Ethanol metabolism resulting in production of ROS by CYP2E1 (Mus musculus)

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1PromoterPPSIPKCζ siRNAROSARESP600125NucleusStressors converted by CYP2E1siRNA2-Difluoromethoxy-2,2-difluoroaceticacidU0126NAPQIDiallyl sulfideSp1staurosporineacetaldehydeethanolCyp2e1MafkMap2k1trifluoroacetic acidSevofluraneMap2k26-hydroxychlorzoxazoneNfe2l2EnfluraneisofluranefluorideacetaminophenchlorzoxazoneMafgmethoxyfluraneMapk8HalothaneProtein kinase CMaffVitamin CPSp1Cyp2e1Cyp2e1Nfe2l2SubstrateOutcome metabolitefluoridefluoride


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes.

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Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123509view05:00, 29 July 2022EgonwMade a pathway clickable
106892view13:36, 17 September 2019MaintBotHMDB identifier normalization
104891view14:23, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98060view07:55, 13 July 2018Fehrhartlayout
97870view12:02, 12 June 2018Marvin M2Modified description
97839view07:25, 10 June 2018EgonwOntology Term : 'xenobiotic metabolic pathway' added !
97299view08:40, 8 May 2018AdoBioInfoConnected ze unconnected line
97143view12:44, 1 May 2018AdoBioInfoAdded pathway node (WP412)
97093view08:52, 27 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97036view14:48, 26 April 2018AdoBioInfoLine was unconnected, however, it was time for change. Change is good. So now the line is connected. Noice.
97013view12:11, 26 April 2018AdoBioInfoChanged remaining human genes into mouse genes.
97012view09:41, 26 April 2018AdoBioInfoAttached some loose links.
97011view09:40, 26 April 2018AdoBioInfoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-hydroxychlorzoxazoneMetaboliteHMDB60998 (HMDB)
Cyp2e1GeneProductENSMUSG00000025479 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB14373 (HMDB)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
MaffGeneProductENSMUSG00000042622 (Ensembl)
MafgGeneProductENSMUSG00000051510 (Ensembl)
MafkGeneProductENSMUSG00000018143 (Ensembl)
Map2k1GeneProductENSMUSG00000004936 (Ensembl)
Map2k2GeneProductENSMUSG00000035027 (Ensembl)
Mapk8GeneProductENSMUSG00000021936 (Ensembl)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
Nfe2l2GeneProductENSMUSG00000015839 (Ensembl)
Protein kinase CProteinQ1MX41 (Uniprot-TrEMBL)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
Sp1GeneProductENSMUSG00000001280 (Ensembl)
U0126MetaboliteCHEBI:64208 (ChEBI)
Vitamin CMetaboliteCHEBI:13861 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)
acetaminophenMetaboliteCHEBI:46195 (ChEBI)
chlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
ethanolMetaboliteCHEBI:16236 (ChEBI)
fluorideMetaboliteCHEBI:49593 (ChEBI)
isofluraneMetaboliteCHEBI:6015 (ChEBI)
methoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
staurosporineMetaboliteCHEBI:57491 (ChEBI)
trifluoroacetic acidMetaboliteCHEBI:27111 (ChEBI)

Annotated Interactions

No annotated interactions

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