Translation factors (Drosophila melanogaster)

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60S SubunitscanningHOMOLOGY MAPPm7G43S Pre-initiation Complexand first peptide bondPre-initiation ComplexmRNAInitiationElongationAUGBinds aminoacyl-tRNARecruitment of 43S40S SubunitGuanine Nucleotide ExchangeAAAAAAAAAAAAAAATranslocationTerminationRecruitment of 60S subunitCap Binding ComplexEIF4EBP2EIF2AK1EIF4EBP3eIF5BeIF2B-epsilonEIF4G1Trip1EIF2AK2eIF-4aEf2bRbp2eIF5eIF-3p40Ef1alpha100EGSPT2Su(var)3-9CG17737eRF1eIF2B-betaeIF-3p66CG10881eIF-4GeIF-4EAdameIF3-S10CG9769KIAA0664EEF2KCG17737eIF-5APEKEIF1AYeIF-2betaeIF3-S9Ef1alpha48DInt6eIF-1AeIF2B-alphaEIF3S8Ef1betaCG8963EIF4EBP1EIF4A1Ef1gammapAbpeEF1deltaeIF2B-deltaeIF-4BeIF-2alphaeIF6eIF2B-gamma


Description

Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. This pathway gives an overview of the translation factors involved in this process. Description from source pathway: http://wikipathways.org/index.php/Pathway:WP107 (translated via homology)

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116932view09:46, 16 May 2021EweitzModified title
91897view19:19, 3 April 2017KhanspersModified description
80966view17:30, 5 July 2015EgonwAdded the Ensembl ID for EIF4G1.
80957view05:34, 2 July 2015EgonwAdded the Entrez ID for this gene, via Entrez gene, derived from flybase, based on the name. It's not found via homologene.
80650view07:07, 29 June 2015Mkutmonremoved datasource from xrefs with missing identifier
79365view19:23, 21 March 2015Khanspersupdated
79364view19:23, 21 March 2015KhanspersReverted to version '11:53, 26 June 2013' by Khanspers
71522view19:22, 17 October 2013MaintBotAutomated update of data sources
68728view22:03, 6 July 2013MaintBotUpdated to 2013 gpml schema
67713view11:53, 26 June 2013DdiglesOntology Term : 'translation pathway' added !
40904view22:35, 1 March 2011MaintBotRemoved redundant pathway information and comments
21810view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:Translation Factors]] moved to [[Pathway:WP537]]: Moved to stable identifier
8528view14:02, 7 January 2008MaintBotAdded to category $category
8526view14:02, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AdamGeneProduct36037 (Entrez Gene)
CG10881GeneProduct42422 (Entrez Gene)
CG17737GeneProduct38398 (Entrez Gene)
CG8963GeneProduct36913 (Entrez Gene)
CG9769GeneProduct40587 (Entrez Gene)
EEF2KGeneProduct
EIF1AYGeneProduct
EIF2AK1GeneProduct32617 (Entrez Gene)
EIF2AK2GeneProductnow E2K2_HUMAN
EIF3S8GeneProduct
EIF4A1GeneProduct
EIF4EBP1GeneProduct
EIF4EBP2GeneProduct
EIF4EBP3GeneProduct
EIF4G1GeneProduct43839 (Entrez Gene) TrEMBL accession number O43177 refers to same protein.
Ef1alpha100EGeneProduct43736 (Entrez Gene)
Ef1alpha48DGeneProduct36271 (Entrez Gene)
Ef1betaGeneProduct45249 (Entrez Gene)
Ef1gammaGeneProduct44791 (Entrez Gene)
Ef2bGeneProduct35422 (Entrez Gene)
GSPT2GeneProduct
Int6GeneProduct39877 (Entrez Gene)
KIAA0664GeneProduct
PEKGeneProduct40653 (Entrez Gene)
Rbp2GeneProduct49809 (Entrez Gene)
Su(var)3-9GeneProduct41843 (Entrez Gene)
Trip1GeneProduct33710 (Entrez Gene)
eEF1deltaGeneProduct34363 (Entrez Gene)
eIF-1AGeneProduct44260 (Entrez Gene)
eIF-2alphaGeneProduct32617 (Entrez Gene)
eIF-2betaGeneProduct39433 (Entrez Gene)
eIF-3p40GeneProduct45682 (Entrez Gene)
eIF-3p66GeneProduct42789 (Entrez Gene)
eIF-4BGeneProduct3355041 (Entrez Gene)
eIF-4EGeneProduct45525 (Entrez Gene)
eIF-4GGeneProduct43839 (Entrez Gene)
eIF-4aGeneProduct33835 (Entrez Gene)
eIF-5AGeneProduct37846 (Entrez Gene)
eIF2B-alphaGeneProduct43549 (Entrez Gene)
eIF2B-betaGeneProduct31256 (Entrez Gene)
eIF2B-deltaGeneProduct37706 (Entrez Gene)
eIF2B-epsilonGeneProduct31156 (Entrez Gene)
eIF2B-gammaGeneProduct36722 (Entrez Gene)
eIF3-S10GeneProduct40563 (Entrez Gene)
eIF3-S9GeneProduct36981 (Entrez Gene)
eIF5GeneProduct32566 (Entrez Gene)
eIF5BGeneProduct44261 (Entrez Gene)
eIF6GeneProduct37776 (Entrez Gene)
eRF1GeneProduct40240 (Entrez Gene)
pAbpGeneProduct37070 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP537"
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