NRF2 pathway (Homo sapiens)

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21Growth factor and receptorsOtherTranscription FactorsTranscriptionTransportAntioxidant proteinsDegradationPhase 2 proteinsPhase 1 proteins1616161616161616LigandSLC2A1CES3ME1PRDX1GSTA1SLC2A11GPX27HGFUGT1A41FGF13BLVRBGCLCMGST3SLC7A11NFE2L2GSTA3SLC2A13ABCC2TXNABCC4SOD3SLC2A9GPX3ADH7EPHA3GSRHSP90AB1GSTT1SLC2A7SLC2A14SRXN1UGT1A7PGD1CBR1ALDH3A1CYP2A6PPARDCBR3TGFB1G6PDUGT1A6TXNRD11TGFB2ABCC3UGT1A9GSTP11CES5APTGR1GSTA5UGT1A11PRDX6HSP90AA1GGT1GSTA4NQO1DNAJB113CES1CES4ATGFAGSTT2UGT2B71SLC2A10SLC2A12GSTA2GCLMABCC5MAFFNRG1SLC2A5MGST2SERPINA1SQSTM1EGR1CES2SLC2A4SLC2A2UGT1A31SLC2A6SLC2A8FTLEPHA2HMOX1MAFGHBEGFHSPA1AKEAP1FTH1TGFBR2SLC2A3PDGFBAGERTXNRD3CYP4A11GenesTATA boxRXRALigandARENRF2 targetgenesGSTM5GSTM1GSTM2GSTM3GSTM4SLC5A2SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14NFE2L2KEAP1NFE2L2LigandNFE2L2


Description

NRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins. This pathway is part the CPTAC Assay Portal.

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Ontology Terms

 

Bibliography

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  26. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
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  32. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  33. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
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  43. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
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  47. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
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  49. Mandard S, Mueller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  50. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
106658view21:18, 12 September 2019KhanspersModified description
105659view05:16, 10 August 2019KhanspersModified description
103057view11:25, 7 February 2019SusanOntology Term : 'nuclear factor, erythroid 2 like 2 signaling pathway' added !
103022view15:44, 31 January 2019L DupuisUpdated Ensembl ID SRXN1
94787view22:51, 5 October 2017AlexanderPicoConverted lines and compacted layout
87956view13:11, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
83041view04:37, 18 November 2015Mkutmonfixed issue with literature references
83017view13:33, 17 November 2015FehrhartUpdate of outdated identifier
79992view20:05, 29 April 2015ZariCorrected Ensembl ID for SRXN1
79616view10:18, 29 March 2015EgonwConverted the 'ligand' labels to DataNode's and gave them ChEBI IDs.
79604view06:12, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79559view13:27, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79518view09:36, 24 March 2015Riannefijtenadded reference
79483view13:02, 23 March 2015Riannefijtenconnected more unconnected lines
79482view13:00, 23 March 2015Riannefijtenchanged target gene categories and connected unconnected lines
79475view12:31, 23 March 2015RiannefijtenModified description
78726view12:08, 20 January 2015Bart SmeetsModified title
78725view12:06, 20 January 2015Bart SmeetsModified title
78560view10:31, 7 January 2015MaintBotadded missing graphIds
78182view10:37, 10 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
ABCC5GeneProductENSG00000114770 (Ensembl)
ADH7GeneProductENSG00000196344 (Ensembl)
AGERGeneProductENSG00000204305 (Ensembl)
ALDH3A1GeneProductENSG00000108602 (Ensembl)
BLVRBGeneProductENSG00000090013 (Ensembl)
CBR1GeneProductENSG00000159228 (Ensembl)
CBR3GeneProductENSG00000159231 (Ensembl)
CES1GeneProductENSG00000198848 (Ensembl)
CES2GeneProductENSG00000172831 (Ensembl)
CES3GeneProductENSG00000172828 (Ensembl)
CES4AGeneProductENSG00000172824 (Ensembl)
CES5AGeneProductENSG00000159398 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP4A11GeneProductENSG00000187048 (Ensembl)
DNAJB1GeneProductENSG00000132002 (Ensembl)
EGR1GeneProductENSG00000120738 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
EPHA3GeneProductENSG00000044524 (Ensembl)
FGF13GeneProductENSG00000129682 (Ensembl)
FTH1GeneProductENSG00000167996 (Ensembl)
FTLGeneProductENSG00000087086 (Ensembl)
G6PDGeneProductENSG00000160211 (Ensembl)
GCLCGeneProductENSG00000001084 (Ensembl)
GCLMGeneProductENSG00000023909 (Ensembl)
GGT1GeneProductENSG00000100031 (Ensembl)
GPX2GeneProductENSG00000176153 (Ensembl)
GPX3GeneProductENSG00000211445 (Ensembl)
GSRGeneProductENSG00000104687 (Ensembl)
GSTA1GeneProductENSG00000243955 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
GSTA3GeneProductENSG00000174156 (Ensembl)
GSTA4GeneProductENSG00000170899 (Ensembl)
GSTA5GeneProductENSG00000182793 (Ensembl)
GSTM1GeneProductENSG00000134184 (Ensembl)
GSTM2GeneProductENSG00000213366 (Ensembl)
GSTM3GeneProductENSG00000134202 (Ensembl)
GSTM4GeneProductENSG00000168765 (Ensembl)
GSTM5GeneProductENSG00000134201 (Ensembl)
GSTP1GeneProductENSG00000084207 (Ensembl)
GSTT1GeneProductENSG00000277656 (Ensembl)
GSTT2GeneProductENSG00000099984 (Ensembl)
HBEGFGeneProductENSG00000113070 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
HMOX1GeneProductENSG00000100292 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
HSP90AB1GeneProductENSG00000096384 (Ensembl)
HSPA1AGeneProductENSG00000204389 (Ensembl)
KEAP1GeneProductENSG00000079999 (Ensembl)
LigandMetaboliteCHEBI:48705 (ChEBI)
MAFFGeneProductENSG00000185022 (Ensembl)
MAFGGeneProductENSG00000197063 (Ensembl)
ME1GeneProductENSG00000065833 (Ensembl)
MGST2GeneProductENSG00000085871 (Ensembl)
MGST3GeneProductENSG00000143198 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
NRG1GeneProductENSG00000157168 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PGDGeneProductENSG00000142657 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PRDX1GeneProductENSG00000117450 (Ensembl)
PRDX6GeneProductENSG00000117592 (Ensembl)
PTGR1GeneProductENSG00000106853 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
SERPINA1GeneProductENSG00000197249 (Ensembl)
SLC2A10GeneProductENSG00000197496 (Ensembl)
SLC2A11GeneProductENSG00000133460 (Ensembl)
SLC2A12GeneProductENSG00000146411 (Ensembl)
SLC2A13GeneProductENSG00000151229 (Ensembl)
SLC2A14GeneProductENSG00000173262 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
SLC2A3GeneProductENSG00000059804 (Ensembl)
SLC2A4GeneProductENSG00000181856 (Ensembl)
SLC2A5GeneProductENSG00000142583 (Ensembl)
SLC2A6GeneProductENSG00000160326 (Ensembl)
SLC2A7GeneProductENSG00000197241 (Ensembl)
SLC2A8GeneProductENSG00000136856 (Ensembl)
SLC2A9GeneProductENSG00000109667 (Ensembl)
SLC39A10GeneProductENSG00000196950 (Ensembl)
SLC39A11GeneProductENSG00000133195 (Ensembl)
SLC39A12GeneProductENSG00000148482 (Ensembl)
SLC39A13GeneProductENSG00000165915 (Ensembl)
SLC39A14GeneProductENSG00000104635 (Ensembl)
SLC39A1GeneProductENSG00000143570 (Ensembl)
SLC39A2GeneProductENSG00000165794 (Ensembl)
SLC39A3GeneProductENSG00000141873 (Ensembl)
SLC39A4GeneProductENSG00000147804 (Ensembl)
SLC39A5GeneProductENSG00000139540 (Ensembl)
SLC39A6GeneProductENSG00000141424 (Ensembl)
SLC39A7GeneProductENSG00000112473 (Ensembl)
SLC39A8GeneProductENSG00000138821 (Ensembl)
SLC39A9GeneProductENSG00000029364 (Ensembl)
SLC5A10GeneProductENSG00000154025 (Ensembl)
SLC5A11GeneProductENSG00000158865 (Ensembl)
SLC5A12GeneProductENSG00000148942 (Ensembl)
SLC5A1GeneProductENSG00000100170 (Ensembl)
SLC5A2GeneProductENSG00000140675 (Ensembl)
SLC5A3GeneProductENSG00000198743 (Ensembl)
SLC5A4GeneProductENSG00000100191 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLC5A6GeneProductENSG00000138074 (Ensembl)
SLC5A7GeneProductENSG00000115665 (Ensembl)
SLC5A8GeneProductENSG00000256870 (Ensembl)
SLC5A9GeneProductENSG00000117834 (Ensembl)
SLC6A11GeneProductENSG00000132164 (Ensembl)
SLC6A13GeneProductENSG00000010379 (Ensembl)
SLC6A14GeneProductENSG00000268104 (Ensembl)
SLC6A15GeneProductENSG00000072041 (Ensembl)
SLC6A16GeneProductENSG00000063127 (Ensembl)
SLC6A17GeneProductENSG00000197106 (Ensembl)
SLC6A18GeneProductENSG00000164363 (Ensembl)
SLC6A19GeneProductENSG00000174358 (Ensembl)
SLC6A1GeneProductENSG00000157103 (Ensembl)
SLC6A20GeneProductENSG00000163817 (Ensembl)
SLC6A2GeneProductENSG00000103546 (Ensembl)
SLC6A3GeneProductENSG00000142319 (Ensembl)
SLC6A4GeneProductENSG00000108576 (Ensembl)
SLC6A5GeneProductENSG00000165970 (Ensembl)
SLC6A6GeneProductENSG00000131389 (Ensembl)
SLC6A7GeneProductENSG00000011083 (Ensembl)
SLC6A8GeneProductENSG00000130821 (Ensembl)
SLC6A9GeneProductENSG00000196517 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SOD3GeneProductENSG00000109610 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
SRXN1GeneProductENSG00000271303 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNRD1GeneProductENSG00000198431 (Ensembl)
TXNRD3GeneProductENSG00000197763 (Ensembl)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A7GeneProductENSG00000244122 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
UGT2B7GeneProductENSG00000171234 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2884"
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