Model of Fgf and Wnt crosstalk in tailbud (Danio rerio)

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1PI3kAutoregulatoryloopfgf8atbx6wnt11spred3gsk3bntldkk1berk2notum1aerk1sptdkk1apik3cbPPPPPpik3cdpik3cgpik3cafgf3fgf10afgf4fgf17fgf19fgf24fgf10bfgf16wnt5bwnt3awnt8awnt3wnt7baAutoregulatoryloop


Description

A simple model of the Fgf and Wnt gene network in the zebrafish tailbud.

Fgf signaling inhibits transcription of the Wnt inhibitors dkk1 and notum1a. PI3k signaling activates the Wnt pathway by phosphorylating (inactivating) Gsk3β. Phosphorylation of Gsk3β also leads to an increase in active Erk levels, suggesting Wnt signaling promotes Mapk activity. Fgf and Wnt have opposing effects on transcription of co-regulated genes, which include Fgf (spred3) and Wnt (dkk1, notum1a) inhibitors. (From Stulberg et al)

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Ontology Terms

 

Bibliography

  1. Stulberg MJ, Lin A, Zhao H, Holley SA; ''Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud.''; Dev Biol, 2012 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
93043view22:56, 26 July 2017KhanspersOntology Term : 'Wnt signaling pathway' added !
93042view22:56, 26 July 2017KhanspersOntology Term : 'fibroblast growth factor signaling pathway' added !
93041view22:56, 26 July 2017KhanspersModified description
93040view22:54, 26 July 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
dkk1aGeneProductZDB-GENE-090313-406 (ZFIN)
dkk1bGeneProductZDB-GENE-990708-5 (ZFIN)
erk1GeneProductZDB-GENE-040121-1 (ZFIN)
erk2GeneProductZDB-GENE-030722-2 (ZFIN)
fgf10aGeneProductZDB-GENE-030715-1 (ZFIN)
fgf10bGeneProductZDB-GENE-060828-1 (ZFIN)
fgf16GeneProductZDB-GENE-060427-3 (ZFIN)
fgf17GeneProductZDB-GENE-040621-1 (ZFIN)
fgf19GeneProductZDB-GENE-030729-32 (ZFIN)
fgf24GeneProductZDB-GENE-030708-1 (ZFIN)
fgf3GeneProductZDB-GENE-980526-178 (ZFIN)
fgf4GeneProductZDB-GENE-001006-1 (ZFIN)
fgf8aGeneProductZDB-GENE-990415-72 (ZFIN)
gsk3bGeneProductZDB-GENE-990714-4 (ZFIN)
notum1aGeneProductZDB-GENE-120807-2 (ZFIN)
ntlGeneProductZDB-GENE-980526-437 (ZFIN)
pik3caGeneProductZDB-GENE-130409-1 (ZFIN)
pik3cbGeneProductZDB-GENE-030131-1904 (ZFIN)
pik3cdGeneProductZDB-GENE-040426-1128 (ZFIN)
pik3cgGeneProductZDB-GENE-040426-2532 (ZFIN)
spred3GeneProductZDB-GENE-061207-31 (ZFIN)
sptGeneProductZDB-GENE-990615-5 (ZFIN)
tbx6GeneProductZDB-GENE-020416-5 (ZFIN)
wnt11GeneProductZDB-GENE-990603-12 (ZFIN)
wnt3GeneProductZDB-GENE-081003-1 (ZFIN)
wnt3aGeneProductZDB-GENE-001106-1 (ZFIN)
wnt5bGeneProductZDB-GENE-980526-87 (ZFIN)
wnt7baGeneProductZDB-GENE-041210-178 (ZFIN)
wnt8aGeneProductZDB-GENE-980526-332 (ZFIN)

Annotated Interactions

No annotated interactions

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