Osteoclast signaling (Homo sapiens)
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Description
Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass.
Quality Tags
Ontology Terms
Saving...Bibliography
- Boyle WJ, Simonet WS, Lacey DL; ''Osteoclast differentiation and activation.''; Nature, 2003 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AIMP2 | GeneProduct | ENSG00000106305 (Ensembl)  | |
| Ca2+ | Metabolite | 271 (PubChem-compound) | |
| Cathepsin K | Protein | 1513 (Entrez Gene) | |
| H+ ATPase | Protein | 9550 (Entrez Gene) | |
| H+ | Metabolite | 1038 (PubChem-compound) | |
| IFN-b | Protein | 3456 (Entrez Gene) | |
| MAPK8 | GeneProduct | ENSG00000107643 (Ensembl) | |
| Na+/H+ transporter | Protein | 6548 (Entrez Gene) | |
| Na+ | Metabolite | HMDB00588 (HMDB) | |
| OGR1 | Protein | 8111 (Entrez Gene) | |
| OPG | Protein | 4982 (Entrez Gene) | |
| Osteopontin | Protein | 6696 (Entrez Gene) | |
| PDGFB | Protein | 5155 (Entrez Gene) | |
| Pi | Metabolite | CHEBI:35780 (ChEBI) | |
| RANK ligand | Protein | 8600 (Entrez Gene) | |
| RANK | Protein | 8792 (Entrez Gene) | |
| TRAP | Protein | 54 (Entrez Gene) | |
| TRPV | Protein | 56302 (Entrez Gene) | |
| Type 1 interferon receptor | Protein | 3454 (Entrez Gene) | |
| b3 integrin | Protein | 3690 (Entrez Gene) |
Annotated Interactions
No annotated interactions
