Nucleosome assembly (Homo sapiens)

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1, 3, 6, 7, 10...1, 3, 6, 11, 1473, 4, 10, 12NPM1 HIST1H2BJ HIST1H2BJ HIST3H2BB CENPW H2AFJ CENPN CCAN:DNA:CASC5:Mis18complex:HJURPcomplex:CENPA:H4CENPM CCAN:DNA:CASC5:Mis18complexHIST1H2BC CENPI HIST1H2BM RBBP4 H2AFV CENPT CENPQ CENPT HIST1H2BH HIST1H2AJ STRA13 SMARCA5 HIST2H2AA3 CENPN HJURP:NPM1:RBBP4:RBBP7:RUVBL1RSF1 ITGB3BP CENPO CENPO CCAN:DNA:CASC5RSF ComplexHIST1H2BB HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4CENPI HJURP HIST1H2BC HIST1H2AD HIST1H2BK CENPW CCAN:DNA:CASC5:Centromeric nucleosome:RSF complexCENPA CENPP CENPN NPM1 CASC5 H2AFB1 HIST1H2AC H2AFJ HJURP CENPL CENPA HJURP RBBP4 CENPL CENPI CENPH CENPL MIS18BP1 HIST2H2AC HIST1H4 CASC5 Histone H2BCENPQ STRA13 APITD1 CENPC HIST1H2BO CENPN CENPH CENPL CENPA DNA HIST1H2BM HIST1H2BB CENPC H2BFS HIST1H2BA H2AFZ CENPP OIP5 MIS18A OIP5 MIS18A HIST2H2AA3 CENPQ HIST1H2BD HIST1H2AB MLF1IP STRA13 CENPP CENPM NPM1 H2AFZ HIST2H2BE CENPT APITD1 HIST1H2BO H2AFB1 ITGB3BP CENPO HIST1H2BJ CENPM CENPM HIST1H2AC CENPK HIST1H2BB HIST1H2BC RUVBL1 HIST2H2AC MLF1IP CENPM RSF1 DNA CENPL H2AFB1 HIST1H4 CENPO HIST1H2BK CENPN HIST1H2AJ CENPH MLF1IP CENPW HIST1H2BN CENPT CENPI HJURP RBBP4 ITGB3BP HIST1H4 SMARCA5 HIST1H4 CENPK HIST1H2BL CASC5 APITD1 CENPW CENPW H2BFS CENPC Histone H2AHIST1H2BD RBBP7 RBBP7 HIST2H2BE CENPK DNA CASC5 H2AFX HIST1H2AC CENPQ RUVBL1 MLF1IP APITD1 CENPH RBBP7 CENPH HIST1H2BN CENPC HIST1H2BL HIST1H2AJ CENPP HIST1H2AD HIST1H2BN HIST1H2BO HIST1H2AB HIST1H2BA HIST1H2AD ITGB3BP CENPT APITD1 CENPK CENPQ MIS18BP1 CCAN:DNA:CASC5:Mis18complex:HJURPcomplex:New CENPAnucleosomeHIST1H2BL RUVBL1 H2AFJ MIS18A H2AFZ STRA13 MLF1IP RBBP7 STRA13 H2BFS CENPO OIP5 CENPP HIST3H2BB MIS18A RBBP4 HIST1H2BK CENPA MIS18BP1 HIST1H2BH HIST1H2BD H2AFX HIST3H2BB HIST2H2AA3 H2AFX DNA Mis18 ComplexMIS18BP1 ITGB3BP H2AFV HIST1H2BH HIST2H2AC RUVBL1 DNA CENPK OIP5 HIST1H2AB HIST1H2BA CASC5 CENPC H2AFV NPM1 CENPI HIST2H2BE HIST1H2BM 1, 6, 147, 82, 5, 9, 101, 3, 7, 8, 10...33, 81, 6, 8, 141, 6, 147


Description

The formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 774815
Reactome-version 
Reactome version: 61
Reactome Author 
Reactome Author: Matthews, Lisa

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Ontology Terms

 

Bibliography

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  1. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW.; ''The human CENP-A centromeric nucleosome-associated complex.''; PubMed Europe PMC Scholia
  2. Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland DW.; ''Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.''; PubMed Europe PMC Scholia
  3. Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K.; ''Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.''; PubMed Europe PMC Scholia
  4. Mellone BG, Zhang W, Karpen GH.; ''Frodos found: Behold the CENP-a "Ring" bearers.''; PubMed Europe PMC Scholia
  5. Barnhart MC, Kuich PH, Stellfox ME, Ward JA, Bassett EA, Black BE, Foltz DR.; ''HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore.''; PubMed Europe PMC Scholia
  6. Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G.; ''HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.''; PubMed Europe PMC Scholia
  7. Shuaib M, Ouararhni K, Dimitrov S, Hamiche A.; ''HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres.''; PubMed Europe PMC Scholia
  8. Perpelescu M, Nozaki N, Obuse C, Yang H, Yoda K.; ''Active establishment of centromeric CENP-A chromatin by RSF complex.''; PubMed Europe PMC Scholia
  9. Carroll CW, Silva MC, Godek KM, Jansen LE, Straight AF.; ''Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.''; PubMed Europe PMC Scholia
  10. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T.; ''The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.''; PubMed Europe PMC Scholia
  11. Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M.; ''Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.''; PubMed Europe PMC Scholia
  12. Hayashi T, Fujita Y, Iwasaki O, Adachi Y, Takahashi K, Yanagida M.; ''Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.''; PubMed Europe PMC Scholia
  13. Maddox PS, Hyndman F, Monen J, Oegema K, Desai A.; ''Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.''; PubMed Europe PMC Scholia
  14. Carroll CW, Milks KJ, Straight AF.; ''Dual recognition of CENP-A nucleosomes is required for centromere assembly.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114914view16:43, 25 January 2021ReactomeTeamReactome version 75
113359view11:43, 2 November 2020ReactomeTeamReactome version 74
112568view15:53, 9 October 2020ReactomeTeamReactome version 73
101481view11:34, 1 November 2018ReactomeTeamreactome version 66
101019view21:14, 31 October 2018ReactomeTeamreactome version 65
100554view19:48, 31 October 2018ReactomeTeamreactome version 64
100102view16:33, 31 October 2018ReactomeTeamreactome version 63
99652view15:04, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99254view12:45, 31 October 2018ReactomeTeamreactome version 62
93942view13:46, 16 August 2017ReactomeTeamreactome version 61
93736view13:24, 16 August 2017ReactomeTeamreactome version 61
93531view11:26, 9 August 2017ReactomeTeamreactome version 61
88075view09:01, 26 July 2016RyanmillerOntology Term : 'pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis' added !
88074view08:59, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86631view09:22, 11 July 2016ReactomeTeamreactome version 56
83051view09:47, 18 November 2015ReactomeTeamVersion54
81357view12:53, 21 August 2015ReactomeTeamVersion53
76826view08:05, 17 July 2014ReactomeTeamFixed remaining interactions
76530view11:50, 16 July 2014ReactomeTeamFixed remaining interactions
75863view09:51, 11 June 2014ReactomeTeamRe-fixing comment source
75563view10:36, 10 June 2014ReactomeTeamReactome 48 Update
74918view13:44, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74562view08:36, 30 April 2014ReactomeTeamReactome46
68940view17:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
42092view21:56, 4 March 2011MaintBotAutomatic update
39900view05:55, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APITD1 ProteinQ8N2Z9 (Uniprot-TrEMBL)
CASC5 ProteinQ8NG31 (Uniprot-TrEMBL)
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complexComplexR-HSA-606323 (Reactome)
CCAN:DNA:CASC5:Mis18

complex:HJURP

complex:CENPA:H4		ComplexR-HSA-606282 (Reactome)
CCAN:DNA:CASC5:Mis18

complex:HJURP complex:New CENPA

nucleosome		ComplexR-HSA-606328 (Reactome)
CCAN:DNA:CASC5:Mis18 complexComplexR-HSA-606342 (Reactome) The Mis18 complex binds the centromere in late telophase/early G1 phase. The mechanism of interaction between the Mis18 complex and the centromeric core is unknown.
CCAN:DNA:CASC5ComplexR-HSA-606340 (Reactome) The mechanism of interaction between the CENPH-I Complex and the centromeric nucleosome (containing CENPA) is unknown. The CENH-I complex is observed to interact with the centromeric core throughout the cell cycle.
CENPA ProteinP49450 (Uniprot-TrEMBL)
CENPC ProteinQ03188 (Uniprot-TrEMBL)
CENPH ProteinQ9H3R5 (Uniprot-TrEMBL)
CENPI ProteinQ92674 (Uniprot-TrEMBL)
CENPK ProteinQ9BS16 (Uniprot-TrEMBL)
CENPL ProteinQ8N0S6 (Uniprot-TrEMBL)
CENPM ProteinQ9NSP4 (Uniprot-TrEMBL)
CENPN ProteinQ96H22 (Uniprot-TrEMBL)
CENPO ProteinQ9BU64 (Uniprot-TrEMBL)
CENPP ProteinQ6IPU0 (Uniprot-TrEMBL)
CENPQ ProteinQ7L2Z9 (Uniprot-TrEMBL)
CENPT ProteinQ96BT3 (Uniprot-TrEMBL)
CENPW ProteinQ5EE01 (Uniprot-TrEMBL)
DNA R-NUL-29428 (Reactome)
H2AFB1 ProteinP0C5Y9 (Uniprot-TrEMBL)
H2AFJ ProteinQ9BTM1 (Uniprot-TrEMBL)
H2AFV ProteinQ71UI9 (Uniprot-TrEMBL)
H2AFX ProteinP16104 (Uniprot-TrEMBL)
H2AFZ ProteinP0C0S5 (Uniprot-TrEMBL)
H2BFS ProteinP57053 (Uniprot-TrEMBL)
HIST1H2AB ProteinP04908 (Uniprot-TrEMBL)
HIST1H2AC ProteinQ93077 (Uniprot-TrEMBL)
HIST1H2AD ProteinP20671 (Uniprot-TrEMBL)
HIST1H2AJ ProteinQ99878 (Uniprot-TrEMBL)
HIST1H2BA ProteinQ96A08 (Uniprot-TrEMBL)
HIST1H2BB ProteinP33778 (Uniprot-TrEMBL)
HIST1H2BC ProteinP62807 (Uniprot-TrEMBL)
HIST1H2BD ProteinP58876 (Uniprot-TrEMBL)
HIST1H2BH ProteinQ93079 (Uniprot-TrEMBL)
HIST1H2BJ ProteinP06899 (Uniprot-TrEMBL)
HIST1H2BK ProteinO60814 (Uniprot-TrEMBL)
HIST1H2BL ProteinQ99880 (Uniprot-TrEMBL)
HIST1H2BM ProteinQ99879 (Uniprot-TrEMBL)
HIST1H2BN ProteinQ99877 (Uniprot-TrEMBL)
HIST1H2BO ProteinP23527 (Uniprot-TrEMBL)
HIST1H4 ProteinP62805 (Uniprot-TrEMBL)
HIST2H2AA3 ProteinQ6FI13 (Uniprot-TrEMBL)
HIST2H2AC ProteinQ16777 (Uniprot-TrEMBL)
HIST2H2BE ProteinQ16778 (Uniprot-TrEMBL)
HIST3H2BB ProteinQ8N257 (Uniprot-TrEMBL)
HJURP ProteinQ8NCD3 (Uniprot-TrEMBL)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4ComplexR-HSA-606319 (Reactome)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1ComplexR-HSA-606330 (Reactome)
Histone H2AComplexR-HSA-181899 (Reactome)
Histone H2BComplexR-HSA-181911 (Reactome)
ITGB3BP ProteinQ13352 (Uniprot-TrEMBL)
MIS18A ProteinQ9NYP9 (Uniprot-TrEMBL)
MIS18BP1 ProteinQ6P0N0 (Uniprot-TrEMBL)
MLF1IP ProteinQ71F23 (Uniprot-TrEMBL)
Mis18 ComplexComplexR-HSA-606346 (Reactome)
NPM1 ProteinP06748 (Uniprot-TrEMBL)
OIP5 ProteinO43482 (Uniprot-TrEMBL)
RBBP4 ProteinQ09028 (Uniprot-TrEMBL)
RBBP7 ProteinQ16576 (Uniprot-TrEMBL)
RSF ComplexComplexR-HSA-606288 (Reactome)
RSF1 ProteinQ96T23 (Uniprot-TrEMBL)
RUVBL1 ProteinQ9Y265 (Uniprot-TrEMBL)
SMARCA5 ProteinO60264 (Uniprot-TrEMBL)
STRA13 ProteinA8MT69 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complexArrowR-HSA-606287 (Reactome)
CCAN:DNA:CASC5:Mis18

complex:HJURP

complex:CENPA:H4		ArrowR-HSA-606326 (Reactome)
CCAN:DNA:CASC5:Mis18

complex:HJURP

complex:CENPA:H4		R-HSA-606289 (Reactome)
CCAN:DNA:CASC5:Mis18

complex:HJURP complex:New CENPA

nucleosome		ArrowR-HSA-606289 (Reactome)
CCAN:DNA:CASC5:Mis18

complex:HJURP complex:New CENPA

nucleosome		R-HSA-606287 (Reactome)
CCAN:DNA:CASC5:Mis18 complexArrowR-HSA-606349 (Reactome)
CCAN:DNA:CASC5:Mis18 complexR-HSA-606326 (Reactome)
CCAN:DNA:CASC5R-HSA-606349 (Reactome)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4R-HSA-606326 (Reactome)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1ArrowR-HSA-606287 (Reactome)
Histone H2AR-HSA-606289 (Reactome)
Histone H2BR-HSA-606289 (Reactome)
Mis18 ComplexArrowR-HSA-606287 (Reactome)
Mis18 ComplexR-HSA-606349 (Reactome)
R-HSA-606287 (Reactome) The RSF complex binds the centromere in mid-G1 phase after deposition of new CENPA-containing nucleosomes has occurred. The RSF complex is required for stable incorporation of the previously deposited CENPA-containing nucleosomes.
R-HSA-606289 (Reactome) A new centromeric nucleosome containing histone H2A, histone H2B, histone H4, and CENPA is deposited at the centromere in late telophase/early G1 phase. The exact mechanism by which the new CENPA-containing nucleosome is transferred to DNA is unknown. HJURP directly binds newly synthesized CENPA before deposition. The Mis18 and HJURP complexes are required for deposition of newly synthesized CENPA-containing nucleosomes. The exact stoichiometries and interactions of the complexes are unknown.
R-HSA-606326 (Reactome) The HJURP complex binds free, newly synthesized CENPA-H4 tetramers. A direct interaction occurs between HJURP and CENPA. The CATD domain of CENPA is sufficient for the interaction. The complex then localizes to the centromere in early G1 phase. HJURP is required for deposition of new CENPA-containing nucleosomes.
R-HSA-606349 (Reactome) The Mis18 complex (containing Mis18-alpha, Mis18-beta, Mis18BP1, RBap46, and RbAp48) transiently binds the centromere in late anaphase-telophase to early G1. The mechanism by which the Mis18 complex binds the centromere is unknown. The Mis18 complex is required for deposition of new CENPA-containing nucleosomes at the centromere. The CENPH-I complex is constitutively associated with centromeres and is required for deposition of new CENPA-containing nucleosomes.
RSF ComplexR-HSA-606287 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1874"
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