Phosphodiesterases in neuronal function (Homo sapiens)

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2341nucleusfrontal cortexsynaptic gapnucleus accumbens/caudate-putamenglutamergic neuron Legendrelease of neurotransmitters into synaptic gapbindingstimulationinhibitionNOS1CalciumGUCY1A3RolipramGUCY1B2PDE1BDARPP-32DopamineD2DRD1AMPNitric oxideCREBCaffeineGUCY1B3Cyclic GMPPDE10AAC GRIN2DPDE?ADORA2APKAL-GlutamatePKGPDE4DGRIN2BCaMKPDE3BCilostazolPDE3AGRIN1GRIN2CSildenafilPDE5AGMPGRIN2AGUCY1A2AMPACyclic AMPPDEL-GlutamateL-GlutamateCyclic AMPDopamineneuron dopamergic neuron from substantianigra pars compacta (SNc)and/or ventral tegmental areaDopaminePDE10APDE4DPDE1BPDE4DL-GlutamateDopaminePKAD2GRIN1GRIN2DGRIN2CGRIN2AGRIN2BAMPAspiny neuronD1 direct pathwayspiny neuron D2 indirect pathwaystriatal interneuronGMPCyclic GMPGUCY1A3GUCY1A2GUCY1B2GUCY1B3GMPCyclic GMPPDE1BnucleusCREBPKGAMPAGRIN1GRIN2DGRIN2CGRIN2AGRIN2BDRD1nucleusCREBPKGGUCY1A2GUCY1B3GUCY1A3GUCY1B2


Description

Phosphodiesterases are enzymes which break phosphodiester bonds and play an importan role in signaling pathways, especially in second messenger pathways which involve cyclic AMP or GMP.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, Jones BA, Howard ML, McAllister-Lucas LM, Sonnenburg WK, Francis SH, Corbin JD, Beavo JA, Ferguson K; ''Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.''; Gene, 1998 PubMed Europe PMC Scholia
  2. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, Kimura Y, Ikeda Y, Shiku H, Nishikawa M.; ''Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo.''; Life Sci. , 1997 PubMed Europe PMC Scholia
  3. Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG; ''Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.''; Cell, 2015 PubMed Europe PMC Scholia
  4. Heckman PR, van Duinen MA, Bollen EP, Nishi A, Wennogle LP, Blokland A, Prickaerts J; ''''; , PubMed Europe PMC Scholia
  5. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, Deschepper CF, Petrof BJ, Des Rosiers C.; ''Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency.''; Proc Natl Acad Sci U S A., 2008 PubMed Europe PMC Scholia
  6. Kitabchi AE, Wilson DB, Sharma RK.; ''Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE).''; vBiochem Biophys Res Commun. , 1971 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
132625view17:31, 7 June 2024Khanspersupdated incorrect mim-modification to mim-binding
124530view14:17, 5 November 2022EgonwMade a pathway clickable
124484view13:48, 31 October 2022Cenna Doornbos
124483view13:46, 31 October 2022Cenna DoornbosUppdated non-annotated nodes
124482view13:06, 31 October 2022Cenna DoornbosUpdated sildenafil pathway and protein names.
107160view14:24, 17 September 2019MaintBotChEBI identifier normalization
106137view12:03, 16 August 2019MaintBotHMDB identifier normalization
105135view12:00, 10 July 2019EgonwFixed the identifier for L-glutamate (a more accurate record)
96808view11:35, 9 April 2018Fehrhartfixed data node annotation
96231view13:22, 1 March 2018FehrhartOntology Term : 'attention deficit hyperactivity disorder' added !
96230view13:22, 1 March 2018FehrhartOntology Term : 'obsessive-compulsive disorder' added !
96229view13:22, 1 March 2018FehrhartOntology Term : 'Gilles de la Tourette syndrome' added !
96228view13:22, 1 March 2018FehrhartOntology Term : 'Huntington's disease' added !
96227view13:21, 1 March 2018FehrhartOntology Term : 'Parkinson's disease' added !
96226view13:21, 1 March 2018FehrhartOntology Term : 'schizophrenia' added !
96225view13:20, 1 March 2018FehrhartOntology Term : 'Alzheimer's disease' added !
96224view13:19, 1 March 2018FehrhartOntology Term : 'glutamate signaling pathway' added !
96223view13:19, 1 March 2018FehrhartOntology Term : 'dopamine signaling pathway' added !
96222view13:18, 1 March 2018FehrhartOntology Term : 'neuron-to-neuron signaling pathways' added !
96221view13:18, 1 March 2018FehrhartOntology Term : 'neuron' added !
96220view13:17, 1 March 2018Fehrhartwork in progress
96219view11:02, 1 March 2018Fehrhartwork in progress
96218view10:15, 1 March 2018FehrhartModified title
96216view15:31, 28 February 2018Fehrhartwork in progress
96215view15:00, 28 February 2018Fehrhartwork in progress
96214view14:21, 28 February 2018FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AC GeneProduct
ADORA2AGeneProductENSG00000128271
AMPAGeneProductENSG00000155511
AMPMetaboliteHMDB03540 (HMDB)
CREBGeneProductENSG00000118260
CaMK GeneProduct
CaffeineMetaboliteHMDB01847 (HMDB)
CalciumMetaboliteHMDB00464 (HMDB)
CilostazolMetaboliteHMDB15297 (HMDB)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
D2GeneProductENSG00000149295
DARPP-32GeneProductENSG00000131771
DRD1GeneProductENSG00000184845
DopamineMetaboliteHMDB00073 (HMDB)
GMPMetaboliteHMDB0001397 (HMDB)
GRIN1GeneProductENSG00000176884
GRIN2AGeneProductENSG00000183454
GRIN2BGeneProductENSG00000273079
GRIN2CGeneProductENSG00000161509
GRIN2DGeneProductENSG00000105464
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
L-GlutamateMetaboliteHMDB60475 (HMDB)
NOS1GeneProductENSG00000089250 (Ensembl)
Nitric oxideMetaboliteHMDB03378 (HMDB)
PDEGeneProduct
PDE10AGeneProductENSG00000112541
PDE1BGeneProductENSG00000123360
PDE3AGeneProductENSG00000172572 (Ensembl)
PDE3BGeneProductENSG00000152270 (Ensembl)
PDE4DGeneProductENSG00000113448
PDE5AGeneProductENSG00000138735 (Ensembl)
PDE?GeneProduct
PKAGeneProduct
PKGGeneProduct
RolipramMetabolite104872 (ChEBI)
SildenafilMetaboliteHMDB05039 (HMDB)

Annotated Interactions

No annotated interactions

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