Wnt myofibroblastic activation of hepatic stellate cells (Rattus norvegicus)

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1Epigenetic RepressionHSC myofibroblastic activationSer/Cys PeptidasesDPIWnt-3aLeupeptinMeCP2FJ9Ppar-yBeta-Catenin


Description

This pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases MeCP2 stability and induces epigenetic repression of Ppar-y leading to hepatic stellate cell myofibroblastic activation causing liver fibrosis which can lead to liver cirrhosis.

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Ontology Terms

 

Bibliography

  1. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H; ''Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells.''; PLoS One, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129294view17:31, 25 March 2024Khanspersupdated xrefs, updated label
116515view10:51, 7 May 2021EweitzModified title
89262view16:54, 27 August 2016Khanspersupdated xref for beta-catenin
89261view16:50, 27 August 2016KhanspersQuick edit to datanode annotation or property
89219view20:58, 23 August 2016Khansperschanged FJ9 node to metabolite
88841view17:38, 15 August 2016AAR&CoEdited nodes
88840view17:32, 15 August 2016AAR&CoPeriodical save, work in progress
88839view15:40, 15 August 2016AAR&CoPeriodical save, work in progress
88451view15:28, 8 August 2016AAR&CoConnected Lines
88204view13:46, 31 July 2016AAR&CoEdited Data Node
88203view13:44, 31 July 2016AAR&CoAdded Data Node
88202view13:41, 31 July 2016AAR&CoEdited Data Nodes
87862view11:58, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87284view17:09, 20 July 2016AAR&CoModified description
87283view17:01, 20 July 2016AAR&CoOntology Term : 'liver cirrhosis' added !
87282view16:59, 20 July 2016AAR&CoOntology Term : 'hepatic stellate cell' added !
87281view16:54, 20 July 2016AAR&CoAdded metabolites
87280view16:49, 20 July 2016AAR&CoModified description
87278view16:44, 20 July 2016AAR&CoFixed unconnected line and label
86149view19:50, 1 July 2016EgonwReplaced a mim-conversion with Arrow.
85629view15:44, 3 June 2016AAR&CoAdd Literature Citation
85626view15:41, 3 June 2016AAR&CoSpecify description
85625view15:36, 3 June 2016AAR&CoPeriodical save, work in progress
85624view15:23, 3 June 2016AAR&CoPeriodical save, work in progress
85622view13:23, 3 June 2016AAR&CoPeriodical save, work in progress
85621view12:53, 3 June 2016AAR&CoPeriodical save, work in progress
85619view12:43, 3 June 2016AAR&CoPeriodical save, work in progress
85618view12:33, 3 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Beta-CateninProteinENSRNOP00000068620 (Ensembl Rat)
DPIMetabolite3101 (PubChem-compound)
FJ9ProteinSmall molecule inhibitor, see article for more information.
LeupeptinMetabolite72429 (PubChem-compound)
MeCP2ProteinENSRNOG00000056659 (Ensembl)
Ppar-yProteinENSRNOG00000008839 (Ensembl)
Ser/Cys PeptidasesProteinNot specified by literature
Wnt-3aProteinENSRNOT00000064505 (Ensembl)

Annotated Interactions

No annotated interactions

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