Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)

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166381, 626466665NucelusColorectal epithelial cellClaudinsOther effectorsCollagensUbiquitin-mediateddegradationDegradationEpithelial-Mesenchymal TransitionHypoxiaTGFb and Ras/MAPKRBPJGDF15TMPRSS4TRAF6TWIST1pre-miR-9-2GSK3BNUBPLFMNL2CLDN1TUSC3TGFBR1MAP2K1RAF1FZD10SMAD4MAPK3MEF2DCytokeratinsMMPsSTRAPCTNNB1CDH1Tyrosine kinase receptorsNRP2COL4A1CollagenTGFB1NOTCH1HRASEIF5A2ClaudinsTP53JAG1JUPPROX1WNT16AKT1PIK3CAFOXQ1PP9-12NR2C2MAP2K3MAP2K6MAP2K4MAPK14MAPK8SHC1GRB2SOS1SOS2KRAS13, 14MAP2K2MAPK1AKT2AKT3SNAI1SNAI2NOTCH2NOTCH3NOTCH46HIF1A6JAG2DLL1DLL3DLL4DLK1CDKL2TWIST2PCDH2ZEB2FOXC2FOXM1FN1SNAI1SNAI1PPPSNAI1PCTDSP1SNAI1PPPKD1PAK1LATS2TWIST1PTWIST2PTWIST1TWIST2ZEB2SumoZEB2SumoSUZ12RBBP4EEDEZH2ZEB1677TGFBR2TGFB2TGFB3MAPK11MAPK13MAPK12SNAI1PSMAD2SMAD3DSPPKP1PKP2CRB3MPP5VTNMMP15MMP26MMP9ID1ID26CDH16ClaudinsOCLNDSPCDH2FN1VTNSPARCITGA5CDH1PKP1PKP2CRB3TJP1CDH2VTNOCLNCLDN2CLDN3CLDN4CLDN5CLDN6CLDN7CLDN8CLDN9CLDN10CLDN11CLDN12CLDN14CLDN15CLDN16CLDN17CLDN18CLDN19CLDN20CLDN22CLDN23CLDN24COL4A2COL4A3COL4A4COL4A5COL4A6WNT1WNT4WNT2WNT3WNT5AWNT6WNT7AWNT7BWNT8AWNT8BWNT10BWNT11WNT2BWNT9AWNT9BWNT10AWNT5BWNT3AWNT3AFZD2FZD5FZD3FZD1FZD4FZD6FZD7FZD8FZD9LRP5LRP6PIK3CBPIK3CDPIK3R1PIK3R2PIK3R3


Description

Epithelial to mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, and gain mesenchymal properties, such as increased motility. In colorectal cancer (CRC), EMT is associated with an invasive or metastatic phenotype. During EMT, tumor cells undergo tight junction dissolution, disruption of apical–basal polarity, and reorganization of the cytoskeletal architecture, which enable cells to develop an invasive phenotype. In cancer cells, EMT is abnormally regulated by extracellular stimuli derived from the tumor microenvironment, including growth factors and inflammatory cytokines, along with intra-tumoral physical stresses such as hypoxia. Therefore, EMT programming allows tumor cells to adapt to the constant changes of the human tumor microenvironment, and thus to successfully metastasize. This pathway summarizes the major signaling pathways and inducers that promote EMT in CRC.

A set of core transcription factors regulate EMT: SNAIL family of zinc-finger transcription factors SNAIL/SLUG; the zinc finger E-box binding homeobox (ZEB) family of transcription factors ZEB1/ZEB2, and the TWIST family of basic helix-loop-helix (bHLH) transcription factors TWIST1/TWIST2. (Adapted from Vu et al.)

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
128751view12:36, 21 February 2024EweitzUpgrade disease node
127351view18:25, 20 September 2023Khanspersupdated phospho sites
127236view20:17, 25 August 2023Khanspersadded lit ref and updated description
126531view23:07, 25 May 2023Khanspersupdated phosphorylation interaction type
118997view09:29, 8 June 2021FinterlyRemoved empty Comment
111457view23:37, 10 August 2020KhanspersAdded interaction between PDCD6 and RAF1
108129view10:28, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106393view21:28, 28 August 2019KhanspersModified description
105464view05:12, 8 August 2019KhanspersModified description
103784view20:45, 5 April 2019Khanspersunified node size and added lit refs for mutations
97604view12:00, 29 May 2018AMTanOntology Term : 'colon epithelial cell' added !
97583view22:40, 26 May 2018AlexanderPicoModified title
97138view22:02, 30 April 2018Khanspersadded cell label
97137view21:54, 30 April 2018KhanspersModified title
97006view23:30, 25 April 2018KhanspersModified title
96593view23:50, 22 March 2018KhanspersModified description
96592view23:17, 22 March 2018KhanspersOntology Term : 'disease of cellular proliferation' added !
96591view20:56, 22 March 2018KhanspersModified description
96590view20:45, 22 March 2018Khansperswork in progress
96586view16:45, 22 March 2018KhanspersOntology Term : 'colorectal cancer' added !
96585view04:27, 22 March 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDH2GeneProductENSG00000170558 (Ensembl)
CDKL2GeneProductENSG00000138769 (Ensembl)
CLDN10GeneProductENSG00000134873 (Ensembl)
CLDN11GeneProductENSG00000013297 (Ensembl)
CLDN12GeneProductENSG00000157224 (Ensembl)
CLDN14GeneProductENSG00000159261 (Ensembl)
CLDN15GeneProductENSG00000106404 (Ensembl)
CLDN16GeneProductENSG00000113946 (Ensembl)
CLDN17GeneProductENSG00000156282 (Ensembl)
CLDN18GeneProductENSG00000066405 (Ensembl)
CLDN19GeneProductENSG00000164007 (Ensembl)
CLDN1GeneProductENSG00000163347 (Ensembl)
CLDN20GeneProductENSG00000171217 (Ensembl)
CLDN22GeneProductENSG00000177300 (Ensembl)
CLDN23GeneProductENSG00000253958 (Ensembl)
CLDN24GeneProductENSG00000185758 (Ensembl)
CLDN2GeneProductENSG00000165376 (Ensembl)
CLDN3GeneProductENSG00000165215 (Ensembl)
CLDN4GeneProductENSG00000189143 (Ensembl)
CLDN5GeneProductENSG00000184113 (Ensembl)
CLDN6GeneProductENSG00000184697 (Ensembl)
CLDN7GeneProductENSG00000181885 (Ensembl)
CLDN8GeneProductENSG00000156284 (Ensembl)
CLDN9GeneProductENSG00000213937 (Ensembl)
COL4A1GeneProductENSG00000187498 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
COL4A3GeneProductENSG00000169031 (Ensembl)
COL4A4GeneProductENSG00000081052 (Ensembl)
COL4A5GeneProductENSG00000188153 (Ensembl)
COL4A6GeneProductENSG00000197565 (Ensembl)
CRB3GeneProductENSG00000130545 (Ensembl)
CTDSP1GeneProductENSG00000144579 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
ClaudinsGeneProduct
CollagenGeneProduct
CytokeratinsGeneProduct
DLK1GeneProductENSG00000185559 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DLL3GeneProductENSG00000090932 (Ensembl)
DLL4GeneProductENSG00000128917 (Ensembl)
DSPGeneProductENSG00000096696 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EIF5A2GeneProductENSG00000163577 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FMNL2GeneProductENSG00000157827 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
FOXC2GeneProductENSG00000176692 (Ensembl)
FOXM1GeneProductENSG00000111206 (Ensembl)
FOXQ1GeneProductENSG00000164379 (Ensembl)
FZD10GeneProductENSG00000111432 (Ensembl)
FZD1GeneProductENSG00000157240 (Ensembl)
FZD2GeneProductENSG00000180340 (Ensembl)
FZD3GeneProductENSG00000104290 (Ensembl)
FZD4GeneProductENSG00000174804 (Ensembl)
FZD5GeneProductENSG00000163251 (Ensembl)
FZD6GeneProductENSG00000164930 (Ensembl)
FZD7GeneProductENSG00000155760 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
FZD9GeneProductENSG00000188763 (Ensembl)
GDF15GeneProductENSG00000130513 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
ITGA5GeneProductENSG00000161638 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
JAG2GeneProductENSG00000184916 (Ensembl)
JUPGeneProductENSG00000173801 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP2K4GeneProductENSG00000065559 (Ensembl)
MAP2K6GeneProductENSG00000108984 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MEF2DGeneProductENSG00000116604 (Ensembl)
MMP15GeneProductENSG00000102996 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MMPsGeneProduct
MPP5GeneProductENSG00000072415 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
NOTCH3GeneProductENSG00000074181 (Ensembl)
NOTCH4GeneProductENSG00000204301 (Ensembl)
NR2C2GeneProductENSG00000177463 (Ensembl)
NRP2GeneProductENSG00000118257 (Ensembl)
NUBPLGeneProductENSG00000151413 (Ensembl)
OCLNGeneProductENSG00000197822 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PKD1GeneProductENSG00000008710 (Ensembl)
PKP1GeneProductENSG00000081277 (Ensembl)
PKP2GeneProductENSG00000057294 (Ensembl)
PROX1GeneProductENSG00000117707 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RBPJGeneProductENSG00000168214 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SPARCGeneProductENSG00000113140 (Ensembl)
STRAPGeneProductENSG00000023734 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TJP1GeneProductENSG00000104067 (Ensembl)
TMPRSS4GeneProductENSG00000137648 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TUSC3GeneProductENSG00000104723 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)
TWIST2GeneProductENSG00000233608 (Ensembl)
Tyrosine kinase receptorsGeneProduct
VTNGeneProductENSG00000109072 (Ensembl)
WNT10AGeneProductENSG00000135925 (Ensembl)
WNT10BGeneProductENSG00000169884 (Ensembl)
WNT11GeneProductENSG00000085741 (Ensembl)
WNT16GeneProductENSG00000002745 (Ensembl)
WNT1GeneProductENSG00000125084 (Ensembl)
WNT2BGeneProductENSG00000134245 (Ensembl)
WNT2GeneProductENSG00000105989 (Ensembl)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNT3GeneProductENSG00000108379 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WNT5AGeneProductENSG00000114251 (Ensembl)
WNT5BGeneProductENSG00000111186 (Ensembl)
WNT6GeneProductENSG00000115596 (Ensembl)
WNT7AGeneProductENSG00000154764 (Ensembl)
WNT7BGeneProductENSG00000188064 (Ensembl)
WNT8AGeneProductENSG00000061492 (Ensembl)
WNT8BGeneProductENSG00000075290 (Ensembl)
WNT9AGeneProductENSG00000143816 (Ensembl)
WNT9BGeneProductENSG00000158955 (Ensembl)
ZEB1GeneProductENSG00000148516 (Ensembl)
ZEB2GeneProductENSG00000169554 (Ensembl)
pre-miR-9-2GeneProductENSG00000284447 (Ensembl)

Annotated Interactions

No annotated interactions

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