Interleukin-20 family signaling (Homo sapiens)

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25, 74883, 61, 4, 9cytosolIL22RA2IL22RA1 IL22RA1:IL20RB:IL20,IL24IL22 IL20RB IL22 IL22RA1:IL20RBIL20,IL24IL20 IL22RA1IL24 IL22RA2 IL19 IL20RAIL19 IL24 IL20RB IL10RB IL22RA1 IL24 IL22RA2:IL22IL20RA:IL20RB:IL19,IL20,IL24IL22RA1 IL22RA1 IL20RA IL22IL20RB IL10RBIL22RA1:IL22:IL10RBIL22 IL20 IL22RA1:IL22IL19,IL20,IL24IL20 IL20RA:IL20RBIL20RBIL20RA IL20RB IL20 IL24


Description

The interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor subunits and similarities in their target-cell profiles and biological functions. Members of the IL20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. Much of the understanding of this group of cytokines is based on IL22, which is the most studied member (Rutz et al. 2014). View original pathway at:Reactome.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114997view16:53, 25 January 2021ReactomeTeamReactome version 75
113441view11:51, 2 November 2020ReactomeTeamReactome version 74
112642view16:02, 9 October 2020ReactomeTeamReactome version 73
101557view11:43, 1 November 2018ReactomeTeamreactome version 66
101093view21:25, 31 October 2018ReactomeTeamreactome version 65
100622view20:00, 31 October 2018ReactomeTeamreactome version 64
100173view16:44, 31 October 2018ReactomeTeamreactome version 63
99723view15:11, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99297view12:46, 31 October 2018ReactomeTeamreactome version 62
94490view08:53, 14 September 2017Mkutmonreactome pathway rename
87863view12:06, 25 July 2016RyanmillerOntology Term : 'signaling pathway' added !
86561view09:21, 11 July 2016ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
IL10RB ProteinQ08334 (Uniprot-TrEMBL)
IL10RBProteinQ08334 (Uniprot-TrEMBL)
IL19 ProteinQ9UHD0 (Uniprot-TrEMBL)
IL19,IL20,IL24ComplexR-HSA-448716 (Reactome)
IL20 ProteinQ9NYY1 (Uniprot-TrEMBL)
IL20,IL24ComplexR-HSA-448734 (Reactome)
IL20RA ProteinQ9UHF4 (Uniprot-TrEMBL)
IL20RA:IL20RB:IL19,IL20,IL24ComplexR-HSA-448743 (Reactome)
IL20RA:IL20RBComplexR-HSA-448724 (Reactome)
IL20RAProteinQ9UHF4 (Uniprot-TrEMBL)
IL20RB ProteinQ6UXL0 (Uniprot-TrEMBL)
IL20RBProteinQ6UXL0 (Uniprot-TrEMBL)
IL22 ProteinQ9GZX6 (Uniprot-TrEMBL)
IL22ProteinQ9GZX6 (Uniprot-TrEMBL)
IL22RA1 ProteinQ8N6P7 (Uniprot-TrEMBL)
IL22RA1:IL20RB:IL20,IL24ComplexR-HSA-448735 (Reactome)
IL22RA1:IL20RBComplexR-HSA-448727 (Reactome)
IL22RA1:IL22:IL10RBComplexR-HSA-8854697 (Reactome)
IL22RA1:IL22ComplexR-HSA-448411 (Reactome)
IL22RA1ProteinQ8N6P7 (Uniprot-TrEMBL)
IL22RA2 ProteinQ969J5 (Uniprot-TrEMBL)
IL22RA2:IL22ComplexR-HSA-448738 (Reactome)
IL22RA2ProteinQ969J5 (Uniprot-TrEMBL)
IL24 ProteinQ13007 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
IL10RBR-HSA-8854645 (Reactome)
IL19,IL20,IL24R-HSA-448728 (Reactome)
IL20,IL24R-HSA-448708 (Reactome)
IL20RA:IL20RB:IL19,IL20,IL24ArrowR-HSA-448728 (Reactome)
IL20RA:IL20RBArrowR-HSA-448744 (Reactome)
IL20RA:IL20RBR-HSA-448728 (Reactome)
IL20RAR-HSA-448744 (Reactome)
IL20RBR-HSA-448744 (Reactome)
IL22R-HSA-448480 (Reactome)
IL22R-HSA-448741 (Reactome)
IL22RA1:IL20RB:IL20,IL24ArrowR-HSA-448708 (Reactome)
IL22RA1:IL20RBR-HSA-448708 (Reactome)
IL22RA1:IL22:IL10RBArrowR-HSA-8854645 (Reactome)
IL22RA1:IL22ArrowR-HSA-448480 (Reactome)
IL22RA1:IL22R-HSA-8854645 (Reactome)
IL22RA1R-HSA-448480 (Reactome)
IL22RA2:IL22ArrowR-HSA-448741 (Reactome)
IL22RA2:IL22TBarR-HSA-448480 (Reactome)
IL22RA2R-HSA-448741 (Reactome)
R-HSA-448480 (Reactome) The Interleukin-22 receptor is a heterodimer of Interleukin-22 receptor subunit alpha-1 (IL22RA1) and Interleukin-10 receptor subunit beta (IL10RB), a component of the receptors for IL10, IL22, IL26, IL28, and IFNL1. Temporal models suggest that the first event in IL22 receptor formation is binding of Interleukin-22 (IL22) to IL22RA (Li et al. 2004).
R-HSA-448708 (Reactome) IL20 and IL24 can activate a heterodimer of IL22RA and IL20RB (Dumoutier et al. 2001, Parrish-Novak et al. 2002). As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain event.
R-HSA-448728 (Reactome) The dimer of Interleukin 20 receptor A (IL20RA) and Interleukin 20 receptor B (IL20RB) is a receptor for Interleukin-19 (IL19), IL20 and IL24 (Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain event.
R-HSA-448741 (Reactome) Interleukin-22 receptor subunit alpha-2 (IL22RA2), also known as Interleukin-22 binding protein (IL22BP), is a soluble receptor that binds Interleukin-22 (IL22) within the extracellular region, preventing IL22 from binding to the functional membrane-associated IL22 receptor (Xu et al. 2001). This may play a regulatory role in inflammation.
R-HSA-448744 (Reactome) Interleukin 20 receptor A (IL20RA) and Interleukin 20 receptor B (IL20RB) form a receptor for Interleukin-19 (IL19), IL20 and IL24. IL20 and IL24 can also activate a heterodimer of IL22RA:IL20RB (Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain event.
R-HSA-8854645 (Reactome) Temporal models suggest that binding of Interleukin-22 (IL22) to Interleukin-22 receptor subunit alpha-1 (IL22RA1) creates a surface that is bound by the extracellular region of Interleukin-10 receptor beta chain (IL10RB) (Li et al. 2004).
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