Cell cycle and cell division (Saccharomyces cerevisiae)

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Pheromone(mating signal)DNASTARTMCM (Mini-Chromosome26SProteasomeUbiquitin mediated proteolysisORC (OrigninNutrientsRecognition Complex)pre-RCSSBFARSlowSCBMCondensineUnattached kinetochoresSpindle checkpointlowUBC (E2)highS-phaseproteinsG2SCF (E3)Maintenance) ComplexMCBDNA damage checkpointsMBFDNADNAG1UBA (E1)APC/Cyclosomee2Grr1MAPK signalingpathwayPho80Apc11APCCdc6Clb5Ssn6Mad3Cdh1Dcd1Apc9CondensinCdc53Gin4Cdc4Mad2Cdc28Dam1Swi6Mec3Rad24Cdc5Cdc34Cdc46Rad9Cdc20Far1Chk1Cdc34Dbf20Cdc45Bub3Rad17Cln3Mbp1Rad1Pho4DNA biosynthesisSwe1Sco1Doc1Pds1Uba1Fus3Orc5Cdc26Dbf4Pho85Met30Apc5Mik1Mcm2Sic1Rad24Mcm3Esc5Bub2Cyclic AMPPcl1Rad26Mih1Pds1Mad1Orc4Pho5Hsl1Esp1Skp1Skp1Smc2Pho85Cdc28Cdc53Dbf2Tup1Cdc7Ycg1Rad53Cdc14Orc6Cak1Apc4Mps1Pho81Cdc23Cdc27Clb1Smc4PhosphateLte1Apc1Hus1Brn1Cdc5Cdc16Cdc28Orc3Crt1Rad9Cdc53Scc2Rad25Cln1Cdc15Swi5Cks1Cdc28Apc8Mcm6Clb3Cdc34Swi4MCMTem1Second messanger signaling pathwayLoc7Mob1Skp1Pho2Rad9Mec1Cdc47Hsl7Swi6Sic1Bub1Apc2Cdc28Byr4ORCOrc1Cdc54Orc2PPPPPPPP1PPPPPPPPPPPPPAPC


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/sce/sce04110.html

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kang J, Yu H; ''Kinase signaling in the spindle checkpoint.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  2. Taylor SS; ''Chromosome segregation: dual control ensures fidelity.''; Curr Biol, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117274view10:45, 20 May 2021EweitzModified title
107024view13:48, 17 September 2019MaintBotHMDB identifier normalization
97053view15:16, 26 April 2018AdoBioInfoFixed unconnected lines. For free. *Godsplan by Drake starts playing*
89528view11:04, 16 September 2016Mkutmonontology tag fix
89487view13:39, 15 September 2016Mkutmonremove space from ontology term id
78393view10:25, 7 January 2015MaintBotadded missing graphIds
76251view22:37, 23 June 2014Khanspersconnected lines, added states, general cleanup
71351view18:02, 17 October 2013MaintBotAutomated update of data sources
70079view09:51, 12 July 2013Mkutmonfixed unconnected lines
69871view17:49, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69659view20:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67105view10:07, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
62698view23:08, 1 May 2013MaintBotUpdated UniProt data source
60654view10:02, 25 March 2013StephanieWiddisonOne of the two bub1's should probably be bub3. Added litrefs.
41898view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
35394view09:43, 12 February 2010MartijnVanIerselConnected right half
35386view09:28, 12 February 2010MartijnVanIerselConnected lines (left half)
35385view09:27, 12 February 2010MartijnVanIerselPeriodical save, work in progress
35368view09:15, 12 February 2010MartijnVanIerselModified description
21554view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Cell Cycle KEGG]] moved to [[Pathway:WP414]]: Moved to stable identifier
12668view07:57, 17 May 2008MaintBotautomated metabolite conversion
8537view14:02, 7 January 2008MaintBotAdded to category $category
19400view14:02, 7 January 2008BruceConklinUploaded new pathway
8535view14:02, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProduct
Apc11GeneProductS000002166 (SGD)
Apc1GeneProductS000005116 (SGD)
Apc2GeneProductS000004117 (SGD)
Apc4GeneProductS000002525 (SGD)
Apc5GeneProductS000005775 (SGD)
Apc8GeneProduct
Apc9GeneProductS000004092 (SGD)
Brn1GeneProductS000000193 (SGD)
Bub1GeneProductS000003420 (SGD)
Bub2GeneProductS000004659 (SGD)
Bub3GeneProductS000005552 (SGD)
Byr4GeneProductS000003814 (SGD)
Cak1GeneProductS000001865 (SGD)
Cdc14GeneProductS000001924 (SGD)
Cdc15GeneProductS000000072 (SGD)
Cdc16GeneProductS000001505 (SGD)
Cdc20GeneProductS000003084 (SGD)
Cdc23GeneProductS000001209 (SGD)
Cdc26GeneProductS000001932 (SGD)
Cdc27GeneProductS000000180 (SGD)
Cdc28GeneProductS000000364 (SGD)
Cdc34GeneProductS000002461 (SGD)
Cdc45GeneProductS000004093 (SGD)
Cdc46GeneProductS000004264 (SGD)
Cdc47GeneProductS000000406 (SGD)
Cdc4GeneProductS000001885 (SGD)
Cdc53GeneProductS000002290 (SGD)
Cdc54GeneProductS000006223 (SGD)
Cdc5GeneProductS000004603 (SGD)
Cdc6GeneProductS000003730 (SGD)
Cdc7GeneProductS000002175 (SGD)
Cdh1GeneProductS000002971 (SGD)
Chk1GeneProductS000000478 (SGD)
Cks1GeneProductS000000339 (SGD)
Clb1GeneProductS000003340 (SGD)
Clb3GeneProductS000002314 (SGD)
Clb5GeneProductS000006324 (SGD)
Cln1GeneProductS000004812 (SGD)
Cln3GeneProductS000000038 (SGD)
CondensinGeneProduct
Crt1GeneProductS000003746 (SGD)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
DNA biosynthesisPathway
Dam1GeneProductS000003345 (SGD)
Dbf20GeneProductS000006315 (SGD)
Dbf2GeneProductS000003324 (SGD)
Dbf4GeneProductS000002459 (SGD)
Dcd1GeneProductS000006115 (SGD)
Doc1GeneProductS000003209 (SGD)
Esc5GeneProductS000003612 (SGD)
Esp1GeneProductS000003330 (SGD)
Far1GeneProductS000003693 (SGD)
Fus3GeneProductS000000112 (SGD)
Gin4GeneProductS000002915 (SGD)
Grr1GeneProductS000003850 (SGD)
Hsl1GeneProductS000001584 (SGD)
Hsl7GeneProductS000000337 (SGD)
Hus1GeneProductS000005424 (SGD)
Loc7GeneProductS000004262 (SGD)
Lte1GeneProductS000000022 (SGD)
MAPK signaling pathwayPathwayWP510 (WikiPathways)
MCMGeneProduct
Mad1GeneProductS000003054 (SGD)
Mad2GeneProductS000003567 (SGD)
Mad3GeneProductS000003550 (SGD)
Mbp1GeneProductS000002214 (SGD)
Mcm2GeneProductS000000119 (SGD)
Mcm3GeneProductS000000758 (SGD)
Mcm6GeneProductS000003169 (SGD)
Mec1GeneProductS000000340 (SGD)
Mec3GeneProductS000004279 (SGD)
Met30GeneProductS000001308 (SGD)
Mih1GeneProductS000004639 (SGD)
Mik1GeneProduct
Mob1GeneProductS000001368 (SGD)
Mps1GeneProductS000002186 (SGD)
ORCGeneProduct
Orc1GeneProductS000004530 (SGD)
Orc2GeneProductS000000264 (SGD)
Orc3GeneProductS000003927 (SGD)
Orc4GeneProductS000006366 (SGD)
Orc5GeneProductS000005205 (SGD)
Orc6GeneProductS000001160 (SGD)
Pcl1GeneProductS000005233 (SGD)
Pds1GeneProductS000002520 (SGD)
Pho2GeneProductS000002264 (SGD)
Pho4GeneProductS000001930 (SGD)
Pho5GeneProductS000000297 (SGD)
Pho80GeneProductS000005361 (SGD)
Pho81GeneProductS000003465 (SGD)
Pho85GeneProductS000005952 (SGD)
PhosphateMetabolite14265-44-2 (CAS)
Rad17GeneProductS000005895 (SGD)
Rad1GeneProductS000005943 (SGD)
Rad24GeneProductS000000975 (SGD)
Rad25GeneProductS000001405 (SGD)
Rad26GeneProductS000003796 (SGD)
Rad53GeneProductS000006074 (SGD)
Rad9GeneProductS000002625 (SGD)
Scc2GeneProductS000002588 (SGD)
Sco1GeneProductS000000241 (SGD)
Second messanger signaling pathwayPathway
Sic1GeneProductS000004069 (SGD)
Skp1GeneProductS000002736 (SGD)
Smc2GeneProductS000001927 (SGD)
Smc4GeneProductS000004076 (SGD)
Ssn6GeneProductS000000316 (SGD)
Swe1GeneProductS000003723 (SGD)
Swi4GeneProductS000000913 (SGD)
Swi5GeneProductS000002553 (SGD)
Swi6GeneProductS000004172 (SGD)
Tem1GeneProductS000004529 (SGD)
Tup1GeneProductS000000680 (SGD)
Uba1GeneProductS000001693 (SGD)
Ycg1GeneProductS000002733 (SGD)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP414"
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