Endometrial cancer (Homo sapiens)

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333133LegendEndometriumNucleus+Activating mutationCell survivalFree beta-cateninAdherens junctionPIP3dovitinibFOSp53 Signaling PathwayTrastuzumabnintedanibponatinibEGFMAPK SignalingPathwaycenersen sodiumbrivanibERBB Signaling PathwaylenvatinibEGFRGRB2SOS1SOS2HRASKRASNRASARAFBRAFRAF1MAP2K1PMAP2K2PPPMAPK1PPMAPK3PPELK1PPPPTENPIK3CAPIK3CBPIK3CDPIK3R1PIK3R2PIK3R3PDPK1ILKAKT1PAKT2PAKT3PFOXO3PBADPPPPPPCASP9PPPPI3K-Akt Signaling PathwayCDH1CTNNB1CTNNA1CTNNA2CTNNA3AXIN1AXIN2APCAPC2GSK3BCTNNB1PCTNNB1Wnt Signaling PathwayTCF7LEF1TCF7L1TCF7L2CCND1MYCCell growth and proliferationProliferationERBB22+Cell CycleUncontrolled proliferationIncreased survivalGenomic instabilityBAXCDKN1ADDB2GADD45AGADD45BGADD45GBAK1POLKDNA damageTP53Inactivating mutationFGFR2FGF1FGF2FGFR1FGFR333Amplification


Description

Endometrial cancer (EC) is the most common gynecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.

Phosphorylation information collected from PhosphoSitePlus (https://www.phosphosite.org)

This pathway is part the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. Buza N, Roque DM, Santin AD; ''HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges.''; Arch Pathol Lab Med, 2014 PubMed Europe PMC Scholia
  3. Winterhoff B, Konecny GE; ''Targeting fibroblast growth factor pathways in endometrial cancer.''; Curr Probl Cancer, 2017 PubMed Europe PMC Scholia
  4. Hipskind RA, Rao VN, Mueller CG, Reddy ES, Nordheim A; ''Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF.''; Nature, 1991 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128568view02:50, 13 February 2024EweitzStandardize metabolite color, tailor width for readability
128567view02:47, 13 February 2024EweitzFix phosphorylation site placements
128566view02:45, 13 February 2024EweitzEconomize layout
128565view02:32, 13 February 2024EweitzMitigate site-PathVisio graphics discrepancy
128564view02:30, 13 February 2024EweitzEconomize layout
128562view01:17, 13 February 2024EweitzStandardize case
127497view18:47, 11 October 2023Khanspersupdated phosphosites for CASP9
127383view19:50, 26 September 2023Khanspersupdated phospho sites
127316view23:15, 12 September 2023Khanspersupdated phospho sites
127232view20:11, 25 August 2023Khanspersadded lit ref
127186view22:07, 9 August 2023Khanspersupdate phosphosites
123347view10:41, 17 July 2022EgonwMade five pathways clickable
119086view04:58, 17 June 2021Khanspersupdated ptms
119085view00:36, 17 June 2021Khanspersupdating ptms
112038view05:55, 16 September 2020Khanspersupdated phospho sites
108106view10:17, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106779view13:25, 17 September 2019MaintBotHMDB identifier normalization
106402view21:32, 28 August 2019KhanspersModified description
105446view04:56, 8 August 2019KhanspersModified description
105335view00:08, 1 August 2019Khanspersupdated layout, added drugs
105007view04:57, 28 June 2019KhanspersModified description
103782view20:28, 5 April 2019Khanspersmoved lit ref from state to parent node
103771view01:02, 5 April 2019Khanspersupdated ERBB2 amplification status and legend
97135view21:34, 30 April 2018Khanspersupdated lit refs and added cell type
95371view16:29, 10 December 2017Khanspersadded FGFR drug targeting
95023view23:46, 1 November 2017KhanspersAdded FGFR signaling, updated signaling through ERBB2
94899view19:39, 12 October 2017Khanspersmoved comment from node to state
94811view00:45, 6 October 2017AlexanderPicoOntology Term : 'endometrial cancer pathway' added !
94810view00:44, 6 October 2017AlexanderPicoOntology Term : 'disease pathway' added !
94809view00:44, 6 October 2017AlexanderPicoUpdated layout, labels and lines connecting to non-datanodes
94800view23:25, 5 October 2017Khansperslayout change - move Type I part to the left
94778view21:23, 5 October 2017AlexanderPicoAdded 5 more FOXO3 PTMs
94777view19:49, 5 October 2017Khanspersadditional phosphosites
94776view19:42, 5 October 2017KhanspersOntology Term : 'epithelial cell of uterus' added !
94775view19:41, 5 October 2017KhanspersOntology Term : 'endometrial cancer' added !
94774view19:41, 5 October 2017KhanspersModified description
94773view19:39, 5 October 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
AXIN2GeneProductENSG00000168646 (Ensembl)
Adherens junctionPathway
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CTNNA1GeneProductENSG00000044115 (Ensembl)
CTNNA2GeneProductENSG00000066032 (Ensembl)
CTNNA3GeneProductENSG00000183230 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Cell CyclePathwayWP179 (WikiPathways)
DDB2GeneProductENSG00000134574 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
ERBB Signaling PathwayPathwayWP673 (WikiPathways)
ERBB2GeneProductENSG00000141736 (Ensembl)
FGF1GeneProductENSG00000113578 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
ILKGeneProductENSG00000166333 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PDPK1GeneProductENSG00000140992 (Ensembl)
PI3K-Akt Signaling PathwayPathwayWP3932 (WikiPathways)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteHMDB04249 (HMDB)
POLKGeneProductENSG00000122008 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TrastuzumabMetaboliteQ412616 (Wikidata)
Wnt Signaling PathwayPathwayWP428 (WikiPathways)
brivanibMetaboliteQ27075503 (Wikidata)
cenersen sodiumMetaboliteQ27275465 (Wikidata)
dovitinibMetaboliteQ27077102 (Wikidata)
lenvatinibMetaboliteCHEBI:85994 (ChEBI)
nintedanibMetaboliteCHEBI:85164 (ChEBI)
p53 Signaling PathwayPathway
ponatinibMetaboliteCHEBI:78543 (ChEBI)

Annotated Interactions

No annotated interactions

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