PTF1A related regulatory pathway (Homo sapiens)

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TrypsinElastaseChymotrypsinogenCarboxypeptidase 108102, 114106, 12951081Acinar-specific genes17310910Documented interaction, positiveDocumented interaction, not in mouseProved interaction from our study, negativeSymbols:Endocrine pancreasPancreas specificationExocrine pancreasHigh levelLowlevelPDX1RBPJmiR-495NKX6-1CTNNB1HES1PROX1RBPJNOTCH1PDX1FGF10KAT2BmiR-145RBPJLmiR-18aPTF1A


Description

By summarizing published data together with our own results, this pathway shows a complicated relationships between transcriptional factors, miRNAs and some functional genes which are correlated together to generate a whole sight in early mouse development centered around Ptf1a, although there are some hypothetical relationships and the distinct development of dorsal and ventral pancreas in very early stage is neglected.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway WP201 (rev 69113) with a 81.0% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Masui, T, Long, Q, Beres, T M, Magnuson, M A, MacDonald, R J; ''Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex''; Genes Dev, 2007 PubMed Europe PMC Scholia
  2. Miyatsuka, T, Matsuoka, T A, Shiraiwa, T, Yamamoto, T, Kojima, I, Kaneto, H; ''Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  3. Rodolosse, A, Campos, M L, Rooman, I, Lichtenstein, M, Real, F X; ''P/CAF modulates the activity of the transcription factor p48/PTF1a involved in pancreatic acinar differentiation''; Biochem J, 2008 PubMed Europe PMC Scholia
  4. Junfeng Wang, Gamze Kilic, Muge Aydin, Zoe Burke, Guillermo Oliver, Beatriz Sosa-Pineda; ''Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells''; Developmental Biology, 2005 PubMed Europe PMC Scholia
  5. Jacquemin, P, Yoshitomi, H, Kashima, Y, Rousseau, G G, Lemaigre, F P, Zaret, K S; ''An endothelial-mesenchymal relay pathway regulates early phases of pancreas development''; Dev Biol, 2006 PubMed Europe PMC Scholia
  6. Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI; ''Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)''; J Histochem Cytochem, 1998 PubMed Europe PMC Scholia
  7. Wells, J M, Esni, F, Boivin, G P, Aronow, B J, Stuart, W, Combs, C, Sklenka, A, Leach, S D, Lowy, A M; ''Wnt/beta-catenin signaling is required for development of the exocrine pancreas''; BMC Dev Biol, 2007 PubMed Europe PMC Scholia
  8. Fujikura, J, Hosoda, K, Kawaguchi, Y, Noguchi, M, Iwakura, H, Odori, S, Mori, E, Tomita, T, Hirata, M, Ebihara, K, Masuzaki, H, Fukuda, A, Furuyama, K, Tanigaki, K, Yabe, D, Nakao, K; ''Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development''; Dev Dyn, 2007 PubMed Europe PMC Scholia
  9. Ghosh, B, Leach, S D; ''Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex''; Biochem J, 2006 PubMed Europe PMC Scholia
  10. Dong, P D, Provost, E, Leach, S D, Stainier, D Y; ''Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas''; Genes Dev, 2008 PubMed Europe PMC Scholia
  11. Wiebe, P O, Kormish, J D, Roper, V T, Fujitani, Y, Alston, N I, Zaret, K S, Wright, C V, Stein, R W, Gannon, M; ''Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression''; Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  12. Watada H, Mirmira RG, Leung J, German MS; ''Transcriptional and Translational Regulation of -Cell Differentiation Factor Nkx6.1''; J Biol Chem, 2000 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
94394view12:31, 6 September 2017MkutmonOntology Term : 'transcription factor mediated signaling pathway' added !
94393view12:30, 6 September 2017MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CTNNB1GeneProductENSG00000168036 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006932
FGF10GeneProductENSG00000070193 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021732
HES1GeneProductENSG00000114315 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104853
KAT2BGeneProductENSG00000114166 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000708
NKX6-1GeneProductENSG00000163623 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035187
NOTCH1GeneProductENSG00000148400 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026923
PDX1ProteinENSG00000139515 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029644
PROX1GeneProductENSG00000117707 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010175
PTF1AGeneProductENSG00000168267 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026735
RBPJGeneProductENSG00000168214 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039191
RBPJLGeneProductENSG00000124232 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000017007
miR-145RnaNo homologues found for original id Mb:MI0000169
miR-18aRnaNo homologues found for original id Mb:MI0000567
miR-495RnaNo homologues found for original id Mb:MI0004639

Annotated Interactions

No annotated interactions
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