PI3K-Akt signaling (Homo sapiens)

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Description

PI3K-Akt Signaling Pathway

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Quality Tags

Ontology Terms

Bibliography

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Blume-Jensen P, Hunter T; ''Oncogenic kinase signalling.''; Nature, 2001 PubMed Europe PMC Scholia
Song G, Ouyang G, Bao S; ''The activation of Akt/PKB signaling pathway and cell survival.''; J Cell Mol Med, 2005 PubMed Europe PMC Scholia
Okkenhaug K, Vanhaesebroeck B; ''PI3K in lymphocyte development, differentiation and activation.''; Nat Rev Immunol, 2003 PubMed Europe PMC Scholia
Noguchi M, Ropars V, Roumestand C, Suizu F; ''Proto-oncogene TCL1: more than just a coactivator for Akt.''; FASEB J, 2007 PubMed Europe PMC Scholia
Duronio V; ''The life of a cell: apoptosis regulation by the PI3K/PKB pathway.''; Biochem J, 2008 PubMed Europe PMC Scholia
Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR; ''Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.''; Biochem J, 1998 PubMed Europe PMC Scholia
Hers I, Vincent EE, Tavaré JM; ''Akt signalling in health and disease.''; Cell Signal, 2011 PubMed Europe PMC Scholia
Engelman JA, Luo J, Cantley LC; ''The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.''; Nat Rev Genet, 2006 PubMed Europe PMC Scholia
Richardson CJ, Schalm SS, Blenis J; ''PI3-kinase and TOR: PIKTORing cell growth.''; Semin Cell Dev Biol, 2004 PubMed Europe PMC Scholia
West KA, Castillo SS, Dennis PA; ''Activation of the PI3K/Akt pathway and chemotherapeutic resistance.''; Drug Resist Updat, 2002 PubMed Europe PMC Scholia
Koyasu S; ''The role of PI3K in immune cells.''; Nat Immunol, 2003 PubMed Europe PMC Scholia
Skaper SD; ''The neurotrophin family of neurotrophic factors: an overview.''; Methods Mol Biol, 2012 PubMed Europe PMC Scholia
Georgescu MM; ''PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.''; Genes Cancer, 2010 PubMed Europe PMC Scholia
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M; ''Regulation of Raf-Akt Cross-talk.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
Lemmon MA, Schlessinger J; ''Cell signaling by receptor tyrosine kinases.''; Cell, 2010 PubMed Europe PMC Scholia
Zhang X, Tang N, Hadden TJ, Rishi AK; ''Akt, FoxO and regulation of apoptosis.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
Wymann MP, Pirola L; ''Structure and function of phosphoinositide 3-kinases.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
Kikani CK, Dong LQ, Liu F; ''"New"-clear functions of PDK1: beyond a master kinase in the cytosol?''; J Cell Biochem, 2005 PubMed Europe PMC Scholia
Kim D, Chung J; ''Akt: versatile mediator of cell survival and beyond.''; J Biochem Mol Biol, 2002 PubMed Europe PMC Scholia
Osaki M, Oshimura M, Ito H; ''PI3K-Akt pathway: its functions and alterations in human cancer.''; Apoptosis, 2004 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
134839	view	16:53, 27 July 2024	Eweitz	"CytokineR" -> "Cytokine receptor"
129658	view	00:38, 22 May 2024	Eweitz	Modified title
128769	view	23:08, 21 February 2024	Eweitz	Upgrade disease node
128035	view	17:28, 21 January 2024	Eweitz	Fix typos, tailor node dimensions, standardize case
127493	view	18:34, 11 October 2023	Khanspers	updated phosphosites, updated line type, corrected node height
127444	view	23:39, 2 October 2023	Khanspers	updated phosphosites
127442	view	23:24, 2 October 2023	Khanspers	updated AKT phospho sites
127243	view	00:26, 26 August 2023	Khanspers	added lit ref and updated description
122580	view	16:46, 17 April 2022	Egonw	Made multiple pathways clickable
116400	view	00:03, 7 May 2021	Eweitz	Modified title
112040	view	20:02, 16 September 2020	Khanspers	updated phosphosites
106781	view	13:26, 17 September 2019	MaintBot	HMDB identifier normalization
106516	view	21:14, 5 September 2019	Khanspers	Modified description
105775	view	19:41, 15 August 2019	Khanspers	Modified description
96453	view	11:31, 15 March 2018	Egonw	Replaced a secondary ChEBI identifier with a primary identifier.
95701	view	19:55, 18 January 2018	Khanspers	Ontology Term : 'cell cycle pathway' added !
95695	view	19:49, 18 January 2018	Khanspers	Modified description
95694	view	19:48, 18 January 2018	Khanspers	Modified description
95693	view	19:48, 18 January 2018	Khanspers	Modified description
95684	view	18:19, 18 January 2018	Ariutta	Ontology Term : 'cancer pathway' added !
95683	view	18:18, 18 January 2018	Ariutta	Ontology Term : 'cancer' added !
95682	view	18:08, 18 January 2018	Ariutta	Modified description
95163	view	00:42, 18 November 2017	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
AKT1	GeneProduct	ENSG00000142208 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
AKT2	GeneProduct	ENSG00000105221 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652
AKT3	GeneProduct	ENSG00000117020 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797
AMP	Metabolite	CHEBI:2356 (ChEBI)
ANGPT1	GeneProduct	ENSG00000154188 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11600
ANGPT2	GeneProduct	ENSG00000091879 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11601
ANGPT4	GeneProduct	ENSG00000101280 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11602
ATF2	GeneProduct	ENSG00000115966 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11909
ATF4	GeneProduct	ENSG00000128272 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11911
ATF6B	GeneProduct	ENSG00000213676 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12915
Angiogenesis	Pathway	WP1539 (WikiPathways)
Apoptosis	Pathway	WP254 (WikiPathways)
B Cell Receptor Signaling Pathway	Pathway	WP23 (WikiPathways)
BAD	GeneProduct	ENSG00000002330 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015
BCL2	GeneProduct	ENSG00000171791 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCL2L11	GeneProduct	ENSG00000153094 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCL2L1	GeneProduct	ENSG00000171552 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCR	GeneProduct	102723407 (Entrez Gene)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
BDNF	GeneProduct	ENSG00000176697 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785
BRCA1	GeneProduct	ENSG00000012048 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
C8orf44-SGK3	GeneProduct	ENSG00000270024 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
CASP9	GeneProduct	ENSG00000132906 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12371
CCND1	GeneProduct	ENSG00000110092 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCND2	GeneProduct	ENSG00000118971 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCND3	GeneProduct	ENSG00000112576 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCNE1	GeneProduct	ENSG00000105173 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCNE2	GeneProduct	ENSG00000175305 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CD19	GeneProduct	ENSG00000177455 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
CDC37	GeneProduct	ENSG00000105401 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12539
CDK2	GeneProduct	ENSG00000123374 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDK4	GeneProduct	ENSG00000135446 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDK6	GeneProduct	ENSG00000105810 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDKN1A	GeneProduct	ENSG00000124762 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12575
CDKN1B	GeneProduct	ENSG00000111276 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CHAD	GeneProduct	ENSG00000136457 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12643
CHRM1	GeneProduct	ENSG00000168539 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12669
CHRM2	GeneProduct	ENSG00000181072 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:243764
CHUK	GeneProduct	ENSG00000213341 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
COL1A1	GeneProduct	ENSG00000108821 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12842
COL1A2	GeneProduct	ENSG00000164692 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12843
COL2A1	GeneProduct	ENSG00000139219 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12824
COL4A1	GeneProduct	ENSG00000187498 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12826
COL4A2	GeneProduct	ENSG00000134871 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12827
COL4A3	GeneProduct	ENSG00000169031 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12814
COL4A4	GeneProduct	ENSG00000081052 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12829
COL4A5	GeneProduct	ENSG00000188153 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12815
COL4A6	GeneProduct	ENSG00000197565 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94216
COL6A1	GeneProduct	ENSG00000142156 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12825
COL6A2	GeneProduct	ENSG00000142173 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12834
COL6A3	GeneProduct	ENSG00000163359 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12831
COL6A5	GeneProduct	ENSG00000172752 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL6A6	GeneProduct	ENSG00000206384 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12832
COL9A1	GeneProduct	ENSG00000112280 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL9A2	GeneProduct	ENSG00000049089 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL9A3	GeneProduct	ENSG00000092758 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COMP	GeneProduct	ENSG00000105664 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12845
CREB1	GeneProduct	ENSG00000118260 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912
CREB3	GeneProduct	ENSG00000107175 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12913
CREB3L1	GeneProduct	ENSG00000157613 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26427
CREB3L2	GeneProduct	ENSG00000182158 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208647
CREB3L3	GeneProduct	ENSG00000060566 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208677
CREB3L4	GeneProduct	ENSG00000143578 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78284
CREB5	GeneProduct	ENSG00000146592 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:231991
CSF1	GeneProduct	ENSG00000184371 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12977
CSF1R	GeneProduct	ENSG00000182578 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
CSF3	GeneProduct	ENSG00000108342 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12985
CSF3R	GeneProduct	ENSG00000119535 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
CSH1	GeneProduct	ENSG00000136488 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
CSH2	GeneProduct	ENSG00000213218 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
Cell Cycle	Pathway	WP179 (WikiPathways)
Cell proliferation	Pathway
Chemokine Signaling Pathway	Pathway	WP3929 (WikiPathways)
DDIT4	GeneProduct	ENSG00000168209 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
DNA Repair	Pathway	WP707 (WikiPathways)
EFNA1	GeneProduct	ENSG00000169242 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13636
EFNA2	GeneProduct	ENSG00000099617 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13637
EFNA3	GeneProduct	ENSG00000143590 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13638
EFNA4	GeneProduct	ENSG00000243364 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13639
EFNA5	GeneProduct	ENSG00000184349 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
EGF	GeneProduct	ENSG00000138798 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13645
EGFR	GeneProduct	ENSG00000146648 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
EIF4B	GeneProduct	ENSG00000063046 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75705
EIF4E1B	GeneProduct	ENSG00000175766 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218268
EIF4E2	GeneProduct	ENSG00000135930 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26987
EIF4EBP1	GeneProduct	ENSG00000187840 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13685
EIF4E	GeneProduct	ENSG00000151247 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13684
EPHA2	GeneProduct	ENSG00000142627 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
EPO	GeneProduct	ENSG00000130427 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13856
EPOR	GeneProduct	ENSG00000187266 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13857
ErbB Signaling Pathway	Pathway	WP673 (WikiPathways)
F2R	GeneProduct	ENSG00000181104 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14062
FASLG	GeneProduct	ENSG00000117560 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
FGF10	GeneProduct	ENSG00000070193 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14165
FGF11	GeneProduct	ENSG00000161958 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14166
FGF12	GeneProduct	ENSG00000114279 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14167
FGF13	GeneProduct	ENSG00000129682 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80903
FGF14	GeneProduct	ENSG00000102466 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14169
FGF17	GeneProduct	ENSG00000158815 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14171
FGF18	GeneProduct	ENSG00000156427 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF19	GeneProduct	ENSG00000162344 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF1	GeneProduct	ENSG00000113578 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14164
FGF20	GeneProduct	ENSG00000078579 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80857
FGF21	GeneProduct	ENSG00000105550 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56636
FGF22	GeneProduct	ENSG00000070388 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67112
FGF23	GeneProduct	ENSG00000118972 (Ensembl)
FGF2	GeneProduct	ENSG00000138685 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14173
FGF3	GeneProduct	ENSG00000186895 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14174
FGF4	GeneProduct	ENSG00000075388 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14175
FGF5	GeneProduct	ENSG00000138675 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14168
FGF6	GeneProduct	ENSG00000111241 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14177
FGF7	GeneProduct	ENSG00000140285 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14178
FGF8	GeneProduct	ENSG00000107831 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14179
FGF9	GeneProduct	ENSG00000102678 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14180
FGFR1	GeneProduct	ENSG00000077782 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
FGFR2	GeneProduct	ENSG00000066468 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
FGFR3	GeneProduct	ENSG00000068078 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
FGFR4	GeneProduct	ENSG00000160867 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FLT1	GeneProduct	ENSG00000102755 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT3	GeneProduct	ENSG00000122025 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FLT3LG	GeneProduct	ENSG00000090554 (Ensembl)
FLT4	GeneProduct	ENSG00000037280 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FN1	GeneProduct	ENSG00000115414 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14268
FOXO3	GeneProduct	ENSG00000118689 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56484
Focal Adhesion	Pathway	WP306 (WikiPathways)
FoxO Signaling Pathway	Pathway
G6PC2	GeneProduct	ENSG00000152254 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
G6PC3	GeneProduct	ENSG00000141349 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
G6PC	GeneProduct	ENSG00000131482 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
GH1	GeneProduct	ENSG00000259384 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
GH2	GeneProduct	ENSG00000136487 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
GHR	GeneProduct	ENSG00000112964 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14600
GNB1	GeneProduct	ENSG00000078369 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14688
GNB2	GeneProduct	ENSG00000172354 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14693
GNB3	GeneProduct	ENSG00000111664 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14695
GNB4	GeneProduct	ENSG00000114450 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14696
GNB5	GeneProduct	ENSG00000069966 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702
GNG10	GeneProduct	ENSG00000242616 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14700
GNG11	GeneProduct	ENSG00000127920 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66066
GNG12	GeneProduct	ENSG00000172380 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14701
GNG13	GeneProduct	ENSG00000127588 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64337
GNG2	GeneProduct	ENSG00000186469 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702
GNG3	GeneProduct	ENSG00000162188 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14704
GNG4	GeneProduct	ENSG00000168243 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14706
GNG5	GeneProduct	ENSG00000174021 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14707
GNG7	GeneProduct	ENSG00000176533 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14708
GNG8	GeneProduct	ENSG00000167414 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14709
GNGT1	GeneProduct	ENSG00000127928 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14699
GNGT2	GeneProduct	ENSG00000167083 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14710
GRB2	GeneProduct	ENSG00000177885 (Ensembl)	GRB2; growth factor receptor-bound protein 2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14784
GSK3B	GeneProduct	ENSG00000082701 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56637
GYS1	GeneProduct	ENSG00000104812 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
GYS2	GeneProduct	ENSG00000111713 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
Glycolysis and Gluconeogenesis	Pathway	WP534 (WikiPathways)
HGF	GeneProduct	ENSG00000019991 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15234
HRAS	GeneProduct	ENSG00000174775 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
HSP90AA1	GeneProduct	ENSG00000080824 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15519
HSP90AB1	GeneProduct	ENSG00000096384 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15516
HSP90B1	GeneProduct	ENSG00000166598 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22027
IBSP	GeneProduct	ENSG00000029559 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15891
IFNA10	GeneProduct	ENSG00000186803 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15972
IFNA13	GeneProduct	ENSG00000233816 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:404549
IFNA14	GeneProduct	ENSG00000228083 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA16	GeneProduct	ENSG00000147885 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA17	GeneProduct	ENSG00000234829 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA1	GeneProduct	ENSG00000197919 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15962
IFNA21	GeneProduct	ENSG00000137080 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA2	GeneProduct	ENSG00000188379 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15964
IFNA4	GeneProduct	ENSG00000236637 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15965
IFNA5	GeneProduct	ENSG00000147873 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15967
IFNA6	GeneProduct	ENSG00000120235 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15968
IFNA7	GeneProduct	ENSG00000214042 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15969
IFNA8	GeneProduct	ENSG00000120242 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15970
IFNAR1	GeneProduct	ENSG00000142166 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15975
IFNAR2	GeneProduct	ENSG00000159110 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15976
IFNB1	GeneProduct	ENSG00000171855 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15977
IGF1	GeneProduct	ENSG00000017427 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16000
IGF1R	GeneProduct	ENSG00000140443 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
IGF2	GeneProduct	ENSG00000167244 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
IKBKB	GeneProduct	ENSG00000104365 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16150
IKBKG	GeneProduct	ENSG00000269335 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
IL2	GeneProduct	ENSG00000109471 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL2RA	GeneProduct	ENSG00000134460 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16184
IL2RB	GeneProduct	ENSG00000100385 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16185
IL2RG	GeneProduct	ENSG00000147168 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16186
IL3	GeneProduct	ENSG00000164399 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL3RA	GeneProduct	ENSG00000185291 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16188
IL4	GeneProduct	ENSG00000113520 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL4R	GeneProduct	ENSG00000077238 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16190
IL6	GeneProduct	ENSG00000136244 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL6R	GeneProduct	ENSG00000160712 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16194
IL7	GeneProduct	ENSG00000104432 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL7R	GeneProduct	ENSG00000168685 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16197
INS	GeneProduct	ENSG00000254647 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16334
INSR	GeneProduct	ENSG00000171105 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
IRS1	GeneProduct	ENSG00000169047 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
ITGA10	GeneProduct	ENSG00000143127 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000090210
ITGA11	GeneProduct	ENSG00000137809 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319480
ITGA1	GeneProduct	ENSG00000213949 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105083
ITGA2B	GeneProduct	ENSG00000005961 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16399
ITGA2	GeneProduct	ENSG00000164171 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16398
ITGA3	GeneProduct	ENSG00000005884 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16400
ITGA4	GeneProduct	ENSG00000115232 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16401
ITGA5	GeneProduct	ENSG00000161638 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16402
ITGA6	GeneProduct	ENSG00000091409 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16403
ITGA7	GeneProduct	ENSG00000135424 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16404
ITGA8	GeneProduct	ENSG00000077943 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:241226
ITGA9	GeneProduct	ENSG00000144668 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104099
ITGAV	GeneProduct	ENSG00000138448 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96608
ITGB1	GeneProduct	ENSG00000150093 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16412
ITGB3	GeneProduct	ENSG00000259207 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16416
ITGB4	GeneProduct	ENSG00000132470 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192897
ITGB5	GeneProduct	ENSG00000082781 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16419
ITGB6	GeneProduct	ENSG00000115221 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16420
ITGB7	GeneProduct	ENSG00000139626 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16421
ITGB8	GeneProduct	ENSG00000105855 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320910
Insulin Signaling Pathway	Pathway	WP481 (WikiPathways)
JAK/STAT Signaling Pathway	Pathway	WP2593 (WikiPathways)
JAK1	GeneProduct	ENSG00000162434 (Ensembl)	CAV1; caveolin 1 caveolae protein 22kD Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16451
JAK2	GeneProduct	ENSG00000096968 (Ensembl)	CAV2; caveolin 2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
JAK3	GeneProduct	ENSG00000105639 (Ensembl)	CAV3; caveolin 3 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16453
KDR	GeneProduct	ENSG00000128052 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
KIT	GeneProduct	ENSG00000157404 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
KITLG	GeneProduct	ENSG00000049130 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17311
KRAS	GeneProduct	ENSG00000133703 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
Kik1b4	GeneProduct
LAMA1	GeneProduct	ENSG00000101680 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16772
LAMA2	GeneProduct	ENSG00000196569 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16773
LAMA3	GeneProduct	ENSG00000053747 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024421
LAMA4	GeneProduct	ENSG00000112769 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16775
LAMA5	GeneProduct	ENSG00000130702 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16776
LAMB1	GeneProduct	ENSG00000091136 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16777
LAMB2	GeneProduct	ENSG00000172037 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16779
LAMB3	GeneProduct	ENSG00000196878 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16780
LAMB4	GeneProduct	ENSG00000091128 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
LAMC1	GeneProduct	ENSG00000135862 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:226519
LAMC2	GeneProduct	ENSG00000058085 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16782
LAMC3	GeneProduct	ENSG00000050555 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23928
LPAR1	GeneProduct	ENSG00000198121 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14745
LPAR2	GeneProduct	ENSG00000064547 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53978
LPAR3	GeneProduct	ENSG00000171517 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:65086
LPAR4	GeneProduct	ENSG00000147145 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78134
LPAR5	GeneProduct	ENSG00000184574 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:381810
LPAR6	GeneProduct	ENSG00000139679 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67168
MAP2K1	GeneProduct	ENSG00000169032 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26395
MAP2K2	GeneProduct	ENSG00000126934 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26396
MAPK Signaling Pathway	Pathway	WP382 (WikiPathways)
MAPK1	GeneProduct	ENSG00000100030 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
MAPK3	GeneProduct	ENSG00000102882 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26417
MCL1	GeneProduct	ENSG00000143384 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
MDM2	GeneProduct	ENSG00000135679 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
MET	GeneProduct	ENSG00000105976 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
MLST8	GeneProduct	ENSG00000167965 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56716
MTOR	GeneProduct	ENSG00000198793 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56717
MYB	GeneProduct	ENSG00000118513 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
MYC	GeneProduct	ENSG00000136997 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
Mtcp1	GeneProduct		Multiple homologues found: En:ENSG00000214827;En:ENSG00000182712;
NFKB1	GeneProduct	ENSG00000109320 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
NGF	GeneProduct	ENSG00000134259 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18049
NGFR	GeneProduct	ENSG00000064300 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053
NOS3	GeneProduct	ENSG00000164867 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
NRAS	GeneProduct	ENSG00000213281 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176
NTF3	GeneProduct	ENSG00000185652 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
NTF4	GeneProduct	ENSG00000225950 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
NTRK1	GeneProduct	ENSG00000198400 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
NTRK2	GeneProduct	ENSG00000148053 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
Nitric oxide	Metabolite	HMDB03378 (HMDB)
OSM	GeneProduct	ENSG00000099985 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18413
OSMR	GeneProduct	ENSG00000145623 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18414
PCK1	GeneProduct	ENSG00000124253 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
PCK2	GeneProduct	ENSG00000100889 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
PDGFA	GeneProduct	ENSG00000197461 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18590
PDGFB	GeneProduct	ENSG00000100311 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18591
PDGFC	GeneProduct	ENSG00000145431 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54635
PDGFD	GeneProduct	ENSG00000170962 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785
PDGFRA	GeneProduct	ENSG00000134853 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595
PDGFRB	GeneProduct	ENSG00000113721 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596
PDPK1	GeneProduct	ENSG00000140992 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PGF	GeneProduct	ENSG00000119630 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
PHLPP1	GeneProduct	ENSG00000081913 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:98432
PHLPP2	GeneProduct	ENSG00000040199 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:244650
PIK3AP1	GeneProduct	ENSG00000155629 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
PIK3CA	GeneProduct	ENSG00000121879 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CB	GeneProduct	ENSG00000051382 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CD	GeneProduct	ENSG00000171608 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3CG	GeneProduct	ENSG00000105851 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30955
PIK3R1	GeneProduct	ENSG00000145675 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2	GeneProduct	ENSG00000105647 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3	GeneProduct	ENSG00000117461 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PIK3R5	GeneProduct	ENSG00000141506 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320207
PIK3R6	GeneProduct	ENSG00000276231 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320207
PIP2	Metabolite	CHEBI:18348 (ChEBI)
PIP3	Metabolite	HMDB04249 (HMDB)
PKN1	GeneProduct	ENSG00000123143 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PKN2	GeneProduct	ENSG00000065243 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PKN3	GeneProduct	ENSG00000160447 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PPP2CA	GeneProduct	ENSG00000113575 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19052
PPP2CB	GeneProduct	ENSG00000104695 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19053
PPP2R1A	GeneProduct	ENSG00000105568 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:51792
PPP2R1B	GeneProduct	ENSG00000137713 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73699
PPP2R2A	GeneProduct	ENSG00000221914 (Ensembl)
PPP2R2B	GeneProduct	ENSG00000156475 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72930
PPP2R2C	GeneProduct	ENSG00000074211 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:269643
PPP2R2D	GeneProduct	ENSG00000175470 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:52432
PPP2R3A	GeneProduct	ENSG00000073711 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235542
PPP2R3B	GeneProduct	ENSG00000167393 (Ensembl)
PPP2R3C	GeneProduct	ENSG00000092020 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:59032
PPP2R5A	GeneProduct	ENSG00000066027 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:226849
PPP2R5B	GeneProduct	ENSG00000068971 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225849
PPP2R5C	GeneProduct	ENSG00000078304 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26931
PPP2R5D	GeneProduct	ENSG00000112640 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21770
PPP2R5E	GeneProduct	ENSG00000154001 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26932
PRKAA1	GeneProduct	ENSG00000132356 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105787
PRKAA2	GeneProduct	ENSG00000162409 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108079
PRKCA	GeneProduct	ENSG00000154229 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PRL	GeneProduct	ENSG00000172179 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19109
PRLR	GeneProduct	ENSG00000113494 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19116
PTEN	GeneProduct	ENSG00000171862 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19211
PTK2	GeneProduct	ENSG00000169398 (Ensembl)	DOCK1; dedicator of cyto-kinesis Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14083
RAC1	GeneProduct	ENSG00000136238 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
RAF1	GeneProduct	ENSG00000132155 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
RBL2	GeneProduct	ENSG00000103479 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
RELA	GeneProduct	5970 (Entrez Gene)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
RELN	GeneProduct	ENSG00000189056 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19699
RHEB	GeneProduct	ENSG00000106615 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19744
RPS6	GeneProduct	ENSG00000137154 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20104
RPS6KB1	GeneProduct	ENSG00000108443 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72508
RPS6KB2	GeneProduct	ENSG00000175634 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:58988
RPTOR	GeneProduct	ENSG00000141564 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74370
SGK1	GeneProduct	ENSG00000118515 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SGK2	GeneProduct	ENSG00000101049 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SGK3	GeneProduct	ENSG00000104205 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SOS1	GeneProduct	ENSG00000115904 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20662
SOS2	GeneProduct	ENSG00000100485 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20662
SPP1	GeneProduct	ENSG00000118785 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20750
STK11	GeneProduct	ENSG00000118046 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SYK	GeneProduct	ENSG00000165025 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
TCL1A	GeneProduct	ENSG00000100721 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21432
TCL1B	GeneProduct	ENSG00000213231 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:27379
TEK	GeneProduct	ENSG00000120156 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
TGFA	GeneProduct	ENSG00000163235 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
THBS1	GeneProduct	ENSG00000137801 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21825
THBS2	GeneProduct	ENSG00000186340 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21826
THBS3	GeneProduct	ENSG00000169231 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21827
THBS4	GeneProduct	ENSG00000113296 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21828
THEM4	GeneProduct	ENSG00000159445 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74343
TLR2	GeneProduct	ENSG00000137462 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
TLR4	GeneProduct	ENSG00000136869 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
TNC	GeneProduct	ENSG00000041982 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21923
TNN	GeneProduct	ENSG00000120332 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329278
TNR	GeneProduct	ENSG00000116147 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21960
TNXB	GeneProduct	ENSG00000168477 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:81877
TP53	GeneProduct	ENSG00000141510 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
TSC1	GeneProduct	ENSG00000165699 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64930
TSC2	GeneProduct	ENSG00000103197 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22084
Toll-like Receptor Signaling Pathway	Pathway	WP75 (WikiPathways)
VEGF Signaling Pathway	Pathway	WP3888 (WikiPathways)
VEGFA	GeneProduct	ENSG00000112715 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22339
VEGFB	GeneProduct	ENSG00000173511 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22340
VEGFC	GeneProduct	ENSG00000150630 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22341
VEGFD	GeneProduct	ENSG00000165197 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14205
VTN	GeneProduct	ENSG00000109072 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22370
VWF	GeneProduct	ENSG00000110799 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22371
mTOR Signaling Pathway	Pathway

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No annotated interactions

PI3K-Akt signaling (Homo sapiens)

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