Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none CytosolNucleusPCytokine TranscriptionT-cellsRecruitment inflammatory cellsIκKγIκKαIκKβTNF-αIκβαRELANFκB1IL6MUC1NFκB1RELAMUC1RELANFκB1DCMacrophageIκβαPDNAName: Role Altered Glycolysation of MUC1 in Tumour MicroenvironmentOrganism: Homo sapiens


Description

Altered MUC1 glycosylation extends to its role as a promoter of chronic inflammatory conditions that lead to malignant transformation and cancer progression.

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:Wplogo_31.pngCommunity: PancCanNet
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Cascio S, Finn OJ; ''Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis.''; Biomolecules, 2016 PubMed Europe PMC Scholia
  2. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137147
Approved
view23:20, 27 February 2025KhanspersModified description
136650view13:16, 18 February 2025EweitzModified description
136649view13:16, 18 February 2025EweitzOntology Term : 'neoplastic cell' added !
136648view13:14, 18 February 2025EweitzAdd more content per source
136647view13:05, 18 February 2025EweitzAdd cell type label: tumor cell
136646view13:03, 18 February 2025EweitzEconomize layout
136645view12:49, 18 February 2025EweitzModified description
136644view12:46, 18 February 2025EweitzStandardize case
136643view12:44, 18 February 2025EweitzUpgrade state node, align nodes
136642view12:38, 18 February 2025EweitzUse standard cell type name
136641view12:36, 18 February 2025EweitzEconomize layout
129205
PancCanNet
CPTAC
view01:24, 16 March 2024EweitzOntology Term : 'cancer pathway' added !
129204view01:24, 16 March 2024EweitzOntology Term : 'cancer' added !
129203view01:24, 16 March 2024EweitzOntology Term : 'dendritic cell' added !
129202view01:23, 16 March 2024EweitzOntology Term : 'macrophage' added !
129201view01:23, 16 March 2024EweitzOntology Term : 'T cell' added !
129199view16:42, 15 March 2024EgonwOntology Term : 'disease pathway' added !
121701view03:48, 26 February 2022EweitzFix gene symbol
117819view14:55, 22 May 2021EweitzModified title
107458view17:41, 10 October 2019KhanspersModified title
102530view01:31, 4 January 2019Khanspersconnected interactions
102254view10:46, 13 December 2018LaurentVisual aspects
102245view14:04, 12 December 2018LaurentVisual aspects
102239view13:11, 12 December 2018LaurentChanged typos
102238view13:08, 12 December 2018LaurentNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
IL6GeneProduct3569 (Entrez Gene)
IκKαGeneProduct1147 (Entrez Gene)
IκKβGeneProduct3551 (Entrez Gene)
IκKγGeneProduct8517 (Entrez Gene)
IκβαGeneProduct4792 (Entrez Gene)
MUC1GeneProduct4582 (Entrez Gene)
NFκB1GeneProduct4790 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
TNF-αGeneProduct7124 (Entrez Gene)

Annotated Interactions

No annotated interactions

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