Ciliary landscape (Homo sapiens)

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1complex 53complex 7Basal bodycomplex 28complex FOX/RFXcomplex 9IFT-AAxonemeBBSomeDynein-1Proteasomecomplex 5complex 3IQ/CALM1complex 44MAK/ICK/KIAA0556complex 21complex 31complex 47TUBG/NMEMCMANKS/NEKU5-snRNPcomplex 49HSF1/HSPA1L/MAPRE2U4/U6-snRNPNOTcomplex 15TRAPPARL/NPHP/UNC119complex 39complex 5COP9 signalosomecomplex 16complex 19complex 26Exosomecomplex 12complex 29NucleusIFT-B1GIDCell membraneCiliumTransition zoneWNK1IFT122CREBBPIFT43EFTUD2TTC8TFAP2EIFT20IFT140COPS1MCM10DCAF7EHBP1NUP133IFT81COPS6COPS2UQCC1USH1CDGKEHDAC2ERFIFT57NUP88ARL8BCAMK2AMFAP1CEP97RAB3IL1MCM9H3F3AMCM8CCDC40DYNLL1RAB21RAB2AARHGDIAACSL3TFAP2DCDR2DVL3ARFGAP3RBM14CLTCD2BP2CNOT6LMKS1MCM2NINLSNAP29NUDCIFT27GDI1COPS7ASNRPB2AIMP1EXOC8WEE1CTBP2CLUAP1POM121RQCD1CDH23TMED1LSM4RB1BBS9TSSC1MCM6TFAP2BECHS1CTNNB1NME8COPS3COPS4APCDYNLL2TNKS1BP1CBSNDUFA5CEP170RPGRCTSAMCM5LZTFL1RAB14LCA5RHBDD2TFAP2CCNOT1CNOT10COPS7BDNPEPIFT52IFT74HDAC1NDUFA9VPS4ASPATA7MCM3COPS8RABEP2BBIP1IFT46SSNA1TFAP2AGLAYAP1COPS5MSH2UBE2D2EXOSC9NFKB1MCM4MCM7DCAF11Cytosolcomplex 46IFT-B1IFT88IFT80IFT172IFT-B2DynactinDynein-2IFT-B2IFT22TTC30BTTC30ATTC26HSPB11CLUAP1TRAF3IP1EXOC6BEXOC6EXOC7EXOC5EXOC2EXOC3EXOC1EXOC4exocyst-2exocyst-1EXOC2EXOC3EXOC1EXOC6BEXOC6EXOC7EXOC5EXOC4RALBBBSomeBBS1BBS2BBS5BBS4BBS7TCTEX1D2PAFAH1B1DYNLRB2DYNLRB1MAPRE2Dynein-1WDR60DYNLT1WDR34DYNLT3TIPRLTCTEX1D2DYNLT3DYNC1H1DYNLT1PAFAH1B1DYNC1I2DYNC1LI1Dynein-2WHRNVIMZYG11BGLB1NEFLNEFMXPNPEP3NEFGID4ARMC8RANBP9RMND5BRANBP10MAEAMKLN1GID8LCN2WDR26YPEL5EFHC2PGRMC2UBE2HRMND5AHTRA2DDX5ZMYND19RAB8AANKS6ANKS3NEK7NEK8MYL6TBC1D4CEP290IQGAP2CALM1LRPPRCIQCB1IQGAP3IQGAP1COX6CSTOMMYL6BRAC1EIF5BEXOSC2EXOSC4EXOSC7ExosomeTCEB2 PSMD13EHD3AAR2DOCK5FUZPSMD8APMAPSMC4AGPAT2PSMD7AFG3L2RNGTTPSMC6PSMD12VAPBINTUPSMC4


Description

Ciliary landscape pathway - according to Boldt et al. 2016 - was constructed using the results of affinity proteomics for 217 proteins with known or suspected involvement in ciliary function, resulting in a landscape of 1319 proteins and 4905 interactions of which the most important are shown here (derived from Figure 1). Ciliary function is impaired in a wide spectrum of diseases (ciliopathies) including polycystic kidney disease, Usher syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Jeune syndrome.

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Ontology Terms

 

Bibliography

  1. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R; ''An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.''; Nat Commun, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134800view02:56, 27 July 2024EweitzOntology Term : 'Meckel syndrome' added !
134799view02:55, 27 July 2024EweitzOntology Term : 'Bardet-Biedl syndrome' added !
134798view02:55, 27 July 2024EweitzOntology Term : 'Usher syndrome' added !
134797view02:55, 27 July 2024EweitzOntology Term : 'polycystic kidney disease' added !
102218view20:44, 11 December 2018Khanspersfixed unconnected interactions
98719view14:32, 1 October 2018FehrhartProteasome
98718view14:20, 1 October 2018FehrhartIQ/GAP
98717view14:07, 1 October 2018FehrhartGID
98716view13:45, 1 October 2018FehrhartNEF
98715view13:21, 1 October 2018Fehrhartadded BBSome and dynein complexes
98714view12:52, 1 October 2018Fehrhartadded complexes IFTB1 and B2
98599view14:12, 20 September 2018FehrhartModified description
98598view14:06, 20 September 2018FehrhartOntology Term : 'ciliopathy' added !
98597view14:05, 20 September 2018FehrhartOntology Term : 'transport pathway' added !
98596view13:56, 20 September 2018FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AAR2GeneProductENSG00000131043 (Ensembl)
ACSL3GeneProductENSG00000123983 (Ensembl)
AFG3L2GeneProductENSG00000141385 (Ensembl)
AGPAT2GeneProductENSG00000169692 (Ensembl)
AIMP1GeneProductENSG00000164022 (Ensembl)
ANKS3GeneProductENSG00000168096 (Ensembl)
ANKS6GeneProductENSG00000165138 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
APMAPGeneProductENSG00000101474 (Ensembl) no annotation found yet
ARFGAP3GeneProduct26286 (Entrez Gene)
ARHGDIAGeneProductENSG00000141522 (Ensembl)
ARL8BGeneProductENSG00000134108 (Ensembl)
ARMC8GeneProductENSG00000114098 (Ensembl)
BBIP1GeneProductENSG00000214413 (Ensembl)
BBS1GeneProductENSG00000174483 (Ensembl)
BBS2GeneProductENSG00000125124 (Ensembl)
BBS4GeneProductENSG00000140463 (Ensembl)
BBS5GeneProductENSG00000163093 (Ensembl)
BBS7GeneProductENSG00000138686 (Ensembl)
BBS9GeneProductENSG00000122507 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CBSGeneProductENSG00000160200 (Ensembl)
CCDC40GeneProductENSG00000141519 (Ensembl)
CD2BP2GeneProductENSG00000169217 (Ensembl)
CDH23GeneProductENSG00000107736 (Ensembl)
CDR2GeneProductENSG00000140743 (Ensembl)
CEP170GeneProductENSG00000143702 (Ensembl)
CEP290GeneProductENSG00000198707 (Ensembl)
CEP97GeneProductENSG00000182504 (Ensembl)
CLTGeneProductno idea what that should be
CLUAP1GeneProductENSG00000103351 (Ensembl)
CNOT10GeneProductENSG00000182973 (Ensembl)
CNOT1GeneProductENSG00000125107 (Ensembl)
CNOT6LGeneProductENSG00000138767 (Ensembl)
COPS1GeneProductno annotation found yet
COPS2GeneProductENSG00000166200 (Ensembl)
COPS3GeneProductENSG00000141030 (Ensembl)
COPS4GeneProductENSG00000138663 (Ensembl)
COPS5GeneProductCOPS5 (HGNC)
COPS6GeneProductENSG00000168090 (Ensembl)
COPS7AGeneProductENSG00000111652 (Ensembl)
COPS7BGeneProductENSG00000144524 (Ensembl)
COPS8GeneProductENSG00000198612 (Ensembl)
COX6CGeneProductENSG00000164919 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTSAGeneProductENSG00000064601 (Ensembl)
DCAF11GeneProductENSG00000100897 (Ensembl)
DCAF7GeneProductENSG00000136485 (Ensembl)
DDX5GeneProductENSG00000108654 (Ensembl)
DGKEGeneProductENSG00000153933 (Ensembl)
DNPEPGeneProductENSG00000123992 (Ensembl)
DOCK5GeneProductENSG00000147459 (Ensembl)
DVL3GeneProductENSG00000161202 (Ensembl)
DYNC1H1GeneProductENSG00000197102 (Ensembl)
DYNC1I2GeneProductENSG00000077380 (Ensembl)
DYNC1LI1GeneProductENSG00000144635 (Ensembl)
DYNLL1GeneProductENSG00000088986 (Ensembl)
DYNLL2GeneProductENSG00000264364 (Ensembl)
DYNLRB1GeneProductENSG00000125971 (Ensembl)
DYNLRB2GeneProductENSG00000168589 (Ensembl)
DYNLT1GeneProductENSG00000146425 (Ensembl)
DYNLT3GeneProductENSG00000165169 (Ensembl)
ECHS1GeneProductENSG00000127884 (Ensembl)
EFHC2GeneProductENSG00000183690 (Ensembl)
EFTUD2GeneProductENSG00000108883 (Ensembl)
EHBP1GeneProductENSG00000115504 (Ensembl)
EHD3GeneProductENSG00000013016 (Ensembl)
EIF5BGeneProductENSG00000158417 (Ensembl)
ERFGeneProductENSG00000105722 (Ensembl)
EXOC1GeneProductENSG00000090989 (Ensembl)
EXOC2GeneProductENSG00000112685 (Ensembl)
EXOC3GeneProductENSG00000180104 (Ensembl)
EXOC4GeneProductENSG00000131558 (Ensembl)
EXOC5GeneProductENSG00000070367 (Ensembl)
EXOC6BGeneProductENSG00000144036 (Ensembl)
EXOC6GeneProductENSG00000138190 (Ensembl)
EXOC7GeneProductENSG00000182473 (Ensembl)
EXOC8GeneProductENSG00000116903 (Ensembl)
EXOSC2GeneProductENSG00000130713 (Ensembl)
EXOSC4GeneProductENSG00000178896 (Ensembl)
EXOSC7GeneProductENSG00000075914 (Ensembl)
EXOSC9GeneProductENSG00000123737 (Ensembl)
FUZGeneProductENSG00000010361 (Ensembl)
GDI1GeneProductENSG00000203879 (Ensembl)
GID4GeneProductENSG00000141034 (Ensembl)
GID8GeneProductENSG00000101193 (Ensembl)
GLAGeneProductENSG00000102393 (Ensembl)
GLB1GeneProductENSG00000170266 (Ensembl)
H3F3AGeneProductENSG00000163041 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
HSPB11GeneProductENSG00000081870 (Ensembl)
HTRA2GeneProductENSG00000115317 (Ensembl)
IFT122GeneProductENSG00000163913 (Ensembl)
IFT140GeneProductENSG00000187535 (Ensembl)
IFT172GeneProductENSG00000138002 (Ensembl)
IFT20GeneProductENSG00000109083 (Ensembl)
IFT22GeneProductENSG00000128581 (Ensembl)
IFT27GeneProductENSG00000100360 (Ensembl)
IFT43GeneProductENSG00000119650 (Ensembl)
IFT46GeneProductENSG00000118096 (Ensembl)
IFT52GeneProductENSG00000101052 (Ensembl)
IFT57GeneProductENSG00000114446 (Ensembl)
IFT74GeneProductENSG00000096872 (Ensembl)
IFT80GeneProductENSG00000068885 (Ensembl)
IFT81GeneProductENSG00000122970 (Ensembl)
IFT88GeneProductENSG00000032742 (Ensembl)
INTUGeneProductENSG00000164066 (Ensembl) no annotation found yet
IQCB1GeneProductENSG00000173226 (Ensembl)
IQGAP1GeneProductENSG00000140575 (Ensembl)
IQGAP2GeneProductENSG00000145703 (Ensembl)
IQGAP3GeneProductENSG00000183856 (Ensembl)
LCA5GeneProductENSG00000135338 (Ensembl)
LCN2GeneProductENSG00000148346 (Ensembl)
LRPPRCGeneProductENSG00000138095 (Ensembl)
LSM4GeneProductENSG00000130520 (Ensembl)
LZTFL1GeneProductENSG00000163818 (Ensembl)
MAEAGeneProductENSG00000090316 (Ensembl)
MAPRE2GeneProductENSG00000166974 (Ensembl)
MCM10GeneProductENSG00000065328 (Ensembl)
MCM2GeneProductENSG00000073111 (Ensembl)
MCM3GeneProductENSG00000112118 (Ensembl)
MCM4GeneProductENSG00000104738 (Ensembl)
MCM5GeneProductENSG00000100297 (Ensembl)
MCM6GeneProductENSG00000076003 (Ensembl)
MCM7GeneProductENSG00000166508 (Ensembl)
MCM8GeneProductENSG00000125885 (Ensembl)
MCM9GeneProductENSG00000111877 (Ensembl)
MFAP1GeneProductENSG00000140259 (Ensembl)
MKLN1GeneProductENSG00000128585 (Ensembl)
MKS1GeneProductENSG00000011143 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MYL6BGeneProductENSG00000196465 (Ensembl)
MYL6GeneProductENSG00000092841 (Ensembl)
NDUFA5GeneProductENSG00000128609 (Ensembl)
NDUFA9GeneProductENSG00000139180 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NEK7GeneProductENSG00000151414 (Ensembl)
NEK8GeneProductENSG00000160602 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NINLGeneProductENSG00000101004 (Ensembl)
NME8GeneProductENSG00000086288 (Ensembl)
NUDCGeneProductENSG00000090273 (Ensembl)
NUP133GeneProductENSG00000069248 (Ensembl)
NUP88GeneProductENSG00000108559 (Ensembl)
PAFAH1B1GeneProductENSG00000007168 (Ensembl)
PGRMC2GeneProductENSG00000164040 (Ensembl)
POM121GeneProductENSG00000196313 (Ensembl)
PSMC4GeneProductENSG00000013275 (Ensembl)
PSMC6GeneProductENSG00000100519 (Ensembl)
PSMD12GeneProductENSG00000197170 (Ensembl)
PSMD13GeneProductENSG00000185627 (Ensembl)
PSMD7GeneProductENSG00000103035 (Ensembl)
PSMD8GeneProductENSG00000099341 (Ensembl)
RAB14GeneProductENSG00000119396 (Ensembl)
RAB21GeneProductENSG00000080371 (Ensembl)
RAB2AGeneProductENSG00000104388 (Ensembl)
RAB3IL1GeneProductENSG00000167994 (Ensembl)
RAB8AGeneProductENSG00000167461 (Ensembl)
RABEP2GeneProductENSG00000177548 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RALBGeneProductENSG00000144118 (Ensembl)
RANBP10GeneProductENSG00000141084 (Ensembl)
RANBP9GeneProductENSG00000010017 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RBM14GeneProductENSG00000239306 (Ensembl)
RHBDD2GeneProductENSG00000005486 (Ensembl)
RMND5AGeneProductENSG00000153561 (Ensembl)
RMND5BGeneProductENSG00000145916 (Ensembl)
RNGTTGeneProductENSG00000111880 (Ensembl)
RPGRGeneProductENSG00000156313 (Ensembl)
RQCD1ProteinD5MQE1 (Uniprot-TrEMBL)
SMC4GeneProductENSG00000113810 (Ensembl)
SNAP29GeneProductENSG00000099940 (Ensembl)
SNRPB2GeneProductENSG00000125870 (Ensembl)
SPATA7GeneProductENSG00000042317 (Ensembl)
SSNA1GeneProductENSG00000176101 (Ensembl)
STOMGeneProductENSG00000148175 (Ensembl)
TBC1D4GeneProductENSG00000136111 (Ensembl)
TCEB2 GeneProductENSG00000138663 (Ensembl)
TCTEX1D2GeneProductENSG00000213123 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TFAP2BGeneProductENSG00000008196 (Ensembl)
TFAP2CGeneProductENSG00000087510 (Ensembl)
TFAP2DGeneProductENSG00000008197 (Ensembl)
TFAP2EGeneProductENSG00000116819 (Ensembl)
TIPRLGeneProductENSG00000143155 (Ensembl)
TMED1GeneProductENSG00000099203 (Ensembl)
TNKS1BP1GeneProductENSG00000149115 (Ensembl)
TRAF3IP1GeneProductENSG00000204104 (Ensembl)
TSSC1GeneProductENSG00000032389 (Ensembl)
TTC26GeneProductENSG00000105948 (Ensembl)
TTC30AGeneProductENSG00000197557 (Ensembl)
TTC30BGeneProductENSG00000196659 (Ensembl)
TTC8GeneProductENSG00000165533 (Ensembl)
UBE2D2GeneProductENSG00000131508 (Ensembl)
UBE2HGeneProductENSG00000186591 (Ensembl)
UQCC1GeneProductENSG00000101019 (Ensembl)
USH1CGeneProductENSG00000006611 (Ensembl)
VAPBGeneProductENSG00000124164 (Ensembl)
VIMGeneProductENSG00000026025 (Ensembl)
VPS4AGeneProductENSG00000132612 (Ensembl)
WDR26GeneProductENSG00000162923 (Ensembl)
WDR34GeneProductENSG00000119333 (Ensembl)
WDR60GeneProductENSG00000126870 (Ensembl)
WEE1GeneProductENSG00000166483 (Ensembl)
WHRNGeneProductENSG00000095397 (Ensembl)
WNK1GeneProductENSG00000060237 (Ensembl)
XPNPEP3GeneProductENSG00000196236 (Ensembl)
YAP1GeneProductENSG00000137693 (Ensembl)
YPEL5GeneProductENSG00000119801 (Ensembl)
ZMYND19GeneProductENSG00000165724 (Ensembl)
ZYG11BGeneProductENSG00000162378 (Ensembl)

Annotated Interactions

No annotated interactions

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