FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Diffuse large B-cell lymphomaPRC2 complexCell proliferationHistone H3H3F3AH3F3BHIST1H3DHIST1H3JHIST2H3AHIST2H3CHIST2H3DHIST1H3CHIST1H3GHIST1H3HHIST1H3AHIST1H3FHIST1H3BHIST1H3IHIST1H3EHistone 2AH2AFB1H2AFB2H2AFB3H2AFJH2AFVH2AFXH2AFYH2AFY2H2AFZMAP/ERK SignalingUbH2AMeH3MAPK1MAPK3DUSP6MAPK1MAPK3EEDEZH2SUZ12PRC2PCGF1BCORFBXL10BCL6RNF2DUSP6Non-canonical PRC1 complexName: FBXL10 enahncement of MAP/ERK signaling in Diffuse Large B-cell LymphomaOrganism: Homo sapiens


Description

first draft

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Zhao X, Wang X, Li Q, Chen W, Zhang N, Kong Y, Lv J, Cao L, Lin D, Xu G, Wu X; ''FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway.''; Cell Death Dis, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137148
Approved
view23:20, 27 February 2025KhanspersModified description
134687view00:09, 26 July 2024EweitzFix, match histone labels in condensed and expanded nodes
134686view00:06, 26 July 2024EweitzEconomize layout
134685view21:59, 25 July 2024EweitzStandardize case
134684view21:58, 25 July 2024EweitzEconomize layout
129526
CPTAC
view01:14, 9 May 2024EweitzOntology Term : 'B cell' added !
103606view22:05, 20 March 2019KhanspersModified title
103605view22:05, 20 March 2019KhanspersModified title
103593view19:19, 19 March 2019KhanspersOntology Term : 'disease of cellular proliferation' added !
103592view19:18, 19 March 2019KhanspersModified description
103591view19:17, 19 March 2019KhanspersOntology Term : 'altered extracellular signal-regulated Raf/Mek/Erk signaling pathway' added !
103590view19:17, 19 March 2019KhanspersOntology Term : 'diffuse large B-cell lymphoma' added !
103589view19:16, 19 March 2019KhanspersModified description
103588view19:14, 19 March 2019KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BCL6GeneProductENSG00000113916 (Ensembl)
BCORGeneProductENSG00000183337 (Ensembl)
DUSP6GeneProductENSG00000139318 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FBXL10GeneProductENSG00000089094 (Ensembl)
H2AGeneProduct
H2AFB1GeneProductENSG00000274183 (Ensembl)
H2AFB2GeneProductENSG00000277858 (Ensembl)
H2AFB3GeneProductENSG00000277745 (Ensembl)
H2AFJGeneProductENSG00000246705 (Ensembl)
H2AFVGeneProductENSG00000105968 (Ensembl)
H2AFXGeneProductENSG00000188486 (Ensembl)
H2AFY2GeneProductENSG00000099284 (Ensembl)
H2AFYGeneProductENSG00000113648 (Ensembl)
H2AFZGeneProductENSG00000164032 (Ensembl)
H3GeneProduct
H3F3AGeneProductENSG00000163041 (Ensembl)
H3F3BGeneProductENSG00000132475 (Ensembl)
HIST1H3AGeneProductENSG00000275714 (Ensembl)
HIST1H3BGeneProductENSG00000274267 (Ensembl)
HIST1H3CGeneProductENSG00000278272 (Ensembl)
HIST1H3DGeneProductENSG00000197409 (Ensembl)
HIST1H3EGeneProductENSG00000274750 (Ensembl)
HIST1H3FGeneProductENSG00000277775 (Ensembl)
HIST1H3GGeneProductENSG00000273983 (Ensembl)
HIST1H3HGeneProductENSG00000278828 (Ensembl)
HIST1H3IGeneProductENSG00000275379 (Ensembl)
HIST1H3JGeneProductENSG00000197153 (Ensembl)
HIST2H3AGeneProductENSG00000203852 (Ensembl)
HIST2H3CGeneProductENSG00000203811 (Ensembl)
HIST2H3DGeneProductENSG00000183598 (Ensembl)
MAP/ERK SignalingPathway
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
PCGF1GeneProductENSG00000115289 (Ensembl)
RNF2GeneProductENSG00000121481 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)

Annotated Interactions

No annotated interactions

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