Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from:
https://www.synapse.org/#!Synapse:syn1773109
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HomologyConvert
This pathway was inferred from Homo sapiens pathway WP2858(80104) with a 93.0% conversion rate.
''Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis''; , PubMedEurope PMCScholia
''Hedgehog and Gli signaling in embryonic mammary gland development.''; , PubMedEurope PMCScholia
''HESX1- and TCF3-mediated repression of Wnt/خ²-catenin targets is required for normal development of the anterior forebrain''; , PubMedEurope PMCScholia
''Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from embryonic stem cells.''; , PubMedEurope PMCScholia
Van Hateren, N., Shenton, T., Borycki, A.-G; ''Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development ''; , 2006 PubMedEurope PMCScholia
''Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway.''; , PubMedEurope PMCScholia
''Beyond cell adhesion: the role of armadillo proteins in the heart.''; , PubMedEurope PMCScholia
''Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.''; , PubMedEurope PMCScholia
''Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development''; , PubMedEurope PMCScholia
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