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I have two concerns: -- A) It it really the cholesterol biosynthesis pathway and statins are just inhibitors of one obligate step, -- B) If the entire "pathway" to lipoproteins is to be included then the connection of VLDL and HDL secretion from the hepatocyte should be more explicitly represented. At the moment it is not really possible to see that it is VLDL and HDL that are secreted and the other entities coming from other sources.
I'm new here, so let me know if I should be doing something different than raising this concenr in this manner.
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