomodulin
TNFAIP3GeneProduct7128 (Entrez Gene) tumor necrosis factor, alpha-induced protein 3
TNS4GeneProduct84951 (Entrez Gene) tensin 4
TSC22D3GeneProduct1831 (Entrez Gene) TSC22 domain family, member 3
ZIC2GeneProduct7546 (Entrez Gene) Zic family member 2

Annotated Interactions

No annotated interactions

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