miRNA biogenesis (Bos taurus)
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Mature sequence hsa-miR-146a-5p
Accession: MIMAT0000449
Previous: hsa-miR-146;hsa-miR-146a
Mature sequence hsa-miR-146a-3p
Accession: MIMAT0004608
Previous: hsa-miR-146a*
Stem-loop sequence hsa-mir-146a
Accession: MI0000477
Previous: hsa-mir-146
1, 2
pre-miRNA
Transcription
Nucleus
RAN
XPO5
RNA polymerase II
DROSHA
pri-miRNAs
GTP
DICER1
DGCR8
Cytoplasm
DICER1
TARBP2
miRNA duplex
DNA
pre-miRNA
5'
3'
5'
3'
5'
3'
3'
5'
5'
3'
5'
3'
Description
microRNA biogenesis + an example of a miRBase entry.
As an example immature hsa-mir-146a is shown
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP2338(78504)
with a 77.0% conversion rate.
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Bibliography
Wienholds E, Plasterk RH; ''MicroRNA function in animal development.''; FEBS Lett, 2005
PubMed
Europe PMC
Scholia
Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC, Lai EC; ''Widespread regulatory activity of vertebrate microRNA* species.''; RNA, 2011
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
117554
view
11:18, 21 May 2021
Eweitz
Modified title
106016
view
11:54, 16 August 2019
MaintBot
HMDB identifier normalization
80701
view
15:22, 30 June 2015
Mkutmon
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
DGCR8
GeneProduct
ENSBTAG00000019869 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128191
DICER1
GeneProduct
ENSBTAG00000012852 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100697
DROSHA
GeneProduct
ENSBTAG00000017551 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113360
GTP
Metabolite
HMDB0001440 (HMDB)
RAN
GeneProduct
ENSBTAG00000014223 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5901
RNA polymerase II
Protein
TARBP2
Protein
ENSBTAG00000000435 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15633
XPO5
GeneProduct
ENSBTAG00000018970 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124571
pri-miRNAs
Protein
Annotated Interactions
No annotated interactions
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