Eukaryotic translation initiation (Homo sapiens)

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5121825106, 11, 19, 24, 281415, 294, 8, 2011, 19, 24716, 19, 22-24, 264, 87, 14, 19, 24992, 715, 29133, 8, 11, 19, 24...cytosoleIF4A subunitscomplexCeruloplasmin mRNA RPS25 RPS20 RPLP2 EIF3C RPL9 RPS25 60S ribosomalcomplexRPS24 RPL19 RPS15 EIF3J EIF3G RPS2 RPL36A RPS5 RPL10L RPS23 EIF3C RPS8 RPLP1 RPL13 RPS13 RPL19 EIF3B RPL23 RPS15A RPL12 RPS25 RPS27L RPL39 RPS24 RPS27L EIF3D RPL39L RPS11 RPS19 EIF3M RPS9 RPSA RPL10A RPS18 RPS7 RPL26 RPS21 RPS5 RPLP0 RPS19 RPL23A RPL34 43S:CeruloplasminmRNA:eIF4F:eIF4B:eIF4H:PABPEIF5RPL3 EIF2S3 EIF3D RPS20 RPS27A(77-156) EIF3H EIF3C RPL39L EIF4A1 ATPEIF2B1 RPL4 EIF3A RPS27 RPS15A EIF2S2 RPLP2 RPL10A RPS27 RPS3A EIF1AX FAU EIF4G1 RPL18A RPL17 RPS18 RPS27A(77-156) RPS7 RPL26L1 5S rRNA 80S:Met-tRNAi:mRNA:eIF5B:GTPGDP RPL10A RPL6 RPL3L GTP EIF4G1EIF2S1:EIF2S2:EIF2S3RPS13 18S rRNA RPL36A RPL15 RPL3L RPS2 RPS29 RPS23 EIF2B3 EIF3G RPS4Y2 80S ribosomeRPS24 RPL8 eIF2:GDPRPS6 EIF2S2 EIF3L EIF4G1 RPS12 RPL30 RPL41 EIF1AXRPS21 RPL11 EIF4A1 5S rRNA 40S:Met-tRNAi:mRNAGTP RPL24 RPL41 RPS7 RPS23 RPL18 RPS10 RPS14 EIF4G1 EIF4E RPS16 phospho-L13aassociated wth the 3' UTR GAIT elementof ceruloplasminmRNA within thetranslationinitiation complexRPS6 RPL40 EIF1AX RPS16 RPS15 RPS23 RPL15 RPL4 EIF3I EIF5RPS2 RPS27A(77-156) RPL37A RPS4Y1 RPL10A RPS27L RPL37A RPLP2 EIF4A1 RPL7A RPS25 eIF1RPS9 PiRPL27 RPL31 RPS10 RPL10L RPS24 EIF3E ADPRPSA RPL18A 5.8S rRNA RPS10 RPS15 RPS12 EIF3E EIF2S3 RPL28 EIF2S1:EIF2S2:EIF2S3EIF3G RPS17 RPL11 28S rRNA RPS6 RPS28 RPL14 RPS27 RPS18 EIF3H EIF3K RPS13 RPS27L RPL24 RPS10 RPL4 RPS12 RPS20 48S complexRPL36 RPL21 EIF3I EIF3F RPS15 RPL26L1 RPL39 EIF2S1 RPSA RPL17 ATPGDP RPS17 RPS3 RPL31 RPL29 EIF3M EIF3F RPS27L FAU RPLP1 eIF2:GDP: eIF2BRPL36AL RPL39 RPS27 RPS4Y2 EIF5B EIF3G EIF4B RPS4Y2 RPL21 RPS28 RPS14 RPL24 RPS4X RPL40 PiRPL14 RPS19 EIF2S3 RPL11 EIF3C EIF2B2 RPL21 RPS2 RPS2 EIF3L RPSA RPS15A RPL37 60s ribosomalcomplex lackingL13a subunitRPS9 RPL13A RPS15A EIF2S1 RPLP1 PABPC1 EIF3I RPS4Y1 RPS8 RPS2 EIF4A2 RPL36AL RPL32 EIF2S3 5.8S rRNA EIF2S2 mRNPRPL22L1 RPLP1 RPL10L RPL23A EIF2B2 RPL28 p-RPL13A GDPRPL12 ATPRPS18 RPS11 RPS14 RPS13 EIF3G RPS4Y1 EIF3A RPS17 EIF1AX RPL27A EIF3A RPL3L EIF3J EIF2S1 RPS21 EIF3K EIF4E RPS15A RPL9 RPSA RPL23 RPS20 RPL17 RPL7 RPS7 EIF4E EIF3H RPS29 RPL31 RPS7 FAU RPS18 EIF4A2 28S rRNA RPS16 mRNA:eIF4F:eIF4B:eIF4HRPS29 EIF4B RPS25 RPS2 RPS17 EIF4G1 RPS10 RPL32 eIF4E:4E-BPRPS10 RNA-binding protein in RNP (ribonucleoprotein) complexes RPS4X FAU 5.8S rRNA RPS10 RPL36A EIF4BRPS16 43S complexRPS10 RPS29 RNA-binding protein in RNP (ribonucleoprotein) complexes EIF2S1 RPLP0 RPS26 RPS14 RPS8 EIF2S1 RPS26 RPS6 RPS7 RPS12 RPS27A(77-156) EIF2S1 RPS3A RPL14 RPS3 EIF2S2 EIF3C EIF3L RPS8 EIF3E RPS21 RPS3 RPL7 RPSA 18S rRNA RPL35A 28S rRNA RPS12 RPS4Y1 RPS19 RPL22L1 RPL26 EIF3M RPL12 RPL7A RPS3 FAU Met-tRNAi RPL3 RPL18 RPSA RPS28 RPL5 RPL8 RPS8 RPS18 EIF4A2 EIF4E RPS10 RPL14 RPL7A RPL12 RPL10 EIF3L RPL27A RPL26 RPS16 GTP RPS25 RPS18 EIF4A1 RPS14 EIF3L EIF4A1 EIF3F RPL37A EIF3D RPS12 RPS14 RPS6 RPL23 EIF1AX RPS28 EIF3K RPS29 RPS4X RPL27 RPL40 RPS27A(77-156) EIF1AXRPS13 RPL3L RPL9 EIF3K eIF5B:GTPRPS3 RPS4Y2 EIF2B1 18S rRNA RPS7 EIF3B RPS13 RPS11 RPS4X RPS23 eIF4F:mRNPRPS3A RPS11 Met-tRNAi EIF3A RPS21 EIF4H RPS4X RPL37 RPL22 RPL41 GTP RPLP1 RPS14 p-RPL13ARPL4 EIF3D RPL9 Met-tRNAi RPL39L L13a kinaseRPL31 RPL22L1 RPL18A RPL26 RPL11 EIF2S3 RPS19 RPS3A RPS5 eIF1EIF2S2 RPL29 RPS4Y2 RPS24 CeruloplasminmRNA:eIF4F:eIF4B:eIF4HRPS27A(77-156) RPL11 EIF3M RPL32 RPL12 EIF3H RPL34 RPL26L1 RPS7 RPL13ARPL27A RPL5 RPSA RPS9 5.8S rRNA RPS4Y2 RPS5 RPL14 RPS4X EIF4EBP1 RPLP2 RPL32 RPS11 RPS21 Met-tRNAi RPS7 RPS26 RPS15A EIF3L RPL38 EIF3B RPS20 EIF3K RPS27A(77-156) RPL38 RPS21 EIF3C Ceruloplasmin mRNA 18S rRNA RPS23 RPS5 RPS11 RPL41 RPS28 RPS29 RPS15A RPL39L RPS10 RPLP0 RPS18 RPS7 RPS15A RPS21 EIF4EBP1Met-tRNAi EIF3I RPL28 RPS29 EIF3L EIF3A GTP RPS20 RPL19 EIF4A2 EIF2S2 RPS19 RPS15 RPL7 eIF4FRPS25 RPS4Y2 RPS11 RPS27A(77-156) RPL21 RPS4Y1 RPS29 EIF3K RPS4Y1 RPL13A EIF2B4 RPL23A RPL37A FAU RPS19 EIF3D RPS20 RPL18A Ceruloplasmin mRNA RPS26 EIF3C 28S rRNA EIF4H RPS9 RPL34 RPS28 EIF1AX RPL8 RPS8 EIF2S2 RPS27 RPS5 RPLP2 RPS24 RPS3 RPS8 EIF4E EIF3A RPS10 RPS2 RPS21 RPS24 EIF2S1 RPS17 RPS6 RPS3A RPL27 RPS15A RPS3A RPS11 EIF3D RPS28 EIF4A1 RPL19 RNA-binding proteinin RNP(ribonucleoprotein)complexesRPS27L RPS12 RPL39L EIF3J EIF3B RPS6 RPS28 28S rRNA RPS4Y1 RPS9 EIF4A1 EIF3I RPL4 RPL7 RPS3A RPS4X RPL39 RPL34 RPL10L Met-tRNAi EIF4G1 RPL35A Ceruloplasmin mRNA 40S ribosomalcomplexRPS20 RPL6 EIF1AX RPS19 EIF2S2 RPS9 PABPC1RPS8 EIF5B RPL38 RPS25 RPL35 EIF2S3 Met-tRNAi RPL10L RPS5 EIF3F EIF5B RPS20 RPS27L EIF4B RPL21 RPS6 EIF4A2 EIF3G EIF4B EIF4A1 RPS12 RPS17 RPSA RPL6 RPL22 RPL3L RPL26L1 EIF4A2 RPL41 GTP EIF2S2 EIF3K RPS4X RPS28 RPS29 RPS15 FAU RPSA EIF2S1 RPL17 RPL40 RPS8 EIF2S1 EIF2B4 RPS8 RPS26 RPS13 EIF3M EIF3J RPS14 RPL22 RPL26 RPL36 RPS15 5.8S rRNA RPL13A RPSA eIF5B:GDPEIF4A2 RPL15 RPL36 Ceruloplasmin mRNA Ceruloplasmin mRNA RPL15 RPL36AL RPS16 RPS16 RPS3 RPS4X RPS27 EIF3B RPS23 EIF3H EIF3H RPS15 RPS27L RPL23A EIF4H RPL35A RPL35 RPS27L EIF4E EIF4G1 RPS18 18S rRNA GTPEIF2S3 eIF2B subunitscomplexRPS14 GTPternary complexRPS15 RPL9 RPS13 RPS15A 18S rRNA RPS23 EIF3B RPL37 RPS17 RPL36AL RPS4X RPL35A RPL27 EIF3J EIF5RPL10 FAU RPS9 RPL13 RPS7 RPS25 RPL7A Ceruloplasmin mRNA FAU RPL3 RPS13 RPS11 RPL29 RPS27A(77-156) RPS3A RPS23 RPL31 RPL5 Ceruloplasmin mRNA PiRPL10 EIF2S3 RPS21 RPS4Y1 RPS25 RPS12 EIF3E RPS24 RPS26 RPS26 EIF2S3 RPS26 RPL32 RPL8 RPS23 RPS5 RPS20 EIF3F RPL10 RPS11 RPL29 RPS3 5S rRNA RPS16 RPL27 RPS6 RPL8 EIF4B EIF2S1 18S rRNA EIF4A1 EIF1AXRPS24 RPL22L1 RPL13 EIF3J RPL7 RPL37 RPS25 RPL3 RPS27A(77-156) RPS4Y1 RPS26 5S rRNA RPS4X RPL36A RPS27L RPL24 RPS15 RPL35 EIF2B5 EIF2S2 RPL5 RPS3 RPS15A RPS24 RPS9 RPL36 FAU EIF3E RPL22 RPL17 RPL22L1 EIF4HEIF4A2 40S:eIF3:eIF1ARPL35A RPS4Y1 ADPGTP RPL23 RPS27 EIF1AXRPL37A RPL28 RPS19 EIF4E18S rRNA RPL10A RPS27 RPS5 EIF2S3 RPL23 RPL27A RPS3A eIF2:GTPRPS17 RPL13 Ceruloplasmin mRNA EIF4B FAU RPL27A Met-tRNAi Ceruloplasmin mRNA RPS12 RPS11 GTP RPL10 RPS18 EIF4G1 EIF2S1 RPS6 RPL30 RPL22 RPS14 RPL40 PiRPS27 RPS16 RPS27 RPL36 EIF3E EIF2S3 RPS2 RPL29 RPS4Y2 RPS27 EIF2S2 RPS12 EIF3I RPL30 eIF2:GTPEIF4A2 EIF4H EIF4E EIF2S1 RPL6 EIF3F 18S rRNA RPL5 RPS18 43S:mRNA:eIF4F:eIF4B:eIF4HRPS6 PABPC1 EIF3M RPS2 Met-tRNAiRPL39 RPL13A RPS26 5S rRNA RPL36AL RPS3 RPS15 EIF4H RPS9 RPS3A RPL18 EIF2S3 RPS27L RPL36A RPS27A(77-156) RPS19 RPL38 RPS20 EIF4H eIF3 subunitscomplexRPS5 RPL34 RPL19 RPL30 RPL35 RPS3 RPL3 RPL7A RPS9 EIF3F RPLP0 RPS4Y1 GTP RPS4Y2 RPL23A RPS5 RPL13 EIF2B3 RPS16 18S rRNA RPS26 RPL26L1 RPLP0 EIF3D RPS24 RPS14 RPS23 80S:Met-tRNAi:mRNARPS4Y2 18S rRNA EIF3G Met-tRNAi RPL24 RPS13 RPS17 RPL15 EIF3H RPS2 EIF3I RPL28 EIF3M RPS29 EIF3J EIF3A RPL18A EIF3E RPS8 Ceruloplasmin mRNA RPL30 RPL18 RPS28 GTP RPS4Y2 RPS29 RPL35 RPS21 RPL38 EIF2B5 RPL37 RPS3A RPS13 EIF4G1 RPL18 RPS17 RPS28 RPS16 GDP EIF4E EIF3B RPS19 RPS17 RPL6 EIF2S2 EIF4E 1, 211, 211, 211, 21171, 211, 211, 211, 211, 211, 21


Description

Initiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG start codon. Therefore, this mechanism is often called cap-dependent translation initiation. Proximity to the cap, as well as the nucleotides surrounding an AUG codon, influence the efficiency of the start site recognition during the scanning process. However, if the recognition site is poor enough, scanning ribosomal subunits will ignore and skip potential starting AUGs, a phenomenon called leaky scanning. Leaky scanning allows a single mRNA to encode several proteins that differ in their amino-termini. Merrick (2010) provides an overview of this process and hghlights several features of it that remain incompletely understood.

Several eukaryotic cell and viral mRNAs initiate translation by an alternative mechanism that involves internal initiation rather than ribosomal scanning. These mRNAs contain complex nucleotide sequences, called internal ribosomal entry sites, where ribosomes bind in a cap-independent manner and start translation at the closest downstream AUG codon.

Initiation on several viral and cellular mRNAs is cap-independent and is mediated by binding of the ribosome to internal ribosome entry site (IRES) elements. These elements are often found in characteristically long structured regions on the 5'-UTR of an mRNA that may or may not have regulatory upstream open reading frames (uORFs). Both of these features on the 5'-end of the mRNA hinder ribosomal scanning, and thus promote a cap-independent translation initiation mechanism. IRESs act as specific translational enhancers that allow translation initiation to occur in response to specific stimuli and under the control of different trans-acting factors, as for example when cap-dependent protein synthesis is shut off during viral infection. Such regulatory elements have been identified in the mRNAs of growth factors, protooncogenes, angiogenesis factors, and apoptosis regulators, which are translated under a variety of stress conditions, including hypoxia, serum deprivation, irradiation and apoptosis. Thus, cap-independent translational control might have evolved to regulate cellular responses in acute but transient stress conditions that would otherwise lead to cell death, while the same mechanism is of major importance for viral mRNAs to bypass the shutting-off of host protein synthesis after infection. Encephalomyocarditis virus (EMCV) and hepatitis C virus exemplify two distinct mechanisms of IRES-mediated initiation. In contrast to cap-dependent initiation, the eIF4A and eIF4G subunits of eIF4F bind immediately upstream of the EMCV initiation codon and promote binding of a 43S complex. Accordingly, EMCV initiation does not involve scanning and does not require eIF1, eIF1A, and the eIF4E subunit of eIF4F. Nonetheless, initiation on some EMCV-like IRESs requires additional non-canonical initiation factors, which alter IRES conformation and promote binding of eIF4A/eIF4G. Initiation on the hepatitis C virus IRES is simpler: a 43S complex containing only eIF2 and eIF3 binds directly to the initiation codon as a result of specific interaction of the IRES and the 40S subunit.

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Comments

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Pathway is converted from Reactome ID: 72613
Reactome-version 
Reactome version: 63

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Bibliography

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  1. Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N.; ''Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.''; PubMed Europe PMC Scholia
  2. Sampath P, Mazumder B, Seshadri V, Fox PL.; ''Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.''; PubMed Europe PMC Scholia
  3. Pestova TV, Borukhov SI, Hellen CU.; ''Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.''; PubMed Europe PMC Scholia
  4. Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL.; ''Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.''; PubMed Europe PMC Scholia
  5. Grifo JA, Tahara SM, Morgan MA, Shatkin AJ, Merrick WC.; ''New initiation factor activity required for globin mRNA translation.''; PubMed Europe PMC Scholia
  6. Safer B, Adams SL, Anderson WF, Merrick WC.; ''Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.''; PubMed Europe PMC Scholia
  7. Pestova TV, Shatsky IN, Hellen CU.; ''Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.''; PubMed Europe PMC Scholia
  8. Merrick WC.; ''Eukaryotic protein synthesis: still a mystery.''; PubMed Europe PMC Scholia
  9. Kozak M.; ''Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.''; PubMed Europe PMC Scholia
  10. Chakrabarti A, Maitra U.; ''Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex.''; PubMed Europe PMC Scholia
  11. Trachsel H, Erni B, Schreier MH, Staehelin T.; ''Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.''; PubMed Europe PMC Scholia
  12. Rowlands AG, Panniers R, Henshaw EC.; ''The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.''; PubMed Europe PMC Scholia
  13. Iost I, Dreyfus M, Linder P.; ''Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.''; PubMed Europe PMC Scholia
  14. Benne R, Hershey JW.; ''The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.''; PubMed Europe PMC Scholia
  15. Schreier MH, Erni B, Staehelin T.; ''Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.''; PubMed Europe PMC Scholia
  16. Sonenberg N, Rupprecht KM, Hecht SM, Shatkin AJ.; ''Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.''; PubMed Europe PMC Scholia
  17. Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW.; ''Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing.''; PubMed Europe PMC Scholia
  18. Merrick WC, Kemper WM, Anderson WF.; ''Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.''; PubMed Europe PMC Scholia
  19. Asano K, Clayton J, Shalev A, Hinnebusch AG.; ''A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.''; PubMed Europe PMC Scholia
  20. Peterson DT, Merrick WC, Safer B.; ''Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.''; PubMed Europe PMC Scholia
  21. Goumans H, Thomas A, Verhoeven A, Voorma HO, Benne R.; ''The role of eIF-4C in protein synthesis initiation complex formation.''; PubMed Europe PMC Scholia
  22. Imataka H, Gradi A, Sonenberg N.; ''A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.''; PubMed Europe PMC Scholia
  23. Chuang RY, Weaver PL, Liu Z, Chang TH.; ''Requirement of the DEAD-Box protein ded1p for messenger RNA translation.''; PubMed Europe PMC Scholia
  24. Lahn BT, Page DC.; ''Functional coherence of the human Y chromosome.''; PubMed Europe PMC Scholia
  25. Yoder-Hill J, Pause A, Sonenberg N, Merrick WC.; ''The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.''; PubMed Europe PMC Scholia
  26. Pestova TV, Lomakin IB, Lee JH, Choi SK, Dever TE, Hellen CU.; ''The joining of ribosomal subunits in eukaryotes requires eIF5B.''; PubMed Europe PMC Scholia
  27. Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA.; ''Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.''; PubMed Europe PMC Scholia
  28. Majumdar R, Bandyopadhyay A, Maitra U.; ''Mammalian translation initiation factor eIF1 functions with eIF1A and eIF3 in the formation of a stable 40 S preinitiation complex.''; PubMed Europe PMC Scholia
  29. Dholakia JN, Wahba AJ.; ''Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128373view17:49, 3 February 2024Ash iyerFixing error (check)
128372view17:45, 3 February 2024Ash iyeridentifier added
128371view17:43, 3 February 2024Ash iyereif1 identifier added.
128323view00:28, 1 February 2024EweitzOntology Term : 'translation pathway' added !
117720view12:33, 22 May 2021EweitzModified title
114979view16:50, 25 January 2021ReactomeTeamReactome version 75
113423view11:49, 2 November 2020ReactomeTeamReactome version 74
112625view16:00, 9 October 2020ReactomeTeamReactome version 73
101541view11:40, 1 November 2018ReactomeTeamreactome version 66
101076view21:23, 31 October 2018ReactomeTeamreactome version 65
100606view19:57, 31 October 2018ReactomeTeamreactome version 64
100157view16:42, 31 October 2018ReactomeTeamreactome version 63
99707view15:11, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99288view12:46, 31 October 2018ReactomeTeamreactome version 62
93969view13:48, 16 August 2017ReactomeTeamreactome version 61
93568view11:27, 9 August 2017ReactomeTeamreactome version 61
86670view09:23, 11 July 2016ReactomeTeamreactome version 56
83337view10:49, 18 November 2015ReactomeTeamVersion54
76969view08:25, 17 July 2014ReactomeTeamFixed remaining interactions
76674view12:04, 16 July 2014ReactomeTeamFixed remaining interactions
76136view13:23, 11 June 2014AnweshaRe-fixing comment source
75707view11:05, 10 June 2014ReactomeTeamReactome 48 Update
75062view13:57, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74706view08:46, 30 April 2014ReactomeTeamReactome46
45250view18:36, 7 October 2011AlexanderPicoOntology Term : 'translation initiation pathway' added !
42035view21:51, 4 March 2011MaintBotAutomatic update
39838view05:52, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
18S rRNA ProteinX03205 (EMBL)
28S rRNA ProteinM11167 (EMBL)
40S ribosomal complexComplexR-HSA-72392 (Reactome)
40S:Met-tRNAi:mRNAComplexR-HSA-72508 (Reactome)
40S:eIF3:eIF1AComplexR-HSA-72570 (Reactome)
43S complexComplexR-HSA-72571 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
ComplexR-HSA-156804 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-72592 (Reactome)
48S complexComplexR-HSA-72594 (Reactome)
5.8S rRNA ProteinJ01866 (EMBL)
5S rRNA ProteinV00589 (EMBL)
60S ribosomal complexComplexR-HSA-72499 (Reactome)
60s ribosomal

complex lacking

L13a subunit
ComplexR-HSA-156817 (Reactome)
80S ribosomeComplexR-HSA-72500 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPComplexR-HSA-72504 (Reactome)
80S:Met-tRNAi:mRNAComplexR-HSA-72505 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-156809 (Reactome)
Ceruloplasmin mRNA ProteinM13699 (EMBL)
EIF1AX ProteinP47813 (Uniprot-TrEMBL)
EIF1AXProteinP47813 (Uniprot-TrEMBL)
EIF2B1 ProteinQ14232 (Uniprot-TrEMBL)
EIF2B2 ProteinP49770 (Uniprot-TrEMBL)
EIF2B3 ProteinQ9NR50 (Uniprot-TrEMBL)
EIF2B4 ProteinQ9UI10 (Uniprot-TrEMBL)
EIF2B5 ProteinQ13144 (Uniprot-TrEMBL)
EIF2S1 ProteinP05198 (Uniprot-TrEMBL)
EIF2S1:EIF2S2:EIF2S3ComplexR-HSA-72515 (Reactome)
EIF2S2 ProteinP20042 (Uniprot-TrEMBL)
EIF2S3 ProteinP41091 (Uniprot-TrEMBL)
EIF3A ProteinQ14152 (Uniprot-TrEMBL)
EIF3B ProteinP55884 (Uniprot-TrEMBL)
EIF3C ProteinQ99613 (Uniprot-TrEMBL)
EIF3D ProteinO15371 (Uniprot-TrEMBL)
EIF3E ProteinP60228 (Uniprot-TrEMBL)
EIF3F ProteinO00303 (Uniprot-TrEMBL)
EIF3G ProteinO75821 (Uniprot-TrEMBL)
EIF3H ProteinO15372 (Uniprot-TrEMBL)
EIF3I ProteinQ13347 (Uniprot-TrEMBL)
EIF3J ProteinO75822 (Uniprot-TrEMBL)
EIF3K ProteinQ9UBQ5 (Uniprot-TrEMBL)
EIF3L ProteinQ9Y262 (Uniprot-TrEMBL)
EIF3M ProteinQ7L2H7 (Uniprot-TrEMBL)
EIF4A1 ProteinP60842 (Uniprot-TrEMBL)
EIF4A2 ProteinQ14240 (Uniprot-TrEMBL)
EIF4B ProteinP23588 (Uniprot-TrEMBL)
EIF4BProteinP23588 (Uniprot-TrEMBL)
EIF4E ProteinP06730 (Uniprot-TrEMBL)
EIF4EBP1 ProteinQ13541 (Uniprot-TrEMBL)
EIF4EBP1ProteinQ13541 (Uniprot-TrEMBL)
EIF4EProteinP06730 (Uniprot-TrEMBL)
EIF4G1 ProteinQ04637 (Uniprot-TrEMBL)
EIF4G1ProteinQ04637 (Uniprot-TrEMBL)
EIF4H ProteinQ15056 (Uniprot-TrEMBL)
EIF4HProteinQ15056 (Uniprot-TrEMBL)
EIF5B ProteinO60841 (Uniprot-TrEMBL)
EIF5ProteinP55010 (Uniprot-TrEMBL)
FAU ProteinP62861 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
L13a kinaseR-HSA-170641 (Reactome)
Met-tRNAi R-ALL-72393 (Reactome)
Met-tRNAiR-ALL-72393 (Reactome)
PABPC1 ProteinP11940 (Uniprot-TrEMBL)
PABPC1ProteinP11940 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RNA-binding protein

in RNP (ribonucleoprotein)

complexes
R-ALL-72595 (Reactome)
RNA-binding protein in RNP (ribonucleoprotein) complexes R-ALL-72595 (Reactome)
RPL10 ProteinP27635 (Uniprot-TrEMBL)
RPL10A ProteinP62906 (Uniprot-TrEMBL)
RPL10L ProteinQ96L21 (Uniprot-TrEMBL)
RPL11 ProteinP62913 (Uniprot-TrEMBL)
RPL12 ProteinP30050 (Uniprot-TrEMBL)
RPL13 ProteinP26373 (Uniprot-TrEMBL)
RPL13A ProteinP40429 (Uniprot-TrEMBL)
RPL13AProteinP40429 (Uniprot-TrEMBL)
RPL14 ProteinP50914 (Uniprot-TrEMBL)
RPL15 ProteinP61313 (Uniprot-TrEMBL)
RPL17 ProteinP18621 (Uniprot-TrEMBL)
RPL18 ProteinQ07020 (Uniprot-TrEMBL)
RPL18A ProteinQ02543 (Uniprot-TrEMBL)
RPL19 ProteinP84098 (Uniprot-TrEMBL)
RPL21 ProteinP46778 (Uniprot-TrEMBL)
RPL22 ProteinP35268 (Uniprot-TrEMBL)
RPL22L1 ProteinQ6P5R6 (Uniprot-TrEMBL)
RPL23 ProteinP62829 (Uniprot-TrEMBL)
RPL23A ProteinP62750 (Uniprot-TrEMBL)
RPL24 ProteinP83731 (Uniprot-TrEMBL)
RPL26 ProteinP61254 (Uniprot-TrEMBL)
RPL26L1 ProteinQ9UNX3 (Uniprot-TrEMBL)
RPL27 ProteinP61353 (Uniprot-TrEMBL)
RPL27A ProteinP46776 (Uniprot-TrEMBL)
RPL28 ProteinP46779 (Uniprot-TrEMBL)
RPL29 ProteinP47914 (Uniprot-TrEMBL)
RPL3 ProteinP39023 (Uniprot-TrEMBL)
RPL30 ProteinP62888 (Uniprot-TrEMBL)
RPL31 ProteinP62899 (Uniprot-TrEMBL)
RPL32 ProteinP62910 (Uniprot-TrEMBL)
RPL34 ProteinP49207 (Uniprot-TrEMBL)
RPL35 ProteinP42766 (Uniprot-TrEMBL)
RPL35A ProteinP18077 (Uniprot-TrEMBL)
RPL36 ProteinQ9Y3U8 (Uniprot-TrEMBL)
RPL36A ProteinP83881 (Uniprot-TrEMBL)
RPL36AL ProteinQ969Q0 (Uniprot-TrEMBL)
RPL37 ProteinP61927 (Uniprot-TrEMBL)
RPL37A ProteinP61513 (Uniprot-TrEMBL)
RPL38 ProteinP63173 (Uniprot-TrEMBL)
RPL39 ProteinP62891 (Uniprot-TrEMBL)
RPL39L ProteinQ96EH5 (Uniprot-TrEMBL)
RPL3L ProteinQ92901 (Uniprot-TrEMBL)
RPL4 ProteinP36578 (Uniprot-TrEMBL)
RPL40 ProteinP62987 (Uniprot-TrEMBL)
RPL41 ProteinP62945 (Uniprot-TrEMBL)
RPL5 ProteinP46777 (Uniprot-TrEMBL)
RPL6 ProteinQ02878 (Uniprot-TrEMBL)
RPL7 ProteinP18124 (Uniprot-TrEMBL)
RPL7A ProteinP62424 (Uniprot-TrEMBL)
RPL8 ProteinP62917 (Uniprot-TrEMBL)
RPL9 ProteinP32969 (Uniprot-TrEMBL)
RPLP0 ProteinP05388 (Uniprot-TrEMBL)
RPLP1 ProteinP05386 (Uniprot-TrEMBL)
RPLP2 ProteinP05387 (Uniprot-TrEMBL)
RPS10 ProteinP46783 (Uniprot-TrEMBL)
RPS11 ProteinP62280 (Uniprot-TrEMBL)
RPS12 ProteinP25398 (Uniprot-TrEMBL)
RPS13 ProteinP62277 (Uniprot-TrEMBL)
RPS14 ProteinP62263 (Uniprot-TrEMBL)
RPS15 ProteinP62841 (Uniprot-TrEMBL)
RPS15A ProteinP62244 (Uniprot-TrEMBL)
RPS16 ProteinP62249 (Uniprot-TrEMBL)
RPS17 ProteinP08708 (Uniprot-TrEMBL)
RPS18 ProteinP62269 (Uniprot-TrEMBL)
RPS19 ProteinP39019 (Uniprot-TrEMBL)
RPS2 ProteinP15880 (Uniprot-TrEMBL)
RPS20 ProteinP60866 (Uniprot-TrEMBL)
RPS21 ProteinP63220 (Uniprot-TrEMBL)
RPS23 ProteinP62266 (Uniprot-TrEMBL)
RPS24 ProteinP62847 (Uniprot-TrEMBL)
RPS25 ProteinP62851 (Uniprot-TrEMBL)
RPS26 ProteinP62854 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27A(77-156) ProteinP62979 (Uniprot-TrEMBL)
RPS27L ProteinQ71UM5 (Uniprot-TrEMBL)
RPS28 ProteinP62857 (Uniprot-TrEMBL)
RPS29 ProteinP62273 (Uniprot-TrEMBL)
RPS3 ProteinP23396 (Uniprot-TrEMBL)
RPS3A ProteinP61247 (Uniprot-TrEMBL)
RPS4X ProteinP62701 (Uniprot-TrEMBL)
RPS4Y1 ProteinP22090 (Uniprot-TrEMBL)
RPS4Y2 ProteinQ8TD47 (Uniprot-TrEMBL)
RPS5 ProteinP46782 (Uniprot-TrEMBL)
RPS6 ProteinP62753 (Uniprot-TrEMBL)
RPS7 ProteinP62081 (Uniprot-TrEMBL)
RPS8 ProteinP62241 (Uniprot-TrEMBL)
RPS9 ProteinP46781 (Uniprot-TrEMBL)
RPSA ProteinP08865 (Uniprot-TrEMBL)
eIF1R-ALL-72617 (Reactome)
eIF2:GDP: eIF2BComplexR-HSA-72529 (Reactome)
eIF2:GDPComplexR-HSA-72530 (Reactome)
eIF2:GTPComplexR-HSA-72531 (Reactome)
eIF2B subunits complexComplexR-HSA-72526 (Reactome)
eIF3 subunits complexComplexR-HSA-72555 (Reactome)
eIF4A subunits complexComplexR-HSA-72576 (Reactome)
eIF4E:4E-BPComplexR-HSA-72581 (Reactome)
eIF4F:mRNPComplexR-HSA-72597 (Reactome)
eIF4FComplexR-HSA-72587 (Reactome)
eIF5B:GDPComplexR-HSA-72502 (Reactome)
eIF5B:GTPComplexR-HSA-72503 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-72593 (Reactome)
mRNPComplexR-HSA-72596 (Reactome)
p-RPL13A ProteinP40429 (Uniprot-TrEMBL)
p-RPL13AProteinP40429 (Uniprot-TrEMBL)
phospho-L13a

associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation

initiation complex
ComplexR-HSA-156824 (Reactome)
ternary complexComplexR-HSA-72532 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
40S ribosomal complexArrowR-HSA-72673 (Reactome)
40S ribosomal complexR-HSA-72676 (Reactome)
40S:Met-tRNAi:mRNAArrowR-HSA-72619 (Reactome)
40S:Met-tRNAi:mRNAR-HSA-72672 (Reactome)
40S:eIF3:eIF1AArrowR-HSA-72676 (Reactome)
40S:eIF3:eIF1AR-HSA-72691 (Reactome)
43S complexArrowR-HSA-72691 (Reactome)
43S complexR-HSA-156808 (Reactome)
43S complexR-HSA-157849 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
ArrowR-HSA-156808 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
R-HSA-156823 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HArrowR-HSA-157849 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HR-HSA-72621 (Reactome)
48S complexArrowR-HSA-72621 (Reactome)
48S complexArrowR-HSA-72697 (Reactome)
48S complexR-HSA-72619 (Reactome)
48S complexR-HSA-72697 (Reactome)
60S ribosomal complexArrowR-HSA-72673 (Reactome)
60S ribosomal complexR-HSA-156826 (Reactome)
60S ribosomal complexR-HSA-72672 (Reactome)
60s ribosomal

complex lacking

L13a subunit
ArrowR-HSA-156826 (Reactome)
80S ribosomeR-HSA-72673 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPArrowR-HSA-72672 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPR-HSA-72671 (Reactome)
80S:Met-tRNAi:mRNAArrowR-HSA-72671 (Reactome)
ADPArrowR-HSA-72621 (Reactome)
ADPArrowR-HSA-72647 (Reactome)
ATPArrowR-HSA-72621 (Reactome)
ATPR-HSA-72621 (Reactome)
ATPR-HSA-72647 (Reactome)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4HR-HSA-156808 (Reactome)
EIF1AXArrowR-HSA-156808 (Reactome)
EIF1AXArrowR-HSA-157849 (Reactome)
EIF1AXArrowR-HSA-72619 (Reactome)
EIF1AXArrowR-HSA-72673 (Reactome)
EIF1AXArrowR-HSA-72697 (Reactome)
EIF1AXR-HSA-156808 (Reactome)
EIF1AXR-HSA-157849 (Reactome)
EIF1AXR-HSA-72673 (Reactome)
EIF1AXR-HSA-72676 (Reactome)
EIF1AXR-HSA-72697 (Reactome)
EIF2S1:EIF2S2:EIF2S3ArrowR-HSA-72697 (Reactome)
EIF2S1:EIF2S2:EIF2S3R-HSA-72663 (Reactome)
EIF2S1:EIF2S2:EIF2S3R-HSA-72697 (Reactome)
EIF4BArrowR-HSA-72619 (Reactome)
EIF4BR-HSA-72647 (Reactome)
EIF4Bmim-catalysisR-HSA-72647 (Reactome)
EIF4EArrowR-HSA-72619 (Reactome)
EIF4EArrowR-HSA-72622 (Reactome)
EIF4EBP1ArrowR-HSA-72622 (Reactome)
EIF4ER-HSA-72631 (Reactome)
EIF4G1ArrowR-HSA-72619 (Reactome)
EIF4G1R-HSA-72631 (Reactome)
EIF4HArrowR-HSA-72619 (Reactome)
EIF4HR-HSA-72647 (Reactome)
EIF4Hmim-catalysisR-HSA-72647 (Reactome)
EIF5ArrowR-HSA-72619 (Reactome)
EIF5ArrowR-HSA-72697 (Reactome)
EIF5R-HSA-72619 (Reactome)
EIF5R-HSA-72697 (Reactome)
GDPArrowR-HSA-72722 (Reactome)
GTPArrowR-HSA-72669 (Reactome)
GTPR-HSA-72663 (Reactome)
GTPR-HSA-72722 (Reactome)
L13a kinasemim-catalysisR-HSA-156832 (Reactome)
Met-tRNAiR-HSA-72669 (Reactome)
PABPC1R-HSA-156808 (Reactome)
PiArrowR-HSA-72619 (Reactome)
PiArrowR-HSA-72621 (Reactome)
PiArrowR-HSA-72647 (Reactome)
PiArrowR-HSA-72671 (Reactome)
R-HSA-156808 (Reactome) The precise order of events leading to the circularization of poly (A) mRNA during translation initiation is unknown. Here the association of PABP with the poly (A) mRNA and the association of PABP with eIF4F are represented as occuring simultaneously after formation of the initiation complex. However, it is also possible that these interactions occur during the formation of the translation initiation complex. The binding of eIF4F to the cap and binding of PABP to the poly (A) tail, for example, may occur at the same time. In fact, the eIF4G-PABP interaction helps eIF4F to bind tighter to the cap (Borman et al. 2000.) In addition, eIF4B and eIF4H bind more transiently to the mRNA and may not be part of an initial complex in which PABP has not yet touched eIF4G.
R-HSA-156823 (Reactome) Although the mechanism through which L13a prevents translation initiation has not been determined, Mazumder et al. (2003) have described four alternatives. L13a could (1) inhibit the function of eIF4F, (2) block the recruitment of the 43S preinitiation complex, (3) prevent scanning of the 43S complex to the initiation codon, or 4) interfere with joining of the 60S ribosomal subunit.
R-HSA-156826 (Reactome) The L13a subunit of the 60s ribosome is phosphorylated about 16 hours after INF gamma induction by an unknown kinase. At this time, L13a is also released from the 60s subunit (Mazumder et al.,2003). It is unclear, however, whether phosphorylation occurs before or after the release of L13a. Here, phosphorylation is shown as occurring after release.
R-HSA-156832 (Reactome) The L13a subunit of the 60s ribosome is phosphorylated about 16 hours after INF gamma induction by an unknown kinase. At this time, L13a is also released from the 60s subunit (Mazumder et al.,2003). It is unclear, however, whether phosphorylation occurs before or after the release of L13a. Here, phosphorylation is shown as occurring after release.
R-HSA-157849 (Reactome) The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.
R-HSA-72619 (Reactome) Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA.
R-HSA-72621 (Reactome) The mRNA-bound ribosomal complex moves along the 5'-untranslated region (5'-UTR) of the mRNA from its initial site to the initiation codon to form a 48S complex, in which the initiation codon (AUG) is base paired to the anticodon of the Met-tRNAi. It is not known whether eIF4A (or another ATPase, such as DED1) facilitates scanning by melting mRNA secondary structures or by actively propelling the ribosome.
R-HSA-72622 (Reactome) eIF4E gets released from the inactive eIF4E:4EBP complex.
R-HSA-72631 (Reactome) eIF4A interacts with eIF4G, and eIF4E interacts with the amino-terminal domain of eIF4G to form the cap-binding complex eIF4F.
R-HSA-72635 (Reactome) The factor eIF4E within the eIF4F (cap-binding) complex directly binds the 5'-cap on eukaryotic mRNAs. Note that the mRNA is in complex with cytoplasmic proteins constituting an mRNP complex.
R-HSA-72647 (Reactome) The DEAD-box RNA helicase eIF4A, together with the RNA-binding proteins eIF4B or eIF4H, is thought to unwind RNA secondary structures near the 5'-end of the mRNA and in the presence of ATP.
R-HSA-72663 (Reactome) Activation of eIF2 through direct binding of GTP.
R-HSA-72669 (Reactome) The ternary complex forms upon binding of the initiator methionyl-tRNA to the active eIF2:GTP complex.
R-HSA-72670 (Reactome) Inactive eIF2:GDP binds eIF2B to form an eIF2:GDP:eIF2B intermediate.
R-HSA-72671 (Reactome) Once the 60S subunit joins the translation initiation complex, eIF5B hydrolyzes its GTP and is released from the now 80S monosome. The fully assembled 80s ribosome is now ready to start elongation of the polypeptide chain.
R-HSA-72672 (Reactome) Joining of the 60S subunit to form the 80S ribosome is catalyzed by the presence of GTP-bound eIF5B.
R-HSA-72673 (Reactome) 80S monosomes dissociate into 40S and 60S ribosomal subunits. eIF1A promotes this dissociation.
R-HSA-72676 (Reactome) eIF3 and eIF1A bind to the 40S ribosomal subunit.
R-HSA-72691 (Reactome) The ternary complex (Met-tRNAi:eIF2:GTP) binds to the complex formed by the 40S subunit, eIF3 and eIF1A, to form the 43S complex. eIF1A promotes binding of the ternary complex to the 40S subunit within 43S. The initiator methionyl-tRNA from the ternary complex is positioned at the ribosomal P site.
R-HSA-72697 (Reactome) The AUG initiation codon in the mRNA is recognized by base pairing with the anticodon of the Met-tRNAi. This reaction requires eIF1, eIF1A, eIF2 and eIF5.
R-HSA-72722 (Reactome) eIF2B is a guanine nucleotide releasing factor that is required to cause GDP release so that a new GTP molecule can bind and activate eIF2, so that it can be reused.
RNA-binding protein

in RNP (ribonucleoprotein)

complexes
ArrowR-HSA-72647 (Reactome)
RPL13AArrowR-HSA-156826 (Reactome)
RPL13AR-HSA-156832 (Reactome)
eIF1ArrowR-HSA-72697 (Reactome)
eIF1R-HSA-72619 (Reactome)
eIF1R-HSA-72697 (Reactome)
eIF1mim-catalysisR-HSA-72621 (Reactome)
eIF1mim-catalysisR-HSA-72697 (Reactome)
eIF2:GDP: eIF2BArrowR-HSA-72670 (Reactome)
eIF2:GDP: eIF2BR-HSA-72722 (Reactome)
eIF2:GDPArrowR-HSA-72619 (Reactome)
eIF2:GDPR-HSA-72670 (Reactome)
eIF2:GTPArrowR-HSA-72663 (Reactome)
eIF2:GTPArrowR-HSA-72722 (Reactome)
eIF2:GTPR-HSA-72669 (Reactome)
eIF2B subunits complexArrowR-HSA-72722 (Reactome)
eIF2B subunits complexR-HSA-72670 (Reactome)
eIF2B subunits complexmim-catalysisR-HSA-72722 (Reactome)
eIF3 subunits complexArrowR-HSA-72619 (Reactome)
eIF3 subunits complexR-HSA-72676 (Reactome)
eIF4A subunits complexArrowR-HSA-72619 (Reactome)
eIF4A subunits complexArrowR-HSA-72647 (Reactome)
eIF4A subunits complexR-HSA-72631 (Reactome)
eIF4A subunits complexR-HSA-72647 (Reactome)
eIF4A subunits complexmim-catalysisR-HSA-72647 (Reactome)
eIF4E:4E-BPR-HSA-72622 (Reactome)
eIF4F:mRNPArrowR-HSA-72635 (Reactome)
eIF4F:mRNPR-HSA-72647 (Reactome)
eIF4FArrowR-HSA-72631 (Reactome)
eIF4FR-HSA-72635 (Reactome)
eIF5B:GDPArrowR-HSA-72671 (Reactome)
eIF5B:GTPR-HSA-72672 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HArrowR-HSA-72647 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HR-HSA-157849 (Reactome)
mRNPR-HSA-72635 (Reactome)
p-RPL13AArrowR-HSA-156832 (Reactome)
p-RPL13AR-HSA-156823 (Reactome)
phospho-L13a

associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation

initiation complex
ArrowR-HSA-156823 (Reactome)
ternary complexArrowR-HSA-72669 (Reactome)
ternary complexR-HSA-72691 (Reactome)

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