Pregnane X receptor pathway (Homo sapiens)

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11, 12, 48Phase 2 metabolismOtherDrug and steroid metabolismTranscriptionMulti-drug resistanceLigandNCOA2NCOA3SRCPSMC5HSP90AA1NR1I2NRIP1UnknownPPARGC1ARXRASRPX229NR1I2LigandHSP90AA1CoregulatorsGenesTATA boxXRERXRANR1I2LigandDNAJC7DNAJC7CYP3A7UGT1A622UGT1A34343UGT1A943CYP2A622UGT1A443PXR target genes8, 10SLCO1B18SRPX2NCOA3FOXO1CYP4F1241CYP3A48UGT1A122ABCC488NRIP1CYP2B6GSTA222PSMC58PPARGC1ANCOA1NCOA2ABCB18CoregulatorsCYP2C922CYP3A522CYP2C19SULT2A122ABCC21337ABCC337


Description

The Pregnane X receptor (PXR, a.k.a. NR1I2) is a nuclear receptor whose primary function is sensing xenobiotics. It regulates the gene expression of genes that encode proteins involved in detoxification and clearance of xenobiotics. This pathway is part the CPTAC Assay Portal.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
124933view13:31, 1 January 2023EgonwRemoved biopax duplication
124932view13:30, 1 January 2023EgonwOntology Term : 'signaling pathway' added !
124931view13:30, 1 January 2023EgonwOntology Term : 'PW:0001229' removed !
116466view10:07, 7 May 2021EweitzModified title
110712view14:51, 28 May 2020Fehrhartremoved unknown node
106535view00:00, 6 September 2019KhanspersModified description
105789view19:47, 15 August 2019KhanspersModified description
94905view23:29, 12 October 2017Khanspersremoving empty comment
94792view23:02, 5 October 2017AlexanderPicoConverted lines
94782view22:31, 5 October 2017AlexanderPicoConverted lines
88344view16:04, 1 August 2016FehrhartOntology Term : 'xenobiotic metabolic pathway' added !
79556view12:58, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79537view14:56, 24 March 2015RiannefijtenModified description
79536view14:54, 24 March 2015Riannefijtenchanged pathway nodes to labels
79535view14:52, 24 March 2015Riannefijtenadded reference, fixed unconnected lines
79479view12:49, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for pregnane X receptor agonist.
78484view10:28, 7 January 2015MaintBotadded missing graphIds
78257view22:19, 17 December 2014KhanspersModified title
78218view15:07, 14 December 2014MaintBotUpdated the GPML schema.
78217view15:06, 14 December 2014MaintBotModified title
78089view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB1GeneProductENSG00000085563 (Ensembl)
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP3A5GeneProductENSG00000106258 (Ensembl)
CYP3A7GeneProductENSG00000160870 (Ensembl)
CYP4F12GeneProductENSG00000186204 (Ensembl)
DNAJC7GeneProductENSG00000168259 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
LigandMetaboliteCHEBI:77318 (ChEBI)
NCOA1GeneProductENSG00000084676 (Ensembl)
NCOA2GeneProductENSG00000140396 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NR1I2GeneProductENSG00000144852 (Ensembl)
NRIP1GeneProductENSG00000180530 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PSMC5GeneProductENSG00000087191 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
SLCO1B1GeneProductENSG00000134538 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
SRPX2GeneProductENSG00000102359 (Ensembl)
SULT2A1GeneProductENSG00000105398 (Ensembl)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
Unknown

Annotated Interactions

No annotated interactions

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