Thread:Pathway looks great! (1)

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19:11, 21 June 2016AAR&Co (Talk | contribs)Comment text edited
18:55, 21 June 2016AAR&Co (Talk | contribs)New reply created
21:33, 20 June 2016Khanspers (Talk | contribs)New thread created
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The pathway looks great! After reviewing the original figure, I have a few suggestions: - For the inhibition of Wnt in the extracellular space (DKK3 etc), it would preferred if the inhibition arrow pointed to a copy of Wnt in the extracellular space instead of to the binding arrow. That is a more direct way of representing the information. If you keep the current representation, you could use a dashed arrow instead. - The representation of the destruction complex (with APC/Axin) and how it binds to beta-catenin could be improved. The arrow going from FZD/LRP to beta-catenin should be removed, I think. And while the complex facilitates destruction of beta-catenin like you illustrated, it is doing so while bound to beta-catenin. So I think a representation that is more similar to the one in the figure is more correct, with beta-catenin as part of the complex, with an arrow pointing to a mim-degradation object. - Inside the nucleus, you could use a mim-transcription-translation arrow instead of the regular arrow.

Thank you for the suggestions Dr. Hanspers. We have edited the pathway as directed to better represent the protein interactions.

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