Thread:D-threo-isocitrate (1)
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| 17:38, 4 November 2014 | Khanspers (Talk | contribs) | New reply created | |
| 13:09, 4 November 2014 | CharlesHBennett (Talk | contribs) | New thread created |
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What is this molecule? Clicking on it didn't lead anywhere. I know that oxalosuccinate is an unstable intermediate at around this portion of the citric acid cycle, but am unfamiliar with threo-isocitrate.CharlesHBennett 13:09, 4 November 2014 (UTC)
Hi Charles, The node labeled D-threo-isocitrate is annotated with HMDB00193, you can see the HMDB entry below. The molecule is isocitrate or D-isocitrate, which is produced by the oxidation of citrate by aconitase. The name D-threo-isocitrate is one of many synonyms for this molecule. The original author of the pathway selected this name for the node rather than the standard name, but you are welcome to change it if you believe the standard name or another of the synonyms is preferred for this molecule. http://www.hmdb.ca/metabolites/HMDB00193
Regarding oxalosuccinate, I believe this is an unstable intermediate after isocitrate (http://en.wikipedia.org/wiki/Oxalosuccinic_acid, see diagram at the bottom of the page), in the oxidative decarboxylation of isocitrate to Alpha-Ketoglutarate. Please feel free to add this step to the pathway.
Regards,
Kristina
