Thread:Pathway Incorrect (1)
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from Pathway Talk:WP619
Revision as of 09:25, 20 September 2019.
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I've worked on immune and interferon signaling for years and STAT2 isn't activated by IFNg signaling. STAT2 and ISGF3 complex (STAT1:STAT2:IRF9) formation is unique to type I IFN signaling IFNa/b). I've looked at the paper this pathway is based on and I think they made a mistake. STAT2 can be a transcriptional target of IFNG but is never a part of the signaling cascade.
I guess one of the biggest weaknesses of community derived pathway resources is that lack of evidence/provenance for each link between molecules in the signaling cascade.
