Methylation (Danio rerio)

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1, 2N-methylationSAM synthesis (co-substrate)S-methylationO-methylationS-AdenosylhomocysteinePNMTO-methylated substrateS-Adenosylhomocysteinemat1amat2aaS-AdenosylhomocysteineL-MethioninecomtaTPMT.1S-methylated substrateS-AdenosylmethionineATPN-methylated substratePhosphateS-AdenosylmethionineS-AdenosylmethionineNNMTPhosphatehnmtmat2bSubstratecomtbTPMT.2mat2ab


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP704(r30265) with a 55% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia
  2. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118397view14:09, 27 May 2021EweitzOntology Term : 'protein modification pathway' added !
106070view11:58, 16 August 2019MaintBotHMDB identifier normalization
91984view09:39, 11 April 2017LWackersUpdated annotations
79388view20:06, 21 March 2015KhanspersModified title
68679view05:37, 6 July 2013MaintBotUpdated to 2013 gpml schema
58798view22:46, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40852view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
34234view21:39, 9 December 2009MaintBotAutomatic update of empty xrefs
31923view12:53, 14 August 2009MaintBotFixed group labels
31044view01:19, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB00538 (HMDB)
L-MethionineMetaboliteHMDB00696 (HMDB)
N-methylated substrateMetabolite
NNMTGeneProduct393330 (Entrez Gene)
O-methylated substrateMetabolite
PNMTGeneProductGene not yet validated; Model status on NCBI (11/4/2017)
PhosphateMetaboliteHMDB01429 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TPMT.1GeneProductENSDARG00000055974 (Ensembl)
TPMT.2GeneProductENSDARG00000028012 (Ensembl)
comtaGeneProductENSDARG00000015337 (Ensembl)
comtbGeneProductENSDARG00000025679 (Ensembl)
hnmtGeneProductENSDARG00000012796 (Ensembl)
mat1aGeneProductENSDARG00000039605 (Ensembl)
mat2aaGeneProduct323329 (Entrez Gene)
mat2abGeneProductENSDARG00000037121 (Ensembl)
mat2bGeneProductENSDARG00000012932 (Ensembl)

Annotated Interactions

No annotated interactions
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