Suppression of HMGB1-mediated inflammation by THBD (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none InflammationProteolytic cleavageTHBDHMGB1RAGENFkBHMGB1THBDHMGB1Name: Supression of HMGB1 mediated inflammation by THBDOrganism: Homo sapiens


Description

THBD inhibition of HMGB1 mediated pro-inflammatory pathway via proteolytic cleavage of HMGB1.

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Quality Tags

Image:Unconnected.pngFix interactions
Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Li YH, Kuo CH, Shi GY, Wu HL; ''The role of thrombomodulin lectin-like domain in inflammation.''; J Biomed Sci, 2012 PubMed Europe PMC Scholia
  2. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129206
Approved
view01:26, 16 March 2024EweitzModified title
129198view16:41, 15 March 2024EgonwOntology Term : 'signaling pathway' added !
121700view03:42, 26 February 2022EweitzFix graphics overlap, fix gene symbol
102253view10:41, 13 December 2018LaurentVisual aspects
102244view13:57, 12 December 2018LaurentUpdated collapse of genes due to allignment
102243view13:52, 12 December 2018LaurentUpdated pathway and visual aspects
102240view13:16, 12 December 2018LaurentUpdated visual aspects
102236view09:58, 12 December 2018Laurentchanged typo
102235view09:57, 12 December 2018LaurentModified description
102234view09:56, 12 December 2018LaurentUpdated literature reference
102233view09:54, 12 December 2018LaurentNew pathway

External references

DataNodes

Name  ↓Type  ↓Database reference  ↓Comment  ↓
HMGB1GeneProduct3146 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
RAGEGeneProduct177 (Entrez Gene)
THBDGeneProduct7056 (Entrez Gene)

Annotated Interactions

No annotated interactions

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