Thermogenesis (Homo sapiens)

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Brown or beige adipocyteLipid dropletNucleusmTORC1Low AMP/ATPSecretedHypothalamic AMPKSympathetic nervous systemComplexesI II III IVHeatKDM1Afatty acidArachidonylethanolamideADPDGRHEBGCG3,3',5'-TriiodothyronineSIRT6H+RPS6cAMPATF2FGF21KDM3BPPARGcGMPCoenzyme AGlycerolGNASPRDM16UCP12-ArachidonoylglycerolPRKACAAcylcarnitineRPS6KB1L-noradrenalineRPS6KA3ADRB3ZNF516TGSLC25A20RPTORNicotineACTL6BCPT2CREB3PNPLA2RPS6KA2PLIN1ACSL1RPS6KA1SLC25A29NADHPRKAG3CarnitineFADH2PRKAG2Acetyl-CoAFRS2Estradiol-17betamTOR SignalingPathwayPRKG1GRB2Electron Transport ChainARID1BMGLLRPS6KA6CPT1ABMP8AH+MAP3K5FGF21Regulation oflipolysis in adipocyteUCP1PPARGC1ATCA CyclecAMP SignalingPathwayHRASAcyl-CoAANPMGTSC1PPADCY1PPPADCY2ADCY3ADCY5ADCY6ADCY7ADCY8ADCY9ADCY4ADCY10CNR1NPR1KLBFGFR1BNPSOS1SOS2KRASNRASTSC2PMTORMLST8AKT1S1RPS6KB2PPRKG2LIPEPPRKACBPRKACGMAPK SignalingPathwayMAP2K3PMAPK14PMAPK11PMAPK13PMAPK12PCREB1CREB3L4CREB3L2CREB3L3CREB3L1CREB5KDM3AACTBSMARCA2SMARCA4SMARCB1SMARCC1SMARCC2SMARCD1SMARCD2SMARCD3SMARCE1ACTG1DPF3DPF1ARID1AACTL6AUCP1fatty acidATPAcyl-CoAAcylcarnitineCoenzyme ACarnitineH+ACSL3ACSL4ACSL5ACSL6CPT1BCPT1COxidativePhosphorylationATPaseH+H+H+H+HypothalamusColdOverfeedingPRKAA1PRKAA2PRKAB1PRKAB2PRKAG1EndocannabinoidsBMP8B


Description

Thermogenesis is an essential process of heat production in warm-blooded animals and some plants.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Rosenbaum M, Leibel RL; ''Adaptive thermogenesis in humans.''; Int J Obes (Lond), 2010 PubMed Europe PMC Scholia
  2. Ricquier D; ''Fundamental mechanisms of thermogenesis.''; C R Biol, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142392view04:59, 2 February 2026EgonwAdded two literature references
142391view04:56, 2 February 2026Egonwmim-translocation
140659view06:04, 29 September 2025EgonwH⁺ with unicode
134818view11:38, 27 July 2024EweitzFix truncated labels, standardize case
123362view05:01, 18 July 2022EgonwMade a few pathways clickable
106178view12:07, 16 August 2019MaintBotHMDB identifier normalization
102774view08:51, 24 January 2019EgonwMissed one.
102772view21:11, 23 January 2019EgonwFixed the casing of two ChEBI identifiers (prefix should be CHEBI: instead of ChEBI:)
98055view06:12, 13 July 2018Fehrhartadded ID for MAPK signaling pathway
98002view10:12, 30 June 2018EgonwAdded an identifier for endocannabinoids.
98001view09:22, 30 June 2018EgonwI missed one :(
98000view08:15, 30 June 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97999view20:05, 29 June 2018KhanspersOntology Term : 'electron transport chain pathway' added !
97998view20:04, 29 June 2018KhanspersOntology Term : 'brown fat cell' added !
97997view20:04, 29 June 2018KhanspersOntology Term : 'beige adipocyte' added !
97996view20:03, 29 June 2018KhanspersAdded endocannabinoids etc
97995view19:43, 29 June 2018Khansperswork in progress
97994view19:24, 29 June 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-ArachidonoylglycerolMetaboliteCHEBI:52392 (ChEBI)
3,3',5'-TriiodothyronineMetaboliteCHEBI:11684 (ChEBI)
ACSL1GeneProductENSG00000151726 (Ensembl)
ACSL3GeneProductENSG00000123983 (Ensembl)
ACSL4GeneProductENSG00000068366 (Ensembl)
ACSL5GeneProductENSG00000197142 (Ensembl)
ACSL6GeneProductENSG00000164398 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTL6AGeneProductENSG00000136518 (Ensembl)
ACTL6BGeneProductENSG00000077080 (Ensembl)
ADCY10GeneProductENSG00000143199 (Ensembl)
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY2GeneProduct108 (Entrez Gene)
ADCY3GeneProduct109 (Entrez Gene)
ADCY4GeneProductENSG00000129467 (Ensembl)
ADCY5GeneProductENSG00000173175 (Ensembl)
ADCY6GeneProductENSG00000174233 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADCY8GeneProductENSG00000155897 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
ADPMetaboliteCHEBI:16761 (ChEBI)
ADRB3GeneProductENSG00000188778 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
ANPMetaboliteCHEBI:80233 (ChEBI)
ARID1AGeneProductENSG00000117713 (Ensembl)
ARID1BGeneProductENSG00000049618 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATPMetaboliteCHEBI:15422 (ChEBI)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Acyl-CoAMetaboliteCHEBI:17984 (ChEBI)
AcylcarnitineMetaboliteCHEBI:75659 (ChEBI)
AcylcarnitineMetaboliteChEBI:75659 (ChEBI)
ArachidonylethanolamideMetaboliteCHEBI:2700 (ChEBI)
BMP8AGeneProductENSG00000183682 (Ensembl)
BMP8BGeneProductENSG00000116985 (Ensembl)
BNPMetaboliteCHEBI:80234 (ChEBI)
CNR1GeneProductENSG00000118432 (Ensembl)
CPT1AGeneProductENSG00000110090 (Ensembl)
CPT1BGeneProductENSG00000205560 (Ensembl)
CPT1CGeneProductENSG00000169169 (Ensembl)
CPT2GeneProductENSG00000157184 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CREB3GeneProductENSG00000107175 (Ensembl)
CREB3L1GeneProduct90993 (Entrez Gene)
CREB3L2GeneProductENSG00000182158 (Ensembl)
CREB3L3GeneProductENSG00000060566 (Ensembl)
CREB3L4GeneProductENSG00000143578 (Ensembl)
CREB5GeneProductENSG00000146592 (Ensembl)
CarnitineMetaboliteCHEBI:3424 (ChEBI)
Coenzyme AMetaboliteCHEBI:15346 (ChEBI)
DGMetaboliteCHEBI:18035 (ChEBI)
DPF1GeneProductENSG00000011332 (Ensembl)
DPF3GeneProductENSG00000205683 (Ensembl)
Electron Transport ChainPathwayWP111 (WikiPathways)
EndocannabinoidsMetaboliteQ55282178 (Wikidata)
Estradiol-17betaMetaboliteCHEBI:16469 (ChEBI)
FADH2MetaboliteCHEBI:17877 (ChEBI)
FGF21GeneProductENSG00000105550 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FRS2GeneProductENSG00000166225 (Ensembl)
GCGGeneProductENSG00000115263 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GlycerolMetaboliteCHEBI:17754 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
HRASGeneProductENSG00000174775 (Ensembl)
KDM1AGeneProductENSG00000004487 (Ensembl)
KDM3AGeneProductENSG00000115548 (Ensembl)
KDM3BGeneProductENSG00000120733 (Ensembl)
KLBGeneProductENSG00000134962 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
L-noradrenalineMetaboliteCHEBI:18357 (ChEBI)
LIPEGeneProductENSG00000079435 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MGMetaboliteCHEBI:35759 (ChEBI)
MGLLGeneProductENSG00000074416 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NADHMetaboliteCHEBI:16908 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
NicotineMetaboliteCHEBI:17688 (ChEBI)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
PLIN1GeneProductENSG00000166819 (Ensembl)
PNPLA2GeneProductENSG00000177666 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRDM16GeneProductENSG00000142611 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRKG1GeneProductENSG00000185532 (Ensembl)
PRKG2GeneProductENSG00000138669 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPS6GeneProductENSG00000137154 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl)
RPS6KA2GeneProductENSG00000071242 (Ensembl)
RPS6KA3GeneProductENSG00000177189 (Ensembl)
RPS6KA6GeneProductENSG00000072133 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPS6KB2GeneProductENSG00000175634 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
Regulation of

lipolysis in

adipocyte		Pathway
SIRT6GeneProductENSG00000077463 (Ensembl)
SLC25A20GeneProductENSG00000178537 (Ensembl)
SLC25A29GeneProductENSG00000197119 (Ensembl)
SMARCA2GeneProductENSG00000080503 (Ensembl)
SMARCA4GeneProductENSG00000127616 (Ensembl)
SMARCB1GeneProductENSG00000099956 (Ensembl)
SMARCC1GeneProductENSG00000173473 (Ensembl)
SMARCC2GeneProductENSG00000139613 (Ensembl)
SMARCD1GeneProductENSG00000066117 (Ensembl)
SMARCD2GeneProductENSG00000108604 (Ensembl)
SMARCD3GeneProductENSG00000082014 (Ensembl)
SMARCE1GeneProductENSG00000073584 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCA CyclePathwayWP78 (WikiPathways)
TGMetaboliteCHEBI:75844 (ChEBI)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
UCP1GeneProductENSG00000109424 (Ensembl)
ZNF516GeneProductENSG00000101493 (Ensembl)
cAMP Signaling PathwayPathway
cAMPMetaboliteCHEBI:17489 (ChEBI)
cGMPMetaboliteCHEBI:16356 (ChEBI)
fatty acidMetaboliteCHEBI:35366 (ChEBI)
mTOR Signaling PathwayPathwayWP1471 (WikiPathways)

Annotated Interactions

No annotated interactions

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