Histidine biosynthesis (Saccharomyces cerevisiae)
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Description
Yeast cells contain 3 pathways for the synthesis of glutamate. Two pathways are mediated by two isoforms of glutamate dehydrogenase, encoded by GDH1 and GDH3 (CITS: [2989290])(CITS: [9287019]). The third pathway is driven by the combined activities of glutamine synthetase and glutamate synthase, encoded by GLN1 and GLT1, respectively (CITS: [2570348])(CITS: [8923741]). Studies of GDH1 and GDH3 regulation indicate that the cell uses these isoforms under different growth conditions (CITS: [11562373]). Expression of GDH3 is induced by ethanol and repressed by glucose, whereas GDH1 expression is high in either carbon source. Gdh1p uses alpha-ketoglutarate at a higher rate than Gdh3p. Thus, under fermentative growth conditions, Gdh1p drives glutamate biosynthesis, whereas in nonfermentable or limiting carbon sources, Gdh3p is the key isoform involved in balancing distribution of alpha-ketoglutarate to glutamate biosynthesis and energy metabolism.
SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html
Quality Tags
Ontology Terms
Bibliography
- Rébora K, Laloo B, Daignan-Fornier B; ''Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.''; Genetics, 2005 PubMed Europe PMC Scholia
- Alifano P, Fani R, Liò P, Lazcano A, Bazzicalupo M, Carlomagno MS, Bruni CB; ''Histidine biosynthetic pathway and genes: structure, regulation, and evolution.''; Microbiol Rev, 1996 PubMed Europe PMC Scholia
- Denis V, Boucherie H, Monribot C, Daignan-Fornier B; ''Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis.''; Mol Microbiol, 1998 PubMed Europe PMC Scholia
- ''L-histidine biosynthesis''; YeastPathways,
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AICAR | Metabolite | 3031-94-5 (CAS) | |
ATP | Metabolite | 1927-31-7 (CAS) | |
HIS1 | GeneProduct | S000000857 (SGD) | |
HIS2 | GeneProduct | S000001921 (SGD) | |
HIS3 | GeneProduct | S000005728 (SGD) | |
HIS4 | GeneProduct | S000000535 (SGD) | |
HIS5 | GeneProduct | S000001378 (SGD) | |
HIS6 | GeneProduct | S000001282 (SGD) | |
HIS7 | GeneProduct | S000000452 (SGD) | |
L-glutamate | Metabolite | 56-86-0 (CAS) | |
L-glutamine | Metabolite | 56-85-9 (CAS) | |
L-histidine | Metabolite | 71-00-1 (CAS) | |
NADH | Metabolite | 53-84-9 (CAS) | |
PRPP | Metabolite | 97-55-2 (CAS) | |
phosphate | Metabolite | 14265-44-2 (CAS) | |
pyrophosphate | Metabolite | 2466-09-3 (CAS) |
Annotated Interactions
No annotated interactions