Tryptophan metabolism (Bos taurus)

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3-Methylindolepyruvate3-Hydroxykynurenamine5-HydroxykynurenamineIsophenoxazineQuinolinate2-Oxoglutarate5-Hydroxyindoleacetylglycine5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinateN-Acetylindoxyl5-Hydroxyindolepyruvate4,8-Dihydroxyquinoline5-(2'-Formylethyl)-4,6-dihydroxypicolinateBenzoate degradation via hydroxylation4-(2-Aminophenyl)-2,4-dioxobutanoate3-Methyldioxyindole2-Aminomuconate7,8-Dihydro-7,8-dihydroxykynurenate2-AminomuconateKynurenateAnthranilateIndolepyruvate6-HydroxykynurenateFormyl-5-hydroxykynurenamine2,3-Dihydroxyindole2-OxoadipateCinnavalininate5-Methoxyindoleacetate4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate3-HydroxyanthranilateIndole-3-acetaldehydeC01144Indole-3-acetaldoxime5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolin3-(2-Aminoethyl)-1H-indol-5-olOxaloacetateIndole-3-acetateIndolelactate8-MethoxykynurenateL-Tryptophanyl-tRNA3-IndoleglycolaldehydeIndole-3-ethanolGlucobrassicinAnthranilate7,8-Dihydroxykynurenate6-Hydroxyindolelactate(Z)-5-Oxohex-2-enedioateFormylanthranilateFormyl-N-acetyl-5-methoxykynurenamine2-Amino-3-carboxymuconate2-Formaminobenzoylacetate3-Methoxyanthranilate2-Formylaminobenzaldehyde3-Hydroxy-L-kynurenine5-HydroxyindoleacetateCyp2c39ASMT2.1.1.47L-Tryptophan1.2.1.32AADATCYP3A4HRMT1L23.2.1.1471.1.1.191ABP14.1.1.432.1.1.491.13.99.3Glutaryl-CoAMDM25-Hydroxy-N-formylkynurenineMAOBGlycolysis/GluconeogenesisMAOB3.5.1.491.13.11.10FormylkynurenineALDH9A1AFMIDCyp2a2CYP7B14.2.1.841.13.11.233.5.99.55-MethoxytryptamineUBR5ALDH9A1GCDHKYNU1.13.11.171.14.13.9DDC1.1.1.1104-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoateDHCR24MAOBUBE3A6-HydroxymelatoninCYP2A13TryptamineNicotinate and nicotinamide metabolismALDH1A1UBE3AN-Acetylserotonin5-Hydroxykynurenine3.5.1.4MAOBOGDHMDM2L-KynurenineALDH1A2Phenylalanine, Tyrosine and Tryptophan metabolismDDCAcetyl-CoA1.14.16.3N-AcetylisatinXanthurenic acidAANAT1.4.3.2ALDH3A2N-MethylserotoninCyp2a1HAAOAcetoacetyl-CoA4.1.1.-CYP2E1Cyp2b15KYNUCyp2c12HSD17B101.13.11.-ACAT1CYP1A2N-Methyltryptamine3-Indoleacetonitrile4.1.99.15-(2'-Carboxyethyl)-4,6-DihydroxypicolinateIndole-3-acetamideAOX1INMTKYNU1.14.99.2CYP2F1IDO12.6.1.27CYP1A1MDM2HADHALDH2ALDH1A2CYP1B11.3.1.18CYP4F12GCDH1.1.1.190RNF252.6.1.27WARSMelatonin1.14.16.-Aldh1a41.13.12.31.7.3.2ECHS1TPH1ASMT1.2.3.74,6-DihydroxyquinolineTDO22.6.1.27DDCCYP2J2HRMT1L2RNF255-Hydroxy-L-tryptophan1.2.1.-Benzoate degradation via hydroxylationIndoleIDO11.5.1.-Crotonoyl-CoACyp2d21.10.3.4CYP19A1ACMSDIDO1ALDH1A1CAT3.5.5.13.5.1.9CYP2C185-HydroxyindoleacetaldehydeHRMT1L2Aldh1a4ALDH2AADAT2-AminophenolALDH3A2


Description

This pathway describes the metabolism of tryptophan, an essential amino acid.

Comments

GenMAPP notes 
Converted from rat to human using ortholog information. Link to original KEGG map: http://www.genome.ad.jp/dbget-bin/show pathway?rno00380
GenMAPP remarks 
Edited by Sebastien Burel
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP465(79226) with a 61.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
105983view11:51, 16 August 2019MaintBotHMDB identifier normalization
104911view19:20, 24 June 2019KhanspersModified description
104910view19:19, 24 June 2019Khanspersremoved genmapp comments
104820view12:56, 19 June 2019FehrhartModified description
97841view07:56, 10 June 2018EgonwUndo revision 97773 by [[Special:Contributions/Mick Eikelhof|Mick Eikelhof]] ([[User talk:Mick Eikelhof|Talk]])
97773view13:35, 7 June 2018Mick EikelhofModified description
85056view10:50, 10 April 2016Egonw
80880view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Z)-5-Oxohex-2-enedioateMetabolite(Z)-5-Oxohex-2-enedioate
1.1.1.110GeneProduct
1.1.1.190GeneProduct
1.1.1.191GeneProduct
1.10.3.4GeneProduct
1.13.11.-GeneProduct
1.13.11.10GeneProduct
1.13.11.17GeneProduct
1.13.11.23GeneProduct
1.13.12.3GeneProduct
1.13.99.3GeneProduct
1.14.13.9GeneProduct
1.14.16.-GeneProduct
1.14.16.3GeneProduct
1.14.99.2GeneProduct
1.2.1.-GeneProduct
1.2.1.32GeneProduct
1.2.3.7GeneProduct
1.3.1.18GeneProduct
1.4.3.2GeneProduct
1.5.1.-GeneProduct
1.7.3.2GeneProduct
2,3-DihydroxyindoleMetabolite20546 (Chemspider)
2-Amino-3-carboxymuconateMetabolite2-Amino-3-carboxymuconate
2-AminomuconateMetabolite2-Aminomuconate
2-AminophenolMetabolite95-55-6 (CAS) 2-Aminophenol
2-Formamino benzoylacetateMetabolite2-Formaminobenzoylacetate
2-FormylaminobenzaldehydeMetabolite389 (Chemspider)
2-OxoadipateMetabolite19951093 (Chemspider) 2-Oxoadipate
2-OxoglutarateMetabolite144236 (Chemspider) 2-Oxoglutarate
2.1.1.47GeneProduct
2.1.1.49GeneProduct
2.6.1.27GeneProduct
3-(2-Aminoethyl) -1H-indol-5-olMetabolite5013 (Chemspider) 3-(2-Aminoethyl)-1H-indol-5-ol
3-Hydroxy- L-kynurenineMetabolite3-Hydroxy-L-kynurenine
3-HydroxyanthranilateMetabolite7822291 (Chemspider) 3-Hydroxyanthranilate
3-HydroxykynurenamineMetabolite3-Hydroxykynurenamine
3-IndoleacetonitrileMetabolite771-51-7 (CAS) 3-Indoleacetonitrile
3-IndoleglycolaldehydeMetabolite388979 (Chemspider)
3-MethoxyanthranilateMetabolite7827589 (Chemspider) 3-Methoxyanthranilate
3-MethyldioxyindoleMetabolite
3-MethylindolepyruvateMetabolite3-Methylindolepyruvate
3.2.1.147GeneProduct
3.5.1.4GeneProduct
3.5.1.49GeneProduct
3.5.1.9GeneProduct
3.5.5.1GeneProduct
3.5.99.5GeneProduct
4,6-DihydroxyquinolineMetaboliteHMDB04077 (HMDB)
4,8-DihydroxyquinolineMetabolite389608 (Chemspider) 4,8-Dihydroxyquinoline
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoateMetaboliteHMDB04083 (HMDB)
4-(2-Amino-5-hydroxyphenyl) -2,4-dioxobutanoateMetabolite389617 (Chemspider) 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Aminophenyl)-2,4-dioxobutanoateMetabolite19951260 (Chemspider) 4-(2-Aminophenyl)-2,4-dioxobutanoate
4.1.1.-GeneProduct
4.1.1.43GeneProduct
4.1.99.1GeneProduct
4.2.1.84GeneProduct
5-(2'-Carboxyethyl)-4,6-DihydroxypicolinateMetaboliteHMDB06794 (HMDB)
5-(2'-Formylethyl)-4,6-dihydroxypicolinateMetabolite30791294 (Chemspider) 5-(2'-Formylethyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinMetabolite5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinateMetabolite30791292 (Chemspider) 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
5-Hydroxy-L-tryptophanMetaboliteHMDB00472 (HMDB)
5-Hydroxy-N-formylkynurenineMetaboliteHMDB04086 (HMDB)
5-HydroxyindoleacetaldehydeMetaboliteHMDB04073 (HMDB)
5-HydroxyindoleacetateMetabolite10637170 (Chemspider) 5-Hydroxyindoleacetate
5-HydroxyindoleacetylglycineMetabolite
5-HydroxyindolepyruvateMetabolite
5-HydroxykynurenamineMetabolite5-Hydroxykynurenamine
5-HydroxykynurenineMetabolite484-78-6 (CAS)
5-MethoxyindoleacetateMetabolite14533147 (Chemspider) 5-Methoxyindoleacetate
5-MethoxytryptamineMetabolite608-07-1 (CAS)
6-HydroxyindolelactateMetabolite6-Hydroxyindolelactate
6-HydroxykynurenateMetabolite6-Hydroxykynurenate
6-HydroxymelatoninMetabolite2208-41-5 (CAS)
7,8-Dihydro-7,8-dihydroxykynurenateMetabolite7,8-Dihydro-7,8-dihydroxykynurenate
7,8-DihydroxykynurenateMetabolite7,8-Dihydroxykynurenate
8-MethoxykynurenateMetabolite8-Methoxykynurenate
AADATGeneProductENSBTAG00000010326 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51166
AANATGeneProductENSBTAG00000014682 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:15
ABP1GeneProductENSBTAG00000005419 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26
ACAT1GeneProductENSBTAG00000012885 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:38
ACMSDGeneProductENSBTAG00000008039 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:130013
AFMIDGeneProductENSBTAG00000007125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:125061
ALDH1A1GeneProductENSBTAG00000008103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:216
ALDH1A2GeneProductENSBTAG00000010119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8854
ALDH2GeneProductENSBTAG00000008743 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:217
ALDH3A2GeneProductENSBTAG00000039161 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:224
ALDH9A1GeneProductENSBTAG00000017852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:223
AOX1GeneProductENSBTAG00000009725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:316
ASMTGeneProductENSBTAG00000047124 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:438
Acetoacetyl-CoAMetaboliteC00332 (KEGG Compound)
Acetyl-CoAMetabolite72-89-9 (CAS) Acetyl-CoA
Aldh1a4GeneProduct
AnthranilateMetabolite4573598 (Chemspider) Anthranilate
Benzoate degradation via hydroxylationPathway
C01144Metabolite(S)-3-Hydroxybutanoyl-CoA
CATGeneProductENSBTAG00000020980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:847
CYP19A1GeneProductENSBTAG00000014890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1588
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1543
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1544
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1545
CYP2A13GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1553
CYP2C18GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1562
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1571
CYP2F1GeneProductENSBTAG00000046805 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1572
CYP2J2GeneProductENSBTAG00000013693 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1573
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP4F12GeneProductENSBTAG00000038549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:66002
CYP7B1GeneProductENSBTAG00000001299 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9420
CinnavalininateMetaboliteCinnavalininate
Crotonoyl-CoAMetaboliteC00877 (KEGG Compound)
Cyp2a1GeneProduct
Cyp2a2GeneProduct
Cyp2b15GeneProduct
Cyp2c12GeneProduct
Cyp2c39GeneProduct
Cyp2d2GeneProduct
DDCGeneProductENSBTAG00000020869 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1644
DHCR24GeneProductENSBTAG00000004688 (Ensembl)
  • predicted
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1718
ECHS1GeneProductENSBTAG00000017710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1892
Formyl-5-hydroxykynurenamineMetabolite
Formyl-N-acetyl-5- methoxykynurenamineMetaboliteFormyl-N-acetyl-5-methoxykynurenamine
FormylanthranilateMetaboliteFormylanthranilate
FormylkynurenineMetabolite1022-31-7 (CAS) Formylkynurenine
GCDHGeneProductENSBTAG00000016211 (Ensembl)
  • predicted
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2639
GlucobrassicinMetaboliteGlucobrassicin
Glutaryl-CoAMetaboliteC00527 (KEGG Compound)
Glycolysis/GluconeogenesisPathwayWP534 (WikiPathways)
HAAOGeneProductENSBTAG00000004674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23498
HADHGeneProductENSBTAG00000002049 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3033
HRMT1L2GeneProductENSBTAG00000001357 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3276
HSD17B10GeneProductENSBTAG00000017779 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3028
IDO1GeneProductENSBTAG00000020602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3620
INMTGeneProductENSBTAG00000001448 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11185
Indole-3-acetaldehydeMetabolite778 (Chemspider) Indole-3-acetaldehyde
Indole-3-acetaldoximeMetabolite388896 (Chemspider) Indole-3-acetaldoxime
Indole-3-acetamideMetabolite879-37-8 (CAS) Indole-3-acetamide
Indole-3-acetateMetabolite779 (Chemspider) Indole-3-acetate
Indole-3-ethanolMetabolite10235 (Chemspider)
IndoleMetabolite120-72-9 (CAS)
IndolelactateMetabolite28571995 (Chemspider) Indolelactate
IndolepyruvateMetabolite24775813 (Chemspider) Indolepyruvate
IsophenoxazineMetaboliteIsophenoxazine
KYNUGeneProductENSBTAG00000032277 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8942
KynurenateMetabolite4-Hydroxy-2-quinolinecarboxylic
L-KynurenineMetabolite343-65-7 (CAS) L-Kynurenine
L-TryptophanMetabolite73-22-3 (CAS)
L-Tryptophanyl-tRNAMetabolite
MAOBGeneProductENSBTAG00000001288 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4129
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MelatoninMetaboliteHMDB01389 (HMDB)
N-AcetylindoxylMetaboliteN-Acetylindoxyl
N-AcetylisatinMetabolite574-17-4 (CAS) N-Acetylisatin
N-AcetylserotoninMetabolite1210-83-9 (CAS) N-Acetylserotonin
N-MethylserotoninMetaboliteHMDB04369 (HMDB)
N-MethyltryptamineMetaboliteCHEBI:28136 (ChEBI)
Nicotinate and nicotinamide metabolismPathway
OGDHGeneProductENSBTAG00000006029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4967
OxaloacetateMetabolite2509917 (Chemspider) Oxaloacetate
Phenylalanine, Tyrosine and Tryptophan metabolismPathway
QuinolinateMetabolite2777129 (Chemspider)
RNF25GeneProductENSBTAG00000003817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64320
TDO2GeneProductENSBTAG00000011062 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6999
TPH1GeneProductENSBTAG00000005343 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7166
TryptamineMetabolite61-54-1 (CAS)
UBE3AGeneProductENSBTAG00000002487 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7337
UBR5GeneProductENSBTAG00000021209 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51366
WARSGeneProductENSBTAG00000004679 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7453
Xanthurenic acidMetaboliteHMDB00881 (HMDB)

Annotated Interactions

No annotated interactions
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