Apoptosis modulation by HSP70 (Rattus norvegicus)

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1-8MitochondriaIk alphaTNF-alpha(activation of NFkB)ProteasomeApoptosomedegradationof proteinsCELL SURVIVALSTRESSdegradation ofActivationCasp2BidCycsMap3k1Hspa1aCasp8Pdcd8Tnfrsf1aApaf1FasNF-kB pathwayApoptosisFaddMapk10FaslgCasp3Nfkb1Casp7Casp8FaddHspa1aCasp6CycsRipk1Hspa1aCasp9


Description

This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis.

Comments

GenMAPP notes 
References of HSP70 and inhibition of apoptosis:

1. Garrido C, Schmitt E, Cande C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003 Nov-Dec;2(6):579-84. PMID: 14512773 [PubMed - in process]
2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146-59. PMID: 10982831 [PubMed - indexed for MEDLINE]
3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476-83. PMID: 10934467 [PubMed - indexed for MEDLINE]
4. Schett G, Steiner CW, Groger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833-42. PMID: 10224227 [PubMed - indexed for MEDLINE]
5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1-2):1-4. Review. PMID: 9821948 [PubMed - indexed for MEDLINE]
6. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
EMBO J. 1998 Nov 2;17(21):6124-34. PMID: 9799222 [PubMed - indexed for MEDLINE]
7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci P. The life span determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential. J Biol Chem. 2004 Apr 12 [Epub ahead of print]
PMID: 15078873 [PubMed - as supplied by publisher]
8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669-78.
PMID: 14555980 [PubMed - indexed for MEDLINE]

GenMAPP remarks 
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Quality Tags

Ontology Terms

 

Bibliography

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  1. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
  2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  4. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.''; FASEB J, 1999 PubMed Europe PMC Scholia
  5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.''; FEBS Lett, 1998 PubMed Europe PMC Scholia
  6. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.''; EMBO J, 1998 PubMed Europe PMC Scholia
  7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.''; Oncogene, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116942view10:03, 16 May 2021EweitzModified title
114003view21:56, 16 December 2020EgonwAnother pathway clickable
98536view20:48, 14 September 2018Khanspersremoved GenMAPP comments
98534view20:48, 14 September 2018KhanspersModified description
98533view20:47, 14 September 2018Khanspersupdates
70069view08:42, 12 July 2013Mkutmonfixed unconnected lines
69396view18:59, 8 July 2013MaintBotUpdated to 2013 gpml schema
67055view10:00, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
41717view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
27057view21:34, 17 December 2008SiddarthSpecify description
27055view21:34, 17 December 2008SiddarthMito
21704view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:HSP70 and Apoptosis]] moved to [[Pathway:WP487]]: Moved to stable identifier
8144view13:46, 7 January 2008MaintBot[[Pathway:Rat:HSP70 and Apoptosis]] moved to [[Pathway:Rattus norvegicus:HSP70 and Apoptosis]]: Renaming species
7692view16:10, 18 December 2007MaintBotfixed category names
7234view12:41, 4 November 2007MaintBotAdded categories to GPML
6554view22:20, 22 May 2007I.Reyesgpml file for [[Rat:HSP70_and_Apoptosis]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apaf1GeneProduct78963 (Entrez Gene)
ApoptosisPathwayWP1290 (WikiPathways)
BidGeneProduct64625 (Entrez Gene)
Casp2GeneProduct64314 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp6GeneProduct83584 (Entrez Gene)
Casp7GeneProduct64026 (Entrez Gene)
Casp8GeneProduct64044 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
CycsGeneProduct25309 (Entrez Gene)
FaddGeneProduct266610 (Entrez Gene)
FasGeneProductENSRNOG00000019142 (Ensembl)
FaslgGeneProductENSRNOG00000002978 (Ensembl)
Hspa1aGeneProduct24472 (Entrez Gene)
Map3k1GeneProduct116667 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
NF-kB pathwayPathway
Nfkb1GeneProduct81736 (Entrez Gene)
Pdcd8GeneProduct83533 (Entrez Gene) Apoptosis Inducing Factor
Ripk1GeneProduct306886 (Entrez Gene)
Tnfrsf1aGeneProduct25625 (Entrez Gene)

Annotated Interactions

No annotated interactions
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