PI3K-Akt signaling (Homo sapiens)
From WikiPathways
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle. (Description from [KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04151]
Quality Tags
Ontology Terms
Bibliography
View all... |
- Blume-Jensen P, Hunter T; ''Oncogenic kinase signalling.''; Nature, 2001 PubMed Europe PMC Scholia
- Song G, Ouyang G, Bao S; ''The activation of Akt/PKB signaling pathway and cell survival.''; J Cell Mol Med, 2005 PubMed Europe PMC Scholia
- Okkenhaug K, Vanhaesebroeck B; ''PI3K in lymphocyte development, differentiation and activation.''; Nat Rev Immunol, 2003 PubMed Europe PMC Scholia
- Noguchi M, Ropars V, Roumestand C, Suizu F; ''Proto-oncogene TCL1: more than just a coactivator for Akt.''; FASEB J, 2007 PubMed Europe PMC Scholia
- Duronio V; ''The life of a cell: apoptosis regulation by the PI3K/PKB pathway.''; Biochem J, 2008 PubMed Europe PMC Scholia
- Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
- Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR; ''Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.''; Biochem J, 1998 PubMed Europe PMC Scholia
- Hers I, Vincent EE, Tavaré JM; ''Akt signalling in health and disease.''; Cell Signal, 2011 PubMed Europe PMC Scholia
- Engelman JA, Luo J, Cantley LC; ''The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.''; Nat Rev Genet, 2006 PubMed Europe PMC Scholia
- Richardson CJ, Schalm SS, Blenis J; ''PI3-kinase and TOR: PIKTORing cell growth.''; Semin Cell Dev Biol, 2004 PubMed Europe PMC Scholia
- West KA, Castillo SS, Dennis PA; ''Activation of the PI3K/Akt pathway and chemotherapeutic resistance.''; Drug Resist Updat, 2002 PubMed Europe PMC Scholia
- Koyasu S; ''The role of PI3K in immune cells.''; Nat Immunol, 2003 PubMed Europe PMC Scholia
- Skaper SD; ''The neurotrophin family of neurotrophic factors: an overview.''; Methods Mol Biol, 2012 PubMed Europe PMC Scholia
- Georgescu MM; ''PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.''; Genes Cancer, 2010 PubMed Europe PMC Scholia
- Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M; ''Regulation of Raf-Akt Cross-talk.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
- Lemmon MA, Schlessinger J; ''Cell signaling by receptor tyrosine kinases.''; Cell, 2010 PubMed Europe PMC Scholia
- Zhang X, Tang N, Hadden TJ, Rishi AK; ''Akt, FoxO and regulation of apoptosis.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
- Wymann MP, Pirola L; ''Structure and function of phosphoinositide 3-kinases.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
- Kikani CK, Dong LQ, Liu F; ''"New"-clear functions of PDK1: beyond a master kinase in the cytosol?''; J Cell Biochem, 2005 PubMed Europe PMC Scholia
- Kim D, Chung J; ''Akt: versatile mediator of cell survival and beyond.''; J Biochem Mol Biol, 2002 PubMed Europe PMC Scholia
- Osaki M, Oshimura M, Ito H; ''PI3K-Akt pathway: its functions and alterations in human cancer.''; Apoptosis, 2004 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | ENSG00000142208 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651 |
AKT2 | GeneProduct | ENSG00000105221 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652 |
AKT3 | GeneProduct | ENSG00000117020 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797 |
AMP | Metabolite | CHEBI:16027 (ChEBI) ![]() | |
ANGPT1 | GeneProduct | ENSG00000154188 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11600 |
ANGPT2 | GeneProduct | ENSG00000091879 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11601 |
ANGPT4 | GeneProduct | ENSG00000101280 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11602 |
ATF2 | GeneProduct | ENSG00000115966 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11909 |
ATF4 | GeneProduct | ENSG00000128272 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11911 |
ATF6B | GeneProduct | ENSG00000213676 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12915 |
Angiogenesis | Pathway | WP1539 (WikiPathways) ![]() | |
Apoptosis | Pathway | WP254 (WikiPathways) ![]() | |
B Cell Receptor Signaling Pathway | Pathway | WP23 (WikiPathways) ![]() | |
BAD | GeneProduct | ENSG00000002330 (Ensembl) ![]() |
|
BCL2 | GeneProduct | ENSG00000171791 (Ensembl) ![]() |
|
BCL2L11 | GeneProduct | ENSG00000153094 (Ensembl) ![]() |
|
BCL2L1 | GeneProduct | ENSG00000171552 (Ensembl) ![]() |
|
BCR | GeneProduct | 102723407 (Entrez Gene) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986 |
BDNF | GeneProduct | ENSG00000176697 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785 |
BRCA1 | GeneProduct | ENSG00000012048 (Ensembl) ![]() |
|
C8orf44-SGK3 | GeneProduct | ENSG00000270024 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
CASP9 | GeneProduct | ENSG00000132906 (Ensembl) ![]() |
|
CCND1 | GeneProduct | ENSG00000110092 (Ensembl) ![]() |
|
CCND2 | GeneProduct | ENSG00000118971 (Ensembl) ![]() |
|
CCND3 | GeneProduct | ENSG00000112576 (Ensembl) ![]() |
|
CCNE1 | GeneProduct | ENSG00000105173 (Ensembl) ![]() |
|
CCNE2 | GeneProduct | ENSG00000175305 (Ensembl) ![]() |
|
CD19 | GeneProduct | ENSG00000177455 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986 |
CDC37 | GeneProduct | ENSG00000105401 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12539 |
CDK2 | GeneProduct | ENSG00000123374 (Ensembl) ![]() |
|
CDK4 | GeneProduct | ENSG00000135446 (Ensembl) ![]() |
|
CDK6 | GeneProduct | ENSG00000105810 (Ensembl) ![]() |
|
CDKN1A | GeneProduct | ENSG00000124762 (Ensembl) ![]() |
|
CDKN1B | GeneProduct | ENSG00000111276 (Ensembl) ![]() |
|
CHAD | GeneProduct | ENSG00000136457 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12643 |
CHRM1 | GeneProduct | ENSG00000168539 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12669 |
CHRM2 | GeneProduct | ENSG00000181072 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:243764 |
CHUK | GeneProduct | ENSG00000213341 (Ensembl) ![]() |
|
COL1A1 | GeneProduct | ENSG00000108821 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12842 |
COL1A2 | GeneProduct | ENSG00000164692 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12843 |
COL2A1 | GeneProduct | ENSG00000139219 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12824 |
COL4A1 | GeneProduct | ENSG00000187498 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12826 |
COL4A2 | GeneProduct | ENSG00000134871 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12827 |
COL4A3 | GeneProduct | ENSG00000169031 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12814 |
COL4A4 | GeneProduct | ENSG00000081052 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12829 |
COL4A5 | GeneProduct | ENSG00000188153 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12815 |
COL4A6 | GeneProduct | ENSG00000197565 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94216 |
COL6A1 | GeneProduct | ENSG00000142156 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12825 |
COL6A2 | GeneProduct | ENSG00000142173 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12834 |
COL6A3 | GeneProduct | ENSG00000163359 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12831 |
COL6A5 | GeneProduct | ENSG00000172752 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867 |
COL6A6 | GeneProduct | ENSG00000206384 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12832 |
COL9A1 | GeneProduct | ENSG00000112280 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867 |
COL9A2 | GeneProduct | ENSG00000049089 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867 |
COL9A3 | GeneProduct | ENSG00000092758 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867 |
COMP | GeneProduct | ENSG00000105664 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12845 |
CREB1 | GeneProduct | ENSG00000118260 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912 |
CREB3 | GeneProduct | ENSG00000107175 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12913 |
CREB3L1 | GeneProduct | ENSG00000157613 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26427 |
CREB3L2 | GeneProduct | ENSG00000182158 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208647 |
CREB3L3 | GeneProduct | ENSG00000060566 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208677 |
CREB3L4 | GeneProduct | ENSG00000143578 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78284 |
CREB5 | GeneProduct | ENSG00000146592 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:231991 |
CSF1 | GeneProduct | ENSG00000184371 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12977 |
CSF1R | GeneProduct | ENSG00000182578 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978 |
CSF3 | GeneProduct | ENSG00000108342 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12985 |
CSF3R | GeneProduct | ENSG00000119535 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986 |
CSH1 | GeneProduct | ENSG00000136488 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599 |
CSH2 | GeneProduct | ENSG00000213218 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599 |
Cell Cycle | Pathway | WP179 (WikiPathways) ![]() | |
Cell proliferation | Pathway | ||
Chemokine Signaling Pathway | Pathway | WP3929 (WikiPathways) ![]() | |
DDIT4 | GeneProduct | ENSG00000168209 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
DNA Repair | Pathway | WP707 (WikiPathways) ![]() | |
EFNA1 | GeneProduct | ENSG00000169242 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13636 |
EFNA2 | GeneProduct | ENSG00000099617 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13637 |
EFNA3 | GeneProduct | ENSG00000143590 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13638 |
EFNA4 | GeneProduct | ENSG00000243364 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13639 |
EFNA5 | GeneProduct | ENSG00000184349 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640 |
EGF | GeneProduct | ENSG00000138798 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13645 |
EGFR | GeneProduct | ENSG00000146648 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649 |
EIF4B | GeneProduct | ENSG00000063046 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75705 |
EIF4E1B | GeneProduct | ENSG00000175766 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218268 |
EIF4E2 | GeneProduct | ENSG00000135930 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26987 |
EIF4EBP1 | GeneProduct | ENSG00000187840 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13685 |
EIF4E | GeneProduct | ENSG00000151247 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13684 |
EPHA2 | GeneProduct | ENSG00000142627 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836 |
EPO | GeneProduct | ENSG00000130427 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13856 |
EPOR | GeneProduct | ENSG00000187266 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13857 |
ErbB Signaling Pathway | Pathway | WP673 (WikiPathways) ![]() | |
F2R | GeneProduct | ENSG00000181104 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14062 |
FASLG | GeneProduct | ENSG00000117560 (Ensembl) ![]() |
|
FGF10 | GeneProduct | ENSG00000070193 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14165 |
FGF11 | GeneProduct | ENSG00000161958 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14166 |
FGF12 | GeneProduct | ENSG00000114279 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14167 |
FGF13 | GeneProduct | ENSG00000129682 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80903 |
FGF14 | GeneProduct | ENSG00000102466 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14169 |
FGF17 | GeneProduct | ENSG00000158815 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14171 |
FGF18 | GeneProduct | ENSG00000156427 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172 |
FGF19 | GeneProduct | ENSG00000162344 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172 |
FGF1 | GeneProduct | ENSG00000113578 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14164 |
FGF20 | GeneProduct | ENSG00000078579 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80857 |
FGF21 | GeneProduct | ENSG00000105550 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56636 |
FGF22 | GeneProduct | ENSG00000070388 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67112 |
FGF23 | GeneProduct | ENSG00000118972 (Ensembl) ![]() | |
FGF2 | GeneProduct | ENSG00000138685 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14173 |
FGF3 | GeneProduct | ENSG00000186895 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14174 |
FGF4 | GeneProduct | ENSG00000075388 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14175 |
FGF5 | GeneProduct | ENSG00000138675 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14168 |
FGF6 | GeneProduct | ENSG00000111241 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14177 |
FGF7 | GeneProduct | ENSG00000140285 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14178 |
FGF8 | GeneProduct | ENSG00000107831 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14179 |
FGF9 | GeneProduct | ENSG00000102678 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14180 |
FGFR1 | GeneProduct | ENSG00000077782 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182 |
FGFR2 | GeneProduct | ENSG00000066468 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183 |
FGFR3 | GeneProduct | ENSG00000068078 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184 |
FGFR4 | GeneProduct | ENSG00000160867 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186 |
FLT1 | GeneProduct | ENSG00000102755 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254 |
FLT3 | GeneProduct | ENSG00000122025 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257 |
FLT3LG | GeneProduct | ENSG00000090554 (Ensembl) ![]() | |
FLT4 | GeneProduct | ENSG00000037280 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257 |
FN1 | GeneProduct | ENSG00000115414 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14268 |
FOXO3 | GeneProduct | ENSG00000118689 (Ensembl) ![]() |
|
Focal Adhesion | Pathway | WP306 (WikiPathways) ![]() | |
FoxO Signaling Pathway | Pathway | ||
G6PC2 | GeneProduct | ENSG00000152254 (Ensembl) ![]() |
|
G6PC3 | GeneProduct | ENSG00000141349 (Ensembl) ![]() |
|
G6PC | GeneProduct | ENSG00000131482 (Ensembl) ![]() |
|
GH1 | GeneProduct | ENSG00000259384 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599 |
GH2 | GeneProduct | ENSG00000136487 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599 |
GHR | GeneProduct | ENSG00000112964 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14600 |
GNB1 | GeneProduct | ENSG00000078369 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14688 |
GNB2 | GeneProduct | ENSG00000172354 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14693 |
GNB3 | GeneProduct | ENSG00000111664 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14695 |
GNB4 | GeneProduct | ENSG00000114450 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14696 |
GNB5 | GeneProduct | ENSG00000069966 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702 |
GNG10 | GeneProduct | ENSG00000242616 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14700 |
GNG11 | GeneProduct | ENSG00000127920 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66066 |
GNG12 | GeneProduct | ENSG00000172380 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14701 |
GNG13 | GeneProduct | ENSG00000127588 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64337 |
GNG2 | GeneProduct | ENSG00000186469 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702 |
GNG3 | GeneProduct | ENSG00000162188 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14704 |
GNG4 | GeneProduct | ENSG00000168243 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14706 |
GNG5 | GeneProduct | ENSG00000174021 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14707 |
GNG7 | GeneProduct | ENSG00000176533 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14708 |
GNG8 | GeneProduct | ENSG00000167414 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14709 |
GNGT1 | GeneProduct | ENSG00000127928 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14699 |
GNGT2 | GeneProduct | ENSG00000167083 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14710 |
GRB2 | GeneProduct | ENSG00000177885 (Ensembl) ![]() |
|
GSK3B | GeneProduct | ENSG00000082701 (Ensembl) ![]() |
|
GYS1 | GeneProduct | ENSG00000104812 (Ensembl) ![]() |
|
GYS2 | GeneProduct | ENSG00000111713 (Ensembl) ![]() |
|
Glycolysis and Gluconeogenesis | Pathway | WP534 (WikiPathways) ![]() | |
HGF | GeneProduct | ENSG00000019991 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15234 |
HRAS | GeneProduct | ENSG00000174775 (Ensembl) ![]() |
|
HSP90AA1 | GeneProduct | ENSG00000080824 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15519 |
HSP90AB1 | GeneProduct | ENSG00000096384 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15516 |
HSP90B1 | GeneProduct | ENSG00000166598 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22027 |
IBSP | GeneProduct | ENSG00000029559 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15891 |
IFNA10 | GeneProduct | ENSG00000186803 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15972 |
IFNA13 | GeneProduct | ENSG00000233816 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:404549 |
IFNA14 | GeneProduct | ENSG00000228083 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974 |
IFNA16 | GeneProduct | ENSG00000147885 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974 |
IFNA17 | GeneProduct | ENSG00000234829 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974 |
IFNA1 | GeneProduct | ENSG00000197919 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15962 |
IFNA21 | GeneProduct | ENSG00000137080 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974 |
IFNA2 | GeneProduct | ENSG00000188379 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15964 |
IFNA4 | GeneProduct | ENSG00000236637 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15965 |
IFNA5 | GeneProduct | ENSG00000147873 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15967 |
IFNA6 | GeneProduct | ENSG00000120235 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15968 |
IFNA7 | GeneProduct | ENSG00000214042 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15969 |
IFNA8 | GeneProduct | ENSG00000120242 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15970 |
IFNAR1 | GeneProduct | ENSG00000142166 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15975 |
IFNAR2 | GeneProduct | ENSG00000159110 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15976 |
IFNB1 | GeneProduct | ENSG00000171855 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15977 |
IGF1 | GeneProduct | ENSG00000017427 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16000 |
IGF1R | GeneProduct | ENSG00000140443 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001 |
IGF2 | GeneProduct | ENSG00000167244 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333 |
IKBKB | GeneProduct | ENSG00000104365 (Ensembl) ![]() |
|
IKBKG | GeneProduct | ENSG00000269335 (Ensembl) ![]() |
|
IL2 | GeneProduct | ENSG00000109471 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183 |
IL2RA | GeneProduct | ENSG00000134460 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16184 |
IL2RB | GeneProduct | ENSG00000100385 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16185 |
IL2RG | GeneProduct | ENSG00000147168 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16186 |
IL3 | GeneProduct | ENSG00000164399 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183 |
IL3RA | GeneProduct | ENSG00000185291 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16188 |
IL4 | GeneProduct | ENSG00000113520 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183 |
IL4R | GeneProduct | ENSG00000077238 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16190 |
IL6 | GeneProduct | ENSG00000136244 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183 |
IL6R | GeneProduct | ENSG00000160712 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16194 |
IL7 | GeneProduct | ENSG00000104432 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183 |
IL7R | GeneProduct | ENSG00000168685 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16197 |
INS | GeneProduct | ENSG00000254647 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16334 |
INSR | GeneProduct | ENSG00000171105 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337 |
IRS1 | GeneProduct | ENSG00000169047 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367 |
ITGA10 | GeneProduct | ENSG00000143127 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000090210 |
ITGA11 | GeneProduct | ENSG00000137809 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319480 |
ITGA1 | GeneProduct | ENSG00000213949 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105083 |
ITGA2B | GeneProduct | ENSG00000005961 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16399 |
ITGA2 | GeneProduct | ENSG00000164171 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16398 |
ITGA3 | GeneProduct | ENSG00000005884 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16400 |
ITGA4 | GeneProduct | ENSG00000115232 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16401 |
ITGA5 | GeneProduct | ENSG00000161638 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16402 |
ITGA6 | GeneProduct | ENSG00000091409 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16403 |
ITGA7 | GeneProduct | ENSG00000135424 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16404 |
ITGA8 | GeneProduct | ENSG00000077943 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:241226 |
ITGA9 | GeneProduct | ENSG00000144668 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104099 |
ITGAV | GeneProduct | ENSG00000138448 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96608 |
ITGB1 | GeneProduct | ENSG00000150093 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16412 |
ITGB3 | GeneProduct | ENSG00000259207 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16416 |
ITGB4 | GeneProduct | ENSG00000132470 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192897 |
ITGB5 | GeneProduct | ENSG00000082781 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16419 |
ITGB6 | GeneProduct | ENSG00000115221 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16420 |
ITGB7 | GeneProduct | ENSG00000139626 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16421 |
ITGB8 | GeneProduct | ENSG00000105855 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320910 |
Insulin Signaling Pathway | Pathway | WP481 (WikiPathways) ![]() | |
JAK/STAT Signaling Pathway | Pathway | WP2593 (WikiPathways) ![]() | |
JAK1 | GeneProduct | ENSG00000162434 (Ensembl) ![]() |
|
JAK2 | GeneProduct | ENSG00000096968 (Ensembl) ![]() |
|
JAK3 | GeneProduct | ENSG00000105639 (Ensembl) ![]() |
|
KDR | GeneProduct | ENSG00000128052 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542 |
KIT | GeneProduct | ENSG00000157404 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590 |
KITLG | GeneProduct | ENSG00000049130 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17311 |
KRAS | GeneProduct | ENSG00000133703 (Ensembl) ![]() |
|
Kik1b4 | GeneProduct | ||
LAMA1 | GeneProduct | ENSG00000101680 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16772 |
LAMA2 | GeneProduct | ENSG00000196569 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16773 |
LAMA3 | GeneProduct | ENSG00000053747 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024421 |
LAMA4 | GeneProduct | ENSG00000112769 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16775 |
LAMA5 | GeneProduct | ENSG00000130702 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16776 |
LAMB1 | GeneProduct | ENSG00000091136 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16777 |
LAMB2 | GeneProduct | ENSG00000172037 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16779 |
LAMB3 | GeneProduct | ENSG00000196878 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16780 |
LAMB4 | GeneProduct | ENSG00000091128 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867 |
LAMC1 | GeneProduct | ENSG00000135862 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:226519 |
LAMC2 | GeneProduct | ENSG00000058085 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16782 |
LAMC3 | GeneProduct | ENSG00000050555 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23928 |
LPAR1 | GeneProduct | ENSG00000198121 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14745 |
LPAR2 | GeneProduct | ENSG00000064547 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53978 |
LPAR3 | GeneProduct | ENSG00000171517 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:65086 |
LPAR4 | GeneProduct | ENSG00000147145 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78134 |
LPAR5 | GeneProduct | ENSG00000184574 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:381810 |
LPAR6 | GeneProduct | ENSG00000139679 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67168 |
MAP2K1 | GeneProduct | ENSG00000169032 (Ensembl) ![]() |
|
MAP2K2 | GeneProduct | ENSG00000126934 (Ensembl) ![]() |
|
MAPK Signaling Pathway | Pathway | WP382 (WikiPathways) ![]() | |
MAPK1 | GeneProduct | ENSG00000100030 (Ensembl) ![]() |
|
MAPK3 | GeneProduct | ENSG00000102882 (Ensembl) ![]() |
|
MCL1 | GeneProduct | ENSG00000143384 (Ensembl) ![]() |
|
MDM2 | GeneProduct | ENSG00000135679 (Ensembl) ![]() |
|
MET | GeneProduct | ENSG00000105976 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295 |
MLST8 | GeneProduct | ENSG00000167965 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56716 |
MTOR | GeneProduct | ENSG00000198793 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56717 |
MYB | GeneProduct | ENSG00000118513 (Ensembl) ![]() |
|
MYC | GeneProduct | ENSG00000136997 (Ensembl) ![]() |
|
Mtcp1 | GeneProduct | Multiple homologues found: En:ENSG00000214827;En:ENSG00000182712; | |
NFKB1 | GeneProduct | ENSG00000109320 (Ensembl) ![]() |
|
NGF | GeneProduct | ENSG00000134259 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18049 |
NGFR | GeneProduct | ENSG00000064300 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053 |
NOS3 | GeneProduct | ENSG00000164867 (Ensembl) ![]() |
|
NRAS | GeneProduct | ENSG00000213281 (Ensembl) ![]() |
|
NTF3 | GeneProduct | ENSG00000185652 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654 |
NTF4 | GeneProduct | ENSG00000225950 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654 |
NTRK1 | GeneProduct | ENSG00000198400 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 |
NTRK2 | GeneProduct | ENSG00000148053 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 |
Nitric oxide | Metabolite | HMDB03378 (HMDB) ![]() | |
OSM | GeneProduct | ENSG00000099985 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18413 |
OSMR | GeneProduct | ENSG00000145623 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18414 |
PCK1 | GeneProduct | ENSG00000124253 (Ensembl) ![]() |
|
PCK2 | GeneProduct | ENSG00000100889 (Ensembl) ![]() |
|
PDGFA | GeneProduct | ENSG00000197461 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18590 |
PDGFB | GeneProduct | ENSG00000100311 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18591 |
PDGFC | GeneProduct | ENSG00000145431 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54635 |
PDGFD | GeneProduct | ENSG00000170962 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785 |
PDGFRA | GeneProduct | ENSG00000134853 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595 |
PDGFRB | GeneProduct | ENSG00000113721 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596 |
PDPK1 | GeneProduct | ENSG00000140992 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607 |
PGF | GeneProduct | ENSG00000119630 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654 |
PHLPP1 | GeneProduct | ENSG00000081913 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:98432 |
PHLPP2 | GeneProduct | ENSG00000040199 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:244650 |
PIK3AP1 | GeneProduct | ENSG00000155629 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986 |
PIK3CA | GeneProduct | ENSG00000121879 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706 |
PIK3CB | GeneProduct | ENSG00000051382 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769 |
PIK3CD | GeneProduct | ENSG00000171608 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707 |
PIK3CG | GeneProduct | ENSG00000105851 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30955 |
PIK3R1 | GeneProduct | ENSG00000145675 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708 |
PIK3R2 | GeneProduct | ENSG00000105647 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709 |
PIK3R3 | GeneProduct | ENSG00000117461 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669 |
PIK3R5 | GeneProduct | ENSG00000141506 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320207 |
PIK3R6 | GeneProduct | ENSG00000276231 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320207 |
PIP2 | Metabolite | CHEBI:18348 (ChEBI) ![]() | |
PIP3 | Metabolite | HMDB04249 (HMDB) ![]() | |
PKN1 | GeneProduct | ENSG00000123143 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
PKN2 | GeneProduct | ENSG00000065243 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
PKN3 | GeneProduct | ENSG00000160447 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
PPP2CA | GeneProduct | ENSG00000113575 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19052 |
PPP2CB | GeneProduct | ENSG00000104695 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19053 |
PPP2R1A | GeneProduct | ENSG00000105568 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:51792 |
PPP2R1B | GeneProduct | ENSG00000137713 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73699 |
PPP2R2A | GeneProduct | ENSG00000221914 (Ensembl) ![]() | |
PPP2R2B | GeneProduct | ENSG00000156475 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72930 |
PPP2R2C | GeneProduct | ENSG00000074211 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:269643 |
PPP2R2D | GeneProduct | ENSG00000175470 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:52432 |
PPP2R3A | GeneProduct | ENSG00000073711 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235542 |
PPP2R3B | GeneProduct | ENSG00000167393 (Ensembl) ![]() | |
PPP2R3C | GeneProduct | ENSG00000092020 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:59032 |
PPP2R5A | GeneProduct | ENSG00000066027 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:226849 |
PPP2R5B | GeneProduct | ENSG00000068971 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225849 |
PPP2R5C | GeneProduct | ENSG00000078304 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26931 |
PPP2R5D | GeneProduct | ENSG00000112640 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21770 |
PPP2R5E | GeneProduct | ENSG00000154001 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26932 |
PRKAA1 | GeneProduct | ENSG00000132356 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105787 |
PRKAA2 | GeneProduct | ENSG00000162409 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108079 |
PRKCA | GeneProduct | ENSG00000154229 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
PRL | GeneProduct | ENSG00000172179 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19109 |
PRLR | GeneProduct | ENSG00000113494 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19116 |
PTEN | GeneProduct | ENSG00000171862 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19211 |
PTK2 | GeneProduct | ENSG00000169398 (Ensembl) ![]() |
|
RAC1 | GeneProduct | ENSG00000136238 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367 |
RAF1 | GeneProduct | ENSG00000132155 (Ensembl) ![]() |
|
RBL2 | GeneProduct | ENSG00000103479 (Ensembl) ![]() |
|
RELA | GeneProduct | 5970 (Entrez Gene) ![]() |
|
RELN | GeneProduct | ENSG00000189056 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19699 |
RHEB | GeneProduct | ENSG00000106615 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19744 |
RPS6 | GeneProduct | ENSG00000137154 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20104 |
RPS6KB1 | GeneProduct | ENSG00000108443 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72508 |
RPS6KB2 | GeneProduct | ENSG00000175634 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:58988 |
RPTOR | GeneProduct | ENSG00000141564 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74370 |
SGK1 | GeneProduct | ENSG00000118515 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
SGK2 | GeneProduct | ENSG00000101049 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
SGK3 | GeneProduct | ENSG00000104205 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
SOS1 | GeneProduct | ENSG00000115904 (Ensembl) ![]() |
|
SOS2 | GeneProduct | ENSG00000100485 (Ensembl) ![]() |
|
SPP1 | GeneProduct | ENSG00000118785 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20750 |
STK11 | GeneProduct | ENSG00000118046 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747 |
SYK | GeneProduct | ENSG00000165025 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986 |
TCL1A | GeneProduct | ENSG00000100721 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21432 |
TCL1B | GeneProduct | ENSG00000213231 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:27379 |
TEK | GeneProduct | ENSG00000120156 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 |
TGFA | GeneProduct | ENSG00000163235 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640 |
THBS1 | GeneProduct | ENSG00000137801 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21825 |
THBS2 | GeneProduct | ENSG00000186340 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21826 |
THBS3 | GeneProduct | ENSG00000169231 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21827 |
THBS4 | GeneProduct | ENSG00000113296 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21828 |
THEM4 | GeneProduct | ENSG00000159445 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74343 |
TLR2 | GeneProduct | ENSG00000137462 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986 |
TLR4 | GeneProduct | ENSG00000136869 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986 |
TNC | GeneProduct | ENSG00000041982 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21923 |
TNN | GeneProduct | ENSG00000120332 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329278 |
TNR | GeneProduct | ENSG00000116147 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21960 |
TNXB | GeneProduct | ENSG00000168477 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:81877 |
TP53 | GeneProduct | ENSG00000141510 (Ensembl) ![]() |
|
TSC1 | GeneProduct | ENSG00000165699 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64930 |
TSC2 | GeneProduct | ENSG00000103197 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22084 |
Toll-like Receptor Signaling Pathway | Pathway | WP75 (WikiPathways) ![]() | |
VEGF Signaling Pathway | Pathway | WP3888 (WikiPathways) ![]() | |
VEGFA | GeneProduct | ENSG00000112715 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22339 |
VEGFB | GeneProduct | ENSG00000173511 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22340 |
VEGFC | GeneProduct | ENSG00000150630 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22341 |
VEGFD | GeneProduct | ENSG00000165197 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14205 |
VTN | GeneProduct | ENSG00000109072 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22370 |
VWF | GeneProduct | ENSG00000110799 (Ensembl) ![]() | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22371 |
mTOR Signaling Pathway | Pathway |
Annotated Interactions
No annotated interactions