Synaptic signaling associated with autism spectrum disorder (Homo sapiens)
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Description
Synaptic signaling pathways associated with autism spectrum disorder (ASD).
Changes in mTOR activation is believed to be a risk factor for ASD. mTOR is regulated by the TCS1/2 complex, and several signaling pathways upstream of TSC1/2 positively or negatively regulate this complex, including PI3K–AKT, Ras–ERK, LKB1–AMPK and Wnt–GSK3β pathways.
Quality Tags
Ontology Terms
Saving...Bibliography
- Daghsni M, Rima M, Fajloun Z, Ronjat M, Brusés JL, M'rad R, De Waard M; ''Autism throughout genetics: Perusal of the implication of ion channels.''; Brain Behav, 2018 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AKT1 | GeneProduct | 207 (Entrez Gene)  | Akt |
| AKT2 | GeneProduct | 208 (Entrez Gene) | Akt |
| AKT3 | GeneProduct | 10000 (Entrez Gene) | Akt |
| ARC | GeneProduct | 23237 (Entrez Gene) | ARC |
| BDNF | GeneProduct | 627 (Entrez Gene) | BDNF |
| CACNA1C | GeneProduct | 775 (Entrez Gene) | CACNA1C |
| CAMK2B | GeneProduct | 816 (Entrez Gene) | CaMKII |
| CAMK4 | GeneProduct | ENSG00000152495 (Ensembl) | CaMKII |
| DLG4 | GeneProduct | 1742 (Entrez Gene) | PSD95 |
| EIF4EBP1 | GeneProduct | ENSG00000187840 (Ensembl) | |
| GDP | Metabolite | CHEBI:5212 (ChEBI) | |
| GRIN1 | GeneProduct | 2902 (Entrez Gene) | NMDAR |
| GRIN2A | GeneProduct | 2903 (Entrez Gene) | NMDAR |
| GRIN2B | GeneProduct | 2904 (Entrez Gene) | NMDAR |
| GRIN2C | GeneProduct | 2905 (Entrez Gene) | NMDAR |
| GRIN2D | GeneProduct | 2906 (Entrez Gene) | NMDAR |
| GRIN3A | GeneProduct | 116443 (Entrez Gene) | NMDAR |
| GRIN3B | GeneProduct | 116444 (Entrez Gene) | NMDAR |
| GRM1 | GeneProduct | 2911 (Entrez Gene) | mGluR1 |
| GSK3B | GeneProduct | ENSG00000082701 (Ensembl) | |
| GTP | Metabolite | CHEBI:42934 (ChEBI) | |
| HOMER1 | GeneProduct | 9456 (Entrez Gene) | HOMER1 |
| HRAS | GeneProduct | 3265 (Entrez Gene) | Ras |
| KRAS | GeneProduct | 3845 (Entrez Gene) | Ras |
| MAPK1 | GeneProduct | 5594 (Entrez Gene) | ErK |
| MAPK3 | GeneProduct | 5595 (Entrez Gene) | ErK |
| MTOR | GeneProduct | 2475 (Entrez Gene) | mTOR |
| NF1 | GeneProduct | 4763 (Entrez Gene) | NF1 |
| NRAS | GeneProduct | 4893 (Entrez Gene) | Ras |
| NTRK2 | GeneProduct | 4915 (Entrez Gene) | TRKB |
| PIK3CA | GeneProduct | 5290 (Entrez Gene) | PI3K |
| PIK3CB | GeneProduct | 5291 (Entrez Gene) | PI3K |
| PIK3CD | GeneProduct | 5293 (Entrez Gene) | PI3K |
| PIK3R1 | GeneProduct | ENSG00000145675 (Ensembl) | PI3K |
| PIK3R2 | GeneProduct | ENSG00000105647 (Ensembl) | PI3K |
| PIK3R3 | GeneProduct | 8503 (Entrez Gene) | PI3K |
| PRKAA1 | GeneProduct | 5562 (Entrez Gene) | AMPK |
| PRKAA2 | GeneProduct | 5563 (Entrez Gene) | AMPK |
| PRKAB1 | GeneProduct | 5564 (Entrez Gene) | AMPK |
| PRKAB2 | GeneProduct | 5565 (Entrez Gene) | AMPK |
| PRKAG1 | GeneProduct | 5571 (Entrez Gene) | AMPK |
| PRKAG2 | GeneProduct | 51422 (Entrez Gene) | AMPK |
| PRKAG3 | GeneProduct | 53632 (Entrez Gene) | AMPK |
| PTEN | GeneProduct | 5728 (Entrez Gene) | PTEN |
| RHEB | GeneProduct | 6009 (Entrez Gene) | Rheb |
| RPS6KB1 | GeneProduct | 6198 (Entrez Gene) | S6K1 |
| RPTOR | GeneProduct | 57521 (Entrez Gene) | Raptor |
| SHANK3 | GeneProduct | ENSG00000251322 (Ensembl) | HOMER1 |
| SYNGAP1 | GeneProduct | 8831 (Entrez Gene) | SYNGAP1 |
| TSC1 | GeneProduct | 7248 (Entrez Gene) | TSC1/ |
| TSC2 | GeneProduct | 7249 (Entrez Gene) | TSC2 |
| UBE3A | GeneProduct | 7337 (Entrez Gene) | UBE3A |
| ca 2+ | Metabolite | CHEBI:3308 (ChEBI) | |
| rapamycin | Metabolite | CHEBI:9168 (ChEBI) |
Annotated Interactions
No annotated interactions
