Brain derived neurotrophic factor (Rattus norvegicus)

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4531NucleusMAPK PathwayCell survival, Hippocampal Plasticity,Long term potentiationApoptosis,Atrophy,Long term depression22RasMAP2K1plasminogenRafp75TrkBmBDNFPAI-1tPAproBDNFplasminErk2 (MAPK 1)proBDNFBDNF


Description

Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.

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Bibliography

  1. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B; ''Activation of p75NTR by proBDNF facilitates hippocampal long-term depression.''; Nat Neurosci, 2005 PubMed Europe PMC Scholia
  2. Neeley EW, Berger R, Koenig JI, Leonard S; ''Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains.''; Neuroscience, 2011 PubMed Europe PMC Scholia
  3. Ding Q, Ying Z, Gómez-Pinilla F; ''Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing.''; Neuroscience, 2011 PubMed Europe PMC Scholia
  4. Neeley EW, Berger R, Koenig JI, Leonard S; ''Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains.''; Neuroscience, 2011 PubMed Europe PMC Scholia
  5. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, Teng KK, Yung WH, Hempstead BL, Lu B; ''Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.''; Science, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
90920view23:31, 17 December 2016AlexanderPicoModified description
70121view19:25, 12 July 2013MaintBotupdated to 2013 schema
70076view09:21, 12 July 2013Mkutmonfixed unconnected lines
67954view14:29, 28 June 2013DdiglesOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
58522view20:20, 14 February 2013MaintBotModified categories
47457view10:16, 20 March 2012SchmidtdavSpecify description
47345view15:49, 15 March 2012SchmidtdavPeriodical save, work in progress
47341view15:44, 15 March 2012SchmidtdavSpecify description
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External references

DataNodes

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NameTypeDatabase referenceComment
BDNFGeneProduct24225 (Entrez Gene)
Erk2 (MAPK 1)GeneProduct116590 (Entrez Gene)
MAP2K1GeneProduct170851 (Entrez Gene)
PAI-1GeneProduct24617 (Entrez Gene)
RafGeneProduct24703 (Entrez Gene)
RasGeneProduct24525 (Entrez Gene)
TrkBGeneProduct25054 (Entrez Gene)
mBDNFGeneProduct24225 (Entrez Gene)
p75GeneProduct24596 (Entrez Gene)
plasminGeneProduct
plasminogenGeneProduct85253 (Entrez Gene)
proBDNFGeneProduct24225 (Entrez Gene)
tPAGeneProduct25692 (Entrez Gene)

Annotated Interactions

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