G1 to S cell cycle control (Rattus norvegicus)

From WikiPathways

Revision as of 20:31, 17 October 2013 by MaintBot (Talk | contribs)
Jump to: navigation, search
1bCyclin EspG2 Phase-M phaseCyclin DsG1/S Cell CycleuupE2fcakeDNA replicationG1 CyclinDependant CyclasesCyclinDTTTCC/GCGCpDegradationG1/S transition CyclinDependent Kinasesphosphorylation of proteinsinvolved in G1/S transitionuorigin recognition complexpbG1 PhaseRbDNA polymerasesedp1pCheckpointinactivepCell cycle DNA replication genesG1/S transition PhaseAtf6bCdkn1cPrim2Tp53E2f6Myt1Ccna1Rpa1E2f3Creb3l3Rb1CDKN2DCdkn2bCdk6Cdk4Mcm4Wee1PolePrim1Tfdp1LOC100362927Mcm3Ccne1Cdk2Orc6Ccnb1Ccne2Cdk1Mcm5Cdc45Gadd45aTfdp1Orc3Tfdp2CDKCcnd2Cdk7CDKN2AE2f1Rbl1Rb1Ccne1Pola2Mnat1Cdc25aE2f2Mcm7Cdk6CcnhE2f5PcnaCdkn1aMycCcng2Ccnd1Creb3l4Tp53Cdk7Rb1Creb3Cdkn1bMcm6Creb3l1CDKOrc5Cdk2E2fMcm2Orc4Ccnd3E2f4Orc2Ccne1Mdm2Rpa2Pole2Cdkn2cAtmOrc1Cdk4Creb1E2fCdKCyclinDCdK


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP45 (r95145) with a 92.0% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95749view13:54, 19 January 2018MkutmonHomology conversion update
71777view20:31, 17 October 2013MaintBotAutomated update of data sources
69353view18:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
67267view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
47766view05:20, 6 April 2012Khanspersupdated xrefs
41665view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
35823view21:56, 17 February 2010KhanspersAdded lit ref
35822view21:55, 17 February 2010KhanspersModified description
34060view19:05, 9 December 2009MaintBotAutomatic update of empty xrefs
32403view17:03, 15 August 2009MaintBotFixed text labels
32058view13:33, 14 August 2009MaintBotFixed group labels
31434view21:03, 13 August 2009MaintBotFixed text labels
31019view01:07, 30 July 2009MaintBotConverted from Homo sapiens
21409view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:G1 to S cell cycle Reactome]] moved to [[Pathway:WP348]]: Moved to stable identifier
8070view13:46, 7 January 2008MaintBot[[Pathway:Rat:G1 to S cell cycle Reactome]] moved to [[Pathway:Rattus norvegicus:G1 to S cell cycle Reactome]]: Renaming species
7657view16:07, 18 December 2007MaintBotfixed category names
7228view12:41, 4 November 2007MaintBotAdded categories to GPML
6544view22:20, 22 May 2007A.C.Zambongpml file for [[Rat:G1_to_S_cell_cycle_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Atf6bGeneProductENSRNOG00000000431 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1388
AtmGeneProductENSRNOG00000029773 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:472
CDKGeneProduct
CDKN2AGeneProductNo homologues found for original id L:1029
CDKN2DGeneProductNo homologues found for original id L:1032
Ccna1GeneProductENSRNOG00000014052 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8900
Ccnb1GeneProductENSRNOG00000058539 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:891
Ccnd1GeneProductENSRNOG00000020918 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:595
Ccnd2GeneProductENSRNOG00000057710 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:894
Ccnd3GeneProductENSRNOG00000050258 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:896
Ccne1GeneProductENSRNOG00000014786 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:898
Ccne2GeneProductENSRNOG00000008055 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9134
Ccng2GeneProductENSRNOG00000002089 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:901
CcnhGeneProductENSRNOG00000031656 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:902
Cdc25aGeneProductENSRNOG00000020737 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:993
Cdc45GeneProductENSRNOG00000050071 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8318
Cdk1GeneProductENSRNOG00000000632 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:983
Cdk2GeneProductENSRNOG00000006469 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1017
Cdk4GeneProductENSRNOG00000025602 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1019
Cdk6GeneProductENSRNOG00000009258 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1021
Cdk7GeneProductENSRNOG00000018510 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1022
Cdkn1aGeneProductENSRNOG00000000521 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1026
Cdkn1bGeneProductENSRNOG00000007249 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1027
Cdkn1cGeneProductENSRNOG00000059500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1028
Cdkn2bGeneProductENSRNOG00000006735 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1030
Cdkn2cGeneProductENSRNOG00000008956 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1031
Creb1GeneProductENSRNOG00000013412 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1385
Creb3GeneProductENSRNOG00000016452 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10488
Creb3l1GeneProductENSRNOG00000005413 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:90993
Creb3l3GeneProductENSRNOG00000032202 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84699
Creb3l4GeneProductENSRNOG00000023493 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:148327
E2fGeneProduct
E2f1GeneProductENSRNOG00000016708 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1869
E2f2GeneProductENSRNOG00000047741 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1870
E2f3GeneProductENSRNOG00000029273 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1871
E2f4GeneProductENSRNOG00000015708 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1874
E2f5GeneProductENSRNOG00000010760 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1875
E2f6GeneProductENSRNOG00000004449 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1876
Gadd45aGeneProductENSRNOG00000005615 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1647
LOC100362927GeneProductENSRNOG00000037481 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6119
Mcm2GeneProductENSRNOG00000016316 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4171
Mcm3GeneProductENSRNOG00000012543 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4172
Mcm4GeneProductENSRNOG00000001833 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4173
Mcm5GeneProductENSRNOG00000014336 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4174
Mcm6GeneProductENSRNOG00000003703 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4175
Mcm7GeneProductENSRNOG00000001349 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4176
Mdm2GeneProductENSRNOG00000006304 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4193
Mnat1GeneProductENSRNOG00000007267 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4331
MycGeneProductENSRNOG00000004500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609
Myt1GeneProductENSRNOG00000017346 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4661
Orc1GeneProductENSRNOG00000008841 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4998
Orc2GeneProductENSRNOG00000012558 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4999
Orc3GeneProductENSRNOG00000008314 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23595
Orc4GeneProductENSRNOG00000005021 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5000
Orc5GeneProductENSRNOG00000011519 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5001
Orc6GeneProductENSRNOG00000024043 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23594
PcnaGeneProductENSRNOG00000021264 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5111
Pola2GeneProductENSRNOG00000020906 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23649
Pole2GeneProductENSRNOG00000004242 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5427
PoleGeneProductENSRNOG00000037449 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5426
Prim1GeneProductENSRNOG00000031993 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5557
Prim2GeneProductENSRNOG00000012486 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5558
Rb1GeneProductENSRNOG00000016029 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5925
Rbl1GeneProductENSRNOG00000006921 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5933
Rpa1GeneProductENSRNOG00000003123 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6117
Rpa2GeneProductENSRNOG00000013005 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6118
Tfdp1GeneProductENSRNOG00000019222 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7027
Tfdp2GeneProductENSRNOG00000011241 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7029
Tp53GeneProductENSRNOG00000010756 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157
Wee1GeneProductENSRNOG00000010017 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7465

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP348"
Personal tools