ACE inhibitor pathway (Bos taurus)

From WikiPathways

Revision as of 11:48, 16 August 2019 by MaintBot (Talk | contribs)
Jump to: navigation, search
188EDHFBlood vesselsZona glomerulosa of the adrenal glandMesangial cells aroundblood vessels in the kidneysAGTACE InhibitorACEAGTR1TFsAngiotensin IIAngiotensin IRENCTSGACEAldosteroneAng 1-5TGFB1CMA1ProstacyclinBradykininCa++NOS3DeoxycorticosteroneNR3C2Ang 1-9MAS1CYP11B2BDKRB1TFsATP6AP2BDKRB2AGTR2ACE2KNG1Ang 1-7843744, 63910ACEACE2


Description

The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP554_96328 with a 90.0% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia
  2. Athyros VG, Mikhailidis DP, Kakafika AI, Tziomalos K, Karagiannis A; ''Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?''; Expert Opin Pharmacother, 2007 PubMed Europe PMC Scholia
  3. Ferreira AJ, Raizada MK; ''Are we poised to target ACE2 for the next generation of antihypertensives?''; J Mol Med, 2008 PubMed Europe PMC Scholia
  4. Bassett MH, White PC, Rainey WE; ''The regulation of aldosterone synthase expression.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC Scholia
  5. McDowell SE, Coleman JJ, Ferner RE; ''Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.''; BMJ, 2006 PubMed Europe PMC Scholia
  6. Maron BA, Leopold JA; ''Mineralocorticoid receptor antagonists and endothelial function.''; Curr Opin Investig Drugs, 2008 PubMed Europe PMC Scholia
  7. Batenburg WW, Jan Danser AH; ''The (pro)renin receptor: a new addition to the renin-angiotensin system?''; Eur J Pharmacol, 2008 PubMed Europe PMC Scholia
  8. Weir MR; ''Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?''; Clin Ther, 2007 PubMed Europe PMC Scholia
  9. Schwartz GL, Turner ST; ''Pharmacogenetics of antihypertensive drug responses.''; Am J Pharmacogenomics, 2004 PubMed Europe PMC Scholia
  10. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W; ''Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.''; Kidney Int, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117471view10:58, 21 May 2021EweitzModified title
105956view11:48, 16 August 2019MaintBotHMDB identifier normalization
96331view09:34, 8 March 2018Mkutmonremove redundant ontology tag
96330view09:34, 8 March 2018MkutmonOntology Term : 'angiotensin signaling pathway' added !
96329view09:33, 8 March 2018MkutmonUpdated homology conversion
80846view15:28, 30 June 2015Mkutmonhomology conversion
79145view05:51, 5 March 2015KhanspersModified title
79144view05:42, 5 March 2015KhanspersUpdated conversion from Hs
71401view19:00, 17 October 2013MaintBotAutomated update of data sources
67016view09:53, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
63332view21:13, 9 May 2013MaintBotUpdated to 2013 gpml schema
57076view20:11, 20 January 2013Egonw
40511view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
35048view09:36, 11 February 2010Thomasremoved genmapp notes (invalid link)
35040view09:29, 11 February 2010ThomasModified description
33754view23:59, 8 December 2009MaintBotAutomatic update of empty xrefs
31672view11:42, 14 August 2009MaintBotFixed group labels
30602view22:16, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorMetaboliteCHEBI:35457 (ChEBI)
ACE2GeneProductENSBTAG00000034402 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:59272
ACEGeneProductENSBTAG00000024950 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1636
AGTGeneProductENSBTAG00000012393 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:183
AGTR1GeneProductENSBTAG00000045633 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:185
AGTR2GeneProductENSBTAG00000040386 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:186
ATP6AP2GeneProductENSBTAG00000017801 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10159
AldosteroneMetaboliteHMDB0000037 (HMDB)
Ang 1-5MetaboliteC15852 (KEGG Compound)
Ang 1-7Metabolite110354 (Chemspider)
Ang 1-9MetaboliteC15851 (KEGG Compound)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
BDKRB1GeneProductENSBTAG00000007052 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:623
BDKRB2GeneProductENSBTAG00000021717 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:624
BradykininMetaboliteHMDB0004246 (HMDB)
CMA1GeneProductENSBTAG00000027033 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1215
CTSGGeneProductENSBTAG00000013234 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1511
CYP11B2GeneProductENSBTAG00000037824 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1585
Ca++MetaboliteHMDB0000464 (HMDB)
DeoxycorticosteroneMetaboliteHMDB0000016 (HMDB)
KNG1GeneProductENSBTAG00000005122 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3827
MAS1GeneProductENSBTAG00000031724 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4142
NOS3GeneProductENSBTAG00000017680 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4846
NR3C2GeneProductENSBTAG00000027182 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4306
ProstacyclinMetabolite114805 (PubChem-compound)
RENGeneProductENSBTAG00000021333 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5972
TFsGeneProduct
TGFB1GeneProductENSBTAG00000020457 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7040

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1033"
Personal tools