Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens)

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1, 2CytosolNucleusPCytokine TranscriptionT-cellsRecruitment inflammatory cellsIκKγTNF-αIκKαIκKβIκβαRELAIL6MUC1NFκB1NFκB1RELAMUC1RELANFκB1DCMacrophageIκβαPDNA


Description

Altered MUC1 glycosylation extends to its role as a promoter of chronic inflammatory conditions that lead to malignant transformation and cancer progression.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia
  2. Cascio S, Finn OJ; ''Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis.''; Biomolecules, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129205view01:24, 16 March 2024EweitzOntology Term : 'cancer pathway' added !
129204view01:24, 16 March 2024EweitzOntology Term : 'cancer' added !
129203view01:24, 16 March 2024EweitzOntology Term : 'dendritic cell' added !
129202view01:23, 16 March 2024EweitzOntology Term : 'macrophage' added !
129201view01:23, 16 March 2024EweitzOntology Term : 'T cell' added !
129199view16:42, 15 March 2024EgonwOntology Term : 'disease pathway' added !
121701view03:48, 26 February 2022EweitzFix gene symbol
117819view14:55, 22 May 2021EweitzModified title
107458view17:41, 10 October 2019KhanspersModified title
102530view01:31, 4 January 2019Khanspersconnected interactions
102254view10:46, 13 December 2018LaurentVisual aspects
102245view14:04, 12 December 2018LaurentVisual aspects
102239view13:11, 12 December 2018LaurentChanged typos
102238view13:08, 12 December 2018LaurentNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
IL6GeneProduct3569 (Entrez Gene)
IκKαGeneProduct1147 (Entrez Gene)
IκKβGeneProduct3551 (Entrez Gene)
IκKγGeneProduct8517 (Entrez Gene)
IκβαGeneProduct4792 (Entrez Gene)
MUC1GeneProduct4582 (Entrez Gene)
NFκB1GeneProduct4790 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
TNF-αGeneProduct7124 (Entrez Gene)

Annotated Interactions

No annotated interactions

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