Vitamin E (Homo sapiens)

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Bibliography

1. Kostner GM, Oettl K, Jauhiainen M, Ehnholm C, Esterbauer H, Dieplinger H.; ''Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells.''; PubMed Europe PMC Scholia
2. Traber MG, Ramakrishnan R, Kayden HJ.; ''Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-alpha-tocopherol.''; PubMed Europe PMC Scholia
3. Qian J, Morley S, Wilson K, Nava P, Atkinson J, Manor D.; ''Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein.''; PubMed Europe PMC Scholia
4. Kono N, Arai H.; ''Intracellular transport of fat-soluble vitamins A and E.''; PubMed Europe PMC Scholia
5. Schmölz L, Birringer M, Lorkowski S, Wallert M.; ''Complexity of vitamin E metabolism.''; PubMed Europe PMC Scholia
6. Arita M, Sato Y, Miyata A, Tanabe T, Takahashi E, Kayden HJ, Arai H, Inoue K.; ''Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
TTPA	Protein	P49638 (Uniprot-TrEMBL)
TTPA:alpha-TOH	Complex	R-HSA-8874714 (Reactome)
TTPA:alpha-TOH	Complex	R-HSA-8874722 (Reactome)
TTPA	Protein	P49638 (Uniprot-TrEMBL)
alpha-TOH	Metabolite	CHEBI:18145 (ChEBI)
alpha-TOH	Metabolite	CHEBI:18145 (ChEBI)

Annotated Interactions

Source	Target	Type	Database reference	Comment
			R-HSA-8874705 (Reactome)	Alpha-tocopherol (alpha-TOH) belongs to the fat-soluble vitamin E family and is the major form used by humans as an important antioxidant of plasma lipoproteins and cell membranes. It is secreted from the liver into the blood stream but as it is a lipophilic compound, it requires intracellular binding proteins to bind and transport it to exert its actions. One such protein is alpha-tocopherol transfer protein (TTPA, TPP1), a cytosolic protein highly expressed in liver and placenta (Arita et al. 1995, Kostner et al. 1995). The main function of TTPA is to maintain normal alpha-TOH concentrations in the plasma and extrahepatic tissues by binding to, and facilitating the transport of, alpha-TOH from lysosomes to the plasma membrane followed by the continuous export of alpha-TOH from the liver to the plasma (Traber et al. 1994, Qian et al. 2005; reviews Kono & Arai 2015, Schmolz et al. 2016).
			R-HSA-8874718 (Reactome)	Alpha-tocopherol (alpha-TOH) belongs to the fat-soluble vitamin E family and is the major form used by humans as an important antioxidant of plasma lipoproteins and cell membranes. It is secreted from the liver into the blood stream but as it is a lipophilic compound, it requires intracellular binding proteins to bind and transport it to exert its actions. One such protein is alpha-tocopherol transfer protein (TTPA, TPP1), a cytosolic protein highly expressed in liver and placenta (Arita et al. 1995, Kostner et al. 1995). The main function of TTPA is to maintain normal alpha-TOH concentrations in the plasma and extrahepatic tissues by binding to, and facilitating the transport of, alpha-TOH from lysosomes to the plasma membrane (Qian et al. 2005; reviews Kono & Arai 2015, Schmolz et al. 2016).
	TTPA:alpha-TOH	Arrow	R-HSA-8874705 (Reactome)
	TTPA:alpha-TOH	Arrow	R-HSA-8874718 (Reactome)
TTPA:alpha-TOH			R-HSA-8874705 (Reactome)
TTPA			R-HSA-8874718 (Reactome)
alpha-TOH			R-HSA-8874718 (Reactome)